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Protein

Splicing factor MUD2

Gene

MUD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Splicing factor that contacts pre-mRNA directly and is a component of the pre-mRNA-U1 snRNP complex (commitment complex 2) that forms during early spliceosome assembly in yeast extracts.1 Publication

Miscellaneous

Present with 4170 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • pre-mRNA branch point binding Source: SGD

GO - Biological processi

  • mRNA branch site recognition Source: SGD

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-31870-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor MUD2
Gene namesi
Name:MUD2
Ordered Locus Names:YKL074C
ORF Names:YKL358
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL074C
SGDiS000001557 MUD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816541 – 527Splicing factor MUD2Add BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP36084
PaxDbiP36084
PRIDEiP36084

PTM databases

iPTMnetiP36084

Interactioni

Subunit structurei

MSL5, MUD2 and PRP40 interact to form the commitment complex 2 (CC2), a precursor of mature spliceosomes.

Binary interactionsi

WithEntry#Exp.IntActNotes
MSL5Q121865EBI-11612,EBI-34012

Protein-protein interaction databases

BioGridi34057, 358 interactors
ComplexPortaliCPX-1417 BBP-MUD2 branchpoint-binding complex
DIPiDIP-758N
IntActiP36084, 11 interactors
MINTiP36084
STRINGi4932.YKL074C

Structurei

3D structure databases

ProteinModelPortaliP36084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini424 – 511RRMAdd BLAST88

Phylogenomic databases

InParanoidiP36084
KOiK12837
OMAiDYRINID
OrthoDBiEOG092C1ST8

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR003954 RRM_dom_euk
SMARTiView protein in SMART
SM00361 RRM_1, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

Sequencei

Sequence statusi: Complete.

P36084-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEKRLEDL RSKIMESIGK SEKDVVPIEN KRFNTDNAVI DTHFKRQKSD
60 70 80 90 100
GELPKAPKSR NVSHSNNRGP SSIITMSTNR TTYEQTRAGP HRQSYRDASG
110 120 130 140 150
RSYNRENRYS SHNTGPQWNN NPYNRQRDER RGRNERFDRR GRNGNGNYDR
160 170 180 190 200
FNYQRKNEGS KFNGDRDKRQ LQTNKYDMNY NSQNVMYPGS SFDSPAYYNM
210 220 230 240 250
ASSKANSRLV ISGLSQSSDP SIVARLKDLL ENFISGLQKT ESNAEDFKIS
260 270 280 290 300
NFYIGEGRPD HIIVEFSSQI CSTMVLACRS FFNAKLGTFD LKWRRPNDYV
310 320 330 340 350
QQLDHLVDFC RGTVIALENL ENIGEGEDYR MKELFSSLNV TNGTAKPLFY
360 370 380 390 400
KCSSNTNNTG KESEFTKCIL LSFEVVTQDI LDKLKPYKWF KPNDGKISQV
410 420 430 440 450
TSWITFQSLP NLVTQSVRVE SRVLLLLNCL DPLDLKDETF ITEIKETLKY
460 470 480 490 500
SIAGADTIKI CQPGVDYRLN FENLASGAGN IYIKFKTLEA AKHAMEELPG
510 520
TQFNDRTVLC TYIDEDDFDM MEATQLS
Length:527
Mass (Da):60,460
Last modified:August 16, 2004 - v3
Checksum:i884427AB57A12E12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98A → R in AAA64215 (PubMed:7926772).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22449 Genomic DNA Translation: AAA64215.1
X75780 Genomic DNA Translation: CAA53400.1
Z28074 Genomic DNA Translation: CAA81911.1
BK006944 Genomic DNA Translation: DAA09082.1
PIRiS37899
RefSeqiNP_012849.1, NM_001179640.1

Genome annotation databases

EnsemblFungiiYKL074C; YKL074C; YKL074C
GeneIDi853788
KEGGisce:YKL074C

Similar proteinsi

Entry informationi

Entry nameiMUD2_YEAST
AccessioniPrimary (citable) accession number: P36084
Secondary accession number(s): D6VXL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 16, 2004
Last modified: September 12, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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