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Entry version 153 (18 Sep 2019)
Sequence version 2 (15 Dec 1998)
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Protein

Protein MNN4

Gene

MNN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a positive regulator for mannosylphosphate transferase. Is required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • enzyme activator activity Source: SGD

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31961-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MNN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MNN4
Ordered Locus Names:YKL201C
ORF Names:YKL200C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YKL201C

Saccharomyces Genome Database

More...
SGDi
S000001684 MNN4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini49 – 1178LumenalSequence analysisAdd BLAST1130

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000965251 – 1178Protein MNN4Add BLAST1178

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P36044

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P36044

PRoteomics IDEntifications database

More...
PRIDEi
P36044

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33921, 42 interactors

Database of interacting proteins

More...
DIPi
DIP-4199N

Protein interaction database and analysis system

More...
IntActi
P36044, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YKL201C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P36044

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1042 – 104918
Repeati1050 – 105728
Repeati1058 – 106538
Repeati1066 – 107348
Repeati1074 – 108158
Repeati1082 – 108968
Repeati1090 – 10977; approximate8
Repeati1098 – 110588
Repeati1106 – 11139; approximate8
Repeati1114 – 112110; approximate8
Repeati1122 – 112911; approximate8
Repeati1130 – 1137128
Repeati1138 – 114413; approximate7
Repeati1145 – 115214; approximate8
Repeati1153 – 116015; approximate8
Repeati1161 – 116816; approximate8
Repeati1169 – 117417; truncated6

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1042 – 117417 X 8 AA tandem repeats of K-K-K-K-E-E-E-EAdd BLAST133

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 40Poly-Ile4
Compositional biasi1032 – 1174Arg/Glu/Lys-rich (highly charged)Add BLAST143
Compositional biasi1042 – 1045Poly-Lys4
Compositional biasi1046 – 1049Poly-Glu4
Compositional biasi1050 – 1053Poly-Lys4
Compositional biasi1054 – 1057Poly-Glu4
Compositional biasi1058 – 1061Poly-Lys4
Compositional biasi1062 – 1065Poly-Glu4
Compositional biasi1066 – 1069Poly-Lys4
Compositional biasi1070 – 1073Poly-Glu4
Compositional biasi1074 – 1077Poly-Lys4
Compositional biasi1078 – 1081Poly-Glu4
Compositional biasi1082 – 1085Poly-Lys4
Compositional biasi1086 – 1089Poly-Glu4
Compositional biasi1094 – 1097Poly-Glu4
Compositional biasi1098 – 1101Poly-Lys4
Compositional biasi1102 – 1105Poly-Glu4
Compositional biasi1134 – 1137Poly-Glu4
Compositional biasi1157 – 1160Poly-Glu4
Compositional biasi1165 – 1168Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

To yeast YJR061w.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P36044

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVRPEVY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009644 Fukutin-related
IPR007074 LicD_fam

