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Entry version 176 (03 Jul 2019)
Sequence version 4 (07 Jan 2015)
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Protein

Tyrosine-protein phosphatase 10D

Gene

Ptp10D

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in axon outgrowth and guidance.1 Publication

Miscellaneous

This protein is translated by readthrough of a stop codon. Readthrough of the terminator codon TAG occurs between the codons for Arg-1631 and His-1633. There is currently no sequence that provides the identity of residue 1632.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1436SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1468Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1512SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protein phosphatase
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphatase 10D (EC:3.1.3.48)
Alternative name(s):
Receptor-linked protein-tyrosine phosphatase 10D
Short name:
DPTP10D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ptp10D
ORF Names:CG1817
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004370 Ptp10D

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini43 – 1197ExtracellularSequence analysisAdd BLAST1155
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1198 – 1218HelicalSequence analysisAdd BLAST21
Topological domaini1219 – 1990CytoplasmicSequence analysisAdd BLAST772

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 42Sequence analysisAdd BLAST42
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002542743 – 1990Tyrosine-protein phosphatase 10DAdd BLAST1948

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi486N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi533N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi668N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi687N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi719N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi723N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi823N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi841N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi874N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi908N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi925N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1001N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1136N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1195N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35992

PRoteomics IDEntifications database

More...
PRIDEi
P35992

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In 9-12 hour embryos, expression is specifically seen in the anterior commissure and its junctions with the longitudinal tracts.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Expressed throughout development to adulthood, lowest expression is during second and third larval instars.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004370 Expressed in 24 organ(s), highest expression level in female reproductive system

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35992 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
58524, 10 interactors

Protein interaction database and analysis system

More...
IntActi
P35992, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0303420

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11990
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35992

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 218Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini219 – 314Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini407 – 498Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST92
Domaini499 – 584Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST86
Domaini585 – 674Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini675 – 771Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST97
Domaini775 – 865Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST91
Domaini866 – 956Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST91
Domaini957 – 1057Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST101
Domaini1272 – 1527Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1468 – 1474Substrate bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1673 – 1686Gln-richPROSITE-ProRule annotationAdd BLAST14
Compositional biasi1932 – 1972Gly-richPROSITE-ProRule annotationAdd BLAST41

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0791 Eukaryota
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154814

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35992

KEGG Orthology (KO)

More...
KOi
K05694

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYIATVT

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 9 hits
PF00102 Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 11 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 6 hits
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 9 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoform G is produced by readthrough of a stop codon between the codons for Arg-1631 and His-1633. This is likely to be a rare event with most transcripts using the stop codon following Arg-1631.Curated
Isoform GImported (identifier: P35992-5) [UniParc]FASTAAdd to basket
Also known as: FImported

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLYQLSKATT RIRLKRQKAV PQHRWLWSLA FLAAFTLKDV RCADLAISIP
60 70 80 90 100
NNPGLDDGAS YRLDYSPPFG YPEPNTTIAS REIGDEIQFS RALPGTKYNF
110 120 130 140 150
WLYYTNFTHH DWLTWTVTIT TAPDPPSNLS VQVRSGKNAI ILWSPPTQGS
160 170 180 190 200
YTAFKIKVLG LSEASSSYNR TFQVNDNTFQ HSVKELTPGA TYQVQAYTIY
210 220 230 240 250
DGKESVAYTS RNFTTKPNTP GKFIVWFRNE TTLLVLWQPP YPAGIYTHYK
260 270 280 290 300
VSIEPPDAND SVLYVEKEGE PPGPAQAAFK GLVPGRAYNI SVQTMSEDEI
310 320 330 340 350
SLPTTAQYRT VPLRPLNVTF DRDFITSNSF RVLWEAPKGI SEFDKYQVSV
360 370 380 390 400
ATTRRQSTVP RSNEPVAFFD FRDIAEPGKT FNVIVKTVSG KVTSWPATGD
410 420 430 440 450
VTLRPLPVRN LRSINDDKTN TMIITWEADP ASTQDEYRIV YHELETFNGD
460 470 480 490 500
TSTLTTDRTR FTLESLLPGR NYSLSVQAVS KKMESNETSI FVVTRPSSPI
510 520 530 540 550
IEDLKSIRMG LNISWKSDVN SKQEQYEVLY SRNGTSDLRT QKTKESRLVI
560 570 580 590 600
KNLQPGAGYE LKVFAVSHDL RSEPHAYFQA VYPNPPRNMT IETVRSNSVL
610 620 630 640 650
VHWSPPESGE FTEYSIRYRT DSEQQWVRLP SVRSTEADIT DMTKGEKYTI
660 670 680 690 700
QVNTVSFGVE SPVPQEVNTT VPPNPVSNII QLVDSRNITL EWPKPEGRVE
710 720 730 740 750
SYILKWWPSD NPGRVQTKNV SENKSADDLS TVRVLIGELM PGVQYKFDIQ
760 770 780 790 800
TTSYGILSGI TSLYPRTMPL IQSDVVVANG EKEDERDTIT LSYTPTPQSS
810 820 830 840 850
SKFDIYRFSL GDAEIRDKEK LANDTDRKVT FTGLVPGRLY NITVWTVSGG
860 870 880 890 900
VASLPIQRQD RLYPEPITQL HATNITDTEI SLRWDLPKGE YNDFDIAYLT
910 920 930 940 950
ADNLLAQNMT TRNEITISDL RPHRNYTFTV VVRSGTESSV LRSSSPLSAS
960 970 980 990 1000
FTTNEAVPGR VERFHPTDVQ PSEINFEWSL PSSEANGVIR QFSIAYTNIN
1010 1020 1030 1040 1050
NLTDAGMQDF ESEEAFGVIK NLKPGETYVF KIQAKTAIGF GPEREYRQTM
1060 1070 1080 1090 1100
PILAPPRPAT QVVPTEVYRS SSTIQIRFRK NYFSDQNGQV RMYTIIVAED
1110 1120 1130 1140 1150
DAKNASGLEM PSWLDVQSYS VWLPYQAIDP YYPFENRSVE DFTIGTENCD
1160 1170 1180 1190 1200
NHKIGYCNGP LKSGTTYRVK VRAFTGADKF TDTAYSFPIQ TDQDNTSLIV
1210 1220 1230 1240 1250
AITVPLTIIL VLLVTLLFYK RRRNNCRKTT KDSRANDNMS LPDSVIEQNR
1260 1270 1280 1290 1300
PILIKNFAEH YRLMSADSDF RFSEEFEELK HVGRDQPCTF ADLPCNRPKN
1310 1320 1330 1340 1350
RFTNILPYDH SRFKLQPVDD DEGSDYINAN YVPGHNSPRE FIVTQGPLHS
1360 1370 1380 1390 1400
TRDDFWRMCW ESNSRAIVML TRCFEKGREK CDQYWPNDTV PVFYGDIKVQ
1410 1420 1430 1440 1450
ILNDSHYADW VMTEFMLCRG SEQRILRHFH FTTWPDFGVP NPPQTLVRFV
1460 1470 1480 1490 1500
RAFRDRIGAE QRPIVVHCSA GVGRSGTFIT LDRILQQINT SDYVDIFGIV
1510 1520 1530 1540 1550
YAMRKERVWM VQTEQQYICI HQCLLAVLEG KENIVGPARE MHDNEGYEGQ
1560 1570 1580 1590 1600
QVQLDENGDV VATIEGHLSH HDLQQAEAEA IDDENAAILH DDQQPLTSSF
1610 1620 1630 1640 1650
TGHHTHMPPT TSMSSFGGGG GGHTNVDAPD RXHSVVNQSD NNNSVVIVLV
1660 1670 1680 1690 1700
DNKPSSMICK DSKGGNIDVL ESQQQQQQQQ QQQPNQGGHN ITTISAINGY
1710 1720 1730 1740 1750
NTLQHRRKSQ LITFSSSSCD IKNSLSHEYI NGSNGSAANG PPSSGSGSGS
1760 1770 1780 1790 1800
GPGSNRASRA NVRLSFAEED VMILPQNHSQ QSNHQDDEVF TRRRSLLEVE
1810 1820 1830 1840 1850
IGVEVGEDGE LAPHEMEEDL EEEDEDEELY MHDEFETHID TKSNNANDDS
1860 1870 1880 1890 1900
GGGSYEDSHA LHSSLGGSNR NSLEKDDDDI EVDVISTDVS CYDQLLGSSC
1910 1920 1930 1940 1950
NTRNGDDDDI ATLVGDGDYS TTKLSKASRL SGAGVGGLVV SGGGGGTAIG
1960 1970 1980 1990
GGIAVNGGGV LGNGVGSEAG GGIIYANPFM DDEGIAESGM
Note: No experimental confirmation available.Curated
Length:1,990
Mass (Da):222,740
Last modified:January 7, 2015 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76FAAA08565AE8DA
GO
Isoform BImported (identifier: P35992-1) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     1632-1990: Missing.

Show »
Length:1,631
Mass (Da):185,081
Checksum:i22A59AB61665875D
GO
Isoform EImported (identifier: P35992-2) [UniParc]FASTAAdd to basket
Also known as: Short, IImported

The sequence of this isoform differs from the canonical sequence as follows:
     1549-1980: Missing.

Show »
Length:1,558
Mass (Da):177,366
Checksum:i716C60806FDAC9DD
GO
Isoform HImported (identifier: P35992-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-216: K → SRRTRHKELLDIKILRE
     1191-1191: T → TEMLSSP
     1632-1990: Missing.

Note: No experimental confirmation available.Curated
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Length:1,653
Mass (Da):187,743
Checksum:i2E58394F82C827DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124D → I in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti127S → L in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti188P → L in AAO42638 (Ref. 5) Curated1
Sequence conflicti369F → S in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti369F → S in AAA28952 (PubMed:1657402).Curated1
Sequence conflicti558G → A in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti558G → A in AAA28952 (PubMed:1657402).Curated1
Sequence conflicti810L → S in AAA28484 (PubMed:1657401).Curated1
Sequence conflicti810L → S in AAA28952 (PubMed:1657402).Curated1
Sequence conflicti1403N → S in AAO42638 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_057306216K → SRRTRHKELLDIKILRE in isoform H. Curated1
Alternative sequenceiVSP_0573071191T → TEMLSSP in isoform H. Curated1
Alternative sequenceiVSP_0051431549 – 1980Missing in isoform E. 2 PublicationsAdd BLAST432
Alternative sequenceiVSP_0573081632 – 1990Missing in isoform B and isoform H. 1 PublicationCuratedAdd BLAST359

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M80465 mRNA Translation: AAA28484.1
M80538 mRNA Translation: AAA28952.1
AE014298 Genomic DNA Translation: AAF48072.3
AE014298 Genomic DNA Translation: AAS65319.2
AE014298 Genomic DNA Translation: AAS65320.2
AE014298 Genomic DNA Translation: ACL82919.1
AE014298 Genomic DNA Translation: AGB95296.1
AE014298 Genomic DNA Translation: AGB95297.1
BT004474 mRNA Translation: AAO42638.1
BT126065 mRNA Translation: ADY17764.1

Protein sequence database of the Protein Information Resource

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PIRi
C41214
D41214

NCBI Reference Sequences

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RefSeqi
NP_001138187.1, NM_001144715.2 [P35992-2]
NP_001259453.1, NM_001272524.1 [P35992-6]
NP_001259454.1, NM_001272525.1 [P35992-2]
NP_727544.2, NM_167292.3 [P35992-1]
NP_996413.2, NM_206690.2 [P35992-5]
NP_996414.2, NM_206691.3 [P35992-5]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0073522; FBpp0073369; FBgn0004370 [P35992-1]
FBtr0273235; FBpp0271743; FBgn0004370 [P35992-2]
FBtr0330392; FBpp0303418; FBgn0004370 [P35992-5]
FBtr0330393; FBpp0303419; FBgn0004370 [P35992-5]
FBtr0330394; FBpp0303420; FBgn0004370 [P35992-6]
FBtr0331406; FBpp0303823; FBgn0004370 [P35992-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
32115

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG1817

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80465 mRNA Translation: AAA28484.1
M80538 mRNA Translation: AAA28952.1
AE014298 Genomic DNA Translation: AAF48072.3
AE014298 Genomic DNA Translation: AAS65319.2
AE014298 Genomic DNA Translation: AAS65320.2
AE014298 Genomic DNA Translation: ACL82919.1
AE014298 Genomic DNA Translation: AGB95296.1
AE014298 Genomic DNA Translation: AGB95297.1
BT004474 mRNA Translation: AAO42638.1
BT126065 mRNA Translation: ADY17764.1
PIRiC41214
D41214
RefSeqiNP_001138187.1, NM_001144715.2 [P35992-2]
NP_001259453.1, NM_001272524.1 [P35992-6]
NP_001259454.1, NM_001272525.1 [P35992-2]
NP_727544.2, NM_167292.3 [P35992-1]
NP_996413.2, NM_206690.2 [P35992-5]
NP_996414.2, NM_206691.3 [P35992-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S3EX-ray2.40A/B1250-1533[»]
3S3FX-ray2.70A/B1250-1533[»]
3S3HX-ray2.80A/B1250-1533[»]
3S3KX-ray3.20A/B1250-1533[»]
SMRiP35992
ModBaseiSearch...

Protein-protein interaction databases

BioGridi58524, 10 interactors
IntActiP35992, 5 interactors
STRINGi7227.FBpp0303420

Proteomic databases

PaxDbiP35992
PRIDEiP35992

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073522; FBpp0073369; FBgn0004370 [P35992-1]
FBtr0273235; FBpp0271743; FBgn0004370 [P35992-2]
FBtr0330392; FBpp0303418; FBgn0004370 [P35992-5]
FBtr0330393; FBpp0303419; FBgn0004370 [P35992-5]
FBtr0330394; FBpp0303420; FBgn0004370 [P35992-6]
FBtr0331406; FBpp0303823; FBgn0004370 [P35992-2]
GeneIDi32115
KEGGidme:Dmel_CG1817

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32115
FlyBaseiFBgn0004370 Ptp10D

Phylogenomic databases

eggNOGiKOG0791 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00940000154814
InParanoidiP35992
KOiK05694
OMAiKYIATVT

Enzyme and pathway databases

ReactomeiR-DME-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ptp10D fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32115

Protein Ontology

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PROi
PR:P35992

Gene expression databases

BgeeiFBgn0004370 Expressed in 24 organ(s), highest expression level in female reproductive system
GenevisibleiP35992 DM

Family and domain databases

CDDicd00063 FN3, 9 hits
Gene3Di2.60.40.10, 10 hits
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 9 hits
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 11 hits
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF49265 SSF49265, 6 hits
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTP10_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35992
Secondary accession number(s): A4V4B4
, B7Z142, F0JAM3, M9PEB6, M9PJI5, Q0KHT5, Q86NN9, Q8IR87, Q9VYW1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 7, 2015
Last modified: July 3, 2019
This is version 176 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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