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UniProtKB - P36150 (SUMT_YEAST)

Entry version 159 (07 Oct 2020)
Sequence version 1 (01 Jun 1994)
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Protein

Uroporphyrinogen-III C-methyltransferase

Gene

MET1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Siroheme synthase involved in methionine biosynthesis.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:G3O-32035-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen III methylase
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name:
UROM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MET1
Synonyms:MET20
Ordered Locus Names:YKR069W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:YKR069W

Saccharomyces Genome Database

More...SGDi		S000001777, MET1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001503871 – 593Uroporphyrinogen-III C-methyltransferaseAdd BLAST593

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P36150

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P36150

PRoteomics IDEntifications database

More...PRIDEi		P36150

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P36150

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		34200, 42 interactors

Database of interacting proteins

More...DIPi		DIP-4843N

Protein interaction database and analysis system

More...IntActi		P36150, 2 interactors

Molecular INTeraction database

More...MINTi		P36150

STRING: functional protein association networks

More...STRINGi		4932.YKR069W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P36150, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the precorrin methyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1527, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011276_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P36150

KEGG Orthology (KO)

More...KOi		K00589

Identification of Orthologs from Complete Genome Data

More...OMAi		HQQLAWF

Family and domain databases

Conserved Domains Database

More...CDDi		cd11642, SUMT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.950.10, 1 hit
3.40.1010.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000878, 4pyrrol_Mease
IPR035996, 4pyrrol_Methylase_sf
IPR014777, 4pyrrole_Mease_sub1
IPR014776, 4pyrrole_Mease_sub2
IPR006366, CobA/CysG_C
IPR012066, Met1_fungi
IPR003043, Uropor_MeTrfase_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00590, TP_methylase, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036555, SUMT_yeast, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53790, SSF53790, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00839, SUMT_1, 1 hit
PS00840, SUMT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36150-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRDLVTLPS SLPLITAGFA TDQVHLLIGT GSTDSVSVCK NRIHSILNAG 
        60         70         80         90        100
GNPIVVNPSS PSHTKQLQLE FGKFAKFEIV EREFRLSDLT TLGRVLVCKV 
       110        120        130        140        150
VDRVFVDLPI TQSRLCEEIF WQCQKLRIPI NTFHKPEFST FNMIPTWVDP 
       160        170        180        190        200
KGSGLQISVT TNGNGYILAN RIKRDIISHL PPNISEVVIN MGYLKDRIIN 
       210        220        230        240        250
EDHKALLEEK YYQTDMSLPG FGYGLDEDGW ESHKFNKLIR EFEMTSREQR 
       260        270        280        290        300
LKRTRWLSQI MEYYPMNKLS DIKLEDFETS SSPNKKTKQE TVTEGVVPPT 
       310        320        330        340        350
DENIENGTKQ LQLSEVKKEE GPKKLGKISL VGSGPGSVSM LTIGALQEIK 
       360        370        380        390        400
SADIILADKL VPQAILDLIP PKTETFIAKK FPGNAERAQQ ELLAKGLESL 
       410        420        430        440        450
DNGLKVVRLK QGDPYIFGRG GEEFNFFKDH GYIPVVLPGI SSSLACTVLA 
       460        470        480        490        500
QIPATQRDIA DQVLICTGTG RKGALPIIPE FVESRTTVFL MALHRANVLI 
       510        520        530        540        550
TGLLKHGWDG DVPAAIVERG SCPDQRVTRT LLKWVPEVVE EIGSRPPGVL 
       560        570        580        590 
VVGKAVNALV EKDLINFDES RKFVIDEGFR EFEVDVDSLF KLY
Length:593
Mass (Da):66,125
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C704866B08C0C6D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z28294 Genomic DNA Translation: CAA82148.1
BK006944 Genomic DNA Translation: DAA09220.1

Protein sequence database of the Protein Information Resource

More...PIRi		S38145

NCBI Reference Sequences

More...RefSeqi		NP_012995.3, NM_001179859.3

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YKR069W_mRNA; YKR069W; YKR069W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		853943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YKR069W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28294 Genomic DNA Translation: CAA82148.1
BK006944 Genomic DNA Translation: DAA09220.1
PIRiS38145
RefSeqiNP_012995.3, NM_001179859.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi34200, 42 interactors
DIPiDIP-4843N
IntActiP36150, 2 interactors
MINTiP36150
STRINGi4932.YKR069W

PTM databases

iPTMnetiP36150

Proteomic databases

MaxQBiP36150
PaxDbiP36150
PRIDEiP36150

Genome annotation databases

EnsemblFungiiYKR069W_mRNA; YKR069W; YKR069W
GeneIDi853943
KEGGisce:YKR069W

Organism-specific databases

EuPathDBiFungiDB:YKR069W
SGDiS000001777, MET1

Phylogenomic databases

eggNOGiKOG1527, Eukaryota
HOGENOMiCLU_011276_2_2_1
InParanoidiP36150
KOiK00589
OMAiHQQLAWF

Enzyme and pathway databases

BioCyciMetaCyc:G3O-32035-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P36150
RNActiP36150, protein

Family and domain databases

CDDicd11642, SUMT, 1 hit
Gene3Di3.30.950.10, 1 hit
3.40.1010.10, 1 hit
InterProiView protein in InterPro
IPR000878, 4pyrrol_Mease
IPR035996, 4pyrrol_Methylase_sf
IPR014777, 4pyrrole_Mease_sub1
IPR014776, 4pyrrole_Mease_sub2
IPR006366, CobA/CysG_C
IPR012066, Met1_fungi
IPR003043, Uropor_MeTrfase_CS
PfamiView protein in Pfam
PF00590, TP_methylase, 1 hit
PIRSFiPIRSF036555, SUMT_yeast, 1 hit
SUPFAMiSSF53790, SSF53790, 1 hit
PROSITEiView protein in PROSITE
PS00839, SUMT_1, 1 hit
PS00840, SUMT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUMT_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36150
Secondary accession number(s): D6VXD0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 7, 2020
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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