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UniProtKB - P36150 (SUMT_YEAST)
Protein
Uroporphyrinogen-III C-methyltransferase
Gene
MET1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Siroheme synthase involved in methionine biosynthesis.
2 PublicationsCatalytic activityi
- 2 S-adenosyl-L-methionine + uroporphyrinogen III = H+ + precorrin-2 + 2 S-adenosyl-L-homocysteine1 PublicationEC:2.1.1.1071 Publication
GO - Molecular functioni
- uroporphyrin-III C-methyltransferase activity Source: SGD
GO - Biological processi
- methionine biosynthetic process Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
- siroheme biosynthetic process Source: SGD
- sulfate assimilation Source: InterPro
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | Amino-acid biosynthesis, Methionine biosynthesis, Porphyrin biosynthesis |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Uroporphyrinogen-III C-methyltransferase1 Publication (EC:2.1.1.1071 Publication)Short name: Urogen III methylase1 Publication Alternative name(s): SUMT Uroporphyrinogen III methylase Short name: UROM |
Gene namesi | Ordered Locus Names:YKR069W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001777, MET1 |
VEuPathDBi | FungiDB:YKR069W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150387 | 1 – 593 | Uroporphyrinogen-III C-methyltransferaseAdd BLAST | 593 |
Proteomic databases
MaxQBi | P36150 |
PaxDbi | P36150 |
PRIDEi | P36150 |
PTM databases
iPTMneti | P36150 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34200, 42 interactors |
DIPi | DIP-4843N |
IntActi | P36150, 2 interactors |
MINTi | P36150 |
STRINGi | 4932.YKR069W |
Miscellaneous databases
RNActi | P36150, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 278 – 303 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the precorrin methyltransferase family.Curated
Phylogenomic databases
eggNOGi | KOG1527, Eukaryota |
HOGENOMi | CLU_011276_2_2_1 |
InParanoidi | P36150 |
OMAi | KMTVVVY |
Family and domain databases
CDDi | cd11642, SUMT, 1 hit |
Gene3Di | 3.30.950.10, 1 hit 3.40.1010.10, 1 hit |
InterProi | View protein in InterPro IPR000878, 4pyrrol_Mease IPR035996, 4pyrrol_Methylase_sf IPR014777, 4pyrrole_Mease_sub1 IPR014776, 4pyrrole_Mease_sub2 IPR006366, CobA/CysG_C IPR012066, Met1_fungi IPR003043, Uropor_MeTrfase_CS |
Pfami | View protein in Pfam PF00590, TP_methylase, 1 hit |
PIRSFi | PIRSF036555, SUMT_yeast, 1 hit |
SUPFAMi | SSF53790, SSF53790, 1 hit |
PROSITEi | View protein in PROSITE PS00839, SUMT_1, 1 hit PS00840, SUMT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P36150-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRDLVTLPS SLPLITAGFA TDQVHLLIGT GSTDSVSVCK NRIHSILNAG
60 70 80 90 100
GNPIVVNPSS PSHTKQLQLE FGKFAKFEIV EREFRLSDLT TLGRVLVCKV
110 120 130 140 150
VDRVFVDLPI TQSRLCEEIF WQCQKLRIPI NTFHKPEFST FNMIPTWVDP
160 170 180 190 200
KGSGLQISVT TNGNGYILAN RIKRDIISHL PPNISEVVIN MGYLKDRIIN
210 220 230 240 250
EDHKALLEEK YYQTDMSLPG FGYGLDEDGW ESHKFNKLIR EFEMTSREQR
260 270 280 290 300
LKRTRWLSQI MEYYPMNKLS DIKLEDFETS SSPNKKTKQE TVTEGVVPPT
310 320 330 340 350
DENIENGTKQ LQLSEVKKEE GPKKLGKISL VGSGPGSVSM LTIGALQEIK
360 370 380 390 400
SADIILADKL VPQAILDLIP PKTETFIAKK FPGNAERAQQ ELLAKGLESL
410 420 430 440 450
DNGLKVVRLK QGDPYIFGRG GEEFNFFKDH GYIPVVLPGI SSSLACTVLA
460 470 480 490 500
QIPATQRDIA DQVLICTGTG RKGALPIIPE FVESRTTVFL MALHRANVLI
510 520 530 540 550
TGLLKHGWDG DVPAAIVERG SCPDQRVTRT LLKWVPEVVE EIGSRPPGVL
560 570 580 590
VVGKAVNALV EKDLINFDES RKFVIDEGFR EFEVDVDSLF KLY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28294 Genomic DNA Translation: CAA82148.1 BK006944 Genomic DNA Translation: DAA09220.1 |
PIRi | S38145 |
RefSeqi | NP_012995.3, NM_001179859.3 |
Genome annotation databases
EnsemblFungii | YKR069W_mRNA; YKR069W; YKR069W |
GeneIDi | 853943 |
KEGGi | sce:YKR069W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28294 Genomic DNA Translation: CAA82148.1 BK006944 Genomic DNA Translation: DAA09220.1 |
PIRi | S38145 |
RefSeqi | NP_012995.3, NM_001179859.3 |
3D structure databases
AlphaFoldDBi | P36150 |
SMRi | P36150 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34200, 42 interactors |
DIPi | DIP-4843N |
IntActi | P36150, 2 interactors |
MINTi | P36150 |
STRINGi | 4932.YKR069W |
PTM databases
iPTMneti | P36150 |
Proteomic databases
MaxQBi | P36150 |
PaxDbi | P36150 |
PRIDEi | P36150 |
Genome annotation databases
EnsemblFungii | YKR069W_mRNA; YKR069W; YKR069W |
GeneIDi | 853943 |
KEGGi | sce:YKR069W |
Organism-specific databases
SGDi | S000001777, MET1 |
VEuPathDBi | FungiDB:YKR069W |
Phylogenomic databases
eggNOGi | KOG1527, Eukaryota |
HOGENOMi | CLU_011276_2_2_1 |
InParanoidi | P36150 |
OMAi | KMTVVVY |
Miscellaneous databases
PROi | PR:P36150 |
RNActi | P36150, protein |
Family and domain databases
CDDi | cd11642, SUMT, 1 hit |
Gene3Di | 3.30.950.10, 1 hit 3.40.1010.10, 1 hit |
InterProi | View protein in InterPro IPR000878, 4pyrrol_Mease IPR035996, 4pyrrol_Methylase_sf IPR014777, 4pyrrole_Mease_sub1 IPR014776, 4pyrrole_Mease_sub2 IPR006366, CobA/CysG_C IPR012066, Met1_fungi IPR003043, Uropor_MeTrfase_CS |
Pfami | View protein in Pfam PF00590, TP_methylase, 1 hit |
PIRSFi | PIRSF036555, SUMT_yeast, 1 hit |
SUPFAMi | SSF53790, SSF53790, 1 hit |
PROSITEi | View protein in PROSITE PS00839, SUMT_1, 1 hit PS00840, SUMT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SUMT_YEAST | |
Accessioni | P36150Primary (citable) accession number: P36150 Secondary accession number(s): D6VXD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - SIMILARITY comments
Index of protein domains and families