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Entry version 132 (02 Jun 2021)
Sequence version 1 (01 Jun 1994)
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Protein

PMA1 stabilization in the Golgi protein 1

Gene

PSG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

With EXP1, the specific cargo receptor protein for the plasma membrane ATPase PMA1, is involved in the transport and/or maturation of PMA1 (PubMed:28727280).

EXP1 and PSG1 probably act sequentially to promote PMA1 sorting between the ER and the Golgi, with EXP1 promoting PMA1 export from the ER to the Golgi while PSG1 has a role in PMA1 maturation or quality control in the Golgi (PubMed:28727280).

PSG1 might also couple PMA1 sorting and maturation in the early secretory pathway with the glycosylation machinery (Probable).

1 Publication1 Publication

PSG1 is cleaved by KEX2 in two stable peptides, PSG1-N' and PSG1-C', the former supporting a role in maturation quality control, the latter having a role in modulating vesicular trafficking.

1 Publication

Miscellaneous

Present with 606 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PMA1 stabilization in the Golgi protein 11 Publication
Cleaved into the following 2 chains:
PSG1-N'1 Publication
PSG1-C'1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSG11 Publication
Ordered Locus Names:YKL077W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001560, YKL077W

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YKL077W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini230 – 317Lumenal1 PublicationAdd BLAST88
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 392Cytoplasmic1 PublicationAdd BLAST54

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to enhanced degradation of PMA1 in the vacuole.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020316823 – 392PMA1 stabilization in the Golgi protein 1Add BLAST370
ChainiPRO_000044853523 – 229PSG1-N'1 PublicationAdd BLAST207
ChainiPRO_0000448536230 – 392PSG1-C'1 PublicationAdd BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34O-linked (Man) threonine1 Publication1
Glycosylationi35O-linked (Man) threonine1 Publication1
Glycosylationi36O-linked (Man) serine1 Publication1
Glycosylationi45O-linked (Man) threonine1 Publication1
Glycosylationi49O-linked (Man) serine1 Publication1
Glycosylationi55O-linked (Man) threonine1 Publication1
Glycosylationi57O-linked (Man) threonine1 Publication1
Glycosylationi63O-linked (Man) threonine1 Publication1
Glycosylationi65O-linked (Man) serine1 Publication1
Glycosylationi71O-linked (Man) threonine1 Publication1
Glycosylationi80O-linked (Man) serine1 Publication1
Glycosylationi89O-linked (Man) threonine1 Publication1
Glycosylationi99O-linked (Man) threonine1 Publication1
Glycosylationi107O-linked (Man) serine1 Publication1
Glycosylationi108O-linked (Man) threonine1 Publication1
Glycosylationi112O-linked (Man) threonine1 Publication1
Glycosylationi114O-linked (Man) serine1 Publication1
Glycosylationi115O-linked (Man) serine1 Publication1
Glycosylationi117O-linked (Man) threonine1 Publication1
Glycosylationi119O-linked (Man) serine1 Publication1
Glycosylationi148O-linked (Man) serine1 Publication1
Glycosylationi156O-linked (Man) threonine1 Publication1
Glycosylationi171O-linked (Man) serine1 Publication1
Glycosylationi176O-linked (Man) threonine1 Publication1
Glycosylationi181O-linked (Man) serine1 Publication1
Glycosylationi188O-linked (Man) threonine1 Publication1
Glycosylationi192O-linked (Man) threonine1 Publication1
Glycosylationi195O-linked (Man) threonine1 Publication1
Glycosylationi199O-linked (Man) threonine1 Publication1
Glycosylationi203O-linked (Man) serine1 Publication1
Glycosylationi215O-linked (Man) serine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor protein is cleaved into two polypeptide chains, PSG1-N' and PSG1-C'. The cleavage is performed in the Golgi apparatus by Ca+-dependent serine protease KEX2 between Arg-229 and Asp-230.2 Publications
PSG1-N' is highly O-mannosylated.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei229 – 230Cleavage; by KEX22 Publications2

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P36081

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36081

PRoteomics IDEntifications database

More...
PRIDEi
P36081

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P36081

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36081

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EXP1 (PubMed:28727280). PSG1-N' interacts with ERAD-related proteins involved in PMA1 quality control including EPS1, CDC48, UBX2 and SSM4 (PubMed:28727280). PSG1-C' interacts with the TLG1/2 SNARE complex proteins TLG1, TLG2 and VTI1 (PubMed:28727280).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34055, 215 interactors

Database of interacting proteins

More...
DIPi
DIP-5003N

Protein interaction database and analysis system

More...
IntActi
P36081, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YKL077W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P36081, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVDR, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041040_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36081

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHITEWV

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028000, Pma1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14610, Psg1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P36081-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFHDSILIF FSLASLYQHV HGARQVVRPK EKMTTSEEVK PWLRTVYGSQ
60 70 80 90 100
KELVTPTVIA GVTFSEKPEE TPNPLKPWVS LEHDGRPKTI KPEINKGRTK
110 120 130 140 150
KGRPDYSTYF KTVSSHTYSY EELKAHNMGP NEVFVEEEYI DEDDTYVSLN
160 170 180 190 200
PIVRCTPNLY FNKGLAKDIR SEPFCTPYEN SRWKVDKTYF VTWYTRFFTD
210 220 230 240 250
ENSGKVADKV RVHLSYVKEN PVEKGNYKRD IPATFFSSEW IDNDNGLMPV
260 270 280 290 300
EVRDEWLQDQ FDRRIVVSVQ PIYISDEDFD PLQYGILLYI TKGSKVFKPT
310 320 330 340 350
KEQLALDDAG ITNDQWYYVA LSIPTVVVVF FVFMYFFLYV NGKNRDFTDV
360 370 380 390
TRKALNKKRR VLGKFSEMKK FKNMKNHKYT ELPSYKKTSK QN
Length:392
Mass (Da):46,036
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EEC795903D5D540
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z28077 Genomic DNA Translation: CAA81914.1
BK006944 Genomic DNA Translation: DAA09080.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S37902

NCBI Reference Sequences

More...
RefSeqi
NP_012846.1, NM_001179643.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL077W_mRNA; YKL077W; YKL077W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL077W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28077 Genomic DNA Translation: CAA81914.1
BK006944 Genomic DNA Translation: DAA09080.1
PIRiS37902
RefSeqiNP_012846.1, NM_001179643.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi34055, 215 interactors
DIPiDIP-5003N
IntActiP36081, 1 interactor
STRINGi4932.YKL077W

PTM databases

iPTMnetiP36081

Proteomic databases

MaxQBiP36081
PaxDbiP36081
PRIDEiP36081
TopDownProteomicsiP36081

Genome annotation databases

EnsemblFungiiYKL077W_mRNA; YKL077W; YKL077W
GeneIDi853785
KEGGisce:YKL077W

Organism-specific databases

SGDiS000001560, YKL077W
VEuPathDBiFungiDB:YKL077W

Phylogenomic databases

eggNOGiENOG502QVDR, Eukaryota
HOGENOMiCLU_041040_0_0_1
InParanoidiP36081
OMAiFHITEWV

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P36081
RNActiP36081, protein

Family and domain databases

InterProiView protein in InterPro
IPR028000, Pma1
PfamiView protein in Pfam
PF14610, Psg1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSG1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36081
Secondary accession number(s): D6VXL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 2, 2021
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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