UniProtKB - P36008 (EF1G2_YEAST)
Elongation factor 1-gamma 2
TEF4
Functioni
Subunit of the eukaryotic elongation factor 1 complex (eEF1). Probably plays a role in anchoring the complex to other cellular components (By similarity).
By similarityMiscellaneous
: polypeptide chain elongation Pathwayi
This protein is involved in the pathway polypeptide chain elongation, which is part of Protein biosynthesis.View all proteins of this organism that are known to be involved in the pathway polypeptide chain elongation and in Protein biosynthesis.
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: SGD
- translation elongation factor activity Source: SGD
GO - Biological processi
- glutathione metabolic process Source: InterPro
- translational elongation Source: SGD
Keywordsi
Molecular function | Elongation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00345 |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor 1-gamma 2Short name: EF-1-gamma 2 Alternative name(s): Eukaryotic elongation factor 1Bgamma 2 Short name: eEF1Bgamma 2 Translation elongation factor 1B gamma 2 |
Gene namesi | Name:TEF4 Synonyms:EFC1 Ordered Locus Names:YKL081W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001564, TEF4 |
VEuPathDBi | FungiDB:YKL081W |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Mitochondrion
- mitochondrion Source: SGD
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- cytoplasmic stress granule Source: SGD
- eukaryotic translation elongation factor 1 complex Source: ComplexPortal
- ribosome Source: ComplexPortal
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000208832 | 2 – 412 | Elongation factor 1-gamma 2Add BLAST | 411 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
MaxQBi | P36008 |
PaxDbi | P36008 |
PRIDEi | P36008 |
PTM databases
CarbonylDBi | P36008 |
iPTMneti | P36008 |
Interactioni
Subunit structurei
The eukaryotic elongation factor 1 complex (eEF1) is probably a heterohexamer. Two trimeric complexes, each composed of eEF1A (TEF1 or TEF2), eEF1Balpha (EFB1) and eEF1Bgamma (CAM1 or TEF4), are probably dimerized via the eF1Bgamma subunits. The eEF1B subcomplex with the GEF activity is formed of eEF1Balpha and eEF1Bgamma. TEF4 interacts with EFB1 (By similarity).
By similarityBinary interactionsi
P36008
With | #Exp. | IntAct |
---|---|---|
BUD27 [P43573] | 3 | EBI-6329,EBI-22787 |
Protein-protein interaction databases
BioGRIDi | 34051, 365 interactors |
ComplexPortali | CPX-425, Elongation Factor eEF1 complex, variant TEF4 |
DIPi | DIP-6386N |
IntActi | P36008, 60 interactors |
MINTi | P36008 |
STRINGi | 4932.YKL081W |
Miscellaneous databases
RNActi | P36008, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 77 | GST N-terminalAdd BLAST | 76 | |
Domaini | 86 – 217 | GST C-terminalAdd BLAST | 132 | |
Domaini | 251 – 412 | EF-1-gamma C-terminalPROSITE-ProRule annotationAdd BLAST | 162 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 216 – 253 | DisorderedSequence analysisAdd BLAST | 38 |
Phylogenomic databases
eggNOGi | KOG0867, Eukaryota KOG1627, Eukaryota |
GeneTreei | ENSGT00940000176354 |
HOGENOMi | CLU_011226_3_0_1 |
InParanoidi | P36008 |
OMAi | VQWATEN |
Family and domain databases
Gene3Di | 3.30.70.1010, 1 hit |
InterProi | View protein in InterPro IPR001662, EF1B_G_C IPR036433, EF1B_G_C_sf IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00647, EF1G, 1 hit PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
SMARTi | View protein in SMART SM01183, EF1G, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit SSF89942, SSF89942, 1 hit |
PROSITEi | View protein in PROSITE PS50040, EF1G_C, 1 hit PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSQGTLYINR SPRNYASEAL ISYFKLDVKI VDLEQSSEFA SLFPLKQAPA
60 70 80 90 100
FLGPKGLKLT EALAIQFYLA NQVADEKERA RLLGSDVIEK SQILRWASLA
110 120 130 140 150
NSDVMSNIAR PFLSFKGLIP YNKKDVDACF VKIDNLAAVF DARLRDYTFV
160 170 180 190 200
ATENISLGDL HAAGSWAFGL ATILGPEWRA KHPHLMRWFN TVAASPIVKT
210 220 230 240 250
PFAEVKLAEK ALTYTPPKKQ KAEKPKAEKS KAEKKKDEAK PADDAAPAKK
260 270 280 290 300
PKHPLEALGK STFVLDDWKR KYSNDDTRPV ALPWFWEHYN PEEYSIWKVG
310 320 330 340 350
YKYNDELTLT FMSNNLVGGF FNRLSASTKY MFGCLVVYGE NNNNGIVGAV
360 370 380 390 400
MVRGQDFAPA FDVAPDWESY EYTKLDPTKE EDKEFVNNMW AWDKPVVVNG
410
EDKEIVDGKV LK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | I → L in AAA21473 (PubMed:8041634).Curated | 1 | |
Sequence conflicti | 347 | Missing in AAA21473 (PubMed:8041634).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01880 Genomic DNA Translation: AAA21473.1 Z28081 Genomic DNA Translation: CAA81919.1 Z28080 Genomic DNA Translation: CAA81918.1 M77143 Genomic DNA No translation available. BK006944 Genomic DNA Translation: DAA09076.1 |
PIRi | S37906 |
RefSeqi | NP_012842.1, NM_001179647.1 |
Genome annotation databases
EnsemblFungii | YKL081W_mRNA; YKL081W; YKL081W |
GeneIDi | 853781 |
KEGGi | sce:YKL081W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L01880 Genomic DNA Translation: AAA21473.1 Z28081 Genomic DNA Translation: CAA81919.1 Z28080 Genomic DNA Translation: CAA81918.1 M77143 Genomic DNA No translation available. BK006944 Genomic DNA Translation: DAA09076.1 |
PIRi | S37906 |
RefSeqi | NP_012842.1, NM_001179647.1 |
3D structure databases
AlphaFoldDBi | P36008 |
SMRi | P36008 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34051, 365 interactors |
ComplexPortali | CPX-425, Elongation Factor eEF1 complex, variant TEF4 |
DIPi | DIP-6386N |
IntActi | P36008, 60 interactors |
MINTi | P36008 |
STRINGi | 4932.YKL081W |
PTM databases
CarbonylDBi | P36008 |
iPTMneti | P36008 |
Proteomic databases
MaxQBi | P36008 |
PaxDbi | P36008 |
PRIDEi | P36008 |
Genome annotation databases
EnsemblFungii | YKL081W_mRNA; YKL081W; YKL081W |
GeneIDi | 853781 |
KEGGi | sce:YKL081W |
Organism-specific databases
SGDi | S000001564, TEF4 |
VEuPathDBi | FungiDB:YKL081W |
Phylogenomic databases
eggNOGi | KOG0867, Eukaryota KOG1627, Eukaryota |
GeneTreei | ENSGT00940000176354 |
HOGENOMi | CLU_011226_3_0_1 |
InParanoidi | P36008 |
OMAi | VQWATEN |
Enzyme and pathway databases
UniPathwayi | UPA00345 |
Miscellaneous databases
PROi | PR:P36008 |
RNActi | P36008, protein |
Family and domain databases
Gene3Di | 3.30.70.1010, 1 hit |
InterProi | View protein in InterPro IPR001662, EF1B_G_C IPR036433, EF1B_G_C_sf IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00647, EF1G, 1 hit PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
SMARTi | View protein in SMART SM01183, EF1G, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit SSF89942, SSF89942, 1 hit |
PROSITEi | View protein in PROSITE PS50040, EF1G_C, 1 hit PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EF1G2_YEAST | |
Accessioni | P36008Primary (citable) accession number: P36008 Secondary accession number(s): D6VXK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways