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Protein

Granulocyte colony-stimulating factor

Gene

CSF3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-BTA-449836 Other interleukin signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte colony-stimulating factor
Short name:
G-CSF
Gene namesi
Name:CSF3
Synonyms:GCSF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:27757 CSF3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001556822 – 195Granulocyte colony-stimulating factorAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 63
Disulfide bondi85 ↔ 95
Glycosylationi154O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35833

Expressioni

Gene expression databases

BgeeiENSBTAG00000021462

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028610

Structurei

Secondary structure

1195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 60Combined sources29
Helixi65 – 69Combined sources5
Helixi72 – 75Combined sources4
Helixi83 – 85Combined sources3
Turni87 – 89Combined sources3
Helixi92 – 112Combined sources21
Turni113 – 115Combined sources3
Turni118 – 120Combined sources3
Helixi121 – 145Combined sources25
Helixi164 – 191Combined sources28

3D structure databases

ProteinModelPortaliP35833
SMRiP35833
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35833

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIM2 Eukaryota
ENOG4111DA4 LUCA
GeneTreeiENSGT00390000017328
HOGENOMiHOG000015371
HOVERGENiHBG005411
InParanoidiP35833
KOiK05423
OMAiKLCHPEE
OrthoDBiEOG091G0NDU
TreeFamiTF337698

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PfamiView protein in Pfam
PF16647 GCSF, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLMVLQLLL WHSALWTVHE ATPLGPARSL PQSFLLKCLE QVRKIQADGA
60 70 80 90 100
ELQERLCAAH KLCHPEELML LRHSLGIPQA PLSSCSSQSL QLTSCLNQLH
110 120 130 140 150
GGLFLYQGLL QALAGISPEL APTLDTLQLD VTDFATNIWL QMEDLGAAPA
160 170 180 190
VQPTQGAMPT FTSAFQRRAG GVLVASQLHR FLELAYRGLR YLAEP
Length:195
Mass (Da):21,431
Last modified:April 27, 2001 - v2
Checksum:i8C06119E4ADFBA73
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93 – 94TS → RG (PubMed:7504736).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092533 mRNA Translation: AAD16102.1
RefSeqiNP_776453.1, NM_174028.1
UniGeneiBt.4660

Genome annotation databases

EnsembliENSBTAT00000028610; ENSBTAP00000028610; ENSBTAG00000021462
GeneIDi281096
KEGGibta:281096

Similar proteinsi

Entry informationi

Entry nameiCSF3_BOVIN
AccessioniPrimary (citable) accession number: P35833
Secondary accession number(s): Q9TV89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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