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UniProtKB - P35869 (AHR_HUMAN)

Entry version 218 (25 May 2022)
Sequence version 2 (15 Jul 1998)
Previous versions | rss
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Protein

Aryl hydrocarbon receptor

Gene

AHR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:30373764, PubMed:23275542, PubMed:7961644, PubMed:32818467).

Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (PubMed:30373764, PubMed:23275542, PubMed:7961644).

Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:12213388).

Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644).

Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644).

Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (PubMed:18076143).

Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (PubMed:32866000, PubMed:32818467).

Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (PubMed:32818467).

Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820).

Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:28602820).

The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).

2 Publications6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Receptor, Repressor
Biological processBiological rhythms, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P35869

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1989781, PPARA activates gene expression
R-HSA-211945, Phase I - Functionalization of compounds
R-HSA-211976, Endogenous sterols
R-HSA-211981, Xenobiotics
R-HSA-8937144, Aryl hydrocarbon receptor signalling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P35869

SIGNOR Signaling Network Open Resource

More...SIGNORi		P35869

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aryl hydrocarbon receptor1 Publication
Short name:
Ah receptor1 Publication
Short name:
AhR1 Publication
Alternative name(s):
Class E basic helix-loop-helix protein 76
Short name:
bHLHe76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AHR1 PublicationImported
Synonyms:BHLHE76Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:348, AHR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600253, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35869

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000106546

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinitis pigmentosa 85 (RP85)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP85 is an autosomal recessive form manifesting as early-onset progressive difficulty to adapt in dim light and gradually decreasing visual acuity in both eyes.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40R → D: Decreases transcription factor activity. 1 Publication1
Mutagenesisi50L → D: Interfers with transcription factor activity. 1 Publication1
Mutagenesisi74V → D: Interfers with transcription factor activity. 1 Publication1
Mutagenesisi79A → D: Interfers with transcription factor activity. 1 Publication1
Mutagenesisi82F → D: Interfers with transcription factor activity. 1 Publication1
Mutagenesisi118L → D: Interfers with transcription factor activity. 1 Publication1
Mutagenesisi122L → D: Interfers with transcription factor activity. 1 Publication1
Mutagenesisi136F → D: Interfers with transcription factor activity. 1 Publication1
Mutagenesisi154I → D: Interfers with transcription factor activity. 1 Publication1
Mutagenesisi381V → A: Increases specific ligand binding. 1 Publication1
Mutagenesisi381V → D: Abolishes specific ligand binding. 1 Publication1
Mutagenesisi381V → L or G: No effect on specific ligand binding. 1 Publication1

Keywords - Diseasei

Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...DisGeNETi		196

MalaCards human disease database

More...MalaCardsi		AHR
MIMi618345, phenotype

Open Targets

More...OpenTargetsi		ENSG00000106546

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		791, Retinitis pigmentosa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24641

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P35869, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3201

Drug and drug target database

More...DrugBanki		DB08624, 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine
DB01076, Atorvastatin
DB06732, beta-Naphthoflavone
DB12328, Cantharidin
DB08995, Diosmin
DB07715, Emodin
DB12116, Epigallocatechin gallate
DB00499, Flutamide
DB01404, Ginseng
DB11577, Indigotindisulfonic acid
DB12379, Indirubin
DB02052, Indirubin-3'-monoxime
DB11937, Kynurenic Acid
DB01097, Leflunomide
DB00379, Mexiletine
DB00393, Nimodipine
DB00338, Omeprazole
DB04216, Quercetin
DB02709, Resveratrol

DrugCentral

More...DrugCentrali		P35869

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2951

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AHR

Domain mapping of disease mutations (DMDM)

More...DMDMi		3041653

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000134501 – 10By similarity10
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001345111 – 848Aryl hydrocarbon receptorAdd BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Mono-ADP-ribosylated, leading to inhibit transcription activator activity of AHR.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P35869

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P35869

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P35869

MaxQB - The MaxQuant DataBase

More...MaxQBi		P35869

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35869

PeptideAtlas

More...PeptideAtlasi		P35869

PRoteomics IDEntifications database

More...PRIDEi		P35869

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55159

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35869

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35869

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Expressed in retinal photoreceptors (PubMed:29726989).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced or repressed by TGFB1 and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and 12-O-tetradecanoyl phorbol-13 acetate (TPA).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000106546, Expressed in chorionic villus and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35869, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35869, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000106546, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:10395741, PubMed:28602820).

Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). Binds MYBBP1A (By similarity).

Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT (PubMed:10395741).

Interacts with NEDD8 and IVNS1ABP (PubMed:12215427, PubMed:16582008).

Interacts with ARNTL/BMAL1 (By similarity).

Interacts with HSP90AB1 (By similarity).

Interacts with TIPARP; leading to mono-ADP-ribosylation of AHR and subsequent inhibition of AHR (PubMed:23275542, PubMed:30373764).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106699, 177 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P35869

Database of interacting proteins

More...DIPi		DIP-946N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P35869

Protein interaction database and analysis system

More...IntActi		P35869, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000242057

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P35869

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35869, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1848
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P35869

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35869

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 80bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini111 – 181PAS 1PROSITE-ProRule annotationAdd BLAST71
Domaini275 – 342PAS 2PROSITE-ProRule annotationAdd BLAST68
Domaini348 – 386PACAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 39DisorderedSequence analysisAdd BLAST39
Regioni38 – 66DNA-binding1 PublicationAdd BLAST29
Regioni118 – 126Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activityBy similarity9
Regioni266 – 268Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activityBy similarity3
Regioni824 – 848DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PAS 1 domain is essential for dimerization and also required for AHR:ARNT heterodimerization.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3560, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154486

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010044_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35869

Identification of Orthologs from Complete Genome Data

More...OMAi		GCDAKGQ

Database of Orthologous Groups

More...OrthoDBi		174264at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35869

TreeFam database of animal gene trees

More...TreeFami		TF352074

Family and domain databases

Conserved Domains Database

More...CDDi		cd00130, PAS, 2 hits

Database of protein disorder

More...DisProti		DP00381

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033348, AHR
IPR039091, AHR/AHRR
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR001610, PAC
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR013655, PAS_fold_3

The PANTHER Classification System

More...PANTHERi		PTHR10649, PTHR10649, 1 hit
PTHR10649:SF9, PTHR10649:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00010, HLH, 1 hit
PF00989, PAS, 1 hit
PF08447, PAS_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00353, HLH, 1 hit
SM00086, PAC, 1 hit
SM00091, PAS, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35869-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL 
        60         70         80         90        100
ASLLPFPQDV INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN 
       110        120        130        140        150
CRAANFREGL NLQEGEFLLQ ALNGFVLVVT TDALVFYASS TIQDYLGFQQ 
       160        170        180        190        200
SDVIHQSVYE LIHTEDRAEF QRQLHWALNP SQCTESGQGI EEATGLPQTV 
       210        220        230        240        250
VCYNPDQIPP ENSPLMERCF ICRLRCLLDN SSGFLAMNFQ GKLKYLHGQK 
       260        270        280        290        300
KKGKDGSILP PQLALFAIAT PLQPPSILEI RTKNFIFRTK HKLDFTPIGC 
       310        320        330        340        350
DAKGRIVLGY TEAELCTRGS GYQFIHAADM LYCAESHIRM IKTGESGMIV 
       360        370        380        390        400
FRLLTKNNRW TWVQSNARLL YKNGRPDYII VTQRPLTDEE GTEHLRKRNT 
       410        420        430        440        450
KLPFMFTTGE AVLYEATNPF PAIMDPLPLR TKNGTSGKDS ATTSTLSKDS 
       460        470        480        490        500
LNPSSLLAAM MQQDESIYLY PASSTSSTAP FENNFFNESM NECRNWQDNT 
       510        520        530        540        550
APMGNDTILK HEQIDQPQDV NSFAGGHPGL FQDSKNSDLY SIMKNLGIDF 
       560        570        580        590        600
EDIRHMQNEK FFRNDFSGEV DFRDIDLTDE ILTYVQDSLS KSPFIPSDYQ 
       610        620        630        640        650
QQQSLALNSS CMVQEHLHLE QQQQHHQKQV VVEPQQQLCQ KMKHMQVNGM 
       660        670        680        690        700
FENWNSNQFV PFNCPQQDPQ QYNVFTDLHG ISQEFPYKSE MDSMPYTQNF 
       710        720        730        740        750
ISCNQPVLPQ HSKCTELDYP MGSFEPSPYP TTSSLEDFVT CLQLPENQKH 
       760        770        780        790        800
GLNPQSAIIT PQTCYAGAVS MYQCQPEPQH THVGQMQYNP VLPGQQAFLN 
       810        820        830        840 
KFQNGVLNET YPAELNNINN TQTTTHLQPL HHPSEARPFP DLTSSGFL
Length:848
Mass (Da):96,147
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BFE022871B7B028
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7G1A0A2R8Y7G1_HUMAN
Aryl hydrocarbon receptor
AHR
833Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191E → EG in AAA92082 (PubMed:16696038).Curated1
Sequence conflicti340 – 341MI → SD (PubMed:7515333).Curated2
Sequence conflicti807 – 848LNETY…SSGFL → FK in BAA03857 (PubMed:8393992).CuratedAdd BLAST42

