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Entry version 177 (12 Aug 2020)
Sequence version 1 (01 Jun 1994)
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Protein

Dynein heavy chain, cytoplasmic

Gene

DYN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.1 Publication

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1796 – 1803ATPSequence analysis8
Nucleotide bindingi2074 – 2081ATPSequence analysis8
Nucleotide bindingi2418 – 2425ATPSequence analysis8
Nucleotide bindingi2760 – 2767ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processKaryogamy
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32023-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain, cytoplasmic
Alternative name(s):
Dynein heavy chain, cytosolic
Short name:
DYHC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DYN1
Synonyms:DHC1
Ordered Locus Names:YKR054C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YKR054C

Saccharomyces Genome Database

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SGDi
S000001762, DYN1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146431 – 4092Dynein heavy chain, cytoplasmicAdd BLAST4092

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P36022

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P36022

PRoteomics IDEntifications database

More...
PRIDEi
P36022

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P36022

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The dynein complex consists of at least two heavy chains and a number of intermediate and light chains.

Interacts with DYN3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34185, 349 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1178, Cytoplasmic dynein complex

Database of interacting proteins

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DIPi
DIP-2644N

Protein interaction database and analysis system

More...
IntActi
P36022, 11 interactors

Molecular INTeraction database

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MINTi
P36022

STRING: functional protein association networks

More...
STRINGi
4932.YKR054C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P36022, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14092
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P36022

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1757StemBy similarityAdd BLAST1757
Regioni1758 – 1979AAA 1By similarityAdd BLAST222
Regioni2036 – 2273AAA 2By similarityAdd BLAST238
Regioni2379 – 2628AAA 3By similarityAdd BLAST250
Regioni2722 – 2984AAA 4By similarityAdd BLAST263
Regioni2993 – 3300StalkBy similarityAdd BLAST308
Regioni3370 – 3599AAA 5By similarityAdd BLAST230
Regioni3760 – 3970AAA 6By similarityAdd BLAST211

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili154 – 175Sequence analysisAdd BLAST22
Coiled coili486 – 508Sequence analysisAdd BLAST23
Coiled coili542 – 566Sequence analysisAdd BLAST25
Coiled coili932 – 959Sequence analysisAdd BLAST28
Coiled coili1042 – 1063Sequence analysisAdd BLAST22
Coiled coili1681 – 1705Sequence analysisAdd BLAST25
Coiled coili2993 – 3092Sequence analysisAdd BLAST100
Coiled coili3242 – 3300Sequence analysisAdd BLAST59
Coiled coili3532 – 3608Sequence analysisAdd BLAST77

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3595, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156103

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_7_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P36022

KEGG Orthology (KO)

