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Protein

Trafficking protein particle complex subunit BET3

Gene

BET3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.5 Publications

Miscellaneous

Present with 2370 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

Keywordsi

Biological processAutophagy, ER-Golgi transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32034-MONOMER
ReactomeiR-SCE-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit BET3
Short name:
TRAPP subunit BET3
Alternative name(s):
Transport protein particle 22 kDa subunit
Gene namesi
Name:BET3
Ordered Locus Names:YKR068C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR068C
SGDiS000001776 BET3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi80C → S: Loss of palmitoylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115781 – 193Trafficking protein particle complex subunit BET3Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi80S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiP36149
PaxDbiP36149
PRIDEiP36149

PTM databases

SwissPalmiP36149

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi34199, 492 interactors
ComplexPortaliCPX-1383 TRAPPIII protein complex
CPX-1939 TRAPPII protein complex
CPX-1940 TRAPPI protein complex
DIPiDIP-1710N
IntActiP36149, 27 interactors
MINTiP36149
STRINGi4932.YKR068C

Structurei

3D structure databases

ProteinModelPortaliP36149
SMRiP36149
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP36149

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003880
HOGENOMiHOG000186184
InParanoidiP36149
KOiK20302
OMAiGLWFSNV
OrthoDBiEOG092C4STP

Family and domain databases

CDDicd14942 TRAPPC3_bet3, 1 hit
InterProiView protein in InterPro
IPR016721 Bet3
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
PANTHERiPTHR13048 PTHR13048, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
PIRSFiPIRSF018293 TRAPP_I_complex_Bet3, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

Sequencei

Sequence statusi: Complete.

P36149-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSTTQSRSL KAMGEEIWKN KTEKINTELF TLTYGSIVAQ LCQDYERDFN
60 70 80 90 100
KVNDHLYSMG YNIGCRLIED FLARTALPRC ENLVKTSEVL SKCAFKIFLN
110 120 130 140 150
ITPNITNWSH NKDTFSLILD ENPLADFVEL PMDAMKSLWY SNILCGVLKG
160 170 180 190
SLEMVQLDCD VWFVSDILRG DSQTEIKVKL NRILKDEIPI GED
Length:193
Mass (Da):22,129
Last modified:June 1, 1994 - v1
Checksum:iC802D8A3563DE82B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28293 Genomic DNA Translation: CAA82147.1
AY557896 Genomic DNA Translation: AAS56222.1
BK006944 Genomic DNA Translation: DAA09219.1
PIRiS38144
RefSeqiNP_012994.1, NM_001179858.1

Genome annotation databases

EnsemblFungiiYKR068C; YKR068C; YKR068C
GeneIDi853942
KEGGisce:YKR068C

Similar proteinsi

Entry informationi

Entry nameiBET3_YEAST
AccessioniPrimary (citable) accession number: P36149
Secondary accession number(s): D6VXC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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