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Entry version 128 (13 Feb 2019)
Sequence version 1 (01 Jun 1994)
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Protein

EST/SMG-like protein 2

Gene

ESL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the regulation of gene expression responses of environment-sensing pathways.1 Publication

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32059-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EST/SMG-like protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESL21 Publication
Ordered Locus Names:YKR096WImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YKR096W

Saccharomyces Genome Database

More...
SGDi
S000001804 ESL2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus, Peroxisome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002032291 – 1195EST/SMG-like protein 2Add BLAST1195

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P36168

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36168

PRoteomics IDEntifications database

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PRIDEi
P36168

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36168

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Transiently interacts with PEX14.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34227, 163 interactors

Database of interacting proteins

More...
DIPi
DIP-1929N

Protein interaction database and analysis system

More...
IntActi
P36168, 6 interactors

Molecular INTeraction database

More...
MINTi
P36168

STRING: functional protein association networks

More...
STRINGi
4932.YKR096W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P36168

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P36168

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1025 – 1164PINcSequence analysisAdd BLAST140

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi210 – 250Asn-richAdd BLAST41

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176784

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000142087

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P36168

Identification of Orthologs from Complete Genome Data

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OMAi
EVWKCWG

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002716 PIN_dom
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13638 PIN_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00670 PINc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36168-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPETSVQNPL RLSENENTRS MFLSASQQQR PSATPSFPRL VRNTTANLSL
60 70 80 90 100
SDFQVLNPSS KRQNSNSVYD DINSSKRRIS RPRFSDIEGK NNDHTYPERT
110 120 130 140 150
TVKESEKNPS PRYVSSSKRA LKRENSVGIT QSSALISKSF SENGGSIAHE
160 170 180 190 200
KWSPENMIKP LNVSQNSLAF VDAGSDEQSK SEIVGGFQRK SNNSQEINDK
210 220 230 240 250
DNSARDQDFN NSGNNNNNNN HSSNNNDNNN NNNDDNNNNN NSNSRDNNNN
260 270 280 290 300
SDDSNEREEN DSCKPASNKR SGIALIQKLQ ELYKVIVKQE IELQERCSQL
310 320 330 340 350
TNSQTTELKS LWTIYKINTD LVNNYVTFIT TALLPSQPPH DLVIGQEIVE
360 370 380 390 400
IYRIERRLWV YGTITFLDVL KNFSNFMDPE VCCQFITHVF VSLSTMISDI
410 420 430 440 450
PSKYSITWLQ RLGDLSRMAI ALYPSSFIDW KLSAEHWYTE AMKYIYNHGK
460 470 480 490 500
LYYHMSTVQQ NTLEAFVNLG KSVFCQETFT PSPQYMQLVI DNIYQRAFVE
510 520 530 540 550
RNNGNLRNSL LIEYLKHSEA MLLPSFLESP DLQNVVLSYF IEKFGIDANG
560 570 580 590 600
CNIFNAEDMF VQNPDFFKYF FRHGPSFAQS HILQIVGFGE PKNPFAILFE
610 620 630 640 650
LPKYLKERKD KKERKKSSNN DSSVTESSTG NSRNDNEDDD EIMSSTTSIS
660 670 680 690 700
DHDLLAEFFN DIDTLRRPIL PSMLTNEAWL ETLKFLNMTS LKCGIIVLRK
710 720 730 740 750
FLHGPLGIAL PHILPWIYFI ISICLKSSQL SDPVSKEFWM IIVKRAFPWD
760 770 780 790 800
TMVTFMNVLI VYLLDNQTSN SIIGDLCDDY DKLSLSELLE LFNEGEELPE
810 820 830 840 850
ILGCWGTLWF DTICEKNTHS ISSEDNFQEI GIKDYMALDS PTDGIIFDEK
860 870 880 890 900
DENGEKFWKR ACRTIFLFRE LSRSFPIGVI IRNDPLIYRS SFQNTNILGS
910 920 930 940 950
LVFKLEPLCN IHNNIPVLGA LESIIDISEA RSENNTDLHA VPELSVNEGD
960 970 980 990 1000
NIFHYVGYKK LRADYTCFDK NGEFLSASLY TTWYVPNSNN TNIEDNINYN
1010 1020 1030 1040 1050
SEKENEGLFL ECIKSDYPEI DFKTTYFVFD ATSWLRHSAR IFKLAQNRLL
1060 1070 1080 1090 1100
RFAICLTTFQ ELRFLRKSKD ENVMEAATRG IITIRQLYYE NKVLPLRFTG
1110 1120 1130 1140 1150
NVATHIEENL EFEEQITWRT HVDEFVIESV MKAQEKLESA SEPRLSPRRF
1160 1170 1180 1190
NYVVLISDDD AMKKKAEEKE IKTLSTRFVF SLCTKLGEQR HLCTD
Length:1,195
Mass (Da):137,491
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7251DED6B523622
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z28321 Genomic DNA Translation: CAA82176.1
BK006944 Genomic DNA Translation: DAA09247.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S38174

NCBI Reference Sequences

More...
RefSeqi
NP_013022.1, NM_001179886.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKR096W_mRNA; YKR096W_mRNA; YKR096W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853971

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKR096W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28321 Genomic DNA Translation: CAA82176.1
BK006944 Genomic DNA Translation: DAA09247.1
PIRiS38174
RefSeqiNP_013022.1, NM_001179886.1

3D structure databases

ProteinModelPortaliP36168
SMRiP36168
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34227, 163 interactors
DIPiDIP-1929N
IntActiP36168, 6 interactors
MINTiP36168
STRINGi4932.YKR096W

PTM databases

iPTMnetiP36168

Proteomic databases

MaxQBiP36168
PaxDbiP36168
PRIDEiP36168

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR096W_mRNA; YKR096W_mRNA; YKR096W
GeneIDi853971
KEGGisce:YKR096W

Organism-specific databases

EuPathDBiFungiDB:YKR096W
SGDiS000001804 ESL2

Phylogenomic databases

GeneTreeiENSGT00940000176784
HOGENOMiHOG000142087
InParanoidiP36168
OMAiEVWKCWG

Enzyme and pathway databases

BioCyciYEAST:G3O-32059-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P36168

Family and domain databases

InterProiView protein in InterPro
IPR002716 PIN_dom
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13638 PIN_4, 1 hit
SMARTiView protein in SMART
SM00670 PINc, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESL2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36168
Secondary accession number(s): D6VXF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 13, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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