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UniProtKB - P35968 (VGFR2_HUMAN)

Protein

Vascular endothelial growth factor receptor 2

Gene

KDR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.22 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation2 Publications

Activity regulationi

Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by the small molecule PTK inhibitor SU5614 ((3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one). May be regulated by hydrogen sulfide (H2S) levels via a H2S-sensitive intracellular disulfide bond.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei868ATPCurated1
Active sitei1028Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi840 – 848ATPCurated9

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological processAngiogenesis, Differentiation, Host-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-194306 Neurophilin interactions with VEGF and VEGFR
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization
R-HSA-216083 Integrin cell surface interactions
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5218921 VEGFR2 mediated cell proliferation
SignaLinkiP35968
SIGNORiP35968

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor receptor 2 (EC:2.7.10.1)
Short name:
VEGFR-2
Alternative name(s):
Fetal liver kinase 1
Short name:
FLK-1
Kinase insert domain receptor
Short name:
KDR
Protein-tyrosine kinase receptor flk-1
CD_antigen: CD309
Gene namesi
Name:KDR
Synonyms:FLK1, VEGFR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000128052.8
HGNCiHGNC:6307 KDR
MIMi191306 gene
neXtProtiNX_P35968

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 764ExtracellularSequence analysisAdd BLAST745
Transmembranei765 – 785HelicalSequence analysisAdd BLAST21
Topological domaini786 – 1356CytoplasmicSequence analysisAdd BLAST571

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

Hemangioma, capillary infantile (HCI)3 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA condition characterized by dull red, firm, dome-shaped hemangiomas, sharply demarcated from surrounding skin, usually presenting at birth or occurring within the first two or three months of life. They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring.
See also OMIM:602089
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042057482C → R in HCI; associated with disease susceptibility; expression of FLT1 in hemangioma endothelial cells is markedly reduced and KDR activity is increased compared to controls; low FLT1 expression in hemangioma cells is caused by reduced activity of a pathway involving ITGB1, ANTXR1, KDR and NFATC2IP; the mutation predicts to result in loss-of-function and disruption of the normal association of these molecules. 2 PublicationsCorresponds to variant dbSNP:rs34231037EnsemblClinVar.1
Natural variantiVAR_0631471147P → S in HCI; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121917766EnsemblClinVar.1
Plays a major role in tumor angiogenesis. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi726R → A: Strongly reduced autophosphorylation and activation of MAP kinases. 1 Publication1
Mutagenesisi731D → A: Strongly reduced autophosphorylation and activation of MAP kinases. 1 Publication1
Mutagenesisi801Y → F: Abolishes stimulation of nitric oxide synthesis. 1 Publication1
Mutagenesisi868K → M: Loss of enzyme activity. 1 Publication1
Mutagenesisi951Y → F: Abolishes reorganization of the actin cytoskeleton and cell migration in response to VEGFA. 1 Publication1
Mutagenesisi996Y → F: Strongly reduced autophosphorylation. Reduces phosphorylation of PLCG1. 1 Publication1
Mutagenesisi1045C → A: Significantly higher kinase activity. 1 Publication1
Mutagenesisi1054Y → F: Strongly reduced autophosphorylation. Abolishes phosphorylation of downstream signaling proteins; when associated with F-1059. 1 Publication1
Mutagenesisi1059Y → F: Strongly reduced autophosphorylation. Abolishes phosphorylation of downstream signaling proteins; when associated with F-1054. 1 Publication1
Mutagenesisi1175Y → F: Abolishes phosphorylation of PLCG1 and MAP kinases in response to VEGFA. 1 Publication1
Mutagenesisi1214Y → F: Loss of phosphorylation site. Abolishes reorganization of the actin cytoskeleton in response to VEGFA. 1 Publication1

Organism-specific databases

DisGeNETi3791
MalaCardsiKDR
MIMi602089 phenotype
OpenTargetsiENSG00000128052
Orphaneti91415 Familial capillary hemangioma
PharmGKBiPA30086

Chemistry databases

ChEMBLiCHEMBL279
DrugBankiDB07528 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
DB06938 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
DB06080 ABT-869
DB06626 Axitinib
DB04849 AZD2171
DB08875 Cabozantinib
DB05198 CYC116
DB06101 IMC-1C11
DB09078 Lenvatinib
DB07183 N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
DB09079 Nintedanib
DB06589 Pazopanib
DB08901 Ponatinib
DB05578 Ramucirumab
DB08896 Regorafenib
DB00398 Sorafenib
DB01268 Sunitinib
DB05075 TG100801
DB04879 Vatalanib
DB05153 XL184
DB05146 XL820
DB05030 XL880
DB05014 XL999
GuidetoPHARMACOLOGYi1813

Polymorphism and mutation databases

BioMutaiKDR
DMDMi9087218

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001677120 – 1356Vascular endothelial growth factor receptor 2Add BLAST1337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi53 ↔ 103PROSITE-ProRule annotation
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi150 ↔ 200
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi245N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi246 ↔ 307
Glycosylationi318N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi395N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi445 ↔ 530PROSITE-ProRule annotation
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi571 ↔ 642PROSITE-ProRule annotation
Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi613N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi619N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi675N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi688 ↔ 737PROSITE-ProRule annotation
Glycosylationi704N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi721N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei801Phosphotyrosine2 Publications1
Modified residuei951Phosphotyrosine; by autocatalysis3 Publications1
Modified residuei982PhosphoserineCombined sources1
Modified residuei984PhosphoserineCombined sources1
Modified residuei996Phosphotyrosine; by autocatalysis2 Publications1
Disulfide bondi1024 ↔ 1045Redox-active
Modified residuei1054Phosphotyrosine; by autocatalysis5 Publications1
Modified residuei1059Phosphotyrosine; by autocatalysis6 Publications1
Modified residuei1175Phosphotyrosine; by autocatalysis3 Publications1
Modified residuei1214Phosphotyrosine; by autocatalysis4 Publications1
Modified residuei1231PhosphoserineBy similarity1
Modified residuei1235PhosphoserineBy similarity1
Modified residuei1238PhosphothreonineBy similarity1
Modified residuei1305Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1309Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei1319Phosphotyrosine; by autocatalysis1 Publication1

Post-translational modificationi

N-glycosylated.3 Publications
Ubiquitinated. Tyrosine phosphorylation of the receptor promotes its poly-ubiquitination, leading to its degradation via the proteasome or lysosomal proteases.3 Publications
Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-951 is important for interaction with SH2D2A/TSAD and VEGFA-mediated reorganization of the actin cytoskeleton. Phosphorylation at Tyr-1175 is important for interaction with PLCG1 and SHB. Phosphorylation at Tyr-1214 is important for interaction with NCK1 and FYN. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214.8 Publications
The inhibitory disulfide bond between Cys-1024 and Cys-1045 may serve as a specific molecular switch for H2S-induced modification that regulates VEGFR2 function.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP35968
MaxQBiP35968
PaxDbiP35968
PeptideAtlasiP35968
PRIDEiP35968
ProteomicsDBi55169
55170 [P35968-2]
55171 [P35968-3]

PTM databases

CarbonylDBiP35968
iPTMnetiP35968
PhosphoSitePlusiP35968

Expressioni

Tissue specificityi

Detected in cornea (at protein level). Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000128052 Expressed in 208 organ(s), highest expression level in lung
CleanExiHS_KDR
ExpressionAtlasiP35968 baseline and differential
GenevisibleiP35968 HS

Organism-specific databases

HPAiCAB004028

Interactioni

Subunit structurei

Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD ligands; monomeric in the absence of bound ligands. Can also form heterodimers with FLT1/VEGFR1 and FLT4/VEGFR2. Interacts (tyrosine phosphorylated) with LFYN, NCK1, PLCG1. Interacts (tyrosine-phosphorylated active form preferentially) with DAB2IP (via C2 domain and active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity. Interacts with SHBSH2D2A/TSAD, GRB2, MYOF, CBL and PDCD6. Interacts (via C-terminus domain) with ERN1 (via kinase domain); the interaction is facilitated in a XBP1 isoform 1- and vascular endothelial growth factor (VEGF)-dependent manner in endothelial cells (PubMed:23529610).22 Publications
(Microbial infection) Interacts with HIV-1 Tat.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1175Interaction with SHBBy similarity1

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi109992, 57 interactors
CORUMiP35968
DIPiDIP-486N
IntActiP35968, 38 interactors
MINTiP35968
STRINGi9606.ENSP00000263923

Chemistry databases

BindingDBiP35968

Structurei

Secondary structure

11356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35968
SMRiP35968
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35968

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 110Ig-like C2-type 1Add BLAST65
Domaini141 – 207Ig-like C2-type 2Add BLAST67
Domaini224 – 320Ig-like C2-type 3Add BLAST97
Domaini328 – 414Ig-like C2-type 4Add BLAST87
Domaini421 – 548Ig-like C2-type 5Add BLAST128
Domaini551 – 660Ig-like C2-type 6Add BLAST110
Domaini667 – 753Ig-like C2-type 7Add BLAST87
Domaini834 – 1162Protein kinasePROSITE-ProRule annotationAdd BLAST329

Domaini

The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding.1 Publication

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOVERGENiHBG053432
InParanoidiP35968
KOiK05098
OMAiMFFWLLL
OrthoDBiEOG091G01TL
PhylomeDBiP35968
TreeFamiTF325768

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR009136 VEGFR2_rcpt
PANTHERiPTHR24416:SF45 PTHR24416:SF45, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR01834 VEGFRECEPTR2
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 5 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 7 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P35968-1) [UniParc]FASTAAdd to basket
Also known as: mbVegfr-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSKVLLAVA LWLCVETRAA SVGLPSVSLD LPRLSIQKDI LTIKANTTLQ 
        60         70         80         90        100
ITCRGQRDLD WLWPNNQSGS EQRVEVTECS DGLFCKTLTI PKVIGNDTGA 
       110        120        130        140        150
YKCFYRETDL ASVIYVYVQD YRSPFIASVS DQHGVVYITE NKNKTVVIPC 
       160        170        180        190        200
LGSISNLNVS LCARYPEKRF VPDGNRISWD SKKGFTIPSY MISYAGMVFC 
       210        220        230        240        250
EAKINDESYQ SIMYIVVVVG YRIYDVVLSP SHGIELSVGE KLVLNCTART 
       260        270        280        290        300
ELNVGIDFNW EYPSSKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDGVTRS 
       310        320        330        340        350
DQGLYTCAAS SGLMTKKNST FVRVHEKPFV AFGSGMESLV EATVGERVRI 
       360        370        380        390        400
PAKYLGYPPP EIKWYKNGIP LESNHTIKAG HVLTIMEVSE RDTGNYTVIL 
       410        420        430        440        450
TNPISKEKQS HVVSLVVYVP PQIGEKSLIS PVDSYQYGTT QTLTCTVYAI 
       460        470        480        490        500
PPPHHIHWYW QLEEECANEP SQAVSVTNPY PCEEWRSVED FQGGNKIEVN 
       510        520        530        540        550
KNQFALIEGK NKTVSTLVIQ AANVSALYKC EAVNKVGRGE RVISFHVTRG 
       560        570        580        590        600
PEITLQPDMQ PTEQESVSLW CTADRSTFEN LTWYKLGPQP LPIHVGELPT 
       610        620        630        640        650
PVCKNLDTLW KLNATMFSNS TNDILIMELK NASLQDQGDY VCLAQDRKTK 
       660        670        680        690        700
KRHCVVRQLT VLERVAPTIT GNLENQTTSI GESIEVSCTA SGNPPPQIMW 
       710        720        730        740        750
FKDNETLVED SGIVLKDGNR NLTIRRVRKE DEGLYTCQAC SVLGCAKVEA 
       760        770        780        790        800
FFIIEGAQEK TNLEIIILVG TAVIAMFFWL LLVIILRTVK RANGGELKTG 
       810        820        830        840        850
YLSIVMDPDE LPLDEHCERL PYDASKWEFP RDRLKLGKPL GRGAFGQVIE 
       860        870        880        890        900
ADAFGIDKTA TCRTVAVKML KEGATHSEHR ALMSELKILI HIGHHLNVVN 
       910        920        930        940        950
LLGACTKPGG PLMVIVEFCK FGNLSTYLRS KRNEFVPYKT KGARFRQGKD 
       960        970        980        990       1000
YVGAIPVDLK RRLDSITSSQ SSASSGFVEE KSLSDVEEEE APEDLYKDFL 
      1010       1020       1030       1040       1050
TLEHLICYSF QVAKGMEFLA SRKCIHRDLA ARNILLSEKN VVKICDFGLA 
      1060       1070       1080       1090       1100
RDIYKDPDYV RKGDARLPLK WMAPETIFDR VYTIQSDVWS FGVLLWEIFS 
      1110       1120       1130       1140       1150
LGASPYPGVK IDEEFCRRLK EGTRMRAPDY TTPEMYQTML DCWHGEPSQR 
      1160       1170       1180       1190       1200
PTFSELVEHL GNLLQANAQQ DGKDYIVLPI SETLSMEEDS GLSLPTSPVS 
      1210       1220       1230       1240       1250
CMEEEEVCDP KFHYDNTAGI SQYLQNSKRK SRPVSVKTFE DIPLEEPEVK 
      1260       1270       1280       1290       1300
VIPDDNQTDS GMVLASEELK TLEDRTKLSP SFGGMVPSKS RESVASEGSN 
      1310       1320       1330       1340       1350
QTSGYQSGYH SDDTDTTVYS SEEAELLKLI EIGVQTGSTA QILQPDSGTT 

LSSPPV
Length:1,356
Mass (Da):151,527
Last modified:December 1, 2000 - v2
Checksum:i59E7C44B05CFEBB3
GO
Isoform 2 (identifier: P35968-2) [UniParc]FASTAAdd to basket
Also known as: sVegfr-2

The sequence of this isoform differs from the canonical sequence as follows:
     663-678: ERVAPTITGNLENQTT → GRETILDHCAEAVGMP
     679-1356: Missing.

Show »
Length:678
Mass (Da):75,896
Checksum:iBD4BD2686CE95EB9
GO
Isoform 3 (identifier: P35968-3) [UniParc]FASTAAdd to basket
Also known as: VEGFR2-712

The sequence of this isoform differs from the canonical sequence as follows:
     712-712: G → E
     713-1356: Missing.

Show »
Length:712
Mass (Da):79,634
Checksum:i1043A452AE64A528
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2Q → E in AAC16450 (Ref. 4) Curated1
Sequence conflicti772A → T in AAA59459 (PubMed:1656371).Curated1
Sequence conflicti772A → T in CAA43837 (PubMed:1656371).Curated1
Sequence conflicti787R → G in AAA59459 (PubMed:1656371).Curated1
Sequence conflicti787R → G in CAA43837 (PubMed:1656371).Curated1
Sequence conflicti835K → N in AAA59459 (PubMed:1656371).Curated1
Sequence conflicti835K → N in CAA43837 (PubMed:1656371).Curated1
Sequence conflicti1347S → T in AAA59459 (PubMed:1656371).Curated1
Sequence conflicti1347S → T in CAA43837 (PubMed:1656371).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0420532Q → R in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042054136V → M1 PublicationCorresponds to variant dbSNP:rs35636987EnsemblClinVar.1
Natural variantiVAR_042055248A → G in a renal clear cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_036126275R → L in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_022071297V → I1 PublicationCorresponds to variant dbSNP:rs2305948EnsemblClinVar.1
Natural variantiVAR_042056462L → V1 PublicationCorresponds to variant dbSNP:rs56286620EnsemblClinVar.1
Natural variantiVAR_020353472Q → H2 PublicationsCorresponds to variant dbSNP:rs1870377EnsemblClinVar.1
Natural variantiVAR_042057482C → R in HCI; associated with disease susceptibility; expression of FLT1 in hemangioma endothelial cells is markedly reduced and KDR activity is increased compared to controls; low FLT1 expression in hemangioma cells is caused by reduced activity of a pathway involving ITGB1, ANTXR1, KDR and NFATC2IP; the mutation predicts to result in loss-of-function and disruption of the normal association of these molecules. 2 PublicationsCorresponds to variant dbSNP:rs34231037EnsemblClinVar.1
Natural variantiVAR_042058539G → R1 PublicationCorresponds to variant dbSNP:rs55716939EnsemblClinVar.1
Natural variantiVAR_042059689T → M1 PublicationCorresponds to variant dbSNP:rs34038364EnsemblClinVar.1
Natural variantiVAR_042060814D → N1 PublicationCorresponds to variant dbSNP:rs35603373Ensembl.1
Natural variantiVAR_046679848V → E Strongly reduced autophosphorylation and kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs1139776Ensembl.1
Natural variantiVAR_036127873G → R in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_046680952V → I. Corresponds to variant dbSNP:rs13129474Ensembl.1
Natural variantiVAR_0420611065A → T1 PublicationCorresponds to variant dbSNP:rs56302315Ensembl.1
Natural variantiVAR_0631471147P → S in HCI; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121917766EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041988663 – 678ERVAP…ENQTT → GRETILDHCAEAVGMP in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_041989679 – 1356Missing in isoform 2. 1 PublicationAdd BLAST678
Alternative sequenceiVSP_041990712G → E in isoform 3. 1 Publication1
Alternative sequenceiVSP_041991713 – 1356Missing in isoform 3. 1 PublicationAdd BLAST644

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU826563 mRNA Translation: ACF47599.1
FJ899739 mRNA Translation: ACR78514.1
AF035121 mRNA Translation: AAB88005.1
AF063658 mRNA Translation: AAC16450.1
AC021220 Genomic DNA No translation available.
AC111194 Genomic DNA No translation available.
BC131822 mRNA Translation: AAI31823.1
L04947 mRNA Translation: AAA59459.1
X61656 mRNA Translation: CAA43837.1
X89776 Genomic DNA Translation: CAA61916.1
CCDSiCCDS3497.1 [P35968-1]
PIRiJC1402
RefSeqiNP_002244.1, NM_002253.2 [P35968-1]
UniGeneiHs.479756

Genome annotation databases

EnsembliENST00000263923; ENSP00000263923; ENSG00000128052 [P35968-1]
ENST00000645273; ENSP00000495159; ENSG00000128052 [P35968-1]
GeneIDi3791
KEGGihsa:3791
UCSCiuc003has.4 human [P35968-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU826563 mRNA Translation: ACF47599.1
FJ899739 mRNA Translation: ACR78514.1
AF035121 mRNA Translation: AAB88005.1
AF063658 mRNA Translation: AAC16450.1
AC021220 Genomic DNA No translation available.
AC111194 Genomic DNA No translation available.
BC131822 mRNA Translation: AAI31823.1
L04947 mRNA Translation: AAA59459.1
X61656 mRNA Translation: CAA43837.1
X89776 Genomic DNA Translation: CAA61916.1
CCDSiCCDS3497.1 [P35968-1]
PIRiJC1402
RefSeqiNP_002244.1, NM_002253.2 [P35968-1]
UniGeneiHs.479756

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VR2X-ray2.40A806-1171[»]
1Y6AX-ray2.10A806-1171[»]
1Y6BX-ray2.10A806-1171[»]
1YWNX-ray1.71A806-1171[»]
2M59NMR-A/B759-795[»]
2METNMR-A/B/C759-795[»]
2MEUNMR-A/B759-795[»]
2OH4X-ray2.05A806-1171[»]
2P2HX-ray1.95A815-1171[»]
2P2IX-ray2.40A/B815-1171[»]
2QU5X-ray2.95A815-1171[»]
2QU6X-ray2.10A/B815-1171[»]
2RL5X-ray2.65A815-1171[»]
2X1WX-ray2.70L/M/N/O120-326[»]
2X1XX-ray3.10R120-326[»]
2XIRX-ray1.50A806-1171[»]
3B8QX-ray2.75A/B815-1171[»]
3B8RX-ray2.70A/B815-1171[»]
3BE2X-ray1.75A815-1171[»]
3C7QX-ray2.10A806-1171[»]
3CJFX-ray2.15A806-1168[»]
3CJGX-ray2.25A806-1168[»]
3CP9X-ray2.50A/B815-1171[»]
3CPBX-ray2.70A/B815-1171[»]
3CPCX-ray2.40A/B815-1171[»]
3DTWX-ray2.90A/B815-1171[»]
3EFLX-ray2.20A/B815-1171[»]
3EWHX-ray1.60A815-1171[»]
3KVQX-ray2.70A657-764[»]
3S35X-ray2.20X220-338[»]
3S36X-ray3.20X220-338[»]
3S37X-ray2.70X220-338[»]
3U6JX-ray2.15A815-1171[»]
3V2AX-ray3.20R2-764[»]
3V6BX-ray3.20R132-548[»]
3VHEX-ray1.55A811-1169[»]
3VHKX-ray2.49A806-1171[»]
3VIDX-ray2.30A813-1168[»]
3VNTX-ray1.64A806-1171[»]
3VO3X-ray1.52A806-1171[»]
3WZDX-ray1.57A814-1172[»]
3WZEX-ray1.90A814-1172[»]
4AG8X-ray1.95A806-1171[»]
4AGCX-ray2.00A787-1171[»]
4AGDX-ray2.81A787-1171[»]
4ASDX-ray2.03A787-1171[»]
4ASEX-ray1.83A787-1171[»]
5EW3X-ray2.50A/B806-1171[»]
5OYJX-ray2.38C/D326-549[»]
ProteinModelPortaliP35968
SMRiP35968
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109992, 57 interactors
CORUMiP35968
DIPiDIP-486N
IntActiP35968, 38 interactors
MINTiP35968
STRINGi9606.ENSP00000263923

Chemistry databases

BindingDBiP35968
ChEMBLiCHEMBL279
DrugBankiDB07528 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
DB06938 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
DB06080 ABT-869
DB06626 Axitinib
DB04849 AZD2171
DB08875 Cabozantinib
DB05198 CYC116
DB06101 IMC-1C11
DB09078 Lenvatinib
DB07183 N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
DB09079 Nintedanib
DB06589 Pazopanib
DB08901 Ponatinib
DB05578 Ramucirumab
DB08896 Regorafenib
DB00398 Sorafenib
DB01268 Sunitinib
DB05075 TG100801
DB04879 Vatalanib
DB05153 XL184
DB05146 XL820
DB05030 XL880
DB05014 XL999
GuidetoPHARMACOLOGYi1813

PTM databases

CarbonylDBiP35968
iPTMnetiP35968
PhosphoSitePlusiP35968

Polymorphism and mutation databases

BioMutaiKDR
DMDMi9087218

Proteomic databases

EPDiP35968
MaxQBiP35968
PaxDbiP35968
PeptideAtlasiP35968
PRIDEiP35968
ProteomicsDBi55169
55170 [P35968-2]
55171 [P35968-3]

Protocols and materials databases

DNASUi3791
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263923; ENSP00000263923; ENSG00000128052 [P35968-1]
ENST00000645273; ENSP00000495159; ENSG00000128052 [P35968-1]
GeneIDi3791
KEGGihsa:3791
UCSCiuc003has.4 human [P35968-1]

Organism-specific databases

CTDi3791
DisGeNETi3791
EuPathDBiHostDB:ENSG00000128052.8
GeneCardsiKDR
HGNCiHGNC:6307 KDR
HPAiCAB004028
MalaCardsiKDR
MIMi191306 gene
602089 phenotype
neXtProtiNX_P35968
OpenTargetsiENSG00000128052
Orphaneti91415 Familial capillary hemangioma
PharmGKBiPA30086
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOVERGENiHBG053432
InParanoidiP35968
KOiK05098
OMAiMFFWLLL
OrthoDBiEOG091G01TL
PhylomeDBiP35968
TreeFamiTF325768

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
ReactomeiR-HSA-194306 Neurophilin interactions with VEGF and VEGFR
R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization
R-HSA-216083 Integrin cell surface interactions
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5218921 VEGFR2 mediated cell proliferation
SignaLinkiP35968
SIGNORiP35968

Miscellaneous databases

EvolutionaryTraceiP35968
GeneWikiiKinase_insert_domain_receptor
GenomeRNAii3791
PROiPR:P35968
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128052 Expressed in 208 organ(s), highest expression level in lung
CleanExiHS_KDR
ExpressionAtlasiP35968 baseline and differential
GenevisibleiP35968 HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR001824 Tyr_kinase_rcpt_3_CS
IPR009136 VEGFR2_rcpt
PANTHERiPTHR24416:SF45 PTHR24416:SF45, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR01834 VEGFRECEPTR2
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 5 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 7 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00240 RECEPTOR_TYR_KIN_III, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVGFR2_HUMAN
AccessioniPrimary (citable) accession number: P35968
Secondary accession number(s): A2RRS0
, B5A925, C5IFA0, O60723, Q14178
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 211 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. SIMILARITY comments
    Index of protein domains and families
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  8. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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