UniProtKB - P36056 (RT22_YEAST)
Protein
Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrial
Gene
RSM22
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Probable S-adenosyl-L-methionine-dependent RNA methyltransferase (PubMed:19351663, PubMed:24651469). May provide the activity for methylation of the rRNA of the small mitochondrial subunit, which is required for the assembly and stability of the mitochondrial ribosome (PubMed:22689777). Has no protein methyltransferase activity (PubMed:24651469).2 Publications1 Publication
Miscellaneous
Present with 1900 molecules/cell in log phase SD medium.1 Publication
Although reported constituent of the mitochondrial small ribosomal subunit (PubMed:11278769), it has not been identified in the structure of the yeast mitoribosome (PubMed:28154081), indicating that RSM22 only transiently interacts with the mitoribosome.2 Publications
GO - Molecular functioni
- methyltransferase activity Source: UniProtKB-KW
- structural constituent of ribosome Source: SGD
GO - Biological processi
- methylation Source: UniProtKB-KW
- mitochondrial translation Source: SGD
Keywordsi
Molecular function | Methyltransferase, Ribonucleoprotein, Ribosomal protein, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrial (EC:2.1.1.-) |
Gene namesi | Name:RSM22 Ordered Locus Names:YKL155C ORF Names:YKL610 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YKL155C |
SGDi | S000001638, RSM22 |
Subcellular locationi
Mitochondrion
- Mitochondrion 3 Publications
Mitochondrion
- mitochondrial small ribosomal subunit Source: SGD
- mitochondrion Source: SGD
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 15 | MitochondrionSequence analysisAdd BLAST | 15 | |
ChainiPRO_0000203144 | 16 – 628 | Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrialAdd BLAST | 613 |
Proteomic databases
MaxQBi | P36056 |
PaxDbi | P36056 |
PRIDEi | P36056 |
PTM databases
iPTMneti | P36056 |
Interactioni
Subunit structurei
Associates with mitochondrial ribosomes.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 33982, 91 interactors |
DIPi | DIP-756N |
IntActi | P36056, 7 interactors |
MINTi | P36056 |
STRINGi | 4932.YKL155C |
Miscellaneous databases
RNActi | P36056, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2539, Eukaryota |
GeneTreei | ENSGT00940000175583 |
HOGENOMi | CLU_024759_0_0_1 |
InParanoidi | P36056 |
OMAi | HRKCPLQ |
Family and domain databases
InterProi | View protein in InterPro IPR015324, Ribosomal_Rsm22-like IPR016522, Ribosome_S22_mit_bud IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF09243, Rsm22, 2 hits |
PIRSFi | PIRSF007797, RSM22, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P36056-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMKRCFSILP QNVRFSSKFT SLNLPKLDLA DFIDSNKRGI NVLPSYRDET
60 70 80 90 100
ASTTQATNSK ELRLLSKTLQ GQSYRDQLEL NPDVSKAINN NIMAVHIPNN
110 120 130 140 150
LRRVATNYYK EIQEPNSLHR PCRTKMEVDA HIASIFLQNY GSIFQSLKEL
160 170 180 190 200
QKRVGPDNFK PQRILDVGYG PATGIVALND ILGPNYRPDL KDAVILGNAE
210 220 230 240 250
MQERAKIILS RQLNEVVDTV EENVSTEKEQ ETDRRNKNFQ EDEHIGEVMT
260 270 280 290 300
KKINIMTNLR SSIPASKEYD LIILTHQLLH DGNQFPIQVD ENIEHYLNIL
310 320 330 340 350
APGGHIVIIE RGNPMGFEII ARARQITLRP ENFPDEFGKI PRPWSRGVTV
360 370 380 390 400
RGKKDAELGN ISSNYFLKVI APCPHQRKCP LQVGNPNFYT HKEGKDLKFC
410 420 430 440 450
NFQKSIKRPK FSIELKKGKL LATSWDGSQG NASRLKGTGR RNGRDYEILN
460 470 480 490 500
YSYLIFERSH KDENTLKEIK KLRNENVNGK YDIGSLGDDT QNSWPRIIND
510 520 530 540 550
PVKRKGHVMM DLCAPSGELE KWTVSRSFSK QIYHDARKSK KGDLWASAAK
560 570 580 590 600
TQIKGLGDLN VKKFHKLEKE RIKQLKKEER QKARKAMESY NELEDSLQFD
610 620
DHQFSNFEVM KKLSTFHGND FLQHVNRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26877 Genomic DNA Translation: CAA81498.1 Z28155 Genomic DNA Translation: CAA81996.1 BK006944 Genomic DNA Translation: DAA09009.1 |
PIRi | S37795 |
RefSeqi | NP_012767.1, NM_001179721.1 |
Genome annotation databases
EnsemblFungii | YKL155C_mRNA; YKL155C; YKL155C |
GeneIDi | 853701 |
KEGGi | sce:YKL155C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26877 Genomic DNA Translation: CAA81498.1 Z28155 Genomic DNA Translation: CAA81996.1 BK006944 Genomic DNA Translation: DAA09009.1 |
PIRi | S37795 |
RefSeqi | NP_012767.1, NM_001179721.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33982, 91 interactors |
DIPi | DIP-756N |
IntActi | P36056, 7 interactors |
MINTi | P36056 |
STRINGi | 4932.YKL155C |
PTM databases
iPTMneti | P36056 |
Proteomic databases
MaxQBi | P36056 |
PaxDbi | P36056 |
PRIDEi | P36056 |
Genome annotation databases
EnsemblFungii | YKL155C_mRNA; YKL155C; YKL155C |
GeneIDi | 853701 |
KEGGi | sce:YKL155C |
Organism-specific databases
EuPathDBi | FungiDB:YKL155C |
SGDi | S000001638, RSM22 |
Phylogenomic databases
eggNOGi | KOG2539, Eukaryota |
GeneTreei | ENSGT00940000175583 |
HOGENOMi | CLU_024759_0_0_1 |
InParanoidi | P36056 |
OMAi | HRKCPLQ |
Miscellaneous databases
PROi | PR:P36056 |
RNActi | P36056, protein |
Family and domain databases
InterProi | View protein in InterPro IPR015324, Ribosomal_Rsm22-like IPR016522, Ribosome_S22_mit_bud IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF09243, Rsm22, 2 hits |
PIRSFi | PIRSF007797, RSM22, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RT22_YEAST | |
Accessioni | P36056Primary (citable) accession number: P36056 Secondary accession number(s): D6VX43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | October 7, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD