UniProtKB - P35918 (VGFR2_MOUSE)
Vascular endothelial growth factor receptor 2
Kdr
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation1 PublicationEC:2.7.10.1PROSITE-ProRule annotation1 Publication
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 866 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 1026 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 838 – 846 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cadherin binding Source: MGI
- growth factor binding Source: MGI
- identical protein binding Source: MGI
- integrin binding Source: MGI
- protein tyrosine kinase activity Source: MGI
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
- vascular endothelial growth factor-activated receptor activity Source: MGI
- vascular endothelial growth factor binding Source: MGI
GO - Biological processi
- blood vessel endothelial cell differentiation Source: DFLAT
- branching involved in blood vessel morphogenesis Source: MGI
- branching morphogenesis of an epithelial tube Source: MGI
- calcium ion homeostasis Source: MGI
- calcium-mediated signaling using intracellular calcium source Source: UniProtKB
- cell fate commitment Source: MGI
- cell maturation Source: MGI
- cell migration Source: MGI
- cell migration involved in sprouting angiogenesis Source: BHF-UCL
- cellular response to hydrogen sulfide Source: MGI
- cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
- embryonic hemopoiesis Source: UniProtKB
- endocardium development Source: UniProtKB
- endochondral bone growth Source: MGI
- endothelial cell differentiation Source: MGI
- endothelium development Source: UniProtKB
- ERK1 and ERK2 cascade Source: MGI
- hematopoietic progenitor cell differentiation Source: GO_Central
- hemopoiesis Source: MGI
- lung alveolus development Source: MGI
- lung development Source: MGI
- lymph vessel development Source: MGI
- male gonad development Source: MGI
- multicellular organism development Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of endothelial cell apoptotic process Source: UniProtKB
- negative regulation of gene expression Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- neuron projection morphogenesis Source: MGI
- ovarian follicle development Source: MGI
- peptidyl-tyrosine autophosphorylation Source: BHF-UCL
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of angiogenesis Source: DFLAT
- positive regulation of blood vessel diameter Source: MGI
- positive regulation of blood vessel endothelial cell migration Source: MGI
- positive regulation of BMP signaling pathway Source: DFLAT
- positive regulation of calcium-mediated signaling Source: MGI
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell migration involved in sprouting angiogenesis Source: MGI
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: MGI
- positive regulation of endothelial cell migration Source: MGI
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of epithelial cell proliferation Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of focal adhesion assembly Source: MGI
- positive regulation of kinase activity Source: GO_Central
- positive regulation of long-term neuronal synaptic plasticity Source: MGI
- positive regulation of macroautophagy Source: MGI
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of mesenchymal cell proliferation Source: MGI
- positive regulation of mitochondrial depolarization Source: MGI
- positive regulation of mitochondrial fission Source: MGI
- positive regulation of nitric-oxide synthase biosynthetic process Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of positive chemotaxis Source: MGI
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of TOR signaling Source: MGI
- positive regulation of vascular endothelial growth factor receptor signaling pathway Source: DFLAT
- positive regulation of vasculogenesis Source: UniProtKB
- post-embryonic camera-type eye morphogenesis Source: MGI
- protein autophosphorylation Source: UniProtKB
- protein kinase B signaling Source: MGI
- regulation of bone development Source: MGI
- regulation of cell shape Source: MGI
- regulation of endothelial cell proliferation Source: DFLAT
- regulation of hematopoietic progenitor cell differentiation Source: MGI
- response to drug Source: MGI
- response to hypoxia Source: MGI
- surfactant homeostasis Source: MGI
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- vascular endothelial growth factor receptor-2 signaling pathway Source: MGI
- vascular endothelial growth factor receptor signaling pathway Source: MGI
- vascular endothelial growth factor signaling pathway Source: MGI
- vascular wound healing Source: MGI
- vasculogenesis Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Angiogenesis, Differentiation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-194306, Neurophilin interactions with VEGF and VEGFR R-MMU-195399, VEGF binds to VEGFR leading to receptor dimerization R-MMU-216083, Integrin cell surface interactions R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-5218921, VEGFR2 mediated cell proliferation |
Names & Taxonomyi
Protein namesi | Recommended name: Vascular endothelial growth factor receptor 2 (EC:2.7.10.1)Short name: VEGFR-2 Alternative name(s): Fetal liver kinase 1 Short name: FLK-1 Kinase NYK Protein-tyrosine kinase receptor flk-1 CD_antigen: CD309 |
Gene namesi | Name:Kdr Synonyms:Flk-1, Flk1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96683, Kdr |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Plasma membrane
- Cell membrane By similarity
Other locations
- Cell junction 3 Publications
Note: Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (By similarity). Localized with RAP1A at cell-cell junctions.By similarity
