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UniProtKB - P36011 (STUA_EMENI)

Entry version 114 (10 Feb 2021)
Sequence version 2 (15 Mar 2004)
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Protein

Cell pattern formation-associated protein stuA

Gene

stuA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that regulates asexual reproduction (PubMed:1516832, PubMed:8722771, PubMed:9312029, PubMed:25550299). Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (PubMed:9312029, PubMed:25359270). Required from the very earliest events of asexual reproduction until completion of conidiophore development, but is not specifically required for differentiation of conidia (PubMed:1516832). Represses transcription of the abaA developmental regulatory gene and of the developmentally regulated awh11 gene (PubMed:9312029). Controls the expression of the catalase-peroxidase gene cpeA (PubMed:12455692). Plays an important role in cell wall biogenesis during the development by controlling the transcription level of fksA (PubMed:25359270).6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi163 – 184H-T-H motifPROSITE-ProRule annotationAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processConidiation, Sporulation, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell pattern formation-associated protein stuACurated
Alternative name(s):
Stunted protein A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:stuA1 Publication
ORF Names:AN5836
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to defective conidiophore morphology and impairs conidia production (PubMed:25550299). Affects cell wall beta-1,3-glucan biosynthesis (PubMed:25359270).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722961 – 622Cell pattern formation-associated protein stuAAdd BLAST622

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is increased 50-fold during the establishment of developmental competence (PubMed:1516832, PubMed:2062309, PubMed:17630328). Expression is positively controlled by brlA (PubMed:1516832). Expression is also regulated by the LAMMER kinase lkhA (PubMed:23516554).3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		162425.CADANIAP00007206

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini129 – 235HTH APSES-typePROSITE-ProRule annotationAdd BLAST107

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni565 – 590Nuclear localization domain1 PublicationAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi39 – 129Gln/Pro/Ser-richAdd BLAST91
Compositional biasi253 – 415Gln/Pro/Ser-richAdd BLAST163

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EFG1/PHD1/stuA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QW2C, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016460_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P36011

Identification of Orthologs from Complete Genome Data

More...OMAi		YHPTNQT

Database of Orthologous Groups

More...OrthoDBi		311987at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.260.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029790, EFG1/Phd1/StuA
IPR036887, HTH_APSES_sf
IPR018004, KilA_N/APSES_HTH
IPR003163, Tscrpt_reg_HTH_APSES-type

The PANTHER Classification System

More...PANTHERi		PTHR47792, PTHR47792, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04383, KilA-N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01252, KilA-N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54616, SSF54616, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51299, HTH_APSES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P36011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASMNQPQPY MDVHSHLSSG QTYASHPATA GALTHYQYPQ QPPVLQPTST 
        60         70         80         90        100
YGPASSYSQY PYPNSVASSQ SVPPPTTSIS SQVPAQLLPL PVTNHPVPTH 
       110        120        130        140        150
GYGNNSGTPM QGYVYDPTGQ MAPPGAKPRV TATLWEDEGS LCYQVEAKGV 
       160        170        180        190        200
CVARREDNGM INGTKLLNVA GMTRGRRDGI LKSEKVRNVV KIGPMHLKGV 
       210        220        230        240        250
WIPFDRALEF ANKEKITDLL YPLFVQHISN LLYHPANQNQ RNMTVPDSRR 
       260        270        280        290        300
LEGPQPVVRT PQAQQPPSLH HHSLQTPVPS HMSQPGGRPS LDRAHTFPTP 
       310        320        330        340        350
PASASSLIGI TSQNNSYDWN PGMNSSVPNT QPLSIDTSLS NARSMPTTPA 
       360        370        380        390        400
TTPPGNNLQG MQSYQPQSGY DSKPYYSAAP STHPQYAPQQ PLPQQSMAQY 
       410        420        430        440        450
GHSMPTSSYR DMAPPSSQRG SVTEIESDVK TERYGQGTVA KTEPEQEQEY 
       460        470        480        490        500
AQPDSGYNTG RGSYYTTNPS VGGLAHDHSQ LTPDMTGSPQ QNGSGRMTPR 
       510        520        530        540        550
TSNTAPQWAP GYTTPPRPAA ASSLYNIVSD TRGTSGANGS TSDNYSVASN 
       560        570        580        590        600
SGYSTGMNGS MGSNKRMRDD DDDRIVPPDS RGEFDTKRRK TLTETPVGGP 
       610        620 
VGGVPLGLQP MKAGGSLISA RR
Length:622
Mass (Da):66,956
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05D8AE2FAF497083
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M83569 Genomic DNA Translation: AAA33325.2
AACD01000100 Genomic DNA Translation: EAA58345.1
BN001301 Genomic DNA Translation: CBF70741.1

Protein sequence database of the Protein Information Resource

More...PIRi		A44068

NCBI Reference Sequences

More...RefSeqi		XP_663440.1, XM_658348.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		CBF70741; CBF70741; ANIA_05836
EAA58345; EAA58345; AN5836.2

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2870743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ani:AN5836.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83569 Genomic DNA Translation: AAA33325.2
AACD01000100 Genomic DNA Translation: EAA58345.1
BN001301 Genomic DNA Translation: CBF70741.1
PIRiA44068
RefSeqiXP_663440.1, XM_658348.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi162425.CADANIAP00007206

Genome annotation databases

EnsemblFungiiCBF70741; CBF70741; ANIA_05836
EAA58345; EAA58345; AN5836.2
GeneIDi2870743
KEGGiani:AN5836.2

Phylogenomic databases

eggNOGiENOG502QW2C, Eukaryota
HOGENOMiCLU_016460_0_0_1
InParanoidiP36011
OMAiYHPTNQT
OrthoDBi311987at2759

Family and domain databases

Gene3Di3.10.260.10, 1 hit
InterProiView protein in InterPro
IPR029790, EFG1/Phd1/StuA
IPR036887, HTH_APSES_sf
IPR018004, KilA_N/APSES_HTH
IPR003163, Tscrpt_reg_HTH_APSES-type
PANTHERiPTHR47792, PTHR47792, 1 hit
PfamiView protein in Pfam
PF04383, KilA-N, 1 hit
SMARTiView protein in SMART
SM01252, KilA-N, 1 hit
SUPFAMiSSF54616, SSF54616, 1 hit
PROSITEiView protein in PROSITE
PS51299, HTH_APSES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTUA_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P36011
Secondary accession number(s): C8V024, Q5B0U4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: March 15, 2004
Last modified: February 10, 2021
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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