Low-density lipoprotein receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: ARUK-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes."
    Basak J.M., Verghese P.B., Yoon H., Kim J., Holtzman D.M.
    J. Biol. Chem. 287:13959-13971(2012) [PubMed] [Europe PMC] [Abstract]
• calcium ion binding Source: InterPro
• identical protein binding Source: MGI
• low-density lipoprotein particle binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells."
    Lalanne F., Lambert G., Amar M.J., Chetiveaux M., Zair Y., Jarnoux A.L., Ouguerram K., Friburg J., Seidah N.G., Brewer H.B. Jr., Krempf M., Costet P.
    J. Lipid Res. 46:1312-1319(2005) [PubMed] [Europe PMC] [Abstract]
  • "Increased response to cholesterol feeding in apolipoprotein C1-deficient mice."
    van Ree J.H., Hofker M.H., van den Broek W.J., van Deursen J.M., van der Boom H., Frants R.R., Wieringa B., Havekes L.M.
    Biochem. J. 305:905-911(1995) [PubMed] [Europe PMC] [Abstract]
• low-density lipoprotein particle receptor activity Source: MGIInferred from direct assayⁱ
  • "Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation."
    Kulinski A., Rustaeus S., Vance J.E.
    J. Biol. Chem. 277:31516-31525(2002) [PubMed] [Europe PMC] [Abstract]
• protease binding Source: MGI
• very-low-density lipoprotein particle receptor activity Source: MGIInferred from direct assayⁱ
  • "Apolipoprotein A-V deficiency results in marked hypertriglyceridemia attributable to decreased lipolysis of triglyceride-rich lipoproteins and removal of their remnants."
    Grosskopf I., Baroukh N., Lee S.J., Kamari Y., Harats D., Rubin E.M., Pennacchio L.A., Cooper A.D.
    Arterioscler. Thromb. Vasc. Biol. 25:2573-2579(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• amyloid-beta clearance Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance."
    Kim J., Castellano J.M., Jiang H., Basak J.M., Parsadanian M., Pham V., Mason S.M., Paul S.M., Holtzman D.M.
    Neuron 64:632-644(2009) [PubMed] [Europe PMC] [Abstract]
• amyloid-beta clearance by cellular catabolic process Source: ARUK-UCLInferred from direct assayⁱ
  • "Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes."
    Basak J.M., Verghese P.B., Yoon H., Kim J., Holtzman D.M.
    J. Biol. Chem. 287:13959-13971(2012) [PubMed] [Europe PMC] [Abstract]
• artery morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice."
    Koltsova E.K., Kim G., Lloyd K.M., Saris C.J., von Vietinghoff S., Kronenberg M., Ley K.
    Circ. Res. 111:1274-1285(2012) [PubMed] [Europe PMC] [Abstract]
• cellular response to fatty acid Source: BHF-UCLInferred from genetic interactionⁱ
  • "Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice."
    Loyer X., Potteaux S., Vion A.C., Guerin C.L., Boulkroun S., Rautou P.E., Ramkhelawon B., Esposito B., Dalloz M., Paul J.L., Julia P., Maccario J., Boulanger C.M., Mallat Z., Tedgui A.
    Circ. Res. 114:434-443(2014) [PubMed] [Europe PMC] [Abstract]
• cellular response to low-density lipoprotein particle stimulus Source: MGI
• cholesterol homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia."
    Jones C., Hammer R.E., Li W.-P., Cohen J.C., Hobbs H.H., Herz J.
    J. Biol. Chem. 278:29024-29030(2003) [PubMed] [Europe PMC] [Abstract]
  • "SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion."
    Chen X.W., Wang H., Bajaj K., Zhang P., Meng Z.X., Ma D., Bai Y., Liu H.H., Adams E., Baines A., Yu G., Sartor M.A., Zhang B., Yi Z., Lin J., Young S.G., Schekman R., Ginsburg D.
    Elife 2:e00444-e00444(2013) [PubMed] [Europe PMC] [Abstract]
  • "Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice."
    Veniant M.M., Zlot C.H., Walzem R.L., Pierotti V., Driscoll R., Dichek D., Herz J., Young S.G.
    J. Clin. Invest. 102:1559-1568(1998) [PubMed] [Europe PMC] [Abstract]
• cholesterol import Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes."
    Minahk C., Kim K.W., Nelson R., Trigatti B., Lehner R., Vance D.E.
    J. Biol. Chem. 283:6449-6458(2008) [PubMed] [Europe PMC] [Abstract]
• cholesterol metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance?"
    Zabalawi M., Bharadwaj M., Horton H., Cline M., Willingham M., Thomas M.J., Sorci-Thomas M.G.
    J. Lipid Res. 48:52-65(2007) [PubMed] [Europe PMC] [Abstract]
• cholesterol transport Source: MGIInferred from mutant phenotypeⁱ
  • "Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways."
    Wang M.D., Kiss R.S., Franklin V., McBride H.M., Whitman S.C., Marcel Y.L.
    J. Lipid Res. 48:633-645(2007) [PubMed] [Europe PMC] [Abstract]
• endocytosis Source: MGI
• high-density lipoprotein particle clearance Source: BHF-UCLInferred from genetic interactionⁱ
  • "MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis."
    Meiler S., Baumer Y., Toulmin E., Seng K., Boisvert W.A.
    Arterioscler. Thromb. Vasc. Biol. 35:323-331(2015) [PubMed] [Europe PMC] [Abstract]
• intestinal cholesterol absorption Source: MGI
• lipid metabolic process Source: MGIInferred from genetic interactionⁱ
  • "Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100."
    Veniant M.M., Sullivan M.A., Kim S.K., Ambroziak P., Chu A., Wilson M.D., Hellerstein M.K., Rudel L.L., Walzem R.L., Young S.G.
    J. Clin. Invest. 106:1501-1510(2000) [PubMed] [Europe PMC] [Abstract]
• lipoprotein catabolic process Source: MGIInferred from direct assayⁱ
  • "Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells."
    Lalanne F., Lambert G., Amar M.J., Chetiveaux M., Zair Y., Jarnoux A.L., Ouguerram K., Friburg J., Seidah N.G., Brewer H.B. Jr., Krempf M., Costet P.
    J. Lipid Res. 46:1312-1319(2005) [PubMed] [Europe PMC] [Abstract]
• lipoprotein metabolic process Source: MGIInferred from genetic interactionⁱ
  • "Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100."
    Veniant M.M., Sullivan M.A., Kim S.K., Ambroziak P., Chu A., Wilson M.D., Hellerstein M.K., Rudel L.L., Walzem R.L., Young S.G.
    J. Clin. Invest. 106:1501-1510(2000) [PubMed] [Europe PMC] [Abstract]
  • "Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele."
    Chen Z., Fitzgerald R.L., Li G., Davidson N.O., Schonfeld G.
    J. Lipid Res. 45:155-163(2004) [PubMed] [Europe PMC] [Abstract]
• long-term memory Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner."
    Johnson L.A., Olsen R.H., Merkens L.S., DeBarber A., Steiner R.D., Sullivan P.M., Maeda N., Raber J.
    Neurobiol. Dis. 64:150-162(2014) [PubMed] [Europe PMC] [Abstract]
• low-density lipoprotein particle clearance Source: MGIInferred from direct assayⁱ
  • "CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL."
    Bartuzi P., Billadeau D.D., Favier R., Rong S., Dekker D., Fedoseienko A., Fieten H., Wijers M., Levels J.H., Huijkman N., Kloosterhuis N., van der Molen H., Brufau G., Groen A.K., Elliott A.M., Kuivenhoven J.A., Plecko B., Grangl G.

    , McGaughran J., Horton J.D., Burstein E., Hofker M.H., van de Sluis B.
    Nat Commun 7:10961-10961(2016) [PubMed] [Europe PMC] [Abstract]
• negative regulation of amyloid fibril formation Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance."
    Kim J., Castellano J.M., Jiang H., Basak J.M., Parsadanian M., Pham V., Mason S.M., Paul S.M., Holtzman D.M.
    Neuron 64:632-644(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of astrocyte activation Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance."
    Kim J., Castellano J.M., Jiang H., Basak J.M., Parsadanian M., Pham V., Mason S.M., Paul S.M., Holtzman D.M.
    Neuron 64:632-644(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice."
    Loyer X., Potteaux S., Vion A.C., Guerin C.L., Boulkroun S., Rautou P.E., Ramkhelawon B., Esposito B., Dalloz M., Paul J.L., Julia P., Maccario J., Boulanger C.M., Mallat Z., Tedgui A.
    Circ. Res. 114:434-443(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of microglial cell activation Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance."
    Kim J., Castellano J.M., Jiang H., Basak J.M., Parsadanian M., Pham V., Mason S.M., Paul S.M., Holtzman D.M.
    Neuron 64:632-644(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein metabolic process Source: ARUK-UCLInferred from direct assayⁱ
  • "Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes."
    Basak J.M., Verghese P.B., Yoon H., Kim J., Holtzman D.M.
    J. Biol. Chem. 287:13959-13971(2012) [PubMed] [Europe PMC] [Abstract]
• phagocytosis Source: ARUK-UCLInferred from direct assayⁱ
  • "Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes."
    Basak J.M., Verghese P.B., Yoon H., Kim J., Holtzman D.M.
    J. Biol. Chem. 287:13959-13971(2012) [PubMed] [Europe PMC] [Abstract]
• phospholipid transport Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes."
    Minahk C., Kim K.W., Nelson R., Trigatti B., Lehner R., Vance D.E.
    J. Biol. Chem. 283:6449-6458(2008) [PubMed] [Europe PMC] [Abstract]
• plasma lipoprotein particle clearance Source: ARUK-UCLInferred from direct assayⁱ
  • "Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes."
    Basak J.M., Verghese P.B., Yoon H., Kim J., Holtzman D.M.
    J. Biol. Chem. 287:13959-13971(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice."
    Loyer X., Potteaux S., Vion A.C., Guerin C.L., Boulkroun S., Rautou P.E., Ramkhelawon B., Esposito B., Dalloz M., Paul J.L., Julia P., Maccario J., Boulanger C.M., Mallat Z., Tedgui A.
    Circ. Res. 114:434-443(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response Source: BHF-UCLInferred from genetic interactionⁱ
  • "Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice."
    Loyer X., Potteaux S., Vion A.C., Guerin C.L., Boulkroun S., Rautou P.E., Ramkhelawon B., Esposito B., Dalloz M., Paul J.L., Julia P., Maccario J., Boulanger C.M., Mallat Z., Tedgui A.
    Circ. Res. 114:434-443(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lysosomal protein catabolic process Source: ARUK-UCLInferred from direct assayⁱ
  • "Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes."
    Basak J.M., Verghese P.B., Yoon H., Kim J., Holtzman D.M.
    J. Biol. Chem. 287:13959-13971(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of triglyceride biosynthetic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes."
    Minahk C., Kim K.W., Nelson R., Trigatti B., Lehner R., Vance D.E.
    J. Biol. Chem. 283:6449-6458(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of triglyceride catabolic process Source: MGI
• receptor-mediated endocytosis Source: ARUK-UCLInferred from direct assayⁱ
  • "Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance."
    Kim J., Castellano J.M., Jiang H., Basak J.M., Parsadanian M., Pham V., Mason S.M., Paul S.M., Holtzman D.M.
    Neuron 64:632-644(2009) [PubMed] [Europe PMC] [Abstract]
  • "Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes."
    Basak J.M., Verghese P.B., Yoon H., Kim J., Holtzman D.M.
    J. Biol. Chem. 287:13959-13971(2012) [PubMed] [Europe PMC] [Abstract]
• receptor-mediated endocytosis involved in cholesterol transport Source: MGI
• regulation of cholesterol metabolic process Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner."
    Johnson L.A., Olsen R.H., Merkens L.S., DeBarber A., Steiner R.D., Sullivan P.M., Maeda N., Raber J.
    Neurobiol. Dis. 64:150-162(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of phosphatidylcholine catabolic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes."
    Minahk C., Kim K.W., Nelson R., Trigatti B., Lehner R., Vance D.E.
    J. Biol. Chem. 283:6449-6458(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of protein metabolic process Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner."
    Johnson L.A., Olsen R.H., Merkens L.S., DeBarber A., Steiner R.D., Sullivan P.M., Maeda N., Raber J.
    Neurobiol. Dis. 64:150-162(2014) [PubMed] [Europe PMC] [Abstract]
• response to caloric restriction Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner."
    Johnson L.A., Olsen R.H., Merkens L.S., DeBarber A., Steiner R.D., Sullivan P.M., Maeda N., Raber J.
    Neurobiol. Dis. 64:150-162(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI
• protease binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSTADLMRRW VIALLLAAAG VAAEDSCSRN EFQCRDGKCI ASKWVCDGSP 
        60         70         80         90        100
ECPDGSDESP ETCMSVTCQS NQFSCGGRVS RCIPDSWRCD GQVDCENDSD 
       110        120        130        140        150
EQGCPPKTCS QDDFRCQDGK CISPQFVCDG DRDCLDGSDE AHCQATTCGP 
       160        170        180        190        200
AHFRCNSSIC IPSLWACDGD VDCVDGSDEW PQNCQGRDTA SKGVSSPCSS 
       210        220        230        240        250
LEFHCGSSEC IHRSWVCDGE ADCKDKSDEE HCAVATCRPD EFQCADGSCI 
       260        270        280        290        300
HGSRQCDREH DCKDMSDELG CVNVTQCDGP NKFKCHSGEC ISLDKVCDSA 
       310        320        330        340        350
RDCQDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGSECL CPSGFRLVDL 
       360        370        380        390        400
HRCEDIDECQ EPDTCSQLCV NLEGSYKCEC QAGFHMDPHT RVCKAVGSIG 
       410        420        430        440        450
YLLFTNRHEV RKMTLDRSEY TSLLPNLKNV VALDTEVTNN RIYWSDLSQK 
       460        470        480        490        500
KIYSALMDQA PNLSYDTIIS EDLHAPDGLA VDWIHRNIYW TDSVPGSVSV 
       510        520        530        540        550
ADTKGVKRRT LFQEAGSRPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV 
       560        570        580        590        600
DIHSLVTENI QWPNGITLDL SSGRLYWVDS KLHSISSIDV NGGNRKTILE 
       610        620        630        640        650
DENRLAHPFS LAIYEDKVYW TDVINEAIFS ANRLTGSDVN LVAENLLSPE 
       660        670        680        690        700
DIVLFHKVTQ PRGVNWCETT ALLPNGGCQY LCLPAPQIGP HSPKFTCACP 
       710        720        730        740        750
DGMLLAKDMR SCLTEVDTVL TTQGTSAVRP VVTASATRPP KHSEDLSAPS 
       760        770        780        790        800
TPRQPVDTPG LSTVASVTVS HQVQGDMAGR GNEEQPHGMR FLSIFFPIAL 
       810        820        830        840        850
VALLVLGAVL LWRNWRLKNI NSINFDNPVY QKTTEDELHI CRSQDGYTYP 
       860 
SRQMVSLEDD VA                                          

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot