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UniProtKB - P36147 (PAM17_YEAST)
Protein
Presequence translocated-associated motor subunit PAM17, mitochondrial
Gene
PAM17
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to organize PAM16-PAM18 (TIM16-TIM14) heterodimer.
1 PublicationMiscellaneous
Present with 3000 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- intracellular protein transport Source: ComplexPortal
- protein import into mitochondrial matrix Source: SGD
Keywordsi
Biological process | Protein transport, Translocation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Presequence translocated-associated motor subunit PAM17, mitochondrial |
Gene namesi | Name:PAM17 Synonyms:FMP18 Ordered Locus Names:YKR065C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001773, PAM17 |
VEuPathDBi | FungiDB:YKR065C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane Curated; Multi-pass membrane protein Curated
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrion Source: SGD
- PAM complex, Tim23 associated import motor Source: SGD
- TIM23 mitochondrial import inner membrane translocase complex Source: ComplexPortal
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 14 | MitochondrionSequence analysisAdd BLAST | 14 | |
ChainiPRO_0000043179 | 15 – 197 | Presequence translocated-associated motor subunit PAM17, mitochondrialAdd BLAST | 183 |
Proteomic databases
MaxQBi | P36147 |
PaxDbi | P36147 |
PRIDEi | P36147 |
PTM databases
iPTMneti | P36147 |
Interactioni
Subunit structurei
Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18/TIM14.
1 PublicationProtein-protein interaction databases
BioGRIDi | 34196, 267 interactors |
ComplexPortali | CPX-539, TIM23 mitochondrial inner membrane pre-sequence translocase complex, motor variant |
DIPi | DIP-2128N |
IntActi | P36147, 5 interactors |
MINTi | P36147 |
STRINGi | 4932.YKR065C |
Miscellaneous databases
RNActi | P36147, protein |
Structurei
3D structure databases
AlphaFoldDBi | P36147 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the PAM17 family.Curated
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S1B1, Eukaryota |
HOGENOMi | CLU_068297_2_0_1 |
InParanoidi | P36147 |
OMAi | YKPSVNT |
Family and domain databases
InterProi | View protein in InterPro IPR013875, Pam17 |
PANTHERi | PTHR28021, PTHR28021, 1 hit |
Pfami | View protein in Pfam PF08566, Pam17, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P36147-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFTSAIRLSS QRLFASQPSV TAAALRSTAT TLPLRSYSQP ASLQDSSILT
60 70 80 90 100
WSDFFKLRKQ QRRINVGSSL FTALLGCNVS WAYLSTMEID PTQMLFGFDP
110 120 130 140 150
LTVISAGIIA SGALGYLLGP IVGSQVFKLS HNQQLAQFNN KNKEFLKHII
160 170 180 190
NNRVDASSQS FSNPVPDYYG EKIGSLKEYK QWLRDCHAYA KKAKEFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28290 Genomic DNA Translation: CAA82144.1 BK006944 Genomic DNA Translation: DAA09216.1 |
PIRi | S38141 |
RefSeqi | NP_012991.3, NM_001179855.3 |
Genome annotation databases
EnsemblFungii | YKR065C_mRNA; YKR065C; YKR065C |
GeneIDi | 853939 |
KEGGi | sce:YKR065C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28290 Genomic DNA Translation: CAA82144.1 BK006944 Genomic DNA Translation: DAA09216.1 |
PIRi | S38141 |
RefSeqi | NP_012991.3, NM_001179855.3 |
3D structure databases
AlphaFoldDBi | P36147 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 34196, 267 interactors |
ComplexPortali | CPX-539, TIM23 mitochondrial inner membrane pre-sequence translocase complex, motor variant |
DIPi | DIP-2128N |
IntActi | P36147, 5 interactors |
MINTi | P36147 |
STRINGi | 4932.YKR065C |
PTM databases
iPTMneti | P36147 |
Proteomic databases
MaxQBi | P36147 |
PaxDbi | P36147 |
PRIDEi | P36147 |
Genome annotation databases
EnsemblFungii | YKR065C_mRNA; YKR065C; YKR065C |
GeneIDi | 853939 |
KEGGi | sce:YKR065C |
Organism-specific databases
SGDi | S000001773, PAM17 |
VEuPathDBi | FungiDB:YKR065C |
Phylogenomic databases
eggNOGi | ENOG502S1B1, Eukaryota |
HOGENOMi | CLU_068297_2_0_1 |
InParanoidi | P36147 |
OMAi | YKPSVNT |
Miscellaneous databases
PROi | PR:P36147 |
RNActi | P36147, protein |
Family and domain databases
InterProi | View protein in InterPro IPR013875, Pam17 |
PANTHERi | PTHR28021, PTHR28021, 1 hit |
Pfami | View protein in Pfam PF08566, Pam17, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PAM17_YEAST | |
Accessioni | P36147Primary (citable) accession number: P36147 Secondary accession number(s): D6VXC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - SIMILARITY comments
Index of protein domains and families