Endosome
- Early endosome By similarity
Nucleus
- Nucleus By similarity
Plasma membrane
Other locations
- Cytoplasm By similarity
- Cytoplasmic vesicle By similarity
Note: Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus (By similarity).By similarity
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Endosome
- early endosome Source: BHF-UCL
- endosome Source: MGI
- sorting endosome Source: BHF-UCL
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: BHF-UCL
Other locations
- cell junction Source: UniProtKB
- cell periphery Source: MGI
- cell surface Source: BHF-UCL
- cytoplasm Source: MGI
- membrane raft Source: MGI
- neuron projection Source: MGI
- neuronal cell body Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 762 | ExtracellularSequence analysisAdd BLAST | 743 | |
Transmembranei | 763 – 783 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 784 – 1367 | CytoplasmicSequence analysisAdd BLAST | 584 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Membrane, Nucleus, SecretedPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 866 | K → R: Loss of enzyme activity. Abolishes ubiquitination in response to VEGFA binding. 1 Publication | 1 | |
Mutagenesisi | 1173 | Y → F: Loss of interaction with SHB. 1 Publication | 1 | |
Mutagenesisi | 1188 | S → A: Strongly reduces internalization and down-regulation of the activated receptor; when associated with A-1191. 1 Publication | 1 | |
Mutagenesisi | 1191 | S → A: Strongly reduces internalization and down-regulation of the activated receptor; when associated with A-1188. 1 Publication | 1 | |
Mutagenesisi | 1212 | Y → F: Strongly reduced autophosphorylation. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3337 |
DrugCentrali | P35918 |
GuidetoPHARMACOLOGYi | 1813 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000016772 | 20 – 1367 | Vascular endothelial growth factor receptor 2Add BLAST | 1348 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 46 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 53 ↔ 105 | PROSITE-ProRule annotation | ||
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 152 ↔ 202 | PROSITE-ProRule annotation | ||
Glycosylationi | 160 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 247 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 248 ↔ 309 | PROSITE-ProRule annotation | ||
Glycosylationi | 320 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 376 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 397 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 447 ↔ 528 | PROSITE-ProRule annotation | ||
Glycosylationi | 509 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 521 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 569 ↔ 640 | PROSITE-ProRule annotation | ||
Glycosylationi | 578 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 611 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 617 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 629 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 673 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 686 ↔ 735 | PROSITE-ProRule annotation | ||
Glycosylationi | 702 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 719 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 799 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 949 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 980 | PhosphoserineBy similarity | 1 | |
Modified residuei | 982 | PhosphoserineBy similarity | 1 | |
Modified residuei | 994 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Disulfide bondi | 1022 ↔ 1043 | Redox-activePROSITE-ProRule annotation | ||
Modified residuei | 1052 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1057 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1173 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1212 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 1229 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1233 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1236 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1303 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1307 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1317 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P35918 |
PaxDbi | P35918 |
PRIDEi | P35918 |
PTM databases
GlyGeni | P35918, 17 sites, 12 N-linked glycans (10 sites) |
iPTMneti | P35918 |
PhosphoSitePlusi | P35918 |
Expressioni
Tissue specificityi
Developmental stagei
Interactioni
Subunit structurei
Homodimer in the presence of bound dimeric VEGFA, VEGFC or VEGFD ligands; monomeric in the absence of bound ligands. Can also form heterodimers with FLT1/VEGFR1 and KDR/VEGFR2.
Interacts (tyrosine phosphorylated) with LFYN, NCK1, PLCG1.
Interacts (tyrosine-phosphorylated active form preferentially) with DAB2IP (via C2 domain and active form preferentially); the interaction occurs at the late phase of VEGFA response and inhibits KDR/VEGFR2 activity.
Interacts with SHBSH2D2A/TSAD, GRB2, MYOF, CBL and PDCD6 (PubMed:12796773, PubMed:12881528, PubMed:15026417, PubMed:15673613, PubMed:17702744, PubMed:19668192, PubMed:7681362, PubMed:8356051).
Interacts (via C-terminus domain) with ERN1 (via kinase domain); the interaction is facilitated in a XBP1 isoform 1- and vascular endothelial growth factor (VEGF)-dependent manner in endothelial cells (By similarity).
Interacts (via juxtamembrane region) with chaperone PDCL3 (via thioredoxin fold region); the interaction leads to increased KDR/VEGFR2 abundance through inhibition of its ubiquitination and degradation (By similarity).
Interacts (tyrosine phosphorylated) with CCDC88A/GIV (via SH2-like region); binding requires autophosphorylation of the KDR/VEGFR2 C-terminal region (By similarity).
