UniProtKB - P35914 (HMGCL_HUMAN)
Hydroxymethylglutaryl-CoA lyase, mitochondrial
HMGCL
Functioni
Catalytic activityi
- EC:4.1.3.42 Publications
Cofactori
Activity regulationi
Kineticsi
- KM=200 µM for magnesium ion2 Publications
- KM=48 µM for HMG-CoA2 Publications
- Vmax=191 µmol/min/mg enzyme2 Publications
: (S)-3-hydroxy-3-methylglutaryl-CoA degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA.Proteins known to be involved in this subpathway in this organism are:
- Hydroxymethylglutaryl-CoA lyase, Hydroxymethylglutaryl-CoA lyase, mitochondrial (HMGCL), Hydroxymethylglutaryl-CoA lyase (DKFZp434G1411), 3-hydroxy-3-methylglutarate-CoA lyase (HMGCL), 3-hydroxy-3-methylglutarate-CoA lyase (HMGCL), 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (HMGCLL1), Hydroxymethylglutaryl-CoA lyase (HMGCLL1), Hydroxymethylglutaryl-CoA lyase (HMGCLL1), Hydroxymethylglutaryl-CoA lyase (HMGCLL1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA, the pathway (S)-3-hydroxy-3-methylglutaryl-CoA degradation and in Metabolic intermediate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 41 | Substrate | 1 | |
Metal bindingi | 42 | Divalent metal cation | 1 | |
Metal bindingi | 233 | Divalent metal cation | 1 | |
Metal bindingi | 235 | Divalent metal cation | 1 | |
Active sitei | 266 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 275 | Divalent metal cation | 1 |
GO - Molecular functioni
- carboxylic acid binding Source: Ensembl
- fatty-acyl-CoA binding Source: Ensembl
- hydroxymethylglutaryl-CoA lyase activity Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- manganese ion binding Source: UniProtKB
- metal ion binding Source: UniProtKB
- structural molecule activity Source: UniProtKB
GO - Biological processi
- acyl-CoA metabolic process Source: Ensembl
- ketone body biosynthetic process Source: UniProtKB
- leucine catabolic process Source: GO_Central
- lipid metabolic process Source: BHF-UCL
- liver development Source: Ensembl
- mitochondrion organization Source: Ensembl
- protein localization Source: Reactome
- response to fatty acid Source: Ensembl
- response to nutrient Source: Ensembl
- response to starvation Source: Ensembl
Keywordsi
Molecular function | Lyase |
Ligand | Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS04116-MONOMER |
BRENDAi | 4.1.3.4, 2681 |
PathwayCommonsi | P35914 |
Reactomei | R-HSA-77111, Synthesis of Ketone Bodies R-HSA-9033241, Peroxisomal protein import |
SABIO-RKi | P35914 |
UniPathwayi | UPA00896;UER00863 |
Chemistry databases
SwissLipidsi | SLP:000001292 [P35914-1] |
Names & Taxonomyi
Protein namesi | Recommended name: Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC:4.1.3.42 Publications)Short name: HL Short name: HMG-CoA lyase Alternative name(s): 3-hydroxy-3-methylglutarate-CoA lyase |
Gene namesi | Name:HMGCL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5005, HMGCL |
MIMi | 613898, gene |
neXtProti | NX_P35914 |
VEuPathDBi | HostDB:ENSG00000117305.14 |
Subcellular locationi
Peroxisome
- Peroxisome By similarity
Mitochondrion
- Mitochondrion matrix By similarity
Note: Unprocessed form is peroxisomal.By similarity
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial matrix Source: Reactome
- mitochondrion Source: UniProtKB
Peroxisome
- peroxisomal matrix Source: Reactome
- peroxisome Source: UniProtKB
Other locations
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Mitochondrion, PeroxisomePathology & Biotechi
Involvement in diseasei
3-hydroxy-3-methylglutaryl-CoA lyase deficiency (HMGCLD)10 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058440 | 37 | E → K in HMGCLD; activity lower than 5% respect to the wild-type. 1 Publication | 1 | |
Natural variantiVAR_003744 | 41 | R → Q in HMGCLD; loss of activity and of proton exchange. 2 PublicationsCorresponds to variant dbSNP:rs121964997EnsemblClinVar. | 1 | |
Natural variantiVAR_003745 | 42 | D → E in HMGCLD; reduced activity. 1 Publication | 1 | |
Natural variantiVAR_003746 | 42 | D → G in HMGCLD; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs1467902610Ensembl. | 1 | |
Natural variantiVAR_003747 | 42 | D → H in HMGCLD; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_058441 | 48 | K → N in HMGCLD; abolishes almost all enzymatic activity. 1 Publication | 1 | |
Natural variantiVAR_003748 | 70 | V → L in HMGCLD. Corresponds to variant dbSNP:rs121964996EnsemblClinVar. | 1 | |
Natural variantiVAR_058442 | 75 | S → R in HMGCLD. 1 PublicationCorresponds to variant dbSNP:rs1357942068Ensembl. | 1 | |
Natural variantiVAR_058443 | 142 | S → F in HMGCLD; activity lower than 5% respect to the wild-type. 1 Publication | 1 | |
Natural variantiVAR_065453 | 165 | R → Q in HMGCLD. 1 PublicationCorresponds to variant dbSNP:rs199587895EnsemblClinVar. | 1 | |
Natural variantiVAR_058444 | 174 | C → Y in HMGCLD; activity lower than 5% respect to the wild-type. 1 PublicationCorresponds to variant dbSNP:rs765475941Ensembl. | 1 | |
Natural variantiVAR_058445 | 192 | F → S in HMGCLD; activity lower than 5% respect to the wild-type. 1 Publication | 1 | |
Natural variantiVAR_058446 | 200 | I → F in HMGCLD; activity lower than 5% respect to the wild-type. 1 Publication | 1 | |
Natural variantiVAR_058447 | 201 | S → Y in HMGCLD. 1 PublicationCorresponds to variant dbSNP:rs760106433EnsemblClinVar. | 1 | |
Natural variantiVAR_058448 | 203 | G → E in HMGCLD; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1553131940EnsemblClinVar. | 1 | |
Natural variantiVAR_058449 | 204 | D → N in HMGCLD. 1 Publication | 1 | |
Natural variantiVAR_003749 | 233 | H → R in HMGCLD; loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs727503963EnsemblClinVar. | 1 | |
Natural variantiVAR_058450 | 263 | L → P in HMGCLD. 1 Publication | 1 | |
Natural variantiVAR_014202 | 279 | E → K in HMGCLD. 1 PublicationCorresponds to variant dbSNP:rs121964998EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 37 | E → D: Normal activity. 1 Publication | 1 | |
Mutagenesisi | 41 | R → M: Reduced activity, and loss of proton exchange. 1 Publication | 1 | |
Mutagenesisi | 42 | D → A or N: Loss of activity, and reduced proton exchange rate. 2 Publications | 1 | |
Mutagenesisi | 72 | E → A: Loss of activity, and reduced affinity for metal cofactor and substrate. 1 Publication | 1 | |
Mutagenesisi | 204 | D → A: Reduced activity, and reduced affinity for metal cofactor and substrate. 1 Publication | 1 | |
Mutagenesisi | 233 | H → A: Loss of activity, and reduced proton exchange rate. 2 Publications | 1 | |
Mutagenesisi | 266 | C → A: Loss of activity. | 1 | |
Mutagenesisi | 279 | E → A: Reduced thermal stability, but normal activity. 1 Publication | 1 | |
Mutagenesisi | 280 | D → A: Normal activity. 1 Publication | 1 | |
Mutagenesisi | 323 | C → S: Abolishes interchain homodimerization. Exhibits no DTT stimulated activity. 2 Publications | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 3155 |
MalaCardsi | HMGCL |
MIMi | 246450, phenotype |
OpenTargetsi | ENSG00000117305 |
Orphaneti | 20, 3-hydroxy-3-methylglutaric aciduria |
PharmGKBi | PA29336 |
Miscellaneous databases
Pharosi | P35914, Tbio |
Chemistry databases
DrugBanki | DB04594, 3-hydroxyglutaric acid |
Genetic variation databases
BioMutai | HMGCL |
DMDMi | 24418852 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 27 | MitochondrionAdd BLAST | 27 | |
ChainiPRO_0000013478 | 28 – 325 | Hydroxymethylglutaryl-CoA lyase, mitochondrialAdd BLAST | 298 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 48 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 111 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 137 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 137 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 179 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 179 | N6-succinyllysine; alternateBy similarity | 1 | |
Disulfide bondi | 323 | Interchain1 Publication | ||
Modified residuei | 324 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Disulfide bondProteomic databases
EPDi | P35914 |
jPOSTi | P35914 |
MassIVEi | P35914 |
PaxDbi | P35914 |
PeptideAtlasi | P35914 |
PRIDEi | P35914 |
ProteomicsDBi | 55164 [P35914-1] 55165 [P35914-2] |
PTM databases
iPTMneti | P35914 |
PhosphoSitePlusi | P35914 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000117305, Expressed in right lobe of liver and 241 other tissues |
ExpressionAtlasi | P35914, baseline and differential |
Genevisiblei | P35914, HS |
Organism-specific databases
HPAi | ENSG00000117305, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked. Can also form homotetramers.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 109398, 40 interactors |
IntActi | P35914, 11 interactors |
MINTi | P35914 |
STRINGi | 9606.ENSP00000363614 |
Miscellaneous databases
RNActi | P35914, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P35914 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35914 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 300 | Pyruvate carboxyltransferasePROSITE-ProRule annotationAdd BLAST | 268 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 323 – 325 | Microbody targeting signalSequence analysis | 3 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2368, Eukaryota |
GeneTreei | ENSGT00940000158484 |
HOGENOMi | CLU_022138_3_1_1 |
InParanoidi | P35914 |
OMAi | FGGCPMA |
OrthoDBi | 1029775at2759 |
PhylomeDBi | P35914 |
TreeFami | TF105363 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR000138, HMG_CoA_lyase_AS IPR043594, HMGL IPR000891, PYR_CT |
PANTHERi | PTHR42738, PTHR42738, 1 hit |
Pfami | View protein in Pfam PF00682, HMGL-like, 1 hit |
PROSITEi | View protein in PROSITE PS01062, HMG_COA_LYASE, 1 hit PS50991, PYR_CT, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAMRKALPR RLVGLASLRA VSTSSMGTLP KRVKIVEVGP RDGLQNEKNI
60 70 80 90 100
VSTPVKIKLI DMLSEAGLSV IETTSFVSPK WVPQMGDHTE VLKGIQKFPG
110 120 130 140 150
INYPVLTPNL KGFEAAVAAG AKEVVIFGAA SELFTKKNIN CSIEESFQRF
160 170 180 190 200
DAILKAAQSA NISVRGYVSC ALGCPYEGKI SPAKVAEVTK KFYSMGCYEI
210 220 230 240 250
SLGDTIGVGT PGIMKDMLSA VMQEVPLAAL AVHCHDTYGQ ALANTLMALQ
260 270 280 290 300
MGVSVVDSSV AGLGGCPYAQ GASGNLATED LVYMLEGLGI HTGVNLQKLL
310 320
EAGNFICQAL NRKTSSKVAQ ATCKL
The sequence of this isoform differs from the canonical sequence as follows:
117-187: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
117-187: Missing.
188-250: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y2L7 | H0Y2L7_HUMAN | 3-hydroxy-3-methylglutarate-CoA lya... | HMGCL | 182 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 243 | A → T in AAA92733 (PubMed:8440722).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058440 | 37 | E → K in HMGCLD; activity lower than 5% respect to the wild-type. 1 Publication | 1 | |
Natural variantiVAR_003744 | 41 | R → Q in HMGCLD; loss of activity and of proton exchange. 2 PublicationsCorresponds to variant dbSNP:rs121964997EnsemblClinVar. | 1 | |
Natural variantiVAR_003745 | 42 | D → E in HMGCLD; reduced activity. 1 Publication | 1 | |
Natural variantiVAR_003746 | 42 | D → G in HMGCLD; loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs1467902610Ensembl. | 1 | |
Natural variantiVAR_003747 | 42 | D → H in HMGCLD; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_058441 | 48 | K → N in HMGCLD; abolishes almost all enzymatic activity. 1 Publication | 1 | |
Natural variantiVAR_003748 | 70 | V → L in HMGCLD. Corresponds to variant dbSNP:rs121964996EnsemblClinVar. | 1 | |
Natural variantiVAR_058442 | 75 | S → R in HMGCLD. 1 PublicationCorresponds to variant dbSNP:rs1357942068Ensembl. | 1 | |
Natural variantiVAR_058443 | 142 | S → F in HMGCLD; activity lower than 5% respect to the wild-type. 1 Publication | 1 | |
Natural variantiVAR_065453 | 165 | R → Q in HMGCLD. 1 PublicationCorresponds to variant dbSNP:rs199587895EnsemblClinVar. | 1 | |
Natural variantiVAR_058444 | 174 | C → Y in HMGCLD; activity lower than 5% respect to the wild-type. 1 PublicationCorresponds to variant dbSNP:rs765475941Ensembl. | 1 | |
Natural variantiVAR_058445 | 192 | F → S in HMGCLD; activity lower than 5% respect to the wild-type. 1 Publication | 1 | |
Natural variantiVAR_058446 | 200 | I → F in HMGCLD; activity lower than 5% respect to the wild-type. 1 Publication | 1 | |
Natural variantiVAR_058447 | 201 | S → Y in HMGCLD. 1 PublicationCorresponds to variant dbSNP:rs760106433EnsemblClinVar. | 1 | |
Natural variantiVAR_058448 | 203 | G → E in HMGCLD; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1553131940EnsemblClinVar. | 1 | |
Natural variantiVAR_058449 | 204 | D → N in HMGCLD. 1 Publication | 1 | |
Natural variantiVAR_003749 | 233 | H → R in HMGCLD; loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs727503963EnsemblClinVar. | 1 | |
Natural variantiVAR_058450 | 263 | L → P in HMGCLD. 1 Publication | 1 | |
Natural variantiVAR_014202 | 279 | E → K in HMGCLD. 1 PublicationCorresponds to variant dbSNP:rs121964998EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047444 | 117 – 187 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 71 | |
Alternative sequenceiVSP_043788 | 188 – 250 | Missing in isoform 3. 1 PublicationAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07033 mRNA Translation: AAA92733.1 AK300733 mRNA Translation: BAG62406.1 AK313869 mRNA Translation: BAG36597.1 BT009792 mRNA Translation: AAP88794.1 CR456884 mRNA Translation: CAG33165.1 AL031295 Genomic DNA No translation available. AL590728 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW95094.1 BC010570 mRNA Translation: AAH10570.1 AH003700 Genomic DNA Translation: AAB19099.1 FJ472654 mRNA Translation: ACK58684.1 GU433941 mRNA Translation: ADD21697.1 |
CCDSi | CCDS243.1 [P35914-1] CCDS53279.1 [P35914-2] |
PIRi | A45470 |
RefSeqi | NP_000182.2, NM_000191.2 [P35914-1] NP_001159531.1, NM_001166059.1 [P35914-2] |
Genome annotation databases
Ensembli | ENST00000374490; ENSP00000363614; ENSG00000117305 [P35914-1] ENST00000436439; ENSP00000389281; ENSG00000117305 [P35914-2] |
GeneIDi | 3155 |
KEGGi | hsa:3155 |