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KOi
K10413

Identification of Orthologs from Complete Genome Data

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OMAi
FAPDICS

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR10676, PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36022-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCKNEARLAN ELIEFVAATV TGIKNSPKEN EQAFIDYLHC QYLERFQFFL
60 70 80 90 100
GLLDGREFDT LFVFLFEELD RTIVTIDIGE EAIYDANLAN KKYSTLLIIK
110 120 130 140 150
SRSVIVDAEP IATQISAIYL PGPVNAGNLA SIITHGVSSV FGQLIKSDTK
160 170 180 190 200
TYSVETIDKT RRKLDDISKQ FQQLHTSIET PDLLAMVPSI IKLAVSKGAT
210 220 230 240 250
SHDYANYLPS NDLESMRFLN ILQSIANKWF LVLKQTLAID RDIKNGSFLD
260 270 280 290 300
EVEFWSNFYE VLKSLIEQTQ SQEFQVCLSV LTNAKRFHNL TNLLNEGSLS
310 320 330 340 350
DKFKLADKYN QFLSSIPIDE VRQASNLEDL QELFPVLASS LKKFRYSGYP
360 370 380 390 400
VQRFVVLMDK ISQEVMDAIL SNLSDLFQLE YGSFLGLYEK SAGMIEEWDD
410 420 430 440 450
IVQDVNLLIR EDLRKRAPQE LLIQKLTFTS ASVKATLDEI LSTRKRFFSL
460 470 480 490 500
AETIKSISPS TYHEEIQRLY HPFEQIHDIS VNFRLKLEQA ESEFSKNMLD
510 520 530 540 550
LEKKLQNTLA SFMDSDHCPT EKLSYLVKFK PLMELCPRIK VKVLENQQIL
560 570 580 590 600
LLEIKKDIRQ LETGLELLPK ILHVEALNNI PPISARISYF LNVQSRIDNI
610 620 630 640 650
VQYLEALFGS NWNDTLEGRS ISTSIVQLRK ETNPHDVFLH WLGNFPEKAT
660 670 680 690 700
ANLLTTPILK LIRNNEDDYE LKVNFDFALA AAYSELRSLT YMAFQVPSHI
710 720 730 740 750
VRIARTYMYL YPRAINLVEL IQTFFSLSKS LSYTFYTNIF LKRNVQTVWL
760 770 780 790 800
LLQQILITPW ESLQEESSEM SCSVHSLARL EKSIDGILSD YQILKNSEPQ
810 820 830 840 850
FAKEFSGLKS FDGTADDLHE VEEIISNIQA IFENLFTKGL TNVSDHISTF
860 870 880 890 900
NNLIISIILE KVRLNLKKMH FPKHVLKLSF NEGRITSSPS LAAMKRSLLK
910 920 930 940 950
DIEALLNKVV LINFLHDPDH PLSTTLTFNS LVIKLKDDIQ NCIEQVQNLH
960 970 980 990 1000
CKINSYVKEW QKMEFLWQIT EEAFLEVVDN STQRCFGILK GLLDSQSKFD
1010 1020 1030 1040 1050
LIISRNNFSK NLVLHTEDAQ RHIRSKMDSW ILYVSKHLLT IYERDARKLH
1060 1070 1080 1090 1100
EDMNRDREAV EDMDINFTSL KNITVIIEAV NVNKRHLTER DIQIKLLGSV
1110 1120 1130 1140 1150
MRALTKLKVR FPSHFVYIDQ LDNDFSSLRQ SLSYVEQELQ KHRVVIAKSL
1160 1170 1180 1190 1200
EEGVENINNL SQSLNESWSV RKPISPTLTP PEALKILEFF NESITKLKKK
1210 1220 1230 1240 1250
MHSVAAAAKM LLIPVVLNDQ LTHVVEEVKT YDLVWRSIKN LWEDVQRTFE
1260 1270 1280 1290 1300
TPWCRVDVLL LQSDLANFLR RADELPRAVK QFEMYKSLFS QVNMLTSVNK
1310 1320 1330 1340 1350
ILVELKDGAL KPRHWNMIFR DIGKRQIQKN LLDKLEFSLK DVMVLNLTLN
1360 1370 1380 1390 1400
EILLTKIIER AQKEFVIEKS LNRIKKFWKE AQYEVIEHSS GLKLVREWDV
