UniProtKB - P35869 (AHR_HUMAN)
Aryl hydrocarbon receptor
AHR
Functioni
Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:30373764, PubMed:23275542, PubMed:7961644, PubMed:32818467).
Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:30373764, PubMed:23275542, PubMed:7961644).
Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388).
Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644).
Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644).
Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143).
Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32866000, PubMed:32818467).
Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467).
Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820).
Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820).
The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
2 Publications6 PublicationsGO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: MGI
- DNA binding Source: DFLAT
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- E-box binding Source: UniProtKB
- Hsp90 protein binding Source: BHF-UCL
- nuclear receptor activity Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- sequence-specific double-stranded DNA binding Source: UniProtKB
- TBP-class protein binding Source: CAFA
- TFIID-class transcription factor complex binding Source: CAFA
- transcription cis-regulatory region binding Source: DFLAT
- transcription coactivator binding Source: CAFA
GO - Biological processi
- apoptotic process Source: UniProtKB
- blood vessel development Source: DFLAT
- cAMP-mediated signaling Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- cellular response to 2,3,7,8-tetrachlorodibenzodioxine Source: UniProtKB
- cellular response to cAMP Source: UniProtKB
- cellular response to forskolin Source: UniProtKB
- circadian regulation of gene expression Source: UniProtKB
- negative regulation of T cell mediated immune response to tumor cell Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of adaptive immune response Source: UniProtKB
- regulation of B cell proliferation Source: DFLAT
- regulation of gene expression Source: DFLAT
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: DFLAT
- response to toxic substance Source: UniProtKB
- response to xenobiotic stimulus Source: UniProtKB
- xenobiotic metabolic process Source: DFLAT
Keywordsi
Molecular function | Activator, DNA-binding, Receptor, Repressor |
Biological process | Biological rhythms, Cell cycle, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P35869 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-211945, Phase I - Functionalization of compounds R-HSA-211976, Endogenous sterols R-HSA-211981, Xenobiotics R-HSA-8937144, Aryl hydrocarbon receptor signalling |
SignaLinki | P35869 |
SIGNORi | P35869 |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptor1 PublicationShort name: Ah receptor1 Publication Short name: AhR1 Publication Alternative name(s): Class E basic helix-loop-helix protein 76 Short name: bHLHe76 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:348, AHR |
MIMi | 600253, gene |
neXtProti | NX_P35869 |
VEuPathDBi | HostDB:ENSG00000106546 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
- cytosolic aryl hydrocarbon receptor complex Source: DFLAT
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- aryl hydrocarbon receptor complex Source: GO_Central
- chromatin Source: NTNU_SB
- cytoplasm Source: UniProtKB
- protein-containing complex Source: CAFA
- transcription regulator complex Source: DFLAT
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Retinitis pigmentosa 85 (RP85)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 40 | R → D: Decreases transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 50 | L → D: Interfers with transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 74 | V → D: Interfers with transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 79 | A → D: Interfers with transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 82 | F → D: Interfers with transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 118 | L → D: Interfers with transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 122 | L → D: Interfers with transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 136 | F → D: Interfers with transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 154 | I → D: Interfers with transcription factor activity. 1 Publication | 1 | |
Mutagenesisi | 381 | V → A: Increases specific ligand binding. 1 Publication | 1 | |
Mutagenesisi | 381 | V → D: Abolishes specific ligand binding. 1 Publication | 1 | |
Mutagenesisi | 381 | V → L or G: No effect on specific ligand binding. 1 Publication | 1 |
Keywords - Diseasei
Retinitis pigmentosaOrganism-specific databases
DisGeNETi | 196 |
MalaCardsi | AHR |
MIMi | 618345, phenotype |
OpenTargetsi | ENSG00000106546 |
Orphaneti | 791, Retinitis pigmentosa |
PharmGKBi | PA24641 |
Miscellaneous databases
Pharosi | P35869, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3201 |
DrugBanki | DB08624, 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine DB01076, Atorvastatin DB06732, beta-Naphthoflavone DB12328, Cantharidin DB08995, Diosmin DB07715, Emodin DB12116, Epigallocatechin gallate DB00499, Flutamide DB01404, Ginseng DB11577, Indigotindisulfonic acid DB12379, Indirubin DB02052, Indirubin-3'-monoxime DB11937, Kynurenic Acid DB01097, Leflunomide DB00379, Mexiletine DB00393, Nimodipine DB00338, Omeprazole DB04216, Quercetin DB02709, Resveratrol |
DrugCentrali | P35869 |
GuidetoPHARMACOLOGYi | 2951 |
Genetic variation databases
BioMutai | AHR |
DMDMi | 3041653 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000013450 | 1 – 10 | By similarity | 10 | |
ChainiPRO_0000013451 | 11 – 848 | Aryl hydrocarbon receptorAdd BLAST | 838 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, ADP-ribosylationProteomic databases
EPDi | P35869 |
jPOSTi | P35869 |
MassIVEi | P35869 |
MaxQBi | P35869 |
PaxDbi | P35869 |
PeptideAtlasi | P35869 |
PRIDEi | P35869 |
ProteomicsDBi | 55159 |
PTM databases
iPTMneti | P35869 |
PhosphoSitePlusi | P35869 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000106546, Expressed in chorionic villus and 232 other tissues |
ExpressionAtlasi | P35869, baseline and differential |
Genevisiblei | P35869, HS |
Organism-specific databases
HPAi | ENSG00000106546, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:10395741, PubMed:28602820).
Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). Binds MYBBP1A (By similarity).
Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT (PubMed:10395741).
Interacts with NEDD8 and IVNS1ABP (PubMed:12215427, PubMed:16582008).
Interacts with ARNTL/BMAL1 (By similarity).
Interacts with HSP90AB1 (By similarity).
Interacts with TIPARP; leading to mono-ADP-ribosylation of AHR and subsequent inhibition of AHR (PubMed:23275542, PubMed:30373764).
By similarity6 PublicationsBinary interactionsi
P35869
With | #Exp. | IntAct |
---|---|---|
ARNT [P27540] | 6 | EBI-80780,EBI-80809 |
NCOA7 [Q8NI08] | 2 | EBI-80780,EBI-80799 |
NCOR2 [Q9Y618] | 2 | EBI-80780,EBI-80830 |
EBNA3 [P12977] from Epstein-Barr virus (strain B95-8). | 5 | EBI-80780,EBI-993115 |
GO - Molecular functioni
- Hsp90 protein binding Source: BHF-UCL
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- TBP-class protein binding Source: CAFA
- TFIID-class transcription factor complex binding Source: CAFA
- transcription coactivator binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 106699, 177 interactors |
CORUMi | P35869 |
DIPi | DIP-946N |
ELMi | P35869 |
IntActi | P35869, 20 interactors |
STRINGi | 9606.ENSP00000242057 |
Chemistry databases
BindingDBi | P35869 |
Miscellaneous databases
RNActi | P35869, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P35869 |
SMRi | P35869 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 80 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 111 – 181 | PAS 1PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 275 – 342 | PAS 2PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 348 – 386 | PACAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 38 – 66 | DNA-binding1 PublicationAdd BLAST | 29 | |
