UniProtKB - P35820 (PSC_DROME)
Protein
Polycomb group protein Psc
Gene
Psc
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 263 – 302 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- chromatin binding Source: FlyBase
- DNA binding Source: FlyBase
- promoter-specific chromatin binding Source: GO_Central
- sequence-specific DNA binding Source: FlyBase
- zinc ion binding Source: FlyBase
GO - Biological processi
- axon guidance Source: FlyBase
- chromatin remodeling Source: FlyBase
- chromatin silencing Source: FlyBase
- histone H2A-K119 monoubiquitination Source: GO_Central
- negative regulation of gene expression Source: FlyBase
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- syncytial blastoderm mitotic cell cycle Source: FlyBase
- ventral cord development Source: FlyBase
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-DME-2559580 Oxidative Stress Induced Senescence R-DME-3108214 SUMOylation of DNA damage response and repair proteins R-DME-3899300 SUMOylation of transcription cofactors R-DME-4570464 SUMOylation of RNA binding proteins R-DME-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8943724 Regulation of PTEN gene transcription R-DME-8953750 Transcriptional Regulation by E2F6 |
Names & Taxonomyi
Protein namesi | Recommended name: Polycomb group protein PscAlternative name(s): Protein posterior sex combs |
Gene namesi | Name:Psc ORF Names:CG3886 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0005624 Psc |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- intercalary heterochromatin Source: FlyBase
- nucleus Source: FlyBase
- PcG protein complex Source: FlyBase
- PRC1 complex Source: FlyBase
Other locations
- polytene chromosome band Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056388 | 1 – 1601 | Polycomb group protein PscAdd BLAST | 1601 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 656 | Phosphoserine1 Publication | 1 | |
Modified residuei | 658 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1139 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1222 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1236 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1251 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 1253 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1266 | Phosphoserine1 Publication | 1 | |
Modified residuei | 1274 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P35820 |
PRIDEi | P35820 |
PTM databases
iPTMneti | P35820 |
Expressioni
Gene expression databases
Bgeei | FBgn0005624 Expressed in 27 organ(s), highest expression level in embryo |
ExpressionAtlasi | P35820 baseline and differential |
Genevisiblei | P35820 DM |
Interactioni
Subunit structurei
Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.
2 PublicationsProtein-protein interaction databases
BioGridi | 62201, 42 interactors |
IntActi | P35820, 7 interactors |
STRINGi | 7227.FBpp0086911 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 15 – 155 | Thr-richAdd BLAST | 141 | |
Compositional biasi | 178 – 212 | Ser-richAdd BLAST | 35 | |
Compositional biasi | 565 – 658 | Ser-richAdd BLAST | 94 | |
Compositional biasi | 806 – 878 | Pro-richAdd BLAST | 73 | |
Compositional biasi | 1022 – 1079 | Gly-richAdd BLAST | 58 | |
Compositional biasi | 1170 – 1406 | Pro-richAdd BLAST | 237 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 263 – 302 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2660 Eukaryota ENOG410XPCN LUCA |
