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UniProtKB - P36124 (SET3_YEAST)
Protein
SET domain-containing protein 3
Gene
SET3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity.
1 PublicationMiscellaneous
Present with 623 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 117 – 166 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- methylated histone binding Source: SGD
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- histone deacetylation Source: SGD
- meiotic cell cycle Source: UniProtKB-KW
- negative regulation of meiotic nuclear division Source: ComplexPortal
- protein methylation Source: SGD
- regulation of transcription, DNA-templated Source: SGD
Keywordsi
Molecular function | Activator, Chromatin regulator, Repressor |
Biological process | Meiosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-SCE-3214841, PKMTs methylate histone lysines |
Names & Taxonomyi
Protein namesi | Recommended name: SET domain-containing protein 3 |
Gene namesi | Name:SET3 Ordered Locus Names:YKR029C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001737, SET3 |
VEuPathDBi | FungiDB:YKR029C |
Subcellular locationi
Nucleus
- nucleus Source: ComplexPortal
- Rpd3L-Expanded complex Source: SGD
- Set3 complex Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097696 | 1 – 751 | SET domain-containing protein 3Add BLAST | 751 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 236 | PhosphoserineCombined sources | 1 | |
Modified residuei | 684 | PhosphoserineCombined sources | 1 | |
Modified residuei | 718 | PhosphoserineCombined sources | 1 | |
Modified residuei | 719 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 741 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P36124 |
PaxDbi | P36124 |
PRIDEi | P36124 |
PTM databases
iPTMneti | P36124 |
Interactioni
Subunit structurei
Identified in the Set3C complex with HOS2, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W.
1 PublicationBinary interactionsi
P36124
With | #Exp. | IntAct |
---|---|---|
HHF2 [P02309] | 2 | EBI-16993,EBI-8113 |
HHT2 [P61830] | 2 | EBI-16993,EBI-8098 |
GO - Molecular functioni
- methylated histone binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 34162, 433 interactors |
ComplexPortali | CPX-1342, SET3C histone deacetylase complex |
DIPi | DIP-5632N |
IntActi | P36124, 125 interactors |
MINTi | P36124 |
STRINGi | 4932.YKR029C |
Miscellaneous databases
RNActi | P36124, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P36124 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 313 – 456 | SETPROSITE-ProRule annotationAdd BLAST | 144 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 52 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 79 – 105 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 181 – 258 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 662 – 738 | DisorderedSequence analysisAdd BLAST | 77 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 79 – 103 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 182 – 220 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 221 – 238 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 239 – 256 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 678 – 694 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 703 – 738 | Polar residuesSequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the SET3 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 117 – 166 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1844, Eukaryota |
GeneTreei | ENSGT00940000168747 |
HOGENOMi | CLU_017047_0_0_1 |
InParanoidi | P36124 |
OMAi | WQHAICY |
Family and domain databases
CDDi | cd19183, SET_SpSET3-like, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR044435, Set3/4_SET IPR001214, SET_dom IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00628, PHD, 1 hit PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P36124-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVPNSKEQS LLDDASTLLL FSKGKKRAEE ASKIGSKTDT IEHDESHERE
60 70 80 90 100
KKGAIEMAAA ALATASTVSL PLKKATEQSA AEAATSTAAK EETENQPQKQ
110 120 130 140 150
PQWPVPDSYI VDPDAGIITC ICDLNDDDGF TIQCDHCNRW QHAICYGIKD
160 170 180 190 200
IGMAPDDYLC NSCDPREVDI NLARKIQQER INVKTVEPSS SNNSASNKNN
210 220 230 240 250
GRDRASSTTI SDVGDSFSTD QDNTNHRDKR RKRNPSNNSI DSKNESASVN
260 270 280 290 300
SSDGLTSMPK KKEHFLSAKD AYGAIYLPLK DNVFKSDLIE PFLNKHMDDN
310 320 330 340 350
WVIQYPHKTF KSVSIEVKPY ADIAYSRTYP GFTKLGVYLK KDCIKGDFIQ
360 370 380 390 400
EILGELDFYK NYLTDPRNHY RIWGTAKRRV IFHSHWPIYI DARLSGNSTR
410 420 430 440 450
YLRRSCQPNV ELVTIKLQDT DNRNDKSSGR KSSRIKFVLR ALRDISEDEE
460 470 480 490 500
LYIKWQWDSK HPILKLIKGM TIDSLDDLER YGLINSVETI LSNGECGCGN
510 520 530 540 550
NSKDCYLLKV KRYAQSLYKS VKSRGKMNNR YKLNEILNQY NCKKRREPPI
560 570 580 590 600
LHRLEEKAQN TIERAPILLN NFYRQKFLNR NNGPKIPQKN TIDSTNNPDD
610 620 630 640 650
IAKPFKFALF AQHSSNISVP KKNETSEKPL IITKSTDYDE SHITNIEELP
660 670 680 690 700
IPVLLPINKT SRQTANDVEE SQSKNEHKLS RTPSLSNFNK ELSKEAQHSQ
710 720 730 740 750
AKTKEIMTEA SVNSRRESTP ESIMHLSDFS SSQLHSKKKL SFADYRKKLL
K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28254 Genomic DNA Translation: CAA82101.1 BK006944 Genomic DNA Translation: DAA09184.1 |
PIRi | S38101 |
RefSeqi | NP_012954.3, NM_001179819.3 |
Genome annotation databases
EnsemblFungii | YKR029C_mRNA; YKR029C; YKR029C |
GeneIDi | 853900 |
KEGGi | sce:YKR029C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28254 Genomic DNA Translation: CAA82101.1 BK006944 Genomic DNA Translation: DAA09184.1 |
PIRi | S38101 |
RefSeqi | NP_012954.3, NM_001179819.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5TDR | X-ray | 1.42 | A | 116-184 | [»] | |
5TDW | X-ray | 1.70 | A | 116-184 | [»] | |
SMRi | P36124 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34162, 433 interactors |
ComplexPortali | CPX-1342, SET3C histone deacetylase complex |
DIPi | DIP-5632N |
IntActi | P36124, 125 interactors |
MINTi | P36124 |
STRINGi | 4932.YKR029C |
PTM databases
iPTMneti | P36124 |
Proteomic databases
MaxQBi | P36124 |
PaxDbi | P36124 |
PRIDEi | P36124 |
Genome annotation databases
EnsemblFungii | YKR029C_mRNA; YKR029C; YKR029C |
GeneIDi | 853900 |
KEGGi | sce:YKR029C |
Organism-specific databases
SGDi | S000001737, SET3 |
VEuPathDBi | FungiDB:YKR029C |
Phylogenomic databases
eggNOGi | KOG1844, Eukaryota |
GeneTreei | ENSGT00940000168747 |
HOGENOMi | CLU_017047_0_0_1 |
InParanoidi | P36124 |
OMAi | WQHAICY |
Enzyme and pathway databases
Reactomei | R-SCE-3214841, PKMTs methylate histone lysines |
Miscellaneous databases
PROi | PR:P36124 |
RNActi | P36124, protein |
Family and domain databases
CDDi | cd19183, SET_SpSET3-like, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR044435, Set3/4_SET IPR001214, SET_dom IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00628, PHD, 1 hit PF00856, SET, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SET3_YEAST | |
Accessioni | P36124Primary (citable) accession number: P36124 Secondary accession number(s): D6VX94 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families