Regioni | 118 – 126 | Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activityBy similarity | 9 | |
Regioni | 266 – 268 | Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activityBy similarity | 3 | |
Regioni | 824 – 848 | DisorderedSequence analysisAdd BLAST | 25 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3560, Eukaryota |
GeneTreei | ENSGT00940000154486 |
HOGENOMi | CLU_010044_1_1_1 |
InParanoidi | P35869 |
OMAi | GCDAKGQ |
OrthoDBi | 174264at2759 |
PhylomeDBi | P35869 |
TreeFami | TF352074 |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
DisProti | DP00381 |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR033348, AHR IPR039091, AHR/AHRR IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 |
PANTHERi | PTHR10649, PTHR10649, 1 hit PTHR10649:SF9, PTHR10649:SF9, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL
60 70 80 90 100
ASLLPFPQDV INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN
110 120 130 140 150
CRAANFREGL NLQEGEFLLQ ALNGFVLVVT TDALVFYASS TIQDYLGFQQ
160 170 180 190 200
SDVIHQSVYE LIHTEDRAEF QRQLHWALNP SQCTESGQGI EEATGLPQTV
210 220 230 240 250
VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ GKLKYLHGQK
260 270 280 290 300
KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC
310 320 330 340 350
DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV
360 370 380 390 400
FRLLTKNNRW TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT
410 420 430 440 450
KLPFMFTTGE AVLYEATNPF PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS
460 470 480 490 500
LNPSSLLAAM MQQDESIYLY PASSTSSTAP FENNFFNESM NECRNWQDNT
510 520 530 540 550
APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY SIMKNLGIDF
560 570 580 590 600
EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ
610 620 630 640 650
QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM
660 670 680 690 700
FENWNSNQFV PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF
710 720 730 740 750
ISCNQPVLPQ HSKCTELDYP MGSFEPSPYP TTSSLEDFVT CLQLPENQKH
760 770 780 790 800
GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH THVGQMQYNP VLPGQQAFLN
810 820 830 840
KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP DLTSSGFL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y7G1 | A0A2R8Y7G1_HUMAN | Aryl hydrocarbon receptor | AHR | 833 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | E → EG in AAA92082 (PubMed:16696038).Curated | 1 | |
Sequence conflicti | 340 – 341 | MI → SD (PubMed:7515333).Curated | 2 | |
Sequence conflicti | 807 – 848 | LNETY…SSGFL → FK in BAA03857 (PubMed:8393992).CuratedAdd BLAST | 42 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015516 | 517 | P → S1 PublicationCorresponds to variant dbSNP:rs72552768Ensembl. | 1 | |
Natural variantiVAR_009281 | 554 | R → K3 PublicationsCorresponds to variant dbSNP:rs2066853Ensembl. | 1 | |
Natural variantiVAR_009282 | 570 | V → I2 PublicationsCorresponds to variant dbSNP:rs4986826EnsemblClinVar. | 1 | |
Natural variantiVAR_015517 | 786 | M → V1 PublicationCorresponds to variant dbSNP:rs72552769Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16354 mRNA Translation: BAA03857.1 L19872 mRNA Translation: AAA16210.1 AC003075 Genomic DNA No translation available. CH236948 Genomic DNA Translation: EAL24281.1 CH471073 Genomic DNA Translation: EAW93686.1 BC069390 mRNA Translation: AAH69390.1 BC070080 mRNA Translation: AAH70080.1 U28063 , U27656, U27657, U28060, U28061, U28062 Genomic DNA Translation: AAA92082.1 U28064 Genomic DNA Translation: AAA92083.1 U28066, U28065 Genomic DNA Translation: AAA92084.1 D38044 Genomic DNA Translation: BAA07235.1 |
CCDSi | CCDS5366.1 |
PIRi | S59514 |
RefSeqi | NP_001612.1, NM_001621.4 |
Genome annotation databases
Ensembli | ENST00000242057.9; ENSP00000242057.4; ENSG00000106546.14 ENST00000463496.1; ENSP00000436466.1; ENSG00000106546.14 |
GeneIDi | 196 |
KEGGi | hsa:196 |
MANE-Selecti | ENST00000242057.9; ENSP00000242057.4; NM_001621.5; NP_001612.1 |
UCSCi | uc011jxz.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16354 mRNA Translation: BAA03857.1 L19872 mRNA Translation: AAA16210.1 AC003075 Genomic DNA No translation available. CH236948 Genomic DNA Translation: EAL24281.1 CH471073 Genomic DNA Translation: EAW93686.1 BC069390 mRNA Translation: AAH69390.1 BC070080 mRNA Translation: AAH70080.1 U28063 , U27656, U27657, U28060, U28061, U28062 Genomic DNA Translation: AAA92082.1 U28064 Genomic DNA Translation: AAA92083.1 U28066, U28065 Genomic DNA Translation: AAA92084.1 D38044 Genomic DNA Translation: BAA07235.1 |
CCDSi | CCDS5366.1 |
PIRi | S59514 |
RefSeqi | NP_001612.1, NM_001621.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5NJ8 | X-ray | 3.30 | A/C | 23-273 | [»] | |
AlphaFoldDBi | P35869 | |||||
SMRi | P35869 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106699, 177 interactors |
CORUMi | P35869 |
DIPi | DIP-946N |
ELMi | P35869 |
IntActi | P35869, 20 interactors |
STRINGi | 9606.ENSP00000242057 |
Chemistry databases
BindingDBi | P35869 |
ChEMBLi | CHEMBL3201 |
DrugBanki | DB08624, 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine DB01076, Atorvastatin DB06732, beta-Naphthoflavone DB12328, Cantharidin DB08995, Diosmin DB07715, Emodin DB12116, Epigallocatechin gallate DB00499, Flutamide DB01404, Ginseng DB11577, Indigotindisulfonic acid DB12379, Indirubin DB02052, Indirubin-3'-monoxime DB11937, Kynurenic Acid DB01097, Leflunomide DB00379, Mexiletine DB00393, Nimodipine DB00338, Omeprazole DB04216, Quercetin DB02709, Resveratrol |
DrugCentrali | P35869 |
GuidetoPHARMACOLOGYi | 2951 |
PTM databases
iPTMneti | P35869 |
PhosphoSitePlusi | P35869 |
Genetic variation databases
BioMutai | AHR |
DMDMi | 3041653 |
Proteomic databases
EPDi | P35869 |
jPOSTi | P35869 |
MassIVEi | P35869 |
MaxQBi | P35869 |
PaxDbi | P35869 |
PeptideAtlasi | P35869 |
PRIDEi | P35869 |
ProteomicsDBi | 55159 |
Protocols and materials databases
Antibodypediai | 3909, 1028 antibodies from 46 providers |
DNASUi | 196 |
Genome annotation databases
Ensembli | ENST00000242057.9; ENSP00000242057.4; ENSG00000106546.14 ENST00000463496.1; ENSP00000436466.1; ENSG00000106546.14 |
GeneIDi | 196 |
KEGGi | hsa:196 |
MANE-Selecti | ENST00000242057.9; ENSP00000242057.4; NM_001621.5; NP_001612.1 |
UCSCi | uc011jxz.2, human |
Organism-specific databases
CTDi | 196 |
DisGeNETi | 196 |
GeneCardsi | AHR |
HGNCi | HGNC:348, AHR |
HPAi | ENSG00000106546, Low tissue specificity |
MalaCardsi | AHR |
MIMi | 600253, gene 618345, phenotype |
neXtProti | NX_P35869 |
OpenTargetsi | ENSG00000106546 |
Orphaneti | 791, Retinitis pigmentosa |
PharmGKBi | PA24641 |
VEuPathDBi | HostDB:ENSG00000106546 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3560, Eukaryota |
GeneTreei | ENSGT00940000154486 |
HOGENOMi | CLU_010044_1_1_1 |
InParanoidi | P35869 |
OMAi | GCDAKGQ |
OrthoDBi | 174264at2759 |
PhylomeDBi | P35869 |
TreeFami | TF352074 |
Enzyme and pathway databases
PathwayCommonsi | P35869 |
Reactomei | R-HSA-1989781, PPARA activates gene expression R-HSA-211945, Phase I - Functionalization of compounds R-HSA-211976, Endogenous sterols R-HSA-211981, Xenobiotics R-HSA-8937144, Aryl hydrocarbon receptor signalling |
SignaLinki | P35869 |
SIGNORi | P35869 |
Miscellaneous databases
BioGRID-ORCSi | 196, 79 hits in 1111 CRISPR screens |
ChiTaRSi | AHR, human |
GeneWikii | Aryl_hydrocarbon_receptor |
GenomeRNAii | 196 |
Pharosi | P35869, Tchem |
PROi | PR:P35869 |
RNActi | P35869, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106546, Expressed in chorionic villus and 232 other tissues |
ExpressionAtlasi | P35869, baseline and differential |
Genevisiblei | P35869, HS |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
DisProti | DP00381 |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR033348, AHR IPR039091, AHR/AHRR IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 |
PANTHERi | PTHR10649, PTHR10649, 1 hit PTHR10649:SF9, PTHR10649:SF9, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AHR_HUMAN | |
Accessioni | P35869Primary (citable) accession number: P35869 Secondary accession number(s): A4D130 Q13804 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 218 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references