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UniProtKB - P36021 (MOT8_HUMAN)
Protein
Monocarboxylate transporter 8
Gene
SLC16A2
Organism
Homo sapiens (Human)
Status
Functioni
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.
2 PublicationsMiscellaneous
Abnormal brain development associated with MCT8 deficiency may be the consequence of either decreased or increased intracellular T3 concentrations.1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: ARUK-UCL
- monocarboxylic acid transmembrane transporter activity Source: ProtInc
- symporter activity Source: UniProtKB-KW
- thyroid hormone transmembrane transporter activity Source: ARUK-UCL
- transporter activity Source: ProtInc
GO - Biological processi
- amino acid import across plasma membrane Source: ARUK-UCL
- cellular amino acid metabolic process Source: ARUK-UCL
- monocarboxylic acid transport Source: ProtInc
- negative regulation of neural precursor cell proliferation Source: ARUK-UCL
- thyroid hormone generation Source: Ensembl
- thyroid hormone metabolic process Source: ARUK-UCL
- thyroid hormone transport Source: ARUK-UCL
- thyroid-stimulating hormone secretion Source: Ensembl
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Biological process | Symport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P36021 |
Reactomei | R-HSA-879518, Transport of organic anions |
SignaLinki | P36021 |
SIGNORi | P36021 |
Protein family/group databases
TCDBi | 2.A.1.13.10, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Monocarboxylate transporter 8Short name: MCT 8 Alternative name(s): Monocarboxylate transporter 7 Short name: MCT 7 Solute carrier family 16 member 2 X-linked PEST-containing transporter |
Gene namesi | Name:SLC16A2 Synonyms:MCT8, XPCT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10923, SLC16A2 |
MIMi | 300095, gene |
neXtProti | NX_P36021 |
VEuPathDBi | HostDB:ENSG00000147100 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Multi-pass membrane protein 2 Publications
Plasma Membrane
- apical plasma membrane Source: ARUK-UCL
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: ARUK-UCL
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 96 | CytoplasmicSequence analysisAdd BLAST | 95 | |
Transmembranei | 97 – 117 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 143 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 144 – 164 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 165 – 171 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 172 – 192 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 193 – 200 | ExtracellularSequence analysis | 8 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 222 – 229 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 230 – 250 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 251 – 258 | ExtracellularSequence analysis | 8 | |
Transmembranei | 259 – 279 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 280 – 322 | CytoplasmicSequence analysisAdd BLAST | 43 | |
Transmembranei | 323 – 343 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 344 – 356 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 357 – 377 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 378 – 386 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 387 – 407 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 408 – 409 | ExtracellularSequence analysis | 2 | |
Transmembranei | 410 – 430 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 431 – 447 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 448 – 468 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 469 – 477 | ExtracellularSequence analysis | 9 | |
Transmembranei | 478 – 498 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 499 – 539 | CytoplasmicSequence analysisAdd BLAST | 41 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Monocarboxylate transporter 8 deficiency (MCT8 deficiency)10 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionConsists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059054 | 120 | S → F in MCT8 deficiency; impaired homodimerization. 2 PublicationsCorresponds to variant dbSNP:rs113994162EnsemblClinVar. | 1 | |
