UniProtKB - P36011 (STUA_EMENI)
Cell pattern formation-associated protein stuA
stuA
Functioni
Transcription factor that regulates asexual reproduction (PubMed:1516832, PubMed:8722771, PubMed:9312029, PubMed:25550299).
Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (PubMed:9312029, PubMed:25359270).
Required from the very earliest events of asexual reproduction until completion of conidiophore development, but is not specifically required for differentiation of conidia (PubMed:1516832).
Represses transcription of the abaA developmental regulatory gene and of the developmentally regulated awh11 gene (PubMed:9312029).
Controls the expression of the catalase-peroxidase gene cpeA (PubMed:12455692).
Plays an important role in cell wall biogenesis during the development by controlling the transcription level of fksA (PubMed:25359270).
6 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 163 – 184 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 22 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: AspGD
- sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- conidiophore development Source: AspGD
- conidium formation Source: AspGD
- positive regulation of conidiophore development Source: AspGD
- positive regulation of conidium formation Source: AspGD
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: AspGD
- sporocarp development involved in asexual reproduction Source: AspGD
- sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Conidiation, Sporulation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Cell pattern formation-associated protein stuACuratedAlternative name(s): Stunted protein A1 Publication |
Gene namesi | Name:stuA1 Publication ORF Names:AN5836 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:AN5836 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072296 | 1 – 622 | Cell pattern formation-associated protein stuAAdd BLAST | 622 |
Expressioni
Inductioni
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 235 | HTH APSES-typePROSITE-ProRule annotationAdd BLAST | 107 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 62 – 81 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 239 – 517 | DisorderedSequence analysisAdd BLAST | 279 | |
Regioni | 549 – 622 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 565 – 590 | Nuclear localization domain1 PublicationAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 258 – 283 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 299 – 424 | Polar residuesSequence analysisAdd BLAST | 126 | |
Compositional biasi | 441 – 510 | Polar residuesSequence analysisAdd BLAST | 70 | |
Compositional biasi | 564 – 592 | Basic and acidic residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QW2C, Eukaryota |
HOGENOMi | CLU_016460_0_0_1 |
InParanoidi | P36011 |
OMAi | MDVHSSH |
OrthoDBi | 311987at2759 |
Family and domain databases
Gene3Di | 3.10.260.10, 1 hit |
InterProi | View protein in InterPro IPR029790, EFG1/Phd1/StuA IPR036887, HTH_APSES_sf IPR018004, KilA_N/APSES_HTH IPR003163, Tscrpt_reg_HTH_APSES-type |
PANTHERi | PTHR47792, PTHR47792, 1 hit |
Pfami | View protein in Pfam PF04383, KilA-N, 1 hit |
SMARTi | View protein in SMART SM01252, KilA-N, 1 hit |
SUPFAMi | SSF54616, SSF54616, 1 hit |
PROSITEi | View protein in PROSITE PS51299, HTH_APSES, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MASMNQPQPY MDVHSHLSSG QTYASHPATA GALTHYQYPQ QPPVLQPTST
60 70 80 90 100
YGPASSYSQY PYPNSVASSQ SVPPPTTSIS SQVPAQLLPL PVTNHPVPTH
110 120 130 140 150
GYGNNSGTPM QGYVYDPTGQ MAPPGAKPRV TATLWEDEGS LCYQVEAKGV
160 170 180 190 200
CVARREDNGM INGTKLLNVA GMTRGRRDGI LKSEKVRNVV KIGPMHLKGV
210 220 230 240 250
WIPFDRALEF ANKEKITDLL YPLFVQHISN LLYHPANQNQ RNMTVPDSRR
260 270 280 290 300
LEGPQPVVRT PQAQQPPSLH HHSLQTPVPS HMSQPGGRPS LDRAHTFPTP
310 320 330 340 350
PASASSLIGI TSQNNSYDWN PGMNSSVPNT QPLSIDTSLS NARSMPTTPA
360 370 380 390 400
TTPPGNNLQG MQSYQPQSGY DSKPYYSAAP STHPQYAPQQ PLPQQSMAQY
410 420 430 440 450
GHSMPTSSYR DMAPPSSQRG SVTEIESDVK TERYGQGTVA KTEPEQEQEY
460 470 480 490 500
AQPDSGYNTG RGSYYTTNPS VGGLAHDHSQ LTPDMTGSPQ QNGSGRMTPR
510 520 530 540 550
TSNTAPQWAP GYTTPPRPAA ASSLYNIVSD TRGTSGANGS TSDNYSVASN
560 570 580 590 600
SGYSTGMNGS MGSNKRMRDD DDDRIVPPDS RGEFDTKRRK TLTETPVGGP
610 620
VGGVPLGLQP MKAGGSLISA RR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83569 Genomic DNA Translation: AAA33325.2 AACD01000100 Genomic DNA Translation: EAA58345.1 BN001301 Genomic DNA Translation: CBF70741.1 |
PIRi | A44068 |
RefSeqi | XP_663440.1, XM_658348.1 |
Genome annotation databases
EnsemblFungii | CBF70741; CBF70741; ANIA_05836 EAA58345; EAA58345; AN5836.2 |
GeneIDi | 2870743 |
KEGGi | ani:AN5836.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83569 Genomic DNA Translation: AAA33325.2 AACD01000100 Genomic DNA Translation: EAA58345.1 BN001301 Genomic DNA Translation: CBF70741.1 |
PIRi | A44068 |
RefSeqi | XP_663440.1, XM_658348.1 |
3D structure databases
AlphaFoldDBi | P36011 |
SMRi | P36011 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 162425.CADANIAP00007206 |
Genome annotation databases
EnsemblFungii | CBF70741; CBF70741; ANIA_05836 EAA58345; EAA58345; AN5836.2 |
GeneIDi | 2870743 |
KEGGi | ani:AN5836.2 |
Organism-specific databases
VEuPathDBi | FungiDB:AN5836 |
Phylogenomic databases
eggNOGi | ENOG502QW2C, Eukaryota |
HOGENOMi | CLU_016460_0_0_1 |
InParanoidi | P36011 |
OMAi | MDVHSSH |
OrthoDBi | 311987at2759 |
Family and domain databases
Gene3Di | 3.10.260.10, 1 hit |
InterProi | View protein in InterPro IPR029790, EFG1/Phd1/StuA IPR036887, HTH_APSES_sf IPR018004, KilA_N/APSES_HTH IPR003163, Tscrpt_reg_HTH_APSES-type |
PANTHERi | PTHR47792, PTHR47792, 1 hit |
Pfami | View protein in Pfam PF04383, KilA-N, 1 hit |
SMARTi | View protein in SMART SM01252, KilA-N, 1 hit |
SUPFAMi | SSF54616, SSF54616, 1 hit |
PROSITEi | View protein in PROSITE PS51299, HTH_APSES, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STUA_EMENI | |
Accessioni | P36011Primary (citable) accession number: P36011 Secondary accession number(s): C8V024, Q5B0U4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | March 15, 2004 | |
Last modified: | May 25, 2022 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families