UniProtKB - P35951 (LDLR_MOUSE)
Low-density lipoprotein receptor
Ldlr
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: ARUK-UCL
- calcium ion binding Source: InterPro
- identical protein binding Source: MGI
- low-density lipoprotein particle binding Source: MGI
- low-density lipoprotein particle receptor activity Source: MGI
- protease binding Source: MGI
- very-low-density lipoprotein particle receptor activity Source: MGI
GO - Biological processi
- amyloid-beta clearance Source: ARUK-UCL
- amyloid-beta clearance by cellular catabolic process Source: ARUK-UCL
- artery morphogenesis Source: BHF-UCL
- cellular response to fatty acid Source: BHF-UCL
- cellular response to low-density lipoprotein particle stimulus Source: MGI
- cholesterol homeostasis Source: MGI
- cholesterol import Source: BHF-UCL
- cholesterol metabolic process Source: MGI
- cholesterol transport Source: MGI
- endocytosis Source: MGI
- high-density lipoprotein particle clearance Source: BHF-UCL
- intestinal cholesterol absorption Source: MGI
- lipid metabolic process Source: MGI
- lipoprotein catabolic process Source: MGI
- lipoprotein metabolic process Source: MGI
- long-term memory Source: ARUK-UCL
- low-density lipoprotein particle clearance Source: MGI
- negative regulation of amyloid fibril formation Source: ARUK-UCL
- negative regulation of astrocyte activation Source: ARUK-UCL
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of microglial cell activation Source: ARUK-UCL
- negative regulation of protein metabolic process Source: ARUK-UCL
- phagocytosis Source: ARUK-UCL
- phospholipid transport Source: BHF-UCL
- plasma lipoprotein particle clearance Source: ARUK-UCL
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of lysosomal protein catabolic process Source: ARUK-UCL
- positive regulation of triglyceride biosynthetic process Source: BHF-UCL
- positive regulation of triglyceride catabolic process Source: MGI
- receptor-mediated endocytosis Source: ARUK-UCL
- receptor-mediated endocytosis involved in cholesterol transport Source: MGI
- regulation of cholesterol metabolic process Source: ARUK-UCL
- regulation of phosphatidylcholine catabolic process Source: BHF-UCL
- regulation of protein metabolic process Source: ARUK-UCL
- response to caloric restriction Source: ARUK-UCL
Keywordsi
Molecular function | Receptor |
Biological process | Cholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-8964026, Chylomicron clearance R-MMU-8964038, LDL clearance |
Names & Taxonomyi
Protein namesi | Recommended name: Low-density lipoprotein receptorShort name: LDL receptor |
Gene namesi | Name:Ldlr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96765, Ldlr |
Subcellular locationi
Lysosome
- Lysosome By similarity
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Endosome
- Early endosome By similarity
- Late endosome By similarity
Golgi apparatus
- Golgi apparatus By similarity
Other locations
- clathrin-coated pit 1 Publication
Note: Rapidly endocytosed upon ligand binding.1 Publication
Endosome
- early endosome Source: MGI
- endosome Source: MGI
- late endosome Source: MGI
- recycling endosome membrane Source: MGI
- sorting endosome Source: MGI
Extracellular region or secreted
- extracellular space Source: BHF-UCL
- low-density lipoprotein particle Source: UniProtKB-KW
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Lysosome
- lysosome Source: MGI
Plasma Membrane
- basolateral plasma membrane Source: BHF-UCL
- caveola Source: MGI
- clathrin-coated pit Source: MGI
- external side of plasma membrane Source: MGI
- plasma membrane Source: ARUK-UCL
Other locations
- apical part of cell Source: BHF-UCL
- cell surface Source: BHF-UCL
- integral component of membrane Source: UniProtKB-KW
- PCSK9-LDLR complex Source: BHF-UCL