1410 1420 1430 1440 1450
LEQACKEDLE ELVSMKASNY YKIFEQDCLD LESKLTKLSE IQVNWVEVQF
1460 1470 1480 1490 1500
YWLDLYGILG ENLDIQNFLP LETSKFKSLT SEYKMITTRA FQLDTTIEVI
1510 1520 1530 1540 1550
HIPNFDTTLK LTIDSLKMIK SSLSTFLERQ RRQFPRFYFL GNDDLLKIIG
1560 1570 1580 1590 1600
SGKHHDQVSK FMKKMFGSIE SIIFLEDFIT GVRSVEGEVL NLNEKIELKD
1610 1620 1630 1640 1650
SIQAQEWLNI LDTEIKLSVF TQFRDCLGQL KDGTDIEVVV SKYIFQAILL
1660 1670 1680 1690 1700
SAQVMWTELV EKCLQTNQFS KYWKEVDMKI KGLLDKLNKS SDNVKKKIEA
1710 1720 1730 1740 1750
LLVEYLHFNN VIGQLKNCST KEEARLLWAK VQKFYQKNDT LDDLNSVFIS
1760 1770 1780 1790 1800
QSGYLLQYKF EYIGIPERLI YTPLLLIGFA TLTDSLHQKY GGCFFGPAGT
1810 1820 1830 1840 1850
GKTETVKAFG QNLGRVVVVF NCDDSFDYQV LSRLLVGITQ IGAWGCFDEF
1860 1870 1880 1890 1900
NRLDEKVLSA VSANIQQIQN GLQVGKSHIT LLEEETPLSP HTAVFITLNP
1910 1920 1930 1940 1950
GYNGRSELPE NLKKSFREFS MKSPQSGTIA EMILQIMGFE DSKSLASKIV
1960 1970 1980 1990 2000
HFLELLSSKC SSMNHYHFGL RTLKGVLRNC SPLISEFGEG EKTVVESLKR
2010 2020 2030 2040 2050
VILPSLGDTD ELVFKDELSK IFDSAGTPLN SKAIVQCLKD AGQRSGFSMS
2060 2070 2080 2090 2100
EEFLKKCMQF YYMQKTQQAL ILVGKAGCGK TATWKTVIDA MAIFDGHANV
2110 2120 2130 2140 2150
VYVIDTKVLT KESLYGSMLK ATLEWRDGLF TSILRRVNDD ITGTFKNSRI
2160 2170 2180 2190 2200
WVVFDSDLDP EYVEAMNSVL DDNKILTLPN GERLPIPPNF RILFETDNLD
2210 2220 2230 2240 2250
HTTPATITRC GLLWFSTDVC SISSKIDHLL NKSYEALDNK LSMFELDKLK
2260 2270 2280 2290 2300
DLISDSFDMA SLTNIFTCSN DLVHILGVRT FNKLETAVQL AVHLISSYRQ
2310 2320 2330 2340 2350
WFQNLDDKSL KDVITLLIKR SLLYALAGDS TGESQRAFIQ TINTYFGHDS
2360 2370 2380 2390 2400
QELSDYSTIV IANDKLSFSS FCSEIPSVSL EAHEVMRPDI VIPTIDTIKH
2410 2420 2430 2440 2450
EKIFYDLLNS KRGIILCGPP GSGKTMIMNN ALRNSSLYDV VGINFSKDTT
2460 2470 2480 2490 2500
TEHILSALHR HTNYVTTSKG LTLLPKSDIK NLVLFCDEIN LPKLDKYGSQ
2510 2520 2530 2540 2550
NVVLFLRQLM EKQGFWKTPE NKWVTIERIH IVGACNPPTD PGRIPMSERF
2560 2570 2580 2590 2600
TRHAAILYLG YPSGKSLSQI YEIYYKAIFK LVPEFRSYTE PFARASVHLY
2610 2620 2630 2640 2650
NECKARYSTG LQSHYLFSPR ELTRLVRGVY TAINTGPRQT LRSLIRLWAY
2660 2670 2680 2690 2700
EAWRIFADRL VGVKEKNSFE QLLYETVDKY LPNQDLGNIS STSLLFSGLL
2710 2720 2730 2740 2750
SLDFKEVNKT DLVNFIEERF KTFCDEELEV PMVIHESMVD HILRIDRALK
2760 2770 2780 2790 2800
QVQGHMMLIG ASRTGKTILT RFVAWLNGLK IVQPKIHRHS NLSDFDMILK
2810 2820 2830 2840 2850
KAISDCSLKE SRTCLIIDES NILETAFLER MNTLLANADI PDLFQGEEYD
2860 2870 2880 2890 2900
KLLNNLRNKT RSLGLLLDTE QELYDWFVGE IAKNLHVVFT ICDPTNNKSS
2910 2920 2930 2940 2950
AMISSPALFN RCIINWMGDW DTKTMSQVAN NMVDVIPMEF TDFIVPEVNK
