UniProtKB - P35998 (PRS7_HUMAN)
26S proteasome regulatory subunit 7
PSMC2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 216 – 223 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- proteasome-activating ATPase activity Source: InterPro
- TBP-class protein binding Source: GO_Central
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- neutrophil degranulation Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- osteoblast differentiation Source: UniProtKB
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: GO_Central
- post-translational protein modification Source: Reactome
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: Reactome
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- ubiquitin-dependent protein catabolic process Source: UniProtKB
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P35998 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome regulatory subunit 7Alternative name(s): 26S proteasome AAA-ATPase subunit RPT1 Proteasome 26S subunit ATPase 2 Protein MSS1 |
Gene namesi | Name:PSMC2 Synonyms:MSS1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9548, PSMC2 |
MIMi | 154365, gene |
neXtProti | NX_P35998 |
VEuPathDBi | HostDB:ENSG00000161057.10 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Note: Colocalizes with TRIM5 in cytoplasmic bodies.1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic ribonucleoprotein granule Source: HPA
- dendritic spine Source: GO_Central
- ficolin-1-rich granule lumen Source: Reactome
- membrane Source: UniProtKB
- P-body Source: UniProtKB
- proteasome accessory complex Source: UniProtKB
- proteasome complex Source: UniProtKB
- proteasome regulatory particle, base subcomplex Source: GO_Central
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
Cytoplasm, ProteasomePathology & Biotechi
Organism-specific databases
DisGeNETi | 5701 |
OpenTargetsi | ENSG00000161057 |
PharmGKBi | PA33893 |
Miscellaneous databases
Pharosi | P35998, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
Genetic variation databases
BioMutai | PSMC2 |
DMDMi | 547930 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000084709 | 2 – 433 | 26S proteasome regulatory subunit 7Add BLAST | 432 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 116 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 422 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P35998 |
jPOSTi | P35998 |
MassIVEi | P35998 |
MaxQBi | P35998 |
PaxDbi | P35998 |
PeptideAtlasi | P35998 |
PRIDEi | P35998 |
ProteomicsDBi | 55172 [P35998-1] 6682 |
2D gel databases
OGPi | P35998 |
REPRODUCTION-2DPAGEi | IPI00021435 P35998 |
PTM databases
iPTMneti | P35998 |
MetOSitei | P35998 |
PhosphoSitePlusi | P35998 |
SwissPalmi | P35998 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000161057, Expressed in biceps brachii and 249 other tissues |
ExpressionAtlasi | P35998, baseline and differential |
Genevisiblei | P35998, HS |
Organism-specific databases
HPAi | ENSG00000161057, Low tissue specificity |
Interactioni
Subunit structurei
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components (PubMed:27428775, PubMed:27342858).
Interacts with NDC80/HEC; this interaction is detected only during M phase.
Interacts and SQSTM1 (PubMed:15340068). Interacts with PAAF1 (PubMed:15831487). Directly interacts with TRIM5 (PubMed:22078707).
7 PublicationsBinary interactionsi
Hide detailsP35998
GO - Molecular functioni
- TBP-class protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 111674, 239 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P35998 |
DIPi | DIP-27554N |
IntActi | P35998, 94 interactors |
MINTi | P35998 |
STRINGi | 9606.ENSP00000391211 |
Miscellaneous databases
RNActi | P35998, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0729, Eukaryota |
GeneTreei | ENSGT01000000214468 |
HOGENOMi | CLU_000688_6_1_1 |
InParanoidi | P35998 |
OMAi | IHANTMN |
PhylomeDBi | P35998 |
TreeFami | TF105661 |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR035245, PSMC2 |
PANTHERi | PTHR23073:SF13, PTHR23073:SF13, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED
60 70 80 90 100
DIQQLLKKIN ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK
110 120 130 140 150
IINADSEDPK YIINVKQFAK FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH
160 170 180 190 200
IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC KEQIEKLREV VETPLLHPER
210 220 230 240 250
FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV IGSELVQKYV
260 270 280 290 300
GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML
310 320 330 340 350
ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG
360 370 380 390 400
RTHIFKIHAR SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR
410 420 430
RKIATEKDFL EAVNKVIKSY AKFSATPRYM TYN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JLS9 | C9JLS9_HUMAN | 26S proteasome regulatory subunit 7 | PSMC2 | 130 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | D → V in BAE45763 (PubMed:12880961).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056178 | 1 – 137 | Missing in isoform 2. 1 PublicationAdd BLAST | 137 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D11094 mRNA Translation: BAA01868.1 AB075520 mRNA Translation: BAE45763.1 AK298821 mRNA Translation: BAH12878.1 AC004668 Genomic DNA No translation available. AC093701 Genomic DNA No translation available. CH236947 Genomic DNA Translation: EAL24412.1 CH471070 Genomic DNA Translation: EAW83332.1 BC002589 mRNA Translation: AAH02589.1 |
CCDSi | CCDS5731.1 [P35998-1] |
PIRi | S24353 |
RefSeqi | NP_001191382.1, NM_001204453.1 NP_002794.1, NM_002803.3 [P35998-1] |
Genome annotation databases
Ensembli | ENST00000292644; ENSP00000292644; ENSG00000161057 [P35998-1] ENST00000435765; ENSP00000391211; ENSG00000161057 [P35998-1] |
GeneIDi | 5701 |
KEGGi | hsa:5701 |
UCSCi | uc003vbs.4, human [P35998-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D11094 mRNA Translation: BAA01868.1 AB075520 mRNA Translation: BAE45763.1 AK298821 mRNA Translation: BAH12878.1 AC004668 Genomic DNA No translation available. AC093701 Genomic DNA No translation available. CH236947 Genomic DNA Translation: EAL24412.1 CH471070 Genomic DNA Translation: EAW83332.1 BC002589 mRNA Translation: AAH02589.1 |
CCDSi | CCDS5731.1 [P35998-1] |
PIRi | S24353 |
RefSeqi | NP_001191382.1, NM_001204453.1 NP_002794.1, NM_002803.3 [P35998-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GJQ | electron microscopy | 4.50 | H | 1-433 | [»] | |
5GJR | electron microscopy | 3.50 | H/v | 1-433 | [»] | |
5L4G | electron microscopy | 4.02 | H | 1-433 | [»] | |
5LN3 | electron microscopy | 6.80 | H | 1-433 | [»] | |
5M32 | electron microscopy | 3.80 | c | 1-433 | [»] | |
5T0C | electron microscopy | 3.80 | AA/BA | 1-433 | [»] | |
5T0G | electron microscopy | 4.40 | A | 1-433 | [»] | |
5T0H | electron microscopy | 6.80 | A | 1-433 | [»] | |
5T0I | electron microscopy | 8.00 | A | 1-433 | [»] | |
5T0J | electron microscopy | 8.00 | A | 1-433 | [»] | |
5VFP | electron microscopy | 4.20 | A | 35-433 | [»] | |
5VFQ | electron microscopy | 4.20 | A | 35-433 | [»] | |
5VFR | electron microscopy | 4.90 | A | 35-433 | [»] | |
5VFS | electron microscopy | 3.60 | A | 1-433 | [»] | |
5VFT | electron microscopy | 7.00 | A | 73-433 | [»] | |
5VFU | electron microscopy | 5.80 | A | 73-433 | [»] | |
5VGZ | electron microscopy | 3.70 | A | 73-155 | [»] | |
5VHF | electron microscopy | 5.70 | A | 73-424 | [»] | |
5VHH | electron microscopy | 6.10 | A | 73-424 | [»] | |
5VHI | electron microscopy | 6.80 | A | 73-424 | [»] | |
5VHJ | electron microscopy | 8.50 | A | 180-424 | [»] | |
5VHM | electron microscopy | 8.30 | A | 159-424 | [»] | |
5VHN | electron microscopy | 7.30 | A | 159-424 | [»] | |
5VHO | electron microscopy | 8.30 | A | 158-424 | [»] | |
5VHP | electron microscopy | 7.90 | A | 159-424 | [»] | |
5VHQ | electron microscopy | 8.90 | A | 159-424 | [»] | |
5VHR | electron microscopy | 7.70 | A | 159-424 | [»] | |
5VHS | electron microscopy | 8.80 | A | 73-424 | [»] | |
6MSB | electron microscopy | 3.00 | A | 1-433 | [»] | |
6MSD | electron microscopy | 3.20 | A | 1-433 | [»] | |
6MSE | electron microscopy | 3.30 | M/m | 94-136 | [»] | |
6MSG | electron microscopy | 3.50 | A | 1-433 | [»] | |
6MSH | electron microscopy | 3.60 | A | 1-433 | [»] | |
6MSJ | electron microscopy | 3.30 | A | 1-433 | [»] | |
6MSK | electron microscopy | 3.20 | A | 1-433 | [»] | |
6WJD | electron microscopy | 4.80 | A | 1-433 | [»] | |
6WJN | electron microscopy | 5.70 | A | 35-433 | [»] | |
SMRi | P35998 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111674, 239 interactors |
ComplexPortali | CPX-5993, 26S Proteasome complex |
CORUMi | P35998 |
DIPi | DIP-27554N |
IntActi | P35998, 94 interactors |
MINTi | P35998 |
STRINGi | 9606.ENSP00000391211 |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
PTM databases
iPTMneti | P35998 |
MetOSitei | P35998 |
PhosphoSitePlusi | P35998 |
SwissPalmi | P35998 |
Genetic variation databases
BioMutai | PSMC2 |
DMDMi | 547930 |
2D gel databases
OGPi | P35998 |
REPRODUCTION-2DPAGEi | IPI00021435 P35998 |
Proteomic databases
EPDi | P35998 |
jPOSTi | P35998 |
MassIVEi | P35998 |
MaxQBi | P35998 |
PaxDbi | P35998 |
PeptideAtlasi | P35998 |
PRIDEi | P35998 |
ProteomicsDBi | 55172 [P35998-1] 6682 |
Protocols and materials databases
Antibodypediai | 16901, 347 antibodies |
DNASUi | 5701 |
Genome annotation databases
Ensembli | ENST00000292644; ENSP00000292644; ENSG00000161057 [P35998-1] ENST00000435765; ENSP00000391211; ENSG00000161057 [P35998-1] |
GeneIDi | 5701 |
KEGGi | hsa:5701 |
UCSCi | uc003vbs.4, human [P35998-1] |
Organism-specific databases
CTDi | 5701 |
DisGeNETi | 5701 |
GeneCardsi | PSMC2 |
HGNCi | HGNC:9548, PSMC2 |
HPAi | ENSG00000161057, Low tissue specificity |
MIMi | 154365, gene |
neXtProti | NX_P35998 |
OpenTargetsi | ENSG00000161057 |
PharmGKBi | PA33893 |
VEuPathDBi | HostDB:ENSG00000161057.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0729, Eukaryota |
GeneTreei | ENSGT01000000214468 |
HOGENOMi | CLU_000688_6_1_1 |
InParanoidi | P35998 |
OMAi | IHANTMN |
PhylomeDBi | P35998 |
TreeFami | TF105661 |
Enzyme and pathway databases
PathwayCommonsi | P35998 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 5701, 701 hits in 897 CRISPR screens |
ChiTaRSi | PSMC2, human |
GeneWikii | PSMC2 |
GenomeRNAii | 5701 |
Pharosi | P35998, Tbio |
PROi | PR:P35998 |
RNActi | P35998, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000161057, Expressed in biceps brachii and 249 other tissues |
ExpressionAtlasi | P35998, baseline and differential |
Genevisiblei | P35998, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR035245, PSMC2 |
PANTHERi | PTHR23073:SF13, PTHR23073:SF13, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PRS7_HUMAN | |
Accessioni | P35998Primary (citable) accession number: P35998 Secondary accession number(s): A4D0Q1 Q9UDI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 213 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families