- receptor complex Source: MGI
- somatodendritic compartment Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 790 | ExtracellularBy similarityAdd BLAST | 769 | |
Transmembranei | 791 – 812 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 813 – 862 | Cytoplasmic1 PublicationAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, Coated pit, Endosome, Golgi apparatus, LDL, Lysosome, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000017313 | 22 – 862 | Low-density lipoprotein receptorAdd BLAST | 841 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 52 | By similarity | ||
Disulfide bondi | 46 ↔ 63 | By similarity | ||
Disulfide bondi | 68 ↔ 82 | By similarity | ||
Disulfide bondi | 75 ↔ 95 | By similarity | ||
Disulfide bondi | 89 ↔ 104 | By similarity | ||
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 109 ↔ 121 | By similarity | ||
Disulfide bondi | 116 ↔ 134 | By similarity | ||
Disulfide bondi | 128 ↔ 143 | By similarity | ||
Disulfide bondi | 148 ↔ 160 | By similarity | ||
Disulfide bondi | 155 ↔ 173 | By similarity | ||
Disulfide bondi | 167 ↔ 184 | By similarity | ||
Disulfide bondi | 198 ↔ 210 | By similarity | ||
Disulfide bondi | 205 ↔ 223 | By similarity | ||
Disulfide bondi | 217 ↔ 232 | By similarity | ||
Disulfide bondi | 237 ↔ 249 | By similarity | ||
Disulfide bondi | 244 ↔ 262 | By similarity | ||
Disulfide bondi | 256 ↔ 271 | By similarity | ||
Glycosylationi | 273 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 277 ↔ 290 | By similarity | ||
Disulfide bondi | 285 ↔ 303 | By similarity | ||
Disulfide bondi | 297 ↔ 314 | By similarity | ||
Disulfide bondi | 319 ↔ 330 | By similarity | ||
Disulfide bondi | 326 ↔ 339 | By similarity | ||
Disulfide bondi | 341 ↔ 353 | By similarity | ||
Disulfide bondi | 359 ↔ 369 | By similarity | ||
Disulfide bondi | 365 ↔ 378 | By similarity | ||
Disulfide bondi | 380 ↔ 393 | By similarity | ||
Glycosylationi | 462 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 667 ↔ 682 | By similarity | ||
Disulfide bondi | 678 ↔ 697 | By similarity | ||
Disulfide bondi | 699 ↔ 712 | By similarity | ||
Modified residuei | 725 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 733 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 735 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P35951 |
jPOSTi | P35951 |
PaxDbi | P35951 |
PeptideAtlasi | P35951 |
PRIDEi | P35951 |
PTM databases
GlyGeni | P35951, 3 sites |
iPTMneti | P35951 |
PhosphoSitePlusi | P35951 |
SwissPalmi | P35951 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032193, Expressed in cumulus cell and 305 other tissues |
ExpressionAtlasi | P35951, baseline and differential |
Genevisiblei | P35951, MM |
Interactioni
Subunit structurei
Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (PubMed:11247302).
Interacts (via NPXY motif) with LDLRAP1 (via PID domain) (By similarity).
Interacts with ARRB1 (By similarity).
Interacts with SNX17 (PubMed:12169628).
Interacts with the full-length immature form of PCSK9 (via C-terminus) (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- identical protein binding Source: MGI
- protease binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201133, 8 interactors |
ComplexPortali | CPX-129, LDLR-PCSK9 complex |
IntActi | P35951, 2 interactors |
MINTi | P35951 |
STRINGi | 10090.ENSMUSP00000034713 |
Miscellaneous databases
RNActi | P35951, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 65 | LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 66 – 106 | LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 107 – 145 | LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 146 – 186 | LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 196 – 234 | LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 235 – 273 | LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 275 – 314 | LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 315 – 354 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 355 – 394 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Repeati | 398 – 439 | LDL-receptor class B 1Add BLAST | 42 | |
Repeati | 440 – 485 | LDL-receptor class B 2Add BLAST | 46 | |
Repeati | 486 – 528 | LDL-receptor class B 3Add BLAST | 43 | |
Repeati | 529 – 572 | LDL-receptor class B 4Add BLAST | 44 | |
Repeati | 573 – 615 | LDL-receptor class B 5Add BLAST | 43 | |
Repeati | 616 – 658 | LDL-receptor class B 6Add BLAST | 43 | |
Domaini | 663 – 713 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 722 – 770 | Clustered O-linked oligosaccharidesAdd BLAST | 49 | |
Regioni | 813 – 862 | Required for MYLIP-triggered down-regulation of LDLRBy similarityAdd BLAST | 50 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 825 – 830 | NPXY motifBy similarity | 6 |
Domaini
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000161046 |
HOGENOMi | CLU_008163_2_0_1 |
InParanoidi | P35951 |
OMAi | LCEGPDK |
OrthoDBi | 359795at2759 |
TreeFami | TF351700 |
Family and domain databases
CDDi | cd00112, LDLa, 7 hits |
Gene3Di | 2.120.10.30, 1 hit 4.10.400.10, 6 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR000033, LDLR_classB_rpt IPR002172, LDrepeatLR_classA_rpt |
Pfami | View protein in Pfam PF07645, EGF_CA, 1 hit PF00057, Ldl_recept_a, 7 hits PF00058, Ldl_recept_b, 5 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00179, EGF_CA, 2 hits SM00192, LDLa, 7 hits SM00135, LY, 5 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57424, SSF57424, 6 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01186, EGF_2, 2 hits PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit PS01209, LDLRA_1, 7 hits PS50068, LDLRA_2, 7 hits PS51120, LDLRB, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSTADLMRRW VIALLLAAAG VAAEDSCSRN EFQCRDGKCI ASKWVCDGSP
60 70 80 90 100
ECPDGSDESP ETCMSVTCQS NQFSCGGRVS RCIPDSWRCD GQVDCENDSD
110 120 130 140 150
EQGCPPKTCS QDDFRCQDGK CISPQFVCDG DRDCLDGSDE AHCQATTCGP
160 170 180 190 200
AHFRCNSSIC IPSLWACDGD VDCVDGSDEW PQNCQGRDTA SKGVSSPCSS
210 220 230 240 250
LEFHCGSSEC IHRSWVCDGE ADCKDKSDEE HCAVATCRPD EFQCADGSCI
260 270 280 290 300
HGSRQCDREH DCKDMSDELG CVNVTQCDGP NKFKCHSGEC ISLDKVCDSA
310 320 330 340 350
RDCQDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGSECL CPSGFRLVDL
360 370 380 390 400
HRCEDIDECQ EPDTCSQLCV NLEGSYKCEC QAGFHMDPHT RVCKAVGSIG
410 420 430 440 450
YLLFTNRHEV RKMTLDRSEY TSLLPNLKNV VALDTEVTNN RIYWSDLSQK
460 470 480 490 500
KIYSALMDQA PNLSYDTIIS EDLHAPDGLA VDWIHRNIYW TDSVPGSVSV
510 520 530 540 550
ADTKGVKRRT LFQEAGSRPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV
560 570 580 590 600
DIHSLVTENI QWPNGITLDL SSGRLYWVDS KLHSISSIDV NGGNRKTILE
610 620 630 640 650
DENRLAHPFS LAIYEDKVYW TDVINEAIFS ANRLTGSDVN LVAENLLSPE
660 670 680 690 700
DIVLFHKVTQ PRGVNWCETT ALLPNGGCQY LCLPAPQIGP HSPKFTCACP
710 720 730 740 750
DGMLLAKDMR SCLTEVDTVL TTQGTSAVRP VVTASATRPP KHSEDLSAPS
760 770 780 790 800
TPRQPVDTPG LSTVASVTVS HQVQGDMAGR GNEEQPHGMR FLSIFFPIAL
810 820 830 840 850
VALLVLGAVL LWRNWRLKNI NSINFDNPVY QKTTEDELHI CRSQDGYTYP
860
SRQMVSLEDD VA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1L1SRE8 | A0A1L1SRE8_MOUSE | Low-density lipoprotein receptor | Ldlr | 810 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | A → V in CAA79581 (PubMed:8466528).Curated | 1 | |
Sequence conflicti | 27 | C → G in CAA79581 (PubMed:8466528).Curated | 1 | |
Sequence conflicti | 61 | E → K in CAA79581 (PubMed:8466528).Curated | 1 | |
Sequence conflicti | 144 | Q → P in CAA79581 (PubMed:8466528).Curated | 1 | |
Sequence conflicti | 156 | N → K in CAA79581 (PubMed:8466528).Curated | 1 | |
Sequence conflicti | 178 | D → H in CAA79581 (PubMed:8466528).Curated | 1 | |
Sequence conflicti | 186 – 187 | GR → AE in CAA79581 (PubMed:8466528).Curated | 2 | |
Sequence conflicti | 819 | N → NIT in CAA79581 (PubMed:8466528).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19521 mRNA Translation: CAA79581.1 X64414 mRNA Translation: CAA45759.1 AC161371 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25212.1 BC053041 mRNA Translation: AAH53041.1 |
CCDSi | CCDS22910.1 |
PIRi | I48623, QRMSLD |
RefSeqi | NP_001239587.1, NM_001252658.1 NP_001239588.1, NM_001252659.1 NP_034830.2, NM_010700.3 |
Genome annotation databases
Ensembli | ENSMUST00000034713; ENSMUSP00000034713; ENSMUSG00000032193 |
GeneIDi | 16835 |
KEGGi | mmu:16835 |
UCSCi | uc009omh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z19521 mRNA Translation: CAA79581.1 X64414 mRNA Translation: CAA45759.1 AC161371 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25212.1 BC053041 mRNA Translation: AAH53041.1 |
CCDSi | CCDS22910.1 |
PIRi | I48623, QRMSLD |
RefSeqi | NP_001239587.1, NM_001252658.1 NP_001239588.1, NM_001252659.1 NP_034830.2, NM_010700.3 |
3D structure databases
SMRi | P35951 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201133, 8 interactors |
ComplexPortali | CPX-129, LDLR-PCSK9 complex |
IntActi | P35951, 2 interactors |
MINTi | P35951 |
STRINGi | 10090.ENSMUSP00000034713 |
PTM databases
GlyGeni | P35951, 3 sites |
iPTMneti | P35951 |
PhosphoSitePlusi | P35951 |
SwissPalmi | P35951 |
Proteomic databases
EPDi | P35951 |
jPOSTi | P35951 |
PaxDbi | P35951 |
PeptideAtlasi | P35951 |
PRIDEi | P35951 |
Protocols and materials databases
Antibodypediai | 2424, 854 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034713; ENSMUSP00000034713; ENSMUSG00000032193 |
GeneIDi | 16835 |
KEGGi | mmu:16835 |
UCSCi | uc009omh.2, mouse |
Organism-specific databases
CTDi | 3949 |
MGIi | MGI:96765, Ldlr |
Phylogenomic databases
eggNOGi | KOG1215, Eukaryota |
GeneTreei | ENSGT00940000161046 |
HOGENOMi | CLU_008163_2_0_1 |
InParanoidi | P35951 |
OMAi | LCEGPDK |
OrthoDBi | 359795at2759 |
TreeFami | TF351700 |
Enzyme and pathway databases
Reactomei | R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-8964026, Chylomicron clearance R-MMU-8964038, LDL clearance |
Miscellaneous databases
BioGRID-ORCSi | 16835, 2 hits in 17 CRISPR screens |
ChiTaRSi | Ldlr, mouse |
PROi | PR:P35951 |
RNActi | P35951, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032193, Expressed in cumulus cell and 305 other tissues |
ExpressionAtlasi | P35951, baseline and differential |
Genevisiblei | P35951, MM |
Family and domain databases
CDDi | cd00112, LDLa, 7 hits |
Gene3Di | 2.120.10.30, 1 hit 4.10.400.10, 6 hits |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR036055, LDL_receptor-like_sf IPR023415, LDLR_class-A_CS IPR000033, LDLR_classB_rpt IPR002172, LDrepeatLR_classA_rpt |
Pfami | View protein in Pfam PF07645, EGF_CA, 1 hit PF00057, Ldl_recept_a, 7 hits PF00058, Ldl_recept_b, 5 hits |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00181, EGF, 5 hits SM00179, EGF_CA, 2 hits SM00192, LDLa, 7 hits SM00135, LY, 5 hits |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57424, SSF57424, 6 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01186, EGF_2, 2 hits PS50026, EGF_3, 2 hits PS01187, EGF_CA, 1 hit PS01209, LDLRA_1, 7 hits PS50068, LDLRA_2, 7 hits PS51120, LDLRB, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LDLR_MOUSE | |
Accessioni | P35951Primary (citable) accession number: P35951 Secondary accession number(s): Q6GTJ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | February 6, 2013 | |
Last modified: | December 2, 2020 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families