The PANTHER Classification System

More...
PANTHERi
PTHR15407 PTHR15407, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04991 LicD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36044-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQRISSKLH RRFLSGLLRV KHYPLRRILL PLILLQIIII TFIWSNSPQR
60 70 80 90 100
NGLGRDADYL LPNYNELDSD DDSWYSILTS SFKNDRKIQF AKTLYENLKF
110 120 130 140 150
GTNPKWVNEY TLQNDLLSVK MGPRKGSKLE SVDELKFYDF DPRLTWSVVL
160 170 180 190 200
NHLQNNDADQ PEKLPFSWYD WTTFHELNKL ISIDKTVLPC NFLFQSAFDK
210 220 230 240 250
ESLEAIETEL GEPLFLYERP KYAQKLWYKA ARNQDRIKDS KELKKHCSKL
260 270 280 290 300
FTPDGHGSPK GLRFNTQFQI KELYDKVRPE VYQLQARNYI LTTQSHPLSI
310 320 330 340 350
SIIESDNSTY QVPLQTEKSK NLVQSGLLQE YINDNINSTN KRKKNKQDVE
360 370 380 390 400
FNHNRLFQEF VNNDQVNSLY KLEIEETDKF TFDKDLVYLS PSDFKFDASK
410 420 430 440 450
KIEELEEQKK LYPDKFSAHN ENYLNSLKNS VKTSPALQRK FFYEAGAVKQ
460 470 480 490 500
YKGMGFHRDK RFFNVDTLIN DKQEYQARLN SMIRTFQKFT KANGIISWLS
510 520 530 540 550
HGTLYGYLYN GMAFPWDNDF DLQMPIKHLQ LLSQYFNQSL ILEDPRQGNG
560 570 580 590 600
RYFLDVSDSL TVRINGNGKN NIDARFIDVD TGLYIDITGL ASTSAPSRDY
610 620 630 640 650
LNSYIEERLQ EEHLDINNIP ESNGETATLP DKVDDGLVNM ATLNITELRD
660 670 680 690 700
YITSDENKNH KRVPTDTDLK DLLKKELEEL PKSKTIENKL NPKQRYFLNE
710 720 730 740 750
KLKLYNCRNN HFNSFEELSP LINTVFHGVP ALIPHRHTYC LHNEYHVPDR
760 770 780 790 800
YAFDAYKNTA YLPEFRFWFD YDGLKKCSNI NSWYPNIPSI NSWNPNLLKE
810 820 830 840 850
ISSTKFESKL FDSNKVSEYS FKNLSMDDVR LIYKNIPKAG FIEVFTNLYN
860 870 880 890 900
SFNVTAYRQK ELEIQYCQNL TFIEKKKLLH QLRINVAPKL SSPAKDPFLF
910 920 930 940 950
GYEKAMWKDL SKSMNQTTLD QVTKIVHEEY VGKIIDLSES LKYRNFSLFN
960 970 980 990 1000
ITFDETGTTL DDNTEDYTPA NTVEVNPVDF KSNLNFSSNS FLDLNSYGLD
1010 1020 1030 1040 1050
LFAPTLSDVN RKGIQMFDKD PIIVYEDYAY AKLLEERKRR EKKKKEEEEK
1060 1070 1080 1090 1100
KKKEEEEKKK KEEEEKKKKE EEEKKKKEEE EKKKKEEEEK KKQEEEEKKK
1110 1120 1130 1140 1150
KEEEEKKKQE EGEKMKNEDE ENKKNEDEEK KKNEEEEKKK QEEKNKKNED
1160 1170
EEKKKQEEEE KKKNEEEEKK KQEEGHSN
Length:1,178
Mass (Da):139,381
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC05DAE0AEFCB282
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D83006 Genomic DNA Translation: BAA11676.1
Z28201 Genomic DNA Translation: CAA82046.1
Z28200 Genomic DNA Translation: CAA82044.1
BK006944 Genomic DNA Translation: DAA08967.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S78475

NCBI Reference Sequences

More...
RefSeqi
NP_012721.1, NM_001179766.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL201C_mRNA; YKL201C; YKL201C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL201C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83006 Genomic DNA Translation: BAA11676.1
Z28201 Genomic DNA Translation: CAA82046.1
Z28200 Genomic DNA Translation: CAA82044.1
BK006944 Genomic DNA Translation: DAA08967.1
PIRiS78475
RefSeqiNP_012721.1, NM_001179766.1

3D structure databases

SMRiP36044
ModBaseiSearch...

Protein-protein interaction databases

BioGridi33921, 42 interactors
DIPiDIP-4199N
IntActiP36044, 3 interactors
STRINGi4932.YKL201C

Proteomic databases

MaxQBiP36044
PaxDbiP36044
PRIDEiP36044

Genome annotation databases

EnsemblFungiiYKL201C_mRNA; YKL201C; YKL201C
GeneIDi853634
KEGGisce:YKL201C

Organism-specific databases

EuPathDBiFungiDB:YKL201C
SGDiS000001684 MNN4

Phylogenomic databases

HOGENOMiHOG000113617
InParanoidiP36044
OMAiKVRPEVY

Enzyme and pathway databases

BioCyciYEAST:G3O-31961-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P36044

Family and domain databases

InterProiView protein in InterPro
IPR009644 Fukutin-related
IPR007074 LicD_fam
PANTHERiPTHR15407 PTHR15407, 1 hit
PfamiView protein in Pfam
PF04991 LicD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMNN4_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36044
Secondary accession number(s): D6VX01, P36043, P89095
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: September 18, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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