Natural variantiVAR_074572 | 147 | G → R in MCT8 deficiency; impaired thyroid hormone transporter activity; does not affect localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1602140936EnsemblClinVar. | 1 | |
Natural variantiVAR_074573 | 150 | A → T in MCT8 deficiency; impaired homodimerization. 1 PublicationCorresponds to variant dbSNP:rs373279555EnsemblClinVar. | 1 | |
Natural variantiVAR_022348 | 150 | A → V in MCT8 deficiency; does not affect homodimerization activity. 3 PublicationsCorresponds to variant dbSNP:rs104894936EnsemblClinVar. | 1 | |
Natural variantiVAR_059055 | 156 | Missing in MCT8 deficiency; increased homodimerization activity. 2 Publications | 1 | |
Natural variantiVAR_059056 | 161 | V → M in MCT8 deficiency; increased homodimerization activity. 2 Publications | 1 | |
Natural variantiVAR_074574 | 197 | R → H in MCT8 deficiency; does not affect homodimerization activity. 2 PublicationsCorresponds to variant dbSNP:rs727504155EnsemblClinVar. | 1 | |
Natural variantiVAR_074575 | 208 | G → C in MCT8 deficiency; impaired thyroid hormone transporter activity; impaired localization to the cell membrane. 1 Publication | 1 | |
Natural variantiVAR_075145 | 216 | S → F in MCT8 deficiency; decreased thyroid hormone transport; decreased protein abundance; decreased localization to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs398124232EnsemblClinVar. | 1 | |
Natural variantiVAR_078497 | 217 | L → R in MCT8 deficiency; atypical form; characterized by developmental delay hypotonia and delayed myelination. 1 Publication | 1 | |
Natural variantiVAR_074576 | 247 | P → L in MCT8 deficiency; impaired thyroid hormone transporter activity; does not affect localization to the cell membrane. 1 Publication | 1 | |
Natural variantiVAR_059057 | 360 | L → W in MCT8 deficiency; impaired homodimerization. 2 PublicationsCorresponds to variant dbSNP:rs104894939EnsemblClinVar. | 1 | |
Natural variantiVAR_074577 | 371 | R → C in MCT8 deficiency; impaired homodimerization. 1 PublicationCorresponds to variant dbSNP:rs587784384EnsemblClinVar. | 1 | |
Natural variantiVAR_074578 | 379 | D → V in MCT8 deficiency; impaired thyroid hormone transporter activity; does not affect localization to the cell membrane. 1 Publication | 1 | |
Natural variantiVAR_022349 | 397 | L → P in MCT8 deficiency; does not affect homodimerization activity. 2 PublicationsCorresponds to variant dbSNP:rs122455132EnsemblClinVar. | 1 | |
Natural variantiVAR_059058 | 427 | Missing in MCT8 deficiency. 1 PublicationCorresponds to variant dbSNP:rs113994164Ensembl. | 1 | |
Natural variantiVAR_022350 | 438 | L → P in MCT8 deficiency; does not affect homodimerization activity. 2 PublicationsCorresponds to variant dbSNP:rs104894931EnsemblClinVar. | 1 | |
Natural variantiVAR_074579 | 463 | P → L in MCT8 deficiency; impaired thyroid hormone transporter activity; does not affect localization to the cell membrane. 1 Publication | 1 | |
Natural variantiVAR_074580 | 484 | G → D in MCT8 deficiency; does not affect homodimerization activity; impaired thyroid hormone transporter activity; impaired localization to the cell membrane. 2 Publications | 1 | |
Natural variantiVAR_078498 | 490 | G → E in MCT8 deficiency; results in a mild clinical phenotype; retains some residual thyroid hormone transporter activity. 1 Publication | 1 | |
Natural variantiVAR_059059 | 490 | G → R in MCT8 deficiency; loss of thyroid hormone transport. 2 PublicationsCorresponds to variant dbSNP:rs794727799EnsemblClinVar. | 1 | |
Natural variantiVAR_059060 | 494 | L → P in MCT8 deficiency; does not affect homodimerization activity. 2 PublicationsCorresponds to variant dbSNP:rs104894938EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 118 | H → A: Reduction of thyroid hormone (TH) transport. 1 Publication | 1 | |