2960 2970 2980 2990 3000
ELVFTEPIQT IRDAVVNILI HFDRNFYQKM KVGVNPRSPG YFIDGLRALV
3010 3020 3030 3040 3050
KLVTAKYQDL QENQRFVNVG LEKLNESVLK VNELNKTLSK KSTELTEKEK
3060 3070 3080 3090 3100
EARSTLDKML MEQNESERKQ EATEEIKKIL KVQEEDIRKR KEVVMKSIQD
3110 3120 3130 3140 3150
IEPTILEAQR GVKNIKKQQL TEIRSMVNPP SGVKIVMEAV CAILGYQFSN
3160 3170 3180 3190 3200
WRDIQQFIRK DDFIHNIVHY DTTLHMKPQI RKYMEEEFLS DPNFTYETIN
3210 3220 3230 3240 3250
RASKACGPLY QWVNAQINFS KVLENVDPLR QEMKRIEFES LKTKANLLAA
3260 3270 3280 3290 3300
EEMTQDLEAS IEVSKRKYSL LIRDVEAIKT EMSNVQANLD RSISLVKSLT
3310 3320 3330 3340 3350
FEKERWLNTT KQFSKTSQEL IGNCIISSIY ETYFGHLNER ERADMLVILK
3360 3370 3380 3390 3400
RLLGKFAVKY DVNYRFIDYL VTLDEKMKWL ECGLDKNDYF LENMSIVMNS
3410 3420 3430 3440 3450
QDAVPFLLDP SSHMITVISN YYGNKTVLLS FLEEGFVKRL ENAIRFGSVV
3460 3470 3480 3490 3500
IIQDGEFFDP IISRLISREF NHAGNRVTVE IGDHEVDVSG DFKLFIHSCD
3510 3520 3530 3540 3550
PSGDIPIFLR SRVRLVHFVT NKESIETRIF DITLTEENAE MQRKREDLIK
3560 3570 3580 3590 3600
LNTEYKLKLK NLEKRLLEEL NNSQGNMLEN DELMVTLNNL KKEAMNIEKK
3610 3620 3630 3640 3650
LSESEEFFPQ FDNLVEEYSI IGKHSVKIFS MLEKFGQFHW FYGISIGQFL
3660 3670 3680 3690 3700
SCFKRVFIKK SRETRAARTR VDEILWLLYQ EVYCQFSTAL DKKFKMIMAM
3710 3720 3730 3740 3750
TMFCLYKFDI ESEQYKEAVL TMIGVLSESS DGVPKLTVDT NNDLRYLWDY
3760 3770 3780 3790 3800
VTTKSYISAL NWFKNEFFVD EWNIADVVAN SENNYFTMAS ERDVDGTFKL
3810 3820 3830 3840 3850
IELAKASKES LKIIPLGSIE NLNYAQEEIS KSKIEGGWIL LQNIQMSLSW
3860 3870 3880 3890 3900
VKTYLHKHVE ETKAAEEHEK FKMFMTCHLT GDKLPAPLLQ RTDRFVYEDI
3910 3920 3930 3940 3950
PGILDTVKDL WGSQFFTGKI SGVWSVYCTF LLSWFHALIT ARTRLVPHGF
3960 3970 3980 3990 4000
SKKYYFNDCD FQFASVYLEN VLATNSTNNI PWAQVRDHIA TIVYGGKIDE
4010 4020 4030 4040 4050
EKDLEVVAKL CAHVFCGSDN LQIVPGVRIP QPLLQQSEEE ERARLTAILS
4060 4070 4080 4090
NTIEPADSLS SWLQLPRESI LNYERLQAKE VASSTEQLLQ EM
Length:4,092
Mass (Da):471,348
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D9DF447E8E2D6BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti589Y → C in AAA16055 (PubMed:8234262).Curated1
Sequence conflicti601V → A in AAA16055 (PubMed:8234262).Curated1
Sequence conflicti1364E → A in AAA16055 (PubMed:8234262).Curated1
Sequence conflicti2118 – 2119ML → IV in CAA79923 (PubMed:8248224).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z21877 Genomic DNA Translation: CAA79923.1
L15626 Unassigned DNA Translation: AAA16055.1
Z28279 Genomic DNA Translation: CAA82132.1
BK006944 Genomic DNA Translation: DAA09205.1

