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Protein

Acid phosphatase PHO11

Gene

PHO11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1460 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75NucleophileBy similarity1
Active sitei338Proton donorBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: SGD

GO - Biological processi

  • phosphate-containing compound metabolic process Source: SGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:YAR071W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase PHO11 (EC:3.1.3.2)
Alternative name(s):
P56
Gene namesi
Name:PHO11
Ordered Locus Names:YAR071W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAR071W
SGDiS000000094 PHO11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
ChainiPRO_000002395618 – 467Acid phosphatase PHO11Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated during secretion across the membrane.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP35842
PaxDbiP35842
PRIDEiP35842

Expressioni

Inductioni

S.cerevisiae has 2 types of acid phosphatase: one is constitutive and the other is repressible by inorganic phosphate.

Interactioni

Protein-protein interaction databases

BioGridi31819, 116 interactors
DIPiDIP-4589N
IntActiP35842, 12 interactors
MINTiP35842
STRINGi4932.YAR071W

Structurei

3D structure databases

ProteinModelPortaliP35842
SMRiP35842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00510000050349
HOGENOMiHOG000189191
InParanoidiP35842
KOiK01078
OMAiLFGWCAY
OrthoDBiEOG092C2L5B

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
IPR016274 Histidine_acid_Pase_euk
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
PIRSFiPIRSF000894 Acid_phosphatase, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSAVYSIL AASLVNAGTI PLGKLSDIDK IGTQTEIFPF LGGSGPYYSF
60 70 80 90 100
PGDYGISRDL PESCEMKQVQ MVGRHGERYP TVSKAKSIMT TWYKLSNYTG
110 120 130 140 150
QFSGALSFLN DDYEFFIRDT KNLEMETTLA NSVNVLNPYT GEMNAKRHAR
160 170 180 190 200
DFLAQYGYMV ENQTSFAVFT SNSNRCHDTA QYFIDGLGDK FNISLQTISE
210 220 230 240 250
AESAGANTLS AHHSCPAWDD DVNDDILKKY DTKYLSGIAK RLNKENKGLN
260 270 280 290 300
LTSSDANTFF AWCAYEINAR GYSDICNIFT KDELVRFSYG QDLETYYQTG
310 320 330 340 350
PGYDVVRSVG ANLFNASVKL LKESEVQDQK VWLSFTHDTD ILNYLTTIGI
360 370 380 390 400
IDDKNNLTAE HVPFMENTFH RSWYVPQGAR VYTEKFQCSN DTYVRYVIND
410 420 430 440 450
AVVPIETCST GPGFSCEIND FYDYAEKRVA GTDFLKVCNV SSVSNSTELT
460
FFWDWNTKHY NDTLLKQ
Length:467
Mass (Da):52,758
Last modified:June 1, 1994 - v1
Checksum:iAECDC1C046B326C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17A → L in AAA73479 (Ref. 1) Curated1
Sequence conflicti82 – 83VS → AR in AAA73479 (Ref. 1) Curated2
Sequence conflicti150R → H in AAA73479 (Ref. 1) Curated1
Sequence conflicti354K → Q in AAA73479 (Ref. 1) Curated1
Sequence conflicti423D → G in AAA73479 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19789 Genomic DNA Translation: AAA73479.1
L28920 Genomic DNA Translation: AAC09508.1
BK006935 Genomic DNA Translation: DAA07011.1
PIRiS53476
RefSeqiNP_009434.1, NM_001178239.1

Genome annotation databases

EnsemblFungiiYAR071W; YAR071W; YAR071W
GeneIDi851299
KEGGisce:YAR071W

Similar proteinsi

Entry informationi

Entry nameiPPAB_YEAST
AccessioniPrimary (citable) accession number: P35842
Secondary accession number(s): D6VPP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 18, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

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