Ldlr

Functionⁱ

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.By similarity

GO - Molecular functionⁱ

amyloid-beta binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 22383525
calcium ion binding Source: InterPro
identical protein binding Source: MGI
low-density lipoprotein particle binding
Source: MGI
Inferred from direct assayⁱ
- 15741654
- 7848292
low-density lipoprotein particle receptor activity
Source: MGI
Inferred from direct assayⁱ
- 12072432
protease binding Source: MGI
very-low-density lipoprotein particle receptor activity
Source: MGI
Inferred from direct assayⁱ
- 16166565

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amyloid-beta clearance
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22383525
cellular response to fatty acid
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 24255059
cellular response to low-density lipoprotein particle stimulus Source: MGI
cholesterol homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
cholesterol import
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18175806
cholesterol metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 17071966
cholesterol transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 17148552
endocytosis Source: MGI
high-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 25524771
intestinal cholesterol absorption Source: MGI
lipid metabolic process
Source: MGI
Inferred from genetic interactionⁱ
- 11120757
lipoprotein catabolic process
Source: MGI
Inferred from direct assayⁱ
- 15741654
lipoprotein metabolic process
Source: MGI
Inferred from genetic interactionⁱ
- 11120757
- 13130124
long-term memory
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24412220
low-density lipoprotein particle clearance
Source: MGI
Inferred from direct assayⁱ
- 26965651
negative regulation of amyloid fibril formation
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 20005821
negative regulation of astrocyte activation
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 20005821
negative regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24255059
negative regulation of microglial cell activation
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 20005821
negative regulation of protein metabolic process
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22383525
phospholipid transport
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18175806
positive regulation of amyloid-beta clearance
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22383525
positive regulation of endocytosis
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22383525
positive regulation of gene expression
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 24255059
positive regulation of inflammatory response
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 24255059
positive regulation of lipoprotein particle clearance
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22383525
positive regulation of lysosomal protein catabolic process
Source: ARUK-UCL
Inferred from direct assayⁱ
- 22383525
positive regulation of triglyceride biosynthetic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18175806
positive regulation of triglyceride catabolic process Source: MGI
receptor-mediated endocytosis
Source: ARUK-UCL
Inferred from direct assayⁱ
- 20005821
receptor-mediated endocytosis involved in cholesterol transport Source: MGI
regulation of cholesterol metabolic process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24412220
regulation of phosphatidylcholine catabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18175806
regulation of protein metabolic process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24412220
response to caloric restriction
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 24412220

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Cholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828 Clathrin-mediated endocytosis R-MMU-8964026 Chylomicron clearance R-MMU-8964038 LDL clearance

Reactomeⁱ

R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8964026 Chylomicron clearance
R-MMU-8964038 LDL clearance

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Low-density lipoprotein receptor Short name: LDL receptor
Gene namesⁱ	Name:Ldlr
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:96765 Ldlr

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 790	ExtracellularBy similarityAdd BLAST	769
Transmembraneⁱ	791 – 812	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	813 – 862	Cytoplasmic1 PublicationAdd BLAST	50

Keywords - Cellular componentⁱ

Cell membrane, Coated pit, Endosome, Golgi apparatus, LDL, Lysosome, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	By similarityAdd BLAST		21
ChainⁱPRO_0000017313	22 – 862	Low-density lipoprotein receptorAdd BLAST		841

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	34 ↔ 52	By similarity
Disulfide bondⁱ	46 ↔ 63	By similarity
Disulfide bondⁱ	68 ↔ 82	By similarity
Disulfide bondⁱ	75 ↔ 95	By similarity
Disulfide bondⁱ	89 ↔ 104	By similarity
Glycosylationⁱ	97	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	109 ↔ 121	By similarity
Disulfide bondⁱ	116 ↔ 134	By similarity
Disulfide bondⁱ	128 ↔ 143	By similarity
Disulfide bondⁱ	148 ↔ 160	By similarity
Disulfide bondⁱ	155 ↔ 173	By similarity
Disulfide bondⁱ	167 ↔ 184	By similarity
Disulfide bondⁱ	198 ↔ 210	By similarity
Disulfide bondⁱ	205 ↔ 223	By similarity
Disulfide bondⁱ	217 ↔ 232	By similarity
Disulfide bondⁱ	237 ↔ 249	By similarity
Disulfide bondⁱ	244 ↔ 262	By similarity
Disulfide bondⁱ	256 ↔ 271	By similarity
Glycosylationⁱ	273	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	277 ↔ 290	By similarity
Disulfide bondⁱ	285 ↔ 303	By similarity
Disulfide bondⁱ	297 ↔ 314	By similarity
Disulfide bondⁱ	319 ↔ 330	By similarity
Disulfide bondⁱ	326 ↔ 339	By similarity
Disulfide bondⁱ	341 ↔ 353	By similarity
Disulfide bondⁱ	359 ↔ 369	By similarity
Disulfide bondⁱ	365 ↔ 378	By similarity
Disulfide bondⁱ	380 ↔ 393	By similarity
Glycosylationⁱ	462	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	667 ↔ 682	By similarity
Disulfide bondⁱ	678 ↔ 697	By similarity
Disulfide bondⁱ	699 ↔ 712	By similarity
Modified residueⁱ	725	PhosphothreonineBy similarity	1
Modified residueⁱ	733	PhosphothreonineBy similarity	1
Modified residueⁱ	735	PhosphoserineBy similarity	1

Post-translational modificationⁱ

N- and O-glycosylated.By similarity

Ubiquitinated by MYLIP leading to degradation.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P35951
PaxDbⁱ	P35951
PeptideAtlas More...PeptideAtlasⁱ	P35951
PRIDEⁱ	P35951

PTM databases

iPTMnetⁱ	P35951
PhosphoSitePlusⁱ	P35951
SwissPalmⁱ	P35951

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000032193 Expressed in 288 organ(s), highest expression level in cumulus cell
CleanExⁱ	MM_LDLR
ExpressionAtlasⁱ	P35951 baseline and differential
Genevisibleⁱ	P35951 MM

Interactionⁱ

Subunit structureⁱ

Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (PubMed:11247302). Interacts (via NPXY motif) with LDLRAP1 (via PID domain) (By similarity). Interacts with ARRB1 (By similarity). Interacts with SNX17 (PubMed:12169628). Interacts with the full-length immature form of PCSK9 (via C-terminus) (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

identical protein binding Source: MGI
protease binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201133, 2 interactors
ComplexPortalⁱ	CPX-129 LDLR-PCSK9 complex
IntActⁱ	P35951, 2 interactors
Molecular INTeraction database More...MINTⁱ	P35951
STRINGⁱ	10090.ENSMUSP00000034713

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35951
SMRⁱ	P35951
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 65	LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	66 – 106	LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	107 – 145	LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	146 – 186	LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	196 – 234	LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	235 – 273	LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	275 – 314	LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	315 – 354	EGF-like 1PROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	355 – 394	EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST	40
Repeatⁱ	398 – 439	LDL-receptor class B 1Add BLAST	42
Repeatⁱ	440 – 485	LDL-receptor class B 2Add BLAST	46
Repeatⁱ	486 – 528	LDL-receptor class B 3Add BLAST	43
Repeatⁱ	529 – 572	LDL-receptor class B 4Add BLAST	44
Repeatⁱ	573 – 615	LDL-receptor class B 5Add BLAST	43
Repeatⁱ	616 – 658	LDL-receptor class B 6Add BLAST	43
Domainⁱ	663 – 713	EGF-like 3PROSITE-ProRule annotationAdd BLAST	51

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	722 – 770	Clustered O-linked oligosaccharidesAdd BLAST		49
Regionⁱ	813 – 862	Required for MYLIP-triggered down-regulation of LDLRBy similarityAdd BLAST		50

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	825 – 830	NPXY motifBy similarity		6

Domainⁱ

The NPXY motif mediates the interaction with the clathrin adapter DAB2 and with LDLRAP1 which are involved in receptor internalization. A few residues outside the motif also play a role in the interaction.1 Publication

Sequence similaritiesⁱ

Belongs to the LDLR family.Curated

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410KD0U Eukaryota ENOG410Z5FJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118968
HOGENOMⁱ	HOG000115656
HOVERGENⁱ	HBG006250
InParanoidⁱ	P35951
KEGG Orthology (KO) More...KOⁱ	K12473
OMAⁱ	INVTLCE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01MX
TreeFamⁱ	TF351700

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00112 LDLa, 7 hits
Gene3Dⁱ	2.120.10.30, 1 hit
InterProⁱ	View protein in InterPro IPR011042 6-blade_b-propeller_TolB-like IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR009030 Growth_fac_rcpt_cys_sf IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR000033 LDLR_classB_rpt IPR002172 LDrepeatLR_classA_rpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07645 EGF_CA, 1 hit PF00057 Ldl_recept_a, 7 hits PF00058 Ldl_recept_b, 5 hits
PRINTSⁱ	PR00261 LDLRECEPTOR
SMARTⁱ	View protein in SMART SM00181 EGF, 5 hits SM00179 EGF_CA, 2 hits SM00192 LDLa, 7 hits SM00135 LY, 5 hits
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57424 SSF57424, 6 hits
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS01186 EGF_2, 2 hits PS50026 EGF_3, 2 hits PS01187 EGF_CA, 1 hit PS01209 LDLRA_1, 7 hits PS50068 LDLRA_2, 7 hits PS51120 LDLRB, 5 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P35951-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTADLMRRW VIALLLAAAG VAAEDSCSRN EFQCRDGKCI ASKWVCDGSP 
        60         70         80         90        100
ECPDGSDESP ETCMSVTCQS NQFSCGGRVS RCIPDSWRCD GQVDCENDSD 
       110        120        130        140        150
EQGCPPKTCS QDDFRCQDGK CISPQFVCDG DRDCLDGSDE AHCQATTCGP 
       160        170        180        190        200
AHFRCNSSIC IPSLWACDGD VDCVDGSDEW PQNCQGRDTA SKGVSSPCSS 
       210        220        230        240        250
LEFHCGSSEC IHRSWVCDGE ADCKDKSDEE HCAVATCRPD EFQCADGSCI 
       260        270        280        290        300
HGSRQCDREH DCKDMSDELG CVNVTQCDGP NKFKCHSGEC ISLDKVCDSA 
       310        320        330        340        350
RDCQDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGSECL CPSGFRLVDL 
       360        370        380        390        400
HRCEDIDECQ EPDTCSQLCV NLEGSYKCEC QAGFHMDPHT RVCKAVGSIG 
       410        420        430        440        450
YLLFTNRHEV RKMTLDRSEY TSLLPNLKNV VALDTEVTNN RIYWSDLSQK 
       460        470        480        490        500
KIYSALMDQA PNLSYDTIIS EDLHAPDGLA VDWIHRNIYW TDSVPGSVSV 
       510        520        530        540        550
ADTKGVKRRT LFQEAGSRPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV 
       560        570        580        590        600
DIHSLVTENI QWPNGITLDL SSGRLYWVDS KLHSISSIDV NGGNRKTILE 
       610        620        630        640        650
DENRLAHPFS LAIYEDKVYW TDVINEAIFS ANRLTGSDVN LVAENLLSPE 
       660        670        680        690        700
DIVLFHKVTQ PRGVNWCETT ALLPNGGCQY LCLPAPQIGP HSPKFTCACP 
       710        720        730        740        750
DGMLLAKDMR SCLTEVDTVL TTQGTSAVRP VVTASATRPP KHSEDLSAPS 
       760        770        780        790        800
TPRQPVDTPG LSTVASVTVS HQVQGDMAGR GNEEQPHGMR FLSIFFPIAL 
       810        820        830        840        850
VALLVLGAVL LWRNWRLKNI NSINFDNPVY QKTTEDELHI CRSQDGYTYP 
       860 
SRQMVSLEDD VA

Length:862

Mass (Da):94,947

Last modified:February 6, 2013 - v2

Checksum:ⁱ43E7D6A293BE609C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1L1SRE8	A0A1L1SRE8_MOUSE		Low-density lipoprotein receptor Low-density lipoprotein receptor	Ldlr	810	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	23	A → V in CAA79581 (PubMed:8466528).Curated	1
Sequence conflictⁱ	27	C → G in CAA79581 (PubMed:8466528).Curated	1
Sequence conflictⁱ	61	E → K in CAA79581 (PubMed:8466528).Curated	1
Sequence conflictⁱ	144	Q → P in CAA79581 (PubMed:8466528).Curated	1
Sequence conflictⁱ	156	N → K in CAA79581 (PubMed:8466528).Curated	1
Sequence conflictⁱ	178	D → H in CAA79581 (PubMed:8466528).Curated	1
Sequence conflictⁱ	186 – 187	GR → AE in CAA79581 (PubMed:8466528).Curated	2
Sequence conflictⁱ	819	N → NIT in CAA79581 (PubMed:8466528).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z19521 mRNA Translation: CAA79581.1 X64414 mRNA Translation: CAA45759.1 AC161371 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25212.1 BC053041 mRNA Translation: AAH53041.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22910.1
PIRⁱ	I48623 QRMSLD
NCBI Reference Sequences More...RefSeqⁱ	NP_001239587.1, NM_001252658.1 NP_001239588.1, NM_001252659.1 NP_034830.2, NM_010700.3
UniGeneⁱ	Mm.3213

Genome annotation databases

Ensemblⁱ	ENSMUST00000034713; ENSMUSP00000034713; ENSMUSG00000032193
GeneIDⁱ	16835
KEGGⁱ	mmu:16835
UCSC genome browser More...UCSCⁱ	uc009omh.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35951	Low density lipoprotein receptor		MOUSE		862	UniRef90_P35951
UPI000A31355C		MUSPA		861
UPI000A317DEA		MUSCR		861
Uncharacterized protein		MOUSE		862
Low density lipoprotein receptor		MOUSE		862
+2

Protein	Similar proteins		Species	Score	Length	Source
P35951	Low-density lipoprotein receptor		RAT		879	UniRef50_P35951
Low-density lipoprotein receptor		CRIGR		862
Uncharacterized protein		MOUSE		862
Low density lipoprotein receptor		CANLF		861
low-density lipoprotein receptor		Florida manatee		866
+234

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z19521 mRNA Translation: CAA79581.1 X64414 mRNA Translation: CAA45759.1 AC161371 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25212.1 BC053041 mRNA Translation: AAH53041.1
CCDSⁱ	CCDS22910.1
PIRⁱ	I48623 QRMSLD
RefSeqⁱ	NP_001239587.1, NM_001252658.1 NP_001239588.1, NM_001252659.1 NP_034830.2, NM_010700.3
UniGeneⁱ	Mm.3213

3D structure databases

ProteinModelPortalⁱ	P35951
SMRⁱ	P35951
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201133, 2 interactors
ComplexPortalⁱ	CPX-129 LDLR-PCSK9 complex
IntActⁱ	P35951, 2 interactors
MINTⁱ	P35951
STRINGⁱ	10090.ENSMUSP00000034713

PTM databases

iPTMnetⁱ	P35951
PhosphoSitePlusⁱ	P35951
SwissPalmⁱ	P35951

Proteomic databases

EPDⁱ	P35951
PaxDbⁱ	P35951
PeptideAtlasⁱ	P35951
PRIDEⁱ	P35951

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034713; ENSMUSP00000034713; ENSMUSG00000032193
GeneIDⁱ	16835
KEGGⁱ	mmu:16835
UCSCⁱ	uc009omh.2 mouse

Organism-specific databases

CTDⁱ	3949
MGIⁱ	MGI:96765 Ldlr

Phylogenomic databases

eggNOGⁱ	ENOG410KD0U Eukaryota ENOG410Z5FJ LUCA
GeneTreeⁱ	ENSGT00760000118968
HOGENOMⁱ	HOG000115656
HOVERGENⁱ	HBG006250
InParanoidⁱ	P35951
KOⁱ	K12473
OMAⁱ	INVTLCE
OrthoDBⁱ	EOG091G01MX
TreeFamⁱ	TF351700

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828 Clathrin-mediated endocytosis R-MMU-8964026 Chylomicron clearance R-MMU-8964038 LDL clearance

Reactomeⁱ

R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8964026 Chylomicron clearance
R-MMU-8964038 LDL clearance

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P35951
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032193 Expressed in 288 organ(s), highest expression level in cumulus cell
CleanExⁱ	MM_LDLR
ExpressionAtlasⁱ	P35951 baseline and differential
Genevisibleⁱ	P35951 MM

Family and domain databases

CDDⁱ	cd00112 LDLa, 7 hits
Gene3Dⁱ	2.120.10.30, 1 hit
InterProⁱ	View protein in InterPro IPR011042 6-blade_b-propeller_TolB-like IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR009030 Growth_fac_rcpt_cys_sf IPR036055 LDL_receptor-like_sf IPR023415 LDLR_class-A_CS IPR000033 LDLR_classB_rpt IPR002172 LDrepeatLR_classA_rpt
Pfamⁱ	View protein in Pfam PF07645 EGF_CA, 1 hit PF00057 Ldl_recept_a, 7 hits PF00058 Ldl_recept_b, 5 hits
PRINTSⁱ	PR00261 LDLRECEPTOR
SMARTⁱ	View protein in SMART SM00181 EGF, 5 hits SM00179 EGF_CA, 2 hits SM00192 LDLa, 7 hits SM00135 LY, 5 hits
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57424 SSF57424, 6 hits
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS01186 EGF_2, 2 hits PS50026 EGF_3, 2 hits PS01187 EGF_CA, 1 hit PS01209 LDLRA_1, 7 hits PS50068 LDLRA_2, 7 hits PS51120 LDLRB, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LDLR_MOUSE
Accessionⁱ	P35951Primary (citable) accession number: P35951 Secondary accession number(s): Q6GTJ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	February 6, 2013
	Last modified:	October 10, 2018
	This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35951 (LDLR_MOUSE)

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Low-density lipoprotein receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Golgi apparatus

Lysosome

Endosome

Other locations

Endosome

Extracellular region or secreted

Golgi apparatus

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