Mutagenesisi | 186 | H → A: No effect on thyroid hormone (TH) transport. 1 Publication | 1 | |
Mutagenesisi | 216 | S → A: No effect on thyroid hormone transport. No effect on protein abundance. No effect on protein localization to the plasma membrane. 1 Publication | 1 | |
Mutagenesisi | 376 | H → A: No effect on thyroid hormone (TH) transport. 1 Publication | 1 | |
Mutagenesisi | 490 | G → A: No effect on thyroid hormone (TH) transport. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 6567 |
GeneReviewsi | SLC16A2 |
MalaCardsi | SLC16A2 |
MIMi | 300523, phenotype |
OpenTargetsi | ENSG00000147100 |
Orphaneti | 59, Allan-Herndon-Dudley syndrome |
PharmGKBi | PA35814 |
Miscellaneous databases
Pharosi | P36021, Tbio |
Chemistry databases
DrugBanki | DB00149, Leucine DB00451, Levothyroxine DB01583, Liotrix DB00119, Pyruvic acid DB09100, Thyroid, porcine DB00150, Tryptophan DB00135, Tyrosine |
Genetic variation databases
BioMutai | SLC16A2 |
DMDMi | 114152841 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000211401 | 2 – 539 | Monocarboxylate transporter 8Add BLAST | 538 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P36021 |
jPOSTi | P36021 |
MassIVEi | P36021 |
MaxQBi | P36021 |
PaxDbi | P36021 |
PeptideAtlasi | P36021 |
PRIDEi | P36021 |
ProteomicsDBi | 55173 |
PTM databases
iPTMneti | P36021 |
PhosphoSitePlusi | P36021 |
Expressioni
Tissue specificityi
Highly expressed in liver and heart.1 Publication
Gene expression databases
Bgeei | ENSG00000147100, Expressed in liver and 166 other tissues |
ExpressionAtlasi | P36021, baseline and differential |
Genevisiblei | P36021, HS |
Organism-specific databases
HPAi | ENSG00000147100, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Homodimer.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 112455, 48 interactors |
IntActi | P36021, 3 interactors |
STRINGi | 9606.ENSP00000465734 |
Miscellaneous databases
RNActi | P36021, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 92 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 508 – 539 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 40 – 64 | Pro residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 66 – 80 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2504, Eukaryota |
GeneTreei | ENSGT00940000159450 |
HOGENOMi | CLU_001265_59_5_1 |
InParanoidi | P36021 |
OMAi | EFKTAWV |
OrthoDBi | 916876at2759 |
PhylomeDBi | P36021 |
TreeFami | TF313792 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR030761, MCT8 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF123, PTHR11360:SF123, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P36021-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALQSQASEE AKGPWQEADQ EQQEPVGSPE PESEPEPEPE PEPVPVPPPE
60 70 80 90 100
PQPEPQPLPD PAPLPELEFE SERVHEPEPT PTVETRGTAR GFQPPEGGFG
110 120 130 140 150
WVVVFAATWC NGSIFGIHNS VGILYSMLLE EEKEKNRQVE FQAAWVGALA
160 170 180 190 200
MGMIFFCSPI VSIFTDRLGC RITATAGAAV AFIGLHTSSF TSSLSLRYFT
210 220 230 240 250
YGILFGCGCS FAFQPSLVIL GHYFQRRLGL ANGVVSAGSS IFSMSFPFLI
260 270 280 290 300
RMLGDKIKLA QTFQVLSTFM FVLMLLSLTY RPLLPSSQDT PSKRGVRTLH
310 320 330 340 350
QRFLAQLRKY FNMRVFRQRT YRIWAFGIAA AALGYFVPYV HLMKYVEEEF
360 370 380 390 400
SEIKETWVLL VCIGATSGLG RLVSGHISDS IPGLKKIYLQ VLSFLLLGLM
410 420 430 440 450
SMMIPLCRDF GGLIVVCLFL GLCDGFFITI MAPIAFELVG PMQASQAIGY
460 470 480 490 500
LLGMMALPMI AGPPIAGLLR NCFGDYHVAF YFAGVPPIIG AVILFFVPLM
510 520 530
HQRMFKKEQR DSSKDKMLAP DPDPNGELLP GSPNPEEPI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ELT4 | K7ELT4_HUMAN | Monocarboxylate transporter 8 | SLC16A2 | 229 | Annotation score: | ||
A0A1B0GVB4 | A0A1B0GVB4_HUMAN | Monocarboxylate transporter 8 | SLC16A2 | 69 | Annotation score: |
Sequence cautioni