UCSCi | uc001bib.4, human [P35914-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07033 mRNA Translation: AAA92733.1 AK300733 mRNA Translation: BAG62406.1 AK313869 mRNA Translation: BAG36597.1 BT009792 mRNA Translation: AAP88794.1 CR456884 mRNA Translation: CAG33165.1 AL031295 Genomic DNA No translation available. AL590728 Genomic DNA No translation available. CH471134 Genomic DNA Translation: EAW95094.1 BC010570 mRNA Translation: AAH10570.1 AH003700 Genomic DNA Translation: AAB19099.1 FJ472654 mRNA Translation: ACK58684.1 GU433941 mRNA Translation: ADD21697.1 |
CCDSi | CCDS243.1 [P35914-1] CCDS53279.1 [P35914-2] |
PIRi | A45470 |
RefSeqi | NP_000182.2, NM_000191.2 [P35914-1] NP_001159531.1, NM_001166059.1 [P35914-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CW6 | X-ray | 2.10 | A/B/C/D/E/F | 28-325 | [»] | |
3MP3 | X-ray | 2.40 | A/B/C/D/E/F | 28-325 | [»] | |
3MP4 | X-ray | 2.20 | A/B/C/D/E/F | 28-325 | [»] | |
3MP5 | X-ray | 2.25 | A/B/C/D/E/F | 28-325 | [»] | |
SMRi | P35914 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109398, 40 interactors |
IntActi | P35914, 11 interactors |
MINTi | P35914 |
STRINGi | 9606.ENSP00000363614 |
Chemistry databases
DrugBanki | DB04594, 3-hydroxyglutaric acid |
SwissLipidsi | SLP:000001292 [P35914-1] |
PTM databases
iPTMneti | P35914 |
PhosphoSitePlusi | P35914 |
Genetic variation databases
BioMutai | HMGCL |
DMDMi | 24418852 |
Proteomic databases
EPDi | P35914 |
jPOSTi | P35914 |
MassIVEi | P35914 |
PaxDbi | P35914 |
PeptideAtlasi | P35914 |
PRIDEi | P35914 |
ProteomicsDBi | 55164 [P35914-1] 55165 [P35914-2] |
Protocols and materials databases
Antibodypediai | 1373, 327 antibodies |
DNASUi | 3155 |
Genome annotation databases
Ensembli | ENST00000374490; ENSP00000363614; ENSG00000117305 [P35914-1] ENST00000436439; ENSP00000389281; ENSG00000117305 [P35914-2] |
GeneIDi | 3155 |
KEGGi | hsa:3155 |
UCSCi | uc001bib.4, human [P35914-1] |
Organism-specific databases
CTDi | 3155 |
DisGeNETi | 3155 |
GeneCardsi | HMGCL |
HGNCi | HGNC:5005, HMGCL |
HPAi | ENSG00000117305, Tissue enhanced (liver) |
MalaCardsi | HMGCL |
MIMi | 246450, phenotype 613898, gene |
neXtProti | NX_P35914 |
OpenTargetsi | ENSG00000117305 |
Orphaneti | 20, 3-hydroxy-3-methylglutaric aciduria |
PharmGKBi | PA29336 |
VEuPathDBi | HostDB:ENSG00000117305.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2368, Eukaryota |
GeneTreei | ENSGT00940000158484 |
HOGENOMi | CLU_022138_3_1_1 |
InParanoidi | P35914 |
OMAi | FGGCPMA |
OrthoDBi | 1029775at2759 |
PhylomeDBi | P35914 |
TreeFami | TF105363 |
Enzyme and pathway databases
UniPathwayi | UPA00896;UER00863 |
BioCyci | MetaCyc:HS04116-MONOMER |
BRENDAi | 4.1.3.4, 2681 |
PathwayCommonsi | P35914 |
Reactomei | R-HSA-77111, Synthesis of Ketone Bodies R-HSA-9033241, Peroxisomal protein import |
SABIO-RKi | P35914 |
Miscellaneous databases
BioGRID-ORCSi | 3155, 5 hits in 998 CRISPR screens |
ChiTaRSi | HMGCL, human |
EvolutionaryTracei | P35914 |
GenomeRNAii | 3155 |
Pharosi | P35914, Tbio |
PROi | PR:P35914 |
RNActi | P35914, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117305, Expressed in right lobe of liver and 241 other tissues |
ExpressionAtlasi | P35914, baseline and differential |
Genevisiblei | P35914, HS |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR000138, HMG_CoA_lyase_AS IPR043594, HMGL IPR000891, PYR_CT |
PANTHERi | PTHR42738, PTHR42738, 1 hit |
Pfami | View protein in Pfam PF00682, HMGL-like, 1 hit |
PROSITEi | View protein in PROSITE PS01062, HMG_COA_LYASE, 1 hit PS50991, PYR_CT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HMGCL_HUMAN | |
Accessioni | P35914Primary (citable) accession number: P35914 Secondary accession number(s): B4DUP4 Q96FP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | October 25, 2002 | |
Last modified: | April 7, 2021 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families