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Entry version 87 (02 Dec 2020)
Sequence version 1 (01 Jun 1994)
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Protein

RNA replicase polyprotein

Gene
N/A
Organism
Erysimum latent virus (ELV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei680For protease activityPROSITE-ProRule annotation1
Active sitei766For protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi874 – 881ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA replicase polyprotein (EC:2.7.7.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiErysimum latent virus (ELV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12152 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaAlsuviricetesTymoviralesTymoviridaeTymovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiErysimum [TaxID: 65352]

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002229331 – 1748RNA replicase polyproteinAdd BLAST1748

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35928

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 219Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST162
Domaini627 – 781Peptidase C21PROSITE-ProRule annotationAdd BLAST155
Domaini844 – 1001(+)RNA virus helicase ATP-bindingAdd BLAST158
Domaini1002 – 1138(+)RNA virus helicase C-terminalAdd BLAST137
Domaini1474 – 1580RdRp catalyticPROSITE-ProRule annotationAdd BLAST107

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.70.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR027417, P-loop_NTPase
IPR008043, Peptidase_C21
IPR007094, RNA-dir_pol_PSvirus
IPR043629, Salyut_dom
IPR001788, Tymovirus_RNA-dep_RNA_pol
IPR043181, TYMV_endopept_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05381, Peptidase_C21, 1 hit
PF00978, RdRP_2, 1 hit
PF19227, Salyut, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51738, PEPTIDASE_C21, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P35928-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFQLALDAL SSTTHRDSIS APLLDSSVSQ LQSSLELFPY TVPKELVPQL
60 70 80 90 100
NRMGIQVSGL TSTPHPHAAH KTLELNLLFN HWAKSCNVDS AVVFMKPSKF
110 120 130 140 150
FKLQEKNSHF KSLHNYRLHP HDSNRYPHPS TSLPTEKRFY IHDSLMYFTP
160 170 180 190 200
HQISGLFESC PNLLSLYASL VVPPESSMTD LSLNPDLYRY SIHKSTLHYT
210 220 230 240 250
PEGHSAGSYN QPVNALDWLK ISAIQTPSLS LSVSVLESWG PLHSLLIERS
260 270 280 290 300
SQTQNPDSQK IKDLISFQTP QALILPNPDS LAVPLRHRLV PQKTYDALFT
310 320 330 340 350
YTRATRTLRT SDPAGFVRTQ SNKPEFNWVT SQAWDNLQTY ALLTASYRPP
360 370 380 390 400
VSYTLHRSPL TKLKELLTRN ALKLAAMASP ALTLAIFTTM TALNTNSSKA
410 420 430 440 450
LSFSALKIHL LNPLTGPELL HFQTSVLQQK NSAPLSQAEA KQELDKSAVP
460 470 480 490 500
APSEHDSSAS QSTSLSLSAS SQLLSTEKHP GSELSSKAIP VSTSCPSASK
510 520 530 540 550
QLAPPLTAES HSSVNALLRK FLGPNSPQSN LDNYNLHLHP ESFTLGWKRR
560 570 580 590 600
PLLLDSHSSF LPSSCLQPPA SPSIAAAPHP LPPAQKPPRP PTTVPTPKPL
610 620 630 640 650
ASPSQTQAAQ PATQSPPSIP QTAPVTSLLP APLETDDSCA GPISTFQDLF
660 670 680 690 700
PASYYPHTAN FPCRSKIPGY LEAPYPPLDC MLVALSAQMP QSPQELWSAL
710 720 730 740 750
NTLMPLSALT SPSLRVLGLG TEELTALSYY YHFQAEIHSD NEIYRFGIQT
760 770 780 790 800
ASTKLCLIRD SGPPAHFTAP DPLRAGSPPS RSQTNENSLR RSLLGFRLNG
810 820 830 840 850
NLLPIDQVHS FTSEPSRAKN LASNMKNGFD GILTTLAALS SLSSGPSPRD
860 870 880 890 900
RIFTLDGICD FALPKTVDLI HLSGFAGCGK THPIQQLLKT PHFHNFRVVT
910 920 930 940 950
PTTNLRSEWK SDMALPAHHN WRFSTWESAL LKHAEILVID EIYKLPRGYL
960 970 980 990 1000
DLSLIADPTV KLVILLGDPL QGEYHSTSAH SSNLRLSSEI PRLLPFIDYY
1010 1020 1030 1040 1050
CYWSYRVPKC VAKLFSLPCF NPSEGFIKTT LDFFPSANNL VNSHSVVHIS
1060 1070 1080 1090 1100
EACGWNAVTI SSSQGCTFSD PAFIHLDRNT ALLSPSNCLV ALTRSRSGVY
1110 1120 1130 1140 1150
FKGDFTFLSS LSGSSRMFSL AYSGQPIHLP DFFPEIVFQL NMITAPLTKR
1160 1170 1180 1190 1200
SSSFRSGFQP NISSAPKIPA PPNLPCPPHI PTNYSKDVIV NNQALYGESL
1210 1220 1230 1240 1250
ERRLSVLHLP PTRMTLHSDI NITAPSSSSF QPSDEPVPSD HTAVYPGFDF
1260 1270 1280 1290 1300
FTLAAHFLPA HDPEVKEIEL KDQTSQQFPW LNLDFHISCQ TSSLISARHQ
1310 1320 1330 1340 1350
PGSDSTLLPA SLHKRLRFRP TAAPYQITPS DSFLGNCLYR SWCQVYRRDP
1360 1370 1380 1390 1400
NVRLPFNEAL FLECIAVNDY AQLSSKTQAT IVANASRSDP DWRHTFVKIF
1410 1420 1430 1440 1450
AKSQHKVNDG SIFGPWKACQ TLALMHDYVI LTLGPVKKYQ RLFDQLERPS
1460 1470 1480 1490 1500
HIYYHAGNTP HDLRRWCSKH LETSHCTTND YTAFDQSQHG EAVVFEVLKM
1510 1520 1530 1540 1550
RRLSIPENLI SLHVHLKTNV ETQFGPLTCM RLTGEPGTYD DNTDYNLAVL
1560 1570 1580 1590 1600
NLQYDLRKTP TLVSGDDSYL SGTLSPRSNW PFVKELLHLR LKPSSLIDGL
1610 1620 1630 1640 1650
FCGYYLGPQG CIRNPLALFA KLMIAEDDGS AFDKLPSYLT EFSIGHGLGD
1660 1670 1680 1690 1700
SLWQLLPSDL VLYQSACFDY FCRKATRSQK ILLQPGLVDQ ETLDKIALSA
1710 1720 1730 1740
KFISRPFYSM LSSHARSLIS TKFKLDSSLT TLQDPMVEFE LLPFSNVQ
Length:1,748
Mass (Da):193,908
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9CA5DE87D64A3AA
GO

Sequence databases

Protein sequence database of the Protein Information Resource

More...
PIRi
JQ1555

NCBI Reference Sequences

More...
RefSeqi
NP_047920.1, NC_001977.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1493964

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1493964

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

PIRiJQ1555
RefSeqiNP_047920.1, NC_001977.1

3D structure databases

SMRiP35928
ModBaseiSearch...

Genome annotation databases

GeneIDi1493964
KEGGivg:1493964

Family and domain databases

Gene3Di3.90.70.100, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR002588, Alphavirus-like_MT_dom
IPR043502, DNA/RNA_pol_sf
IPR027417, P-loop_NTPase
IPR008043, Peptidase_C21
IPR007094, RNA-dir_pol_PSvirus
IPR043629, Salyut_dom
IPR001788, Tymovirus_RNA-dep_RNA_pol
IPR043181, TYMV_endopept_dom
PfamiView protein in Pfam
PF05381, Peptidase_C21, 1 hit
PF00978, RdRP_2, 1 hit
PF19227, Salyut, 1 hit
PF01443, Viral_helicase1, 1 hit
PF01660, Vmethyltransf, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51743, ALPHAVIRUS_MT, 1 hit
PS51738, PEPTIDASE_C21, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLR_ELV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35928
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: December 2, 2020
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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