Interacts with isoform 2 of BSG (By similarity).
By similarity8 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1173 | Interaction with SHB | 1 |
Binary interactionsi
Hide detailsP35918
GO - Molecular functioni
- cadherin binding Source: MGI
- growth factor binding Source: MGI
- identical protein binding Source: MGI
- integrin binding Source: MGI
- vascular endothelial growth factor binding Source: MGI
Protein-protein interaction databases
CORUMi | P35918 |
DIPi | DIP-215N |
IntActi | P35918, 13 interactors |
MINTi | P35918 |
STRINGi | 10090.ENSMUSP00000109144 |
Chemistry databases
BindingDBi | P35918 |
Miscellaneous databases
RNActi | P35918, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 111 | Ig-like C2-type 1Add BLAST | 66 | |
Domaini | 143 – 209 | Ig-like C2-type 2Add BLAST | 67 | |
Domaini | 226 – 325 | Ig-like C2-type 3Add BLAST | 100 | |
Domaini | 330 – 416 | Ig-like C2-type 4Add BLAST | 87 | |
Domaini | 423 – 542 | Ig-like C2-type 5Add BLAST | 120 | |
Domaini | 549 – 656 | Ig-like C2-type 6Add BLAST | 108 | |
Domaini | 665 – 751 | Ig-like C2-type 7Add BLAST | 87 | |
Domaini | 832 – 1160 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 329 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
InParanoidi | P35918 |
PhylomeDBi | P35918 |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS IPR041348, VEGFR-2_TMD IPR009136, VEGFR2_rcpt |
PANTHERi | PTHR24416:SF45, PTHR24416:SF45, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF17988, VEGFR-2_TMD, 1 hit |
PRINTSi | PR01834, VEGFRECEPTR2 |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 4 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 7 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESKALLAVA LWFCVETRAA SVGLPGDFLH PPKLSTQKDI LTILANTTLQ
60 70 80 90 100
ITCRGQRDLD WLWPNAQRDS EERVLVTECG GGDSIFCKTL TIPRVVGNDT
110 120 130 140 150
GAYKCSYRDV DIASTVYVYV RDYRSPFIAS VSDQHGIVYI TENKNKTVVI
160 170 180 190 200
PCRGSISNLN VSLCARYPEK RFVPDGNRIS WDSEIGFTLP SYMISYAGMV
210 220 230 240 250
FCEAKINDET YQSIMYIVVV VGYRIYDVIL SPPHEIELSA GEKLVLNCTA
260 270 280 290 300
RTELNVGLDF TWHSPPSKSH HKKIVNRDVK PFPGTVAKMF LSTLTIESVT
310 320 330 340 350
KSDQGEYTCV ASSGRMIKRN RTFVRVHTKP FIAFGSGMKS LVEATVGSQV
360 370 380 390 400
RIPVKYLSYP APDIKWYRNG RPIESNYTMI VGDELTIMEV TERDAGNYTV
410 420 430 440 450
ILTNPISMEK QSHMVSLVVN VPPQIGEKAL ISPMDSYQYG TMQTLTCTVY
460 470 480 490 500
ANPPLHHIQW YWQLEEACSY RPGQTSPYAC KEWRHVEDFQ GGNKIEVTKN
510 520 530 540 550
QYALIEGKNK TVSTLVIQAA NVSALYKCEA INKAGRGERV ISFHVIRGPE
560 570 580 590 600
ITVQPAAQPT EQESVSLLCT ADRNTFENLT WYKLGSQATS VHMGESLTPV
610 620 630 640 650
CKNLDALWKL NGTMFSNSTN DILIVAFQNA SLQDQGDYVC SAQDKKTKKR
660 670 680 690 700
HCLVKQLIIL ERMAPMITGN LENQTTTIGE TIEVTCPASG NPTPHITWFK
710 720 730 740 750
DNETLVEDSG IVLRDGNRNL TIRRVRKEDG GLYTCQACNV LGCARAETLF
760 770 780 790 800
IIEGAQEKTN LEVIILVGTA VIAMFFWLLL VILVRTVKRA NEGELKTGYL
810 820 830 840 850
SIVMDPDELP LDERCERLPY DASKWEFPRD RLKLGKPLGR GAFGQVIEAD
860 870 880 890 900
AFGIDKTATC KTVAVKMLKE GATHSEHRAL MSELKILIHI GHHLNVVNLL
910 920 930 940 950
GACTKPGGPL MVIVEFSKFG NLSTYLRGKR NEFVPYKSKG ARFRQGKDYV
960 970 980 990 1000
GELSVDLKRR LDSITSSQSS ASSGFVEEKS LSDVEEEEAS EELYKDFLTL
1010 1020 1030 1040 1050
EHLICYSFQV AKGMEFLASR KCIHRDLAAR NILLSEKNVV KICDFGLARD
1060 1070 1080 1090 1100
IYKDPDYVRK GDARLPLKWM APETIFDRVY TIQSDVWSFG VLLWEIFSLG
1110 1120 1130 1140 1150
ASPYPGVKID EEFCRRLKEG TRMRAPDYTT PEMYQTMLDC WHEDPNQRPS
1160 1170 1180 1190 1200
FSELVEHLGN LLQANAQQDG KDYIVLPMSE TLSMEEDSGL SLPTSPVSCM
1210 1220 1230 1240 1250