The sequence AAB60374 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAB60375 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059054 | 120 | S → F in MCT8 deficiency; impaired homodimerization. 2 PublicationsCorresponds to variant dbSNP:rs113994162EnsemblClinVar. | 1 | |
Natural variantiVAR_074572 | 147 | G → R in MCT8 deficiency; impaired thyroid hormone transporter activity; does not affect localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1602140936EnsemblClinVar. | 1 | |
Natural variantiVAR_074573 | 150 | A → T in MCT8 deficiency; impaired homodimerization. 1 PublicationCorresponds to variant dbSNP:rs373279555EnsemblClinVar. | 1 | |
Natural variantiVAR_022348 | 150 | A → V in MCT8 deficiency; does not affect homodimerization activity. 3 PublicationsCorresponds to variant dbSNP:rs104894936EnsemblClinVar. | 1 | |
Natural variantiVAR_059055 | 156 | Missing in MCT8 deficiency; increased homodimerization activity. 2 Publications | 1 | |
Natural variantiVAR_059056 | 161 | V → M in MCT8 deficiency; increased homodimerization activity. 2 Publications | 1 | |
Natural variantiVAR_074574 | 197 | R → H in MCT8 deficiency; does not affect homodimerization activity. 2 PublicationsCorresponds to variant dbSNP:rs727504155EnsemblClinVar. | 1 | |
Natural variantiVAR_074575 | 208 | G → C in MCT8 deficiency; impaired thyroid hormone transporter activity; impaired localization to the cell membrane. 1 Publication | 1 | |
Natural variantiVAR_075145 | 216 | S → F in MCT8 deficiency; decreased thyroid hormone transport; decreased protein abundance; decreased localization to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs398124232EnsemblClinVar. | 1 | |
Natural variantiVAR_078497 | 217 | L → R in MCT8 deficiency; atypical form; characterized by developmental delay hypotonia and delayed myelination. 1 Publication | 1 | |
Natural variantiVAR_074576 | 247 | P → L in MCT8 deficiency; impaired thyroid hormone transporter activity; does not affect localization to the cell membrane. 1 Publication | 1 | |
Natural variantiVAR_057723 | 323 | I → L. Corresponds to variant dbSNP:rs12849411Ensembl. | 1 | |
Natural variantiVAR_059057 | 360 | L → W in MCT8 deficiency; impaired homodimerization. 2 PublicationsCorresponds to variant dbSNP:rs104894939EnsemblClinVar. | 1 | |
Natural variantiVAR_074577 | 371 | R → C in MCT8 deficiency; impaired homodimerization. 1 PublicationCorresponds to variant dbSNP:rs587784384EnsemblClinVar. | 1 | |
Natural variantiVAR_074578 | 379 | D → V in MCT8 deficiency; impaired thyroid hormone transporter activity; does not affect localization to the cell membrane. 1 Publication | 1 | |
Natural variantiVAR_022349 | 397 | L → P in MCT8 deficiency; does not affect homodimerization activity. 2 PublicationsCorresponds to variant dbSNP:rs122455132EnsemblClinVar. | 1 | |
Natural variantiVAR_059058 | 427 | Missing in MCT8 deficiency. 1 PublicationCorresponds to variant dbSNP:rs113994164Ensembl. | 1 | |
Natural variantiVAR_022350 | 438 | L → P in MCT8 deficiency; does not affect homodimerization activity. 2 PublicationsCorresponds to variant dbSNP:rs104894931EnsemblClinVar. | 1 | |
Natural variantiVAR_074579 | 463 | P → L in MCT8 deficiency; impaired thyroid hormone transporter activity; does not affect localization to the cell membrane. 1 Publication | 1 | |
Natural variantiVAR_074580 | 484 | G → D in MCT8 deficiency; does not affect homodimerization activity; impaired thyroid hormone transporter activity; impaired localization to the cell membrane. 2 Publications | 1 | |
Natural variantiVAR_078498 | 490 | G → E in MCT8 deficiency; results in a mild clinical phenotype; retains some residual thyroid hormone transporter activity. 1 Publication | 1 | |
Natural variantiVAR_059059 | 490 | G → R in MCT8 deficiency; loss of thyroid hormone transport. 2 PublicationsCorresponds to variant dbSNP:rs794727799EnsemblClinVar. | 1 | |
Natural variantiVAR_059060 | 494 | L → P in MCT8 deficiency; does not affect homodimerization activity. 2 PublicationsCorresponds to variant dbSNP:rs104894938EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U05321 , U05316, U05317, U05318, U05319, U05320 Genomic DNA Translation: AAB60375.1 Sequence problems. U05315 mRNA Translation: AAB60374.1 Different initiation. AB085789 mRNA Translation: BAC76827.1 AC004073 Genomic DNA No translation available. AL157934 Genomic DNA No translation available. |
CCDSi | CCDS14426.2 |
PIRi | I39295 |
RefSeqi | NP_006508.2, NM_006517.4 |
Genome annotation databases
Ensembli | ENST00000587091.6; ENSP00000465734.1; ENSG00000147100.11 |
GeneIDi | 6567 |
KEGGi | hsa:6567 |
MANE-Selecti | ENST00000587091.6; ENSP00000465734.1; NM_006517.5; NP_006508.2 |
UCSCi | uc031tjy.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U05321 , U05316, U05317, U05318, U05319, U05320 Genomic DNA Translation: AAB60375.1 Sequence problems. U05315 mRNA Translation: AAB60374.1 Different initiation. AB085789 mRNA Translation: BAC76827.1 AC004073 Genomic DNA No translation available. AL157934 Genomic DNA No translation available. |
CCDSi | CCDS14426.2 |
PIRi | I39295 |
RefSeqi | NP_006508.2, NM_006517.4 |
3D structure databases
AlphaFoldDBi | P36021 |
SMRi | P36021 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112455, 48 interactors |
IntActi | P36021, 3 interactors |
STRINGi | 9606.ENSP00000465734 |
Chemistry databases
DrugBanki | DB00149, Leucine DB00451, Levothyroxine DB01583, Liotrix DB00119, Pyruvic acid DB09100, Thyroid, porcine DB00150, Tryptophan DB00135, Tyrosine |
Protein family/group databases
TCDBi | 2.A.1.13.10, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | P36021 |
PhosphoSitePlusi | P36021 |
Genetic variation databases
BioMutai | SLC16A2 |
DMDMi | 114152841 |
Proteomic databases
EPDi | P36021 |
jPOSTi | P36021 |
MassIVEi | P36021 |
MaxQBi | P36021 |
PaxDbi | P36021 |
PeptideAtlasi | P36021 |
PRIDEi | P36021 |
ProteomicsDBi | 55173 |
Protocols and materials databases
Antibodypediai | 522, 180 antibodies from 30 providers |
DNASUi | 6567 |
Genome annotation databases
Ensembli | ENST00000587091.6; ENSP00000465734.1; ENSG00000147100.11 |
GeneIDi | 6567 |
KEGGi | hsa:6567 |
MANE-Selecti | ENST00000587091.6; ENSP00000465734.1; NM_006517.5; NP_006508.2 |
UCSCi | uc031tjy.2, human |
Organism-specific databases
CTDi | 6567 |
DisGeNETi | 6567 |
GeneCardsi | SLC16A2 |
GeneReviewsi | SLC16A2 |
HGNCi | HGNC:10923, SLC16A2 |
HPAi | ENSG00000147100, Tissue enhanced (liver) |
MalaCardsi | SLC16A2 |
MIMi | 300095, gene 300523, phenotype |
neXtProti | NX_P36021 |
OpenTargetsi | ENSG00000147100 |
Orphaneti | 59, Allan-Herndon-Dudley syndrome |
PharmGKBi | PA35814 |
VEuPathDBi | HostDB:ENSG00000147100 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2504, Eukaryota |
GeneTreei | ENSGT00940000159450 |
HOGENOMi | CLU_001265_59_5_1 |
InParanoidi | P36021 |
OMAi | EFKTAWV |
OrthoDBi | 916876at2759 |
PhylomeDBi | P36021 |
TreeFami | TF313792 |
Enzyme and pathway databases
PathwayCommonsi | P36021 |
Reactomei | R-HSA-879518, Transport of organic anions |
SignaLinki | P36021 |
SIGNORi | P36021 |
Miscellaneous databases
BioGRID-ORCSi | 6567, 11 hits in 692 CRISPR screens |
ChiTaRSi | SLC16A2, human |
GeneWikii | SLC16A2 |
GenomeRNAii | 6567 |
Pharosi | P36021, Tbio |
PROi | PR:P36021 |
RNActi | P36021, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147100, Expressed in liver and 166 other tissues |
ExpressionAtlasi | P36021, baseline and differential |
Genevisiblei | P36021, HS |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR030761, MCT8 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF123, PTHR11360:SF123, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MOT8_HUMAN | |
Accessioni | P36021Primary (citable) accession number: P36021 Secondary accession number(s): Q7Z797 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | September 5, 2006 | |
Last modified: | May 25, 2022 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families