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Protein

IML2-like protein YKR018C

Gene

YKR018C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 1770 molecules/cell in log phase SD medium.1 Publication

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
YEAST:G3O-31994-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IML2-like protein YKR018C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:YKR018C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001726 YKR018C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002031981 – 725IML2-like protein YKR018CAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei196PhosphothreonineCombined sources1
Modified residuei246PhosphoserineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P36114

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P36114

PRoteomics IDEntifications database

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PRIDEi
P36114

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P36114

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
34150, 136 interactors

Database of interacting proteins

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DIPi
DIP-6636N

Protein interaction database and analysis system

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IntActi
P36114, 2 interactors

STRING: functional protein association networks

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STRINGi
4932.YKR018C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P36114

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P36114

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P36114

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IML2 family.Curated

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000176789

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000066085

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P36114

Identification of Orthologs from Complete Genome Data

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OMAi
FWNGHSR

Database of Orthologous Groups

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OrthoDBi
EOG092C0XWM

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019412 Iml2/TPR_39
IPR011990 TPR-like_helical_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR31859 PTHR31859, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF10300 DUF3808, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36114-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKVFGFGAK EEIPELSQEE KTKAILKQAH DFEQALRAMD YVLDDNADEG
60 70 80 90 100
LALLDESDAK EASDQTINAL ARGVIEFLEA TLGFEAEEMK KASATLAKAE
110 120 130 140 150
ALSLKSRERA QKIGLKSSSL YPPGTVYAVT YTESCLLHAL LMIFSESMME
160 170 180 190 200
AAKAILKLRK SYYMLQEILE TIKAANKAKK LKITSGSEDK ESTPATFITG
210 220 230 240 250
GDAFNSVDIP YELTPEEQKD KDLLQFAEQI HSMRTERLSG AHIGNSPAIN
260 270 280 290 300
RLRGELGLQA MEDLPEEEIT DHKVLSDDID LSQATIDEFV HSGVNLCFGI
310 320 330 340 350
LQVVISLLPP AIGAVLSVVG FRGSREEGLR LVWKATKQRN VHGCIGLLAL
360 370 380 390 400
MFYYDGPFQF TDDDFDIPAA VKDSSNSEDS EDEEMDGPTL LHPGKILEDA
410 420 430 440 450
LLQSRALFPN SALWLLNEAR MLSGKGRLEE AVALMDSIDV SKIRMRQVKS
460 470 480 490 500
LMIFDRAITL IHLHQYDRAA EDILSLLDIS DWSHAFYTYF AGCCYLENWR
510 520 530 540 550
MCEMGLMKSD KKDEYQKKAE ELIFTSVNLL GKKTFKSKNL PLDRFILRKV
560 570 580 590 600
EQFKAKKEEL GVENPLDGIA TSPVHEIAYF YNGYNRMSEE HLELTKKMLT
610 620 630 640 650
EYRNPAIEAL DSDQELIKDL LVSLTLRRLG HIQEGCDILD EKVLPKFFSI
660 670 680 690 700
QNGKVKYIKK TEDPWAYPTA LYERALFTWK LEGMDGLPES KEWLLRAQGY
710 720
ADDYELSTRV GMKIKAAIDR VDHSL
Length:725
Mass (Da):81,754
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2B91BAF52337043
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z28243 Genomic DNA Translation: CAA82090.1
BK006944 Genomic DNA Translation: DAA09173.1

Protein sequence database of the Protein Information Resource

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PIRi
S38087

NCBI Reference Sequences

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RefSeqi
NP_012943.1, NM_001179808.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YKR018C_mRNA; YKR018C_mRNA; YKR018C

Database of genes from NCBI RefSeq genomes

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GeneIDi
853888

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
sce:YKR018C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28243 Genomic DNA Translation: CAA82090.1
BK006944 Genomic DNA Translation: DAA09173.1
PIRiS38087
RefSeqiNP_012943.1, NM_001179808.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PYOX-ray1.65E/F54-57[»]
3EDRX-ray2.45E/F54-57[»]
ProteinModelPortaliP36114
SMRiP36114
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34150, 136 interactors
DIPiDIP-6636N
IntActiP36114, 2 interactors
STRINGi4932.YKR018C

PTM databases

iPTMnetiP36114

Proteomic databases

MaxQBiP36114
PaxDbiP36114
PRIDEiP36114

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKR018C_mRNA; YKR018C_mRNA; YKR018C
GeneIDi853888
KEGGisce:YKR018C

Organism-specific databases

SGDiS000001726 YKR018C

Phylogenomic databases

GeneTreeiENSGT00940000176789
HOGENOMiHOG000066085
InParanoidiP36114
OMAiFWNGHSR
OrthoDBiEOG092C0XWM

Enzyme and pathway databases

BioCyciYEAST:G3O-31994-MONOMER

Miscellaneous databases

EvolutionaryTraceiP36114

Protein Ontology

More...
PROi
PR:P36114

Family and domain databases

InterProiView protein in InterPro
IPR019412 Iml2/TPR_39
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR31859 PTHR31859, 1 hit
PfamiView protein in Pfam
PF10300 DUF3808, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYKR18_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36114
Secondary accession number(s): D6VX83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 5, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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