GeneTreei | ENSGT00940000173039 |
InParanoidi | P35820 |
KOi | K11459 |
OMAi | DTEHLIF |
OrthoDBi | 1203951at2759 |
PhylomeDBi | P35820 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443 RAWUL IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS |
Pfami | View protein in Pfam PF16207 RAWUL, 1 hit |
PROSITEi | View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P35820-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMTPESKAIQ PAAATTKQTA EATATTTMAH TQQKSQLSTL AKTTTTTATN
60 70 80 90 100
KAAKSVVSNA NSSGNNSSKK LALSQSQKTT TTTTPPTTTT TTTAAAAAEA
110 120 130 140 150
TTNADKMQKQ QQLKQQLFAA CSIKVKSENT LATTANAALA AATTTTTTAT
160 170 180 190 200
PALATGKAAK TILENGIKKE STPPAVESVE ASSSSSSSSS SSSSSSSSWP
210 220 230 240 250
TTRRATSEDA SSNGGASADE EKSEEDPTAA VAASSTATTT SDLATTSRPR
260 270 280 290 300
PVLLTAVNPH IICHLCQGYL INATTIVECL HSFCHSCLIN HLRKERFCPR
310 320 330 340 350
CEMVINNAKP NIKSDTTLQA IVYKLVPGLY ERELMRKRAF YKDRPEEAAL
360 370 380 390 400
ATPEQRGDDT EHLIFSPSDD MSLSLEYAEL GELKTDSEPE LVDTLRPRYL
410 420 430 440 450
QCPAMCRVSH LKKFVYDKFE IDAQRFSIDI MYKVKTIVLL DYYTLMDIAY
460 470 480 490 500
IYTWKRDAPM RFYYRVYESP QPLVKPAPRR VLPLKLEKQE RENQEQQLAV
510 520 530 540 550
EVASSKVEPV SLPEDQKAEA SIKVEEQEST REIVKEVIKD VAATPPTETL
560 570 580 590 600
KLVINRNMLD KREKSHSPQM SSKSSSKSSP CTPVSSPSEP NIKLKIDLSK
610 620 630 640 650
QNSVTIIDMS DPERREIVKP LKPEKESRSK KKDKDGSPKS SSSSSSSSSG
660 670 680 690 700
ERKRKSPSPL TVPPLTIRTE RIMSPSGVST LSPRVTSGAF SEDPKSEFLK
710 720 730 740 750
SFALKPIKVK VESPERTLNN RAITPPSPSV QQSASPKSKG NNLDDSILMK
760 770 780 790 800
PPSCMPPKSI ASSKRKSKEP VKAVSKKQKL SPPLPTVDFK IRLPVTNGNS
810 820 830 840 850
SGTASPKIEK PLMPPPAKPP MLAPRKLQPS AQFAPPPSPI HHHAGVQMSA
860 870 880 890 900
PGNRTPIAKR YQPILPKASR PNPFANIPND VNRLLKDAGT EIKSIGGGSV
910 920 930 940 950
ENNSNAAQKP HLYGPKGESK MGPPALPATT PSQGNKNVGK QAGNLPMSAP
960 970 980 990 1000
PNKGNSSNNY LNLALFNSSK CKGKEAPPGC RTPMYTPNSP IYSPSSPQYV
1010 1020 1030 1040 1050
PSYNIPTMPT YKYTPKPTPN SGSGNGGSGS YLQNMLGGGN GGSLGGLFPS
1060 1070 1080 1090 1100
PPTKSDQNTN PAQGGGGSSS ATQSGGNNGI VNNNIYMPNE DAPEKQQVKV
1110 1120 1130 1140 1150
KSLLNSCNIN IPSSLSITIS RDNGDSSSPN NGQHPKHKSP VNNYIEIVKL
1160 1170 1180 1190 1200
PDQPQDQVQA AKEAQKRQSP PAAVPGHLAA KLPPPPPSKA IPSPQHLVSR
1210 1220 1230 1240 1250
MTPPQLPKVA TPPPPSSPRV ITPPKTSPPA NAAKVTPLKP VLTPTQVDKK
1260 1270 1280 1290 1300
TPSPEKRTAA QMGSHSPTAS ENKSPKGGPA GVANSTGGAQ NGDPAAKKFR
1310 1320 1330 1340 1350
PILPRQNGMP ELAPKLPTLA PFVGFNPLQN PAAGKKVPPS KKSPNAGAAA
1360 1370 1380 1390 1400
HQSGQQKLVN GGQSQPAQQK TSPPAQKNQQ QVKKVSKNPT PPPPSLPAVG
1410 1420 1430 1440 1450
KMMPHPVMHS QNAPLSIASS ASAAAVASGQ LDLSNFLKEN LRRVHAAQAA
1460 1470 1480 1490 1500
QAAQVAAAAN QSNMMYNLAQ MGHMTPAMYN YQQAYFREQL SRMQRVGNEV
1510 1520 1530 1540 1550
FNDYLQKLKT AAATGGGGPV EGELKPMLPT VTLPSPGATP PAASPKTSPL
1560 1570 1580 1590 1600
PAGKLTAAAT APQTKGNSSS GAANARQQTA ATGNNGATVP AASLPPATKS
K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD0Z760 | D0Z760_DROME | MIP14548p | Psc 49Ea, D-Bmi, Dmel\CG3886, dPSC, l(2)49Ea | 1,601 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | T → TPEAT (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 94 – 96 | AAA → T in CAA41965 (PubMed:1833647).Curated | 3 | |
Sequence conflicti | 130 | T → A in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 136 | N → T in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 200 | P → S in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 451 | I → T in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 513 | P → A in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 526 – 527 | EQ → GE in CAA41965 (PubMed:1833647).Curated | 2 | |
