Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L12

Gene

Rpl12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds directly to 26S ribosomal RNA.

GO - Molecular functioni

  • large ribosomal subunit rRNA binding Source: MGI
  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L12
Gene namesi
Name:Rpl12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98002 Rpl12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001044571 – 16560S ribosomal protein L12Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei54N6-acetyllysineBy similarity1
Modified residuei165PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP35979
PaxDbiP35979
PeptideAtlasiP35979
PRIDEiP35979

PTM databases

iPTMnetiP35979
PhosphoSitePlusiP35979
SwissPalmiP35979

Expressioni

Gene expression databases

BgeeiENSMUSG00000038900 Expressed in 45 organ(s), highest expression level in mesonephros
CleanExiMM_RPL12
ExpressionAtlasiP35979 baseline and differential
GenevisibleiP35979 MM

Interactioni

Protein-protein interaction databases

BioGridi234630, 4 interactors
IntActiP35979, 7 interactors
MINTiP35979
STRINGi10090.ENSMUSP00000136144

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35979
SMRiP35979
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35979

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0886 Eukaryota
COG0080 LUCA
GeneTreeiENSGT00390000006922
HOGENOMiHOG000082125
HOVERGENiHBG007231
InParanoidiP35979
KOiK02870
OMAiKLGPLGM
OrthoDBiEOG091G0PW6
PhylomeDBiP35979
TreeFamiTF300123

Family and domain databases

CDDicd00349 Ribosomal_L11, 1 hit
Gene3Di1.10.10.250, 1 hit
3.30.1550.10, 1 hit
HAMAPiMF_00736 Ribosomal_L11, 1 hit
InterProiView protein in InterPro
IPR000911 Ribosomal_L11/L12
IPR036796 Ribosomal_L11/L12_N_sf
IPR020783 Ribosomal_L11_C
IPR036769 Ribosomal_L11_C_sf
IPR020785 Ribosomal_L11_CS
IPR020784 Ribosomal_L11_N
PANTHERiPTHR11661 PTHR11661, 1 hit
PfamiView protein in Pfam
PF00298 Ribosomal_L11, 1 hit
PF03946 Ribosomal_L11_N, 1 hit
SMARTiView protein in SMART
SM00649 RL11, 1 hit
SUPFAMiSSF46906 SSF46906, 1 hit
SSF54747 SSF54747, 1 hit
PROSITEiView protein in PROSITE
PS00359 RIBOSOMAL_L11, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35979-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPKFDPNEV KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT
60 70 80 90 100
GDWKGLRITV KLTIQNRQAQ IEVVPSASAL IIKALKEPPR DRKKQKNIKH
110 120 130 140 150
SGNITFDEIV NIARQMRHRS LARELSGTIK EILGTAQSVG CNVDGRHPHD
160
IIDDINSGAV ECPAS
Length:165
Mass (Da):17,805
Last modified:June 16, 2003 - v2
Checksum:i7EEEC00C57193116
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YVW4A0A0A6YVW4_MOUSE
60S ribosomal protein L12
Rpl12 mCG_18564
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79A → G in AAA40066 (PubMed:8359697).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04280 mRNA Translation: AAA40066.1
AK002973 mRNA Translation: BAB22488.1
AK008347 mRNA Translation: BAB25619.1
AK012349 mRNA Translation: BAB28180.1
AK012428 mRNA Translation: BAB28232.1
BC018321 mRNA Translation: AAH18321.1
BC081469 mRNA Translation: AAH81469.1
CCDSiCCDS15936.1
PIRiJN0778
RefSeqiNP_033102.2, NM_009076.3
UniGeneiMm.250030
Mm.381297

Genome annotation databases

EnsembliENSMUST00000126610; ENSMUSP00000117461; ENSMUSG00000038900
GeneIDi269261
KEGGimmu:269261
UCSCiuc008jhe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04280 mRNA Translation: AAA40066.1
AK002973 mRNA Translation: BAB22488.1
AK008347 mRNA Translation: BAB25619.1
AK012349 mRNA Translation: BAB28180.1
AK012428 mRNA Translation: BAB28232.1
BC018321 mRNA Translation: AAH18321.1
BC081469 mRNA Translation: AAH81469.1
CCDSiCCDS15936.1
PIRiJN0778
RefSeqiNP_033102.2, NM_009076.3
UniGeneiMm.250030
Mm.381297

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIBNMR-A2-79[»]
ProteinModelPortaliP35979
SMRiP35979
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234630, 4 interactors
IntActiP35979, 7 interactors
MINTiP35979
STRINGi10090.ENSMUSP00000136144

PTM databases

iPTMnetiP35979
PhosphoSitePlusiP35979
SwissPalmiP35979

Proteomic databases

EPDiP35979
PaxDbiP35979
PeptideAtlasiP35979
PRIDEiP35979

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000126610; ENSMUSP00000117461; ENSMUSG00000038900
GeneIDi269261
KEGGimmu:269261
UCSCiuc008jhe.2 mouse

Organism-specific databases

CTDi6136
MGIiMGI:98002 Rpl12

Phylogenomic databases

eggNOGiKOG0886 Eukaryota
COG0080 LUCA
GeneTreeiENSGT00390000006922
HOGENOMiHOG000082125
HOVERGENiHBG007231
InParanoidiP35979
KOiK02870
OMAiKLGPLGM
OrthoDBiEOG091G0PW6
PhylomeDBiP35979
TreeFamiTF300123

Miscellaneous databases

EvolutionaryTraceiP35979
PROiPR:P35979
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038900 Expressed in 45 organ(s), highest expression level in mesonephros
CleanExiMM_RPL12
ExpressionAtlasiP35979 baseline and differential
GenevisibleiP35979 MM

Family and domain databases

CDDicd00349 Ribosomal_L11, 1 hit
Gene3Di1.10.10.250, 1 hit
3.30.1550.10, 1 hit
HAMAPiMF_00736 Ribosomal_L11, 1 hit
InterProiView protein in InterPro
IPR000911 Ribosomal_L11/L12
IPR036796 Ribosomal_L11/L12_N_sf
IPR020783 Ribosomal_L11_C
IPR036769 Ribosomal_L11_C_sf
IPR020785 Ribosomal_L11_CS
IPR020784 Ribosomal_L11_N
PANTHERiPTHR11661 PTHR11661, 1 hit
PfamiView protein in Pfam
PF00298 Ribosomal_L11, 1 hit
PF03946 Ribosomal_L11_N, 1 hit
SMARTiView protein in SMART
SM00649 RL11, 1 hit
SUPFAMiSSF46906 SSF46906, 1 hit
SSF54747 SSF54747, 1 hit
PROSITEiView protein in PROSITE
PS00359 RIBOSOMAL_L11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL12_MOUSE
AccessioniPrimary (citable) accession number: P35979
Secondary accession number(s): Q9CQK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 16, 2003
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again