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015516517P → S1 PublicationCorresponds to variant dbSNP:rs72552768Ensembl.1
Natural variantiVAR_009281554R → K3 PublicationsCorresponds to variant dbSNP:rs2066853Ensembl.1
Natural variantiVAR_009282570V → I2 PublicationsCorresponds to variant dbSNP:rs4986826EnsemblClinVar.1
Natural variantiVAR_015517786M → V1 PublicationCorresponds to variant dbSNP:rs72552769Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D16354 mRNA Translation: BAA03857.1
L19872 mRNA Translation: AAA16210.1
AC003075 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24281.1
CH471073 Genomic DNA Translation: EAW93686.1
BC069390 mRNA Translation: AAH69390.1
BC070080 mRNA Translation: AAH70080.1
U28063 U28062 Genomic DNA Translation: AAA92082.1
U28064 Genomic DNA Translation: AAA92083.1
U28066, U28065 Genomic DNA Translation: AAA92084.1
D38044 Genomic DNA Translation: BAA07235.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5366.1

Protein sequence database of the Protein Information Resource

More...PIRi		S59514

NCBI Reference Sequences

More...RefSeqi		NP_001612.1, NM_001621.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000242057.9; ENSP00000242057.4; ENSG00000106546.14
ENST00000463496.1; ENSP00000436466.1; ENSG00000106546.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:196

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000242057.9; ENSP00000242057.4; NM_001621.5; NP_001612.1

UCSC genome browser

More...UCSCi		uc011jxz.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16354 mRNA Translation: BAA03857.1
L19872 mRNA Translation: AAA16210.1
AC003075 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24281.1
CH471073 Genomic DNA Translation: EAW93686.1
BC069390 mRNA Translation: AAH69390.1
BC070080 mRNA Translation: AAH70080.1
U28063 U28062 Genomic DNA Translation: AAA92082.1
U28064 Genomic DNA Translation: AAA92083.1
U28066, U28065 Genomic DNA Translation: AAA92084.1
D38044 Genomic DNA Translation: BAA07235.1
CCDSiCCDS5366.1
PIRiS59514
RefSeqiNP_001612.1, NM_001621.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NJ8X-ray3.30A/C23-273[»]
AlphaFoldDBiP35869
SMRiP35869
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106699, 177 interactors
CORUMiP35869
DIPiDIP-946N
ELMiP35869
IntActiP35869, 20 interactors
STRINGi9606.ENSP00000242057

Chemistry databases

BindingDBiP35869
ChEMBLiCHEMBL3201
DrugBankiDB08624, 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine
DB01076, Atorvastatin
DB06732, beta-Naphthoflavone
DB12328, Cantharidin
DB08995, Diosmin
DB07715, Emodin
DB12116, Epigallocatechin gallate
DB00499, Flutamide
DB01404, Ginseng
DB11577, Indigotindisulfonic acid
DB12379, Indirubin
DB02052, Indirubin-3'-monoxime
DB11937, Kynurenic Acid
DB01097, Leflunomide
DB00379, Mexiletine
DB00393, Nimodipine
DB00338, Omeprazole
DB04216, Quercetin
DB02709, Resveratrol
DrugCentraliP35869
GuidetoPHARMACOLOGYi2951

PTM databases

iPTMnetiP35869
PhosphoSitePlusiP35869

Genetic variation databases

BioMutaiAHR
DMDMi3041653

Proteomic databases

EPDiP35869
jPOSTiP35869
MassIVEiP35869
MaxQBiP35869
PaxDbiP35869
PeptideAtlasiP35869
PRIDEiP35869
ProteomicsDBi55159

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3909, 1028 antibodies from 46 providers

The DNASU plasmid repository

More...DNASUi		196

Genome annotation databases

EnsembliENST00000242057.9; ENSP00000242057.4; ENSG00000106546.14
ENST00000463496.1; ENSP00000436466.1; ENSG00000106546.14
GeneIDi196
KEGGihsa:196
MANE-SelectiENST00000242057.9; ENSP00000242057.4; NM_001621.5; NP_001612.1
UCSCiuc011jxz.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		196
DisGeNETi196

GeneCards: human genes, protein and diseases

More...GeneCardsi		AHR
HGNCiHGNC:348, AHR
HPAiENSG00000106546, Low tissue specificity
MalaCardsiAHR
MIMi600253, gene
618345, phenotype
neXtProtiNX_P35869
OpenTargetsiENSG00000106546
Orphaneti791, Retinitis pigmentosa
PharmGKBiPA24641
VEuPathDBiHostDB:ENSG00000106546

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3560, Eukaryota
GeneTreeiENSGT00940000154486
HOGENOMiCLU_010044_1_1_1
InParanoidiP35869
OMAiGCDAKGQ
OrthoDBi174264at2759
PhylomeDBiP35869
TreeFamiTF352074

Enzyme and pathway databases

PathwayCommonsiP35869
ReactomeiR-HSA-1989781, PPARA activates gene expression
R-HSA-211945, Phase I - Functionalization of compounds
R-HSA-211976, Endogenous sterols
R-HSA-211981, Xenobiotics
R-HSA-8937144, Aryl hydrocarbon receptor signalling
SignaLinkiP35869
SIGNORiP35869

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		196, 79 hits in 1111 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AHR, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Aryl_hydrocarbon_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		196
PharosiP35869, Tchem

Protein Ontology

More...PROi		PR:P35869
RNActiP35869, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000106546, Expressed in chorionic villus and 232 other tissues
ExpressionAtlasiP35869, baseline and differential
GenevisibleiP35869, HS

Family and domain databases

CDDicd00130, PAS, 2 hits
DisProtiDP00381
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR033348, AHR
IPR039091, AHR/AHRR
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR001610, PAC
IPR000014, PAS
IPR035965, PAS-like_dom_sf
IPR013767, PAS_fold
IPR013655, PAS_fold_3
PANTHERiPTHR10649, PTHR10649, 1 hit
PTHR10649:SF9, PTHR10649:SF9, 1 hit
PfamiView protein in Pfam
PF00010, HLH, 1 hit
PF00989, PAS, 1 hit
PF08447, PAS_3, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SM00086, PAC, 1 hit
SM00091, PAS, 2 hits
SUPFAMiSSF47459, SSF47459, 1 hit
SSF55785, SSF55785, 2 hits
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit
PS50112, PAS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAHR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35869
Secondary accession number(s): A4D130
, Q13728, Q13803, Q13804
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 15, 1998
Last modified: May 25, 2022
This is version 218 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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