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Protein

Polycomb group protein Psc

Gene

Psc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 302RING-typePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • DNA binding Source: FlyBase
  • zinc ion binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • chromatin remodeling Source: FlyBase
  • chromatin silencing Source: FlyBase
  • syncytial blastoderm mitotic cell cycle Source: FlyBase
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-2559580 Oxidative Stress Induced Senescence
R-DME-4570464 SUMOylation of RNA binding proteins
R-DME-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