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Entry version 108 (05 Jun 2019)
Sequence version 1 (01 Jun 1994)
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Protein

RNA1 polyprotein

Gene
N/A
Organism
Red clover mottle virus (RCMV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Picornain 3C-like protease: Thiol protease that cleaves the RNA1 and RNA2 polyproteins.By similarity
Viral genome-linked protein: Plays a role in RNA replication. It is covalently linked to the 5'terminus of both viral single-stranded RNA1 and RNA2 molecules.By similarity
Protease cofactor: Down-regulates the RNA1 polyprotein processing and enhances trans-cleavage of RNA2 polyproteins. The protease cofactor and the putative helicase seem to target the replication complexes to ER membranes. Their physical association causes the membrane rearrangement of host ER that may result in formation of the small membranous vesicles that are the site of viral RNA synthesis.By similarity
Putative helicase: The protease cofactor and the putative helicase seem to target the replication complexes to ER membranes. Their physical association causes the membrane rearrangement of host ER that may result in formation of the small membranous vesicles that are the site of viral RNA synthesis.By similarity
RNA-directed RNA polymerase: Replicates the viral genome.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei983For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei1019For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei1109For picornain 3C-like protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi483 – 490ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C03.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA1 polyprotein
Alternative name(s):
Genome polyprotein B
P1
Cleaved into the following 5 chains:
Alternative name(s):
32 kDa protein
Putative helicase (EC:3.6.4.-)
Alternative name(s):
58 kDa protein
Membrane-binding protein
NTP-binding protein
Short name:
NTB
Alternative name(s):
VPg
Picornain 3C-like protease (EC:3.4.22.-By similarity)
Short name:
3C-like protease
Alternative name(s):
24 kDa protein
RNA-directed RNA polymerasePROSITE-ProRule annotation (EC:2.7.7.48PROSITE-ProRule annotation)
Alternative name(s):
87 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRed clover mottle virus (RCMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12262 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaPicornaviralesSecoviridaeComovirinaeComovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiTrifolium pratense (Red clover) [TaxID: 57577]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006361 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Putative helicase :
RNA-directed RNA polymerase :
Protease cofactor :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei892 – 912HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host endoplasmic reticulum, Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004458361 – 1864RNA1 polyproteinAdd BLAST1864
ChainiPRO_00000370161 – 315Protease cofactorAdd BLAST315
ChainiPRO_0000037017316 – 915Putative helicaseAdd BLAST600
ChainiPRO_0000037018916 – 943Viral genome-linked proteinAdd BLAST28
ChainiPRO_0000037019944 – 1151Picornain 3C-like proteaseAdd BLAST208
ChainiPRO_00000370201152 – 1864RNA-directed RNA polymeraseAdd BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei916O-(5'-phospho-RNA)-serineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

RNA1 polyprotein: Specific enzymatic cleavages by picornain 3C-like protease in vivo yield mature proteins. Picornain 3C-like protease is autocatalytically processed.By similarity
Viral genome-linked protein: Uridylylated by the polymerase and is covalently linked to the 5'-end of genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei315 – 316Cleavage; by viral proteaseBy similarity2
Sitei915 – 916Cleavage; by viral proteaseBy similarity2
Sitei943 – 944Cleavage; by viral proteaseBy similarity2
Sitei1151 – 1152Cleavage; by viral proteaseBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P35930

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini457 – 622SF3 helicasePROSITE-ProRule annotationAdd BLAST166
Domaini943 – 1146Peptidase C3PROSITE-ProRule annotationAdd BLAST204
Domaini1426 – 1556RdRp catalyticPROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR000199 Peptidase_C3A/C3B_picornavir
IPR009003 Peptidase_S1_PA
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00548 Peptidase_C3, 1 hit
PF00680 RdRP_1, 1 hit
PF00910 RNA_helicase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51874 PCV_3C_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P35930-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYMLTFEPGL CVAGIIRQVR SNPFMHVVQA YARTTETYRE DIEMTKSMLK
60 70 80 90 100
LKADEPLLVM SIVAAAMDFQ TMVMAPIEME ASEFLYGFYA ERMSYIVTNR
110 120 130 140 150
GMSELHEYIQ LQCQRHLLVK VEIDGQYLVQ EHEYEAQGFN IKRVKELITD
160 170 180 190 200
VATWVPKKVK GMIGWSVDAV LDSFQEYFYK VITERIPMAM KVCSWVATVW
210 220 230 240 250
DQIKTWIEDA MTAMSSFLQG CNELLTWGLA TLAACCALNV LERILIFMEF
260 270 280 290 300
LDESIDIAGI FLRTGVVAAA CYHFSSTAKG FTEMMSVLSV ATTAVAAVVC
310 320 330 340 350
ANYFGGSKTK KVNAQGNPVD LLERIAAGLS SISQDSLVSL GKSCSAINSI
360 370 380 390 400
ATSYGHLRNF AGRVLTMLRD FAWKILGLET RFLADAALVF GEDVDGWLQR
410 420 430 440 450
ISALREAYVS KAYSSQDEVF EMNVLLERGY KMRHLMATGS RVSPAIGNML
460 470 480 490 500
MQGLADLERL HRNAAVQGVK GVRKIPFTVF AHGNSRCGKS LLIGKLISDF
510 520 530 540 550
QEHKGLGEDT VYSRNTTETH WSGYRRQPIV VIDDFAAVES DISAEAQLIN
560 570 580 590 600
LVSSTPYSVV MAAIEEKGMT FDSQFIFAST NFLEVSPNGK IRCDDAFRNR
610 620 630 640 650
RHVLIDVKLK PEVEYQSDDF TANQSYNILE HSHGRYNVVA TFDNYEELLA
660 670 680 690 700
YCLTKHEQHE AEQEANLAKL RRTNKFESHF KKFEQVLQLS TYFSSSIERI
710 720 730 740 750
KREALATTDG ADDYHLLYVV PRNGSYLHVA ANKDFQIQQW YGPVEEVAEE
760 770 780 790 800
DILRASERML LGAYEFLLLS TELNVVVKNH LPELICTDNY DHNLEFCGVV
810 820 830 840 850
GDPVYHQQLL KNIRALKPWH RAVLFGIGTL MGAKNPTPWY KRMWEGIKDV
860 870 880 890 900
LYKAYSTEIS QWPVPLKITC GIVLVGIVGA GFWKTVSVLT NAGNGAGLVG
910 920 930 940 950
AAVNSFSVVS TAEAQSRKPN RFEVQQYRYK NVPLTRRSWG NAQMSLDQST
960 970 980 990 1000
VSILNKCHAK FIIASQHAQI VLVPGRRFIG YSHFFCNLKH PLMVQIETAD
1010 1020 1030 1040 1050
RTYFHRYQPE NMEYIEDSEL CVYHSSCLED ISHSCWDLFC WDPDKELPKK
1060 1070 1080 1090 1100
FSADFVSCKY NTWTKSVEPT WANVDAEVIK EDFTICDGEY RNTVSTSIRY
1110 1120 1130 1140 1150
EAPTVMSDCG SMIITNVGGK TKIVGIHVAG RDNKIGMASL LPPLLPCAQA
1160 1170 1180 1190 1200
QGAEKYFNFY PIEYDAAEGI ARVGELKPKL YIPLPKKTSL VKTPEEWHLG
1210 1220 1230 1240 1250
TPCDKVPSIL VKGDPRLADT VHADYDPCLS GLTKYSTPMS PLDSVLLGET
1260 1270 1280 1290 1300
CQEILDEWFD CLPEGFELGE VTINEALNGV DGVDYMDRIP LATSEGFPHV
1310 1320 1330 1340 1350
MSREQGEKGK QRFVQGDGHI VSLIPGTSVH EAYETLSRTI ATEVPTLVGI
1360 1370 1380 1390 1400
ECPKDEKLPF RKVFTKPKTR NFTILPMEYN ILVRQYFLNF VRFIMKKRDV
1410 1420 1430 1440 1450
LPCQVGINPY SMEWSIVASR LKSQGNDILC CDYSSFDGLL SKQIMEMMAD
1460 1470 1480 1490 1500
MINRFCGGGT LICAKRKNLL MACCSRLAIS RDSVWRIECG IPSGFPLTVI
1510 1520 1530 1540 1550
CNSIFNEILV RYHYKLLLQE HNAPNMYVQS FKNLISMVTY GDDNLISVNA
1560 1570 1580 1590 1600
VVKPYFDGTK LKQAMARNGI IITDGKDKTS ATLEFRRLED CDFLKRGFLK
1610 1620 1630 1640 1650
RSSVLWDAPE EKASLWAQLH YVNVNNCEMQ VAYMTNLVNV LRELYMHDPT
1660 1670 1680 1690 1700
EMVEFRRLAL KSIPWLNTTD LPTLYQVKEF YAEQRLRNIP DHNDSLDMLT
1710 1720 1730 1740 1750
SVDLLGPAIL GEGVPQEALV LSELLEVRDL RYHTVPDNDN GKEVWILFNT
1760 1770 1780 1790 1800
MYPQKLLPSN CHSFTWNCGQ GRGGLPTQHW LATNVTRTDS KLNKLIRTAV
1810 1820 1830 1840 1850
AANKKIVLAT KDNILPINVI AVLLAARNKV MPSLATNALL TYVIGAAKKL
1860
NFLTSECQFA FFNV
Length:1,864
Mass (Da):210,256
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DDD9D6C17C2B154
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X64886 Unassigned RNA Translation: CAA46104.1
D00657 Genomic RNA Translation: BAA00547.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JQ1657

NCBI Reference Sequences

More...
RefSeqi
NP_620468.1, NC_003741.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1502336

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1502336

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64886 Unassigned RNA Translation: CAA46104.1
D00657 Genomic RNA Translation: BAA00547.1
PIRiJQ1657
RefSeqiNP_620468.1, NC_003741.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC03.003

Proteomic databases

PRIDEiP35930

Genome annotation databases

GeneIDi1502336
KEGGivg:1502336

Family and domain databases

InterProiView protein in InterPro
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR000199 Peptidase_C3A/C3B_picornavir
IPR009003 Peptidase_S1_PA
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00548 Peptidase_C3, 1 hit
PF00680 RdRP_1, 1 hit
PF00910 RNA_helicase, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS51874 PCV_3C_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL1_RCMV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35930
Secondary accession number(s): Q66182
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 5, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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