UniProtKB - P35971 (HEMA_MEASA)
Hemagglutinin glycoprotein
H
Functioni
Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (By similarity).
By similarityCaution
GO - Molecular functioni
- host cell surface receptor binding Source: InterPro
GO - Biological processi
- viral entry into host cell Source: UniProtKB-KW
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Molecular function | Hemagglutinin |
Biological process | Host-virus interaction, Viral attachment to host cell, Virus entry into host cell |
Names & Taxonomyi
Protein namesi | Recommended name: Hemagglutinin glycoprotein |
Gene namesi | Name:H |
Organismi | Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus) |
Taxonomic identifieri | 36408 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Orthoparamyxovirinae › Morbillivirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion membrane Curated; Single-pass type II membrane protein Curated
- Host cell membrane By similarity; Single-pass type II membrane protein By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | IntravirionSequence analysisAdd BLAST | 37 | |
Transmembranei | 38 – 58 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 59 – 617 | Virion surfaceSequence analysisAdd BLAST | 559 |
Keywords - Cellular componenti
Host cell membrane, Host membrane, Membrane, Viral envelope protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000142598 | 1 – 617 | Hemagglutinin glycoproteinAdd BLAST | 617 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 168 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 187 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 200 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 215 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 238 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Interacts with human NECTIN4; this interaction allows virus infection of the respiratory epithelium (By similarity).
Interacts with human MCP/CD46 antigen and SLAMF1.
By similarity1 PublicationFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR000665, Hemagglutn/HN IPR036278, Sialidase_sf |
Pfami | View protein in Pfam PF00423, HN, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI
60 70 80 90 100
GLLAIAGIRL HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY
160 170 180 190 200
DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN
210 220 230 240 250
MSLSLLDLYL GRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS
260 270 280 290 300
MYRVFEVGVI RNPGLGAPVF HMTNYLEQPV SNDLSNCMVA LGELKLAALC
310 320 330 340 350
HREDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVTLS TDDPVIDRLY
360 370 380 390 400
LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA
410 420 430 440 450
PLKDNRIPSY GVLSVDLSLT VELKIKIASG FGPLITHGSG MDLYKSNHNN
460 470 480 490 500
VYWLTIPPMK NLALGVINTL EWIPRFKVSP YLFNVPIKEA GEDCHAPTYL
510 520 530 540 550
PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS
560 570 580 590 600
YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGMV
610
GMGVSCTVTR EDGTNRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S58435 Genomic RNA Translation: AAB26146.1 |
PIRi | F48556 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S58435 Genomic RNA Translation: AAB26146.1 |
PIRi | F48556 |
3D structure databases
SMRi | P35971 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR000665, Hemagglutn/HN IPR036278, Sialidase_sf |
Pfami | View protein in Pfam PF00423, HN, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HEMA_MEASA | |
Accessioni | P35971Primary (citable) accession number: P35971 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | September 29, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |