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Entry version 157 (12 Aug 2020)
Sequence version 1 (01 Jun 1994)
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Protein

RNA polymerase I-specific transcription initiation factor RRN3

Gene

RRN3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for efficient transcription initiation by RNA polymerase I. Interacts with Pol I in the absence of template DNA and stimulates recruitment of Pol I, but does not remain as part of stable preinitiation complex.

Miscellaneous

Present with 138 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • transcription initiation from RNA polymerase I promoter Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31907-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-73762, RNA Polymerase I Transcription Initiation
R-SCE-73772, RNA Polymerase I Promoter Escape

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA polymerase I-specific transcription initiation factor RRN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RRN3
Ordered Locus Names:YKL125W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YKL125W

Saccharomyces Genome Database

More...
SGDi
S000001608, RRN3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002114301 – 627RNA polymerase I-specific transcription initiation factor RRN3Add BLAST627

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P36070

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36070

PRoteomics IDEntifications database

More...
PRIDEi
P36070

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (Probable).

Interacts with NOP53.

Curated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34011, 157 interactors

Database of interacting proteins

More...
DIPi
DIP-6657N

Protein interaction database and analysis system

More...
IntActi
P36070, 9 interactors

Molecular INTeraction database

More...
MINTi
P36070

STRING: functional protein association networks

More...
STRINGi
4932.YKL125W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P36070, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1627
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P36070

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 259Poly-Asp8
Compositional biasi267 – 274Poly-Asp8
Compositional biasi277 – 280Poly-Asp4
Compositional biasi546 – 549Poly-Asn4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRN3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2434, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010579_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36070

KEGG Orthology (KO)

More...
KOi
K15216

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKHFYAA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007991, RNA_pol_I_trans_ini_fac_RRN3

The PANTHER Classification System

More...
PANTHERi
PTHR12790, PTHR12790, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05327, RRN3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36070-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAFENTSKR PPQDFVAPID QKKRKVQFSD STGLVTLQPE EIKDEVFSAA
60 70 80 90 100
MYSRFVKSAL DDLDKNDSTQ IGIIANQVAL PSKNPERIND KNLNILLDIL
110 120 130 140 150
SSNINRIESS RGTFLIQSII NFEKWWELPP HTLSKYIYFI KILCSSIPKW
160 170 180 190 200
WQDVSMILVS CFILPIKQTV CHHDMLKYFL RMIPSSMGFI DTYLAKFFPN
210 220 230 240 250
KNDTRRKLVN YTSNLLKLRG YCSELGFQIW SLLIEKIISI DVELQNELDE
260 270 280 290 300
LDDDVDDDDL EEVDLEDDDD LDDDSGDDDD ENCGNSNEEL RSGAADGSQS
310 320 330 340 350
DSEDMDIIEG MDGTEEYNVE LTQGIKELST KLDSILTLVS THVEEQVTPE
360 370 380 390 400
SLESGEGVGV FNTLTTLFKT HVLPTYYTRS IQYIMFHVSQ QQLELMDSFL
410 420 430 440 450
VTLIDISFAV NEAAEKKIKS LQYLGSYIAR AKKLSRTQII FVASYLTSWL
460 470 480 490 500
NRYVIEREEE VDQRGGMERF KHFYAAFQAL CYIFCFRHNI FRDTDGNWEC
510 520 530 540 550
ELDKFFQRMV ISKFNPLKFC NENVMLMFAR IAQQESVAYC FSIIENNNNE
560 570 580 590 600
RLRGIIGKAD SDKKENSAQA NTTSSSWSLA TRQQFIDLQS YFPYDPLFLK
610 620
NYKILMKEYY IEWSEASGEY ESDGSDD
Length:627
Mass (Da):72,388
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA31E7386A9873FDB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z71927 Genomic DNA Translation: CAA96470.1
Z28125 Genomic DNA Translation: CAA81966.1
BK006944 Genomic DNA Translation: DAA09036.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S37954

NCBI Reference Sequences

More...
RefSeqi
NP_012797.1, NM_001179691.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL125W_mRNA; YKL125W; YKL125W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853734

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL125W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71927 Genomic DNA Translation: CAA96470.1
Z28125 Genomic DNA Translation: CAA81966.1
BK006944 Genomic DNA Translation: DAA09036.1
PIRiS37954
RefSeqiNP_012797.1, NM_001179691.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TJ1X-ray2.85A/B1-627[»]
5G5Lelectron microscopy4.80O1-627[»]
5N5Yelectron microscopy7.70O1-627[»]
5N5Zelectron microscopy7.70O1-627[»]
5N60electron microscopy7.70O1-627[»]
5N61electron microscopy3.40O1-627[»]
5OA1electron microscopy4.40O1-627[»]
6RQHelectron microscopy3.70O1-627[»]
6RQLelectron microscopy2.90O1-627[»]
6RQTelectron microscopy4.00O1-627[»]
6RRDelectron microscopy3.10O1-627[»]
6RUIelectron microscopy2.70O1-627[»]
6RUOelectron microscopy3.50O1-627[»]
6RWEelectron microscopy3.00O1-627[»]
6TPSelectron microscopy3.54O1-627[»]
SMRiP36070
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi34011, 157 interactors
DIPiDIP-6657N
IntActiP36070, 9 interactors
MINTiP36070
STRINGi4932.YKL125W

Proteomic databases

MaxQBiP36070
PaxDbiP36070
PRIDEiP36070

Genome annotation databases

EnsemblFungiiYKL125W_mRNA; YKL125W; YKL125W
GeneIDi853734
KEGGisce:YKL125W

Organism-specific databases

EuPathDBiFungiDB:YKL125W
SGDiS000001608, RRN3

Phylogenomic databases

eggNOGiKOG2434, Eukaryota
GeneTreeiENSGT00390000001488
HOGENOMiCLU_010579_2_0_1
InParanoidiP36070
KOiK15216
OMAiFKHFYAA

Enzyme and pathway databases

BioCyciYEAST:G3O-31907-MONOMER
ReactomeiR-SCE-73762, RNA Polymerase I Transcription Initiation
R-SCE-73772, RNA Polymerase I Promoter Escape

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P36070
RNActiP36070, protein

Family and domain databases

InterProiView protein in InterPro
IPR007991, RNA_pol_I_trans_ini_fac_RRN3
PANTHERiPTHR12790, PTHR12790, 1 hit
PfamiView protein in Pfam
PF05327, RRN3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRRN3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36070
Secondary accession number(s): D6VX70
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: August 12, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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