EEEEVCDPKF HYDNTAGISH YLQNSKRKSR PVSVKTFEDI PLEEPEVKVI
1260 1270 1280 1290 1300
PDDSQTDSGM VLASEELKTL EDRNKLSPSF GGMMPSKSRE SVASEGSNQT
1310 1320 1330 1340 1350
SGYQSGYHSD DTDTTVYSSD EAGLLKMVDA AVHADSGTTL QLTSCLNGSG
1360
PVPAPPPTPG NHERGAA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ8VCD0 | Q8VCD0_MOUSE | Vascular endothelial growth factor ... | Kdr | 1,345 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | P → T in CAA50192 (PubMed:7681362).Curated | 1 | |
Sequence conflicti | 679 | G → D in AAB25043 (PubMed:8423988).Curated | 1 | |
Sequence conflicti | 783 – 784 | LV → VL in CAA50192 (PubMed:7681362).Curated | 2 | |
Sequence conflicti | 917 | S → C in CAA50192 (PubMed:7681362).Curated | 1 | |
Sequence conflicti | 1341 – 1367 | QLTSC…ERGAA → RSPPV in AAB25043 (PubMed:8423988).CuratedAdd BLAST | 27 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041986 | 661 – 673 | ERMAP…GNLEN → GMEASLGDRIAMP in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_041987 | 674 – 1367 | Missing in isoform 2. 1 PublicationAdd BLAST | 694 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70842 mRNA Translation: CAA50192.1 X59397 mRNA Translation: CAA42040.1 S53103 mRNA Translation: AAB25043.1 EU884114 mRNA Translation: ACJ66293.1 X89777 Genomic DNA Translation: CAA61917.1 |
PIRi | A41228 |
Genome annotation databases
UCSCi | uc012dxk.2, mouse [P35918-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70842 mRNA Translation: CAA50192.1 X59397 mRNA Translation: CAA42040.1 S53103 mRNA Translation: AAB25043.1 EU884114 mRNA Translation: ACJ66293.1 X89777 Genomic DNA Translation: CAA61917.1 |
PIRi | A41228 |
3D structure databases
SMRi | P35918 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | P35918 |
DIPi | DIP-215N |
IntActi | P35918, 13 interactors |
MINTi | P35918 |
STRINGi | 10090.ENSMUSP00000109144 |
Chemistry databases
BindingDBi | P35918 |
ChEMBLi | CHEMBL3337 |
DrugCentrali | P35918 |
GuidetoPHARMACOLOGYi | 1813 |
PTM databases
GlyGeni | P35918, 17 sites, 12 N-linked glycans (10 sites) |
iPTMneti | P35918 |
PhosphoSitePlusi | P35918 |
Proteomic databases
MaxQBi | P35918 |
PaxDbi | P35918 |
PRIDEi | P35918 |
Protocols and materials databases
ABCDi | P35918, 27 sequenced antibodies |
Genome annotation databases
UCSCi | uc012dxk.2, mouse [P35918-2] |
Organism-specific databases
MGIi | MGI:96683, Kdr |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
InParanoidi | P35918 |
PhylomeDBi | P35918 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-194306, Neurophilin interactions with VEGF and VEGFR R-MMU-195399, VEGF binds to VEGFR leading to receptor dimerization R-MMU-216083, Integrin cell surface interactions R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-5218921, VEGFR2 mediated cell proliferation |
Miscellaneous databases
ChiTaRSi | Kdr, mouse |
PROi | PR:P35918 |
RNActi | P35918, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS IPR041348, VEGFR-2_TMD IPR009136, VEGFR2_rcpt |
PANTHERi | PTHR24416:SF45, PTHR24416:SF45, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit PF17988, VEGFR-2_TMD, 1 hit |
PRINTSi | PR01834, VEGFRECEPTR2 |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 4 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 7 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VGFR2_MOUSE | |
Accessioni | P35918Primary (citable) accession number: P35918 Secondary accession number(s): C5H7S5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | October 7, 2020 | |
This is version 202 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index