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UniProtKB - P36023 (OAF3_YEAST)
Protein
Oleate activated transcription factor 3
Gene
OAF3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transcriptional inhibitor with a significantly increased number of target genes in response to oleate.
2 PublicationsMiscellaneous
Present with 149 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 18 – 47 | Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST | 30 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: SGD
- zinc ion binding Source: InterPro
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Oleate activated transcription factor 3 |
Gene namesi | Name:OAF3 Ordered Locus Names:YKR064W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001772, OAF3 |
VEuPathDBi | FungiDB:YKR064W |
Subcellular locationi
Mitochondrion
Nucleus
Cytoplasm and Cytosol
Mitochondrion
- mitochondrion Source: SGD
Nucleus
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115002 | 1 – 863 | Oleate activated transcription factor 3Add BLAST | 863 |
Proteomic databases
MaxQBi | P36023 |
PaxDbi | P36023 |
PRIDEi | P36023 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34195, 71 interactors |
DIPi | DIP-2792N |
IntActi | P36023, 4 interactors |
MINTi | P36023 |
STRINGi | 4932.YKR064W |
Miscellaneous databases
RNActi | P36023, protein |
Structurei
3D structure databases
AlphaFoldDBi | P36023 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 52 – 99 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 52 – 69 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 81 – 99 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the OAF3 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQCV, Eukaryota |
GeneTreei | ENSGT00940000176581 |
HOGENOMi | CLU_018684_0_0_1 |
InParanoidi | P36023 |
OMAi | WCAPEDG |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P36023-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGYDSQVRTK KRHRITVVCT NCKKRKSKCD RTKPCGTCVR LGDVDSCVYL
60 70 80 90 100
TDSSGQPESS PSLNDADPLR KQSTPAERIS PGFIKKRRSS QTRQDEDHWQ
110 120 130 140 150
RVRELENQSS LYYLPIHEET PFFIDLIPNG FYLETKRSAD NLFGLFTDRA
160 170 180 190 200
IENRDPYLQA MVTFRSIAIK KMMDKLGSNG NNVKNGSLPK SFEALSTFDA
210 220 230 240 250
DDERHISDDV VGKGNNFRMH QTIHKSLFNK FAQYRENNAK KFSSETILAK
260 270 280 290 300
DYLPPLKILE SEVLALFEEK IYNMIPIFDM KVLRHEITIF YQNIVEKGNP
310 320 330 340 350
ISIKHYDHMV FCIILLIIKI CRLSVQFSKL TPYIYPVLQE IDTSKFLALV
360 370 380 390 400
KHYLFETKVL RKCNLLQLQC LILLRFLHWC APEDGDGPET QYCQILMGTI
410 420 430 440 450
ISSCKEMGIN WYCFSHPEKY SFKINRHTRP SYDIMKPSDY ISVFRKIWSY
460 470 480 490 500
VLFWDRKMCF ISGEECQIGK TLQCHFKEEA DTPTWYIRML TLDNLMKKIN
510 520 530 540 550
DTLNDDPGKV DLNLLHRLIN DLKRNFHILK SLSKNEKETM RHFDFEMEWI
560 570 580 590 600
IDLFSLSLLH GEMIFYEYDC NITKFYKSFQ DLWDMVIHIS EKCYNYFFNS
610 620 630 640 650
DALEVDSLTK FYTNRIVEIV ANKVLVIVPA FILRGDRFKT IQYADKKKMI
660 670 680 690 700
EFLYGVSSVY FNEFGFEYYR CFRKMFTAKI AYKILNRSCE KDAWRIILKF
710 720 730 740 750
LLNELKLEDN GDSYIDYNDM RLNDICPIIL EFQETVQKYD GYRPDILSIW
760 770 780 790 800
NNEFYPIGKY NDDMTGFKFQ MRIKEMQEFL DMEKYSDRFN IFSSFYDHAS
810 820 830 840 850
SQLAKHTEVD TNISITNEQV AEIPQKELLQ QPLAPALPVN DLIVSEFDVI
860
EDIFDPVDFV SFF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28289 Genomic DNA Translation: CAA82143.1 BK006944 Genomic DNA Translation: DAA09215.1 |
PIRi | S38140 |
RefSeqi | NP_012990.1, NM_001179854.1 |
Genome annotation databases
EnsemblFungii | YKR064W_mRNA; YKR064W; YKR064W |
GeneIDi | 853938 |
KEGGi | sce:YKR064W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z28289 Genomic DNA Translation: CAA82143.1 BK006944 Genomic DNA Translation: DAA09215.1 |
PIRi | S38140 |
RefSeqi | NP_012990.1, NM_001179854.1 |
3D structure databases
AlphaFoldDBi | P36023 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 34195, 71 interactors |
DIPi | DIP-2792N |
IntActi | P36023, 4 interactors |
MINTi | P36023 |
STRINGi | 4932.YKR064W |
Proteomic databases
MaxQBi | P36023 |
PaxDbi | P36023 |
PRIDEi | P36023 |
Genome annotation databases
EnsemblFungii | YKR064W_mRNA; YKR064W; YKR064W |
GeneIDi | 853938 |
KEGGi | sce:YKR064W |
Organism-specific databases
SGDi | S000001772, OAF3 |
VEuPathDBi | FungiDB:YKR064W |
Phylogenomic databases
eggNOGi | ENOG502QQCV, Eukaryota |
GeneTreei | ENSGT00940000176581 |
HOGENOMi | CLU_018684_0_0_1 |
InParanoidi | P36023 |
OMAi | WCAPEDG |
Miscellaneous databases
PROi | PR:P36023 |
RNActi | P36023, protein |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OAF3_YEAST | |
Accessioni | P36023Primary (citable) accession number: P36023 Secondary accession number(s): D6VXC5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - SIMILARITY comments
Index of protein domains and families