Protein sequence database of the Protein Information Resource

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PIRi
S38128

NCBI Reference Sequences

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RefSeqi
NP_012980.1, NM_001179844.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YKR054C_mRNA; YKR054C; YKR054C

Database of genes from NCBI RefSeq genomes

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GeneIDi
853928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKR054C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21877 Genomic DNA Translation: CAA79923.1
L15626 Unassigned DNA Translation: AAA16055.1
Z28279 Genomic DNA Translation: CAA82132.1
BK006944 Genomic DNA Translation: DAA09205.1
PIRiS38128
RefSeqiNP_012980.1, NM_001179844.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J67electron microscopy34.00A1554-4092[»]
3J68electron microscopy30.00A1554-4092[»]
3QMZX-ray6.00A/B1364-4092[»]
4AI6X-ray3.40A/B1364-4092[»]
4AKGX-ray3.30A/B1364-4092[»]
4AKHX-ray3.60A/B1364-4092[»]
4AKIX-ray3.70A/B1364-4092[»]
4W8FX-ray3.54A/B1364-3038[»]
A/B3292-4092[»]
5AFRX-ray5.00A/B1-557[»]
5VH9electron microscopy7.70A1448-4092[»]
5VLJelectron microscopy10.50A1448-4092[»]
6KIOelectron microscopy3.94M3095-3224[»]
6KIQelectron microscopy3.62M3095-3224[»]
6KJNNMR-A3095-3232[»]
6KJONMR-A3095-3232[»]
SMRiP36022
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi34185, 349 interactors
ComplexPortaliCPX-1178, Cytoplasmic dynein complex
DIPiDIP-2644N
IntActiP36022, 11 interactors
MINTiP36022
STRINGi4932.YKR054C

PTM databases

iPTMnetiP36022

Proteomic databases

MaxQBiP36022
PaxDbiP36022
PRIDEiP36022

Genome annotation databases

EnsemblFungiiYKR054C_mRNA; YKR054C; YKR054C
GeneIDi853928
KEGGisce:YKR054C

Organism-specific databases

EuPathDBiFungiDB:YKR054C
SGDiS000001762, DYN1

Phylogenomic databases

eggNOGiKOG3595, Eukaryota
GeneTreeiENSGT00940000156103
HOGENOMiCLU_000038_7_0_1
InParanoidiP36022
KOiK10413
OMAiFAPDICS

Enzyme and pathway databases

BioCyciYEAST:G3O-32023-MONOMER
ReactomeiR-SCE-6798695, Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P36022
RNActiP36022, protein

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR035699, AAA_6
IPR035706, AAA_9
IPR041658, AAA_lid_11
IPR042219, AAA_lid_11_sf
IPR026983, DHC_fam
IPR041589, DNAH3_AAA_lid_1
IPR042228, Dynein_2_C
IPR042222, Dynein_2_N
IPR043157, Dynein_AAA1S
IPR024743, Dynein_HC_stalk
IPR024317, Dynein_heavy_chain_D4_dom
IPR004273, Dynein_heavy_D6_P-loop
IPR013594, Dynein_heavy_dom-1
IPR013602, Dynein_heavy_dom-2
IPR027417, P-loop_NTPase
PANTHERiPTHR10676, PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774, AAA_6, 1 hit
PF12780, AAA_8, 1 hit
PF12781, AAA_9, 1 hit
PF17857, AAA_lid_1, 1 hit
PF18198, AAA_lid_11, 1 hit
PF08385, DHC_N1, 1 hit
PF08393, DHC_N2, 1 hit
PF03028, Dynein_heavy, 1 hit
PF12777, MT, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 3 hits
SUPFAMiSSF52540, SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYHC_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36022
Secondary accession number(s): D6VXB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: August 12, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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