Sequence conflicti | 570 | M → L in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 906 | A → S in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 919 | S → T in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 969 | S → N in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 1279 | P → A in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 1289 | A → T in CAA41965 (PubMed:1833647).Curated | 1 | |
Sequence conflicti | 1364 – 1366 | SQP → PQS in CAA41965 (PubMed:1833647).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59275 mRNA Translation: CAA41965.1 DQ022542 mRNA Translation: AAZ20646.1 AE013599 Genomic DNA Translation: AAF58434.1 |
PIRi | S17983 |
RefSeqi | NP_001286368.1, NM_001299439.1 NP_001286369.1, NM_001299440.1 NP_523725.2, NM_079001.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0087798; FBpp0086911; FBgn0005624 FBtr0345196; FBpp0311395; FBgn0005624 FBtr0345375; FBpp0311526; FBgn0005624 |
GeneIDi | 36431 |
KEGGi | dme:Dmel_CG3886 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59275 mRNA Translation: CAA41965.1 DQ022542 mRNA Translation: AAZ20646.1 AE013599 Genomic DNA Translation: AAF58434.1 |
PIRi | S17983 |
RefSeqi | NP_001286368.1, NM_001299439.1 NP_001286369.1, NM_001299440.1 NP_523725.2, NM_079001.3 |
3D structure databases
SMRi | P35820 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 62201, 42 interactors |
IntActi | P35820, 7 interactors |
STRINGi | 7227.FBpp0086911 |
PTM databases
iPTMneti | P35820 |
Proteomic databases
PaxDbi | P35820 |
PRIDEi | P35820 |
Genome annotation databases
EnsemblMetazoai | FBtr0087798; FBpp0086911; FBgn0005624 FBtr0345196; FBpp0311395; FBgn0005624 FBtr0345375; FBpp0311526; FBgn0005624 |
GeneIDi | 36431 |
KEGGi | dme:Dmel_CG3886 |
Organism-specific databases
CTDi | 100653366 |
FlyBasei | FBgn0005624 Psc |
Phylogenomic databases
eggNOGi | KOG2660 Eukaryota ENOG410XPCN LUCA |
GeneTreei | ENSGT00940000173039 |
InParanoidi | P35820 |
KOi | K11459 |
OMAi | DTEHLIF |
OrthoDBi | 1203951at2759 |
PhylomeDBi | P35820 |
Enzyme and pathway databases
Reactomei | R-DME-2559580 Oxidative Stress Induced Senescence R-DME-3108214 SUMOylation of DNA damage response and repair proteins R-DME-3899300 SUMOylation of transcription cofactors R-DME-4570464 SUMOylation of RNA binding proteins R-DME-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-DME-8943724 Regulation of PTEN gene transcription R-DME-8953750 Transcriptional Regulation by E2F6 |
Miscellaneous databases
ChiTaRSi | Psc fly |
GenomeRNAii | 36431 |
PROi | PR:P35820 |
Gene expression databases
Bgeei | FBgn0005624 Expressed in 27 organ(s), highest expression level in embryo |
ExpressionAtlasi | P35820 baseline and differential |
Genevisiblei | P35820 DM |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443 RAWUL IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS |
Pfami | View protein in Pfam PF16207 RAWUL, 1 hit |
PROSITEi | View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSC_DROME | |
Accessioni | P35820Primary (citable) accession number: P35820 Secondary accession number(s): Q9V6I9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | September 27, 2005 | |
Last modified: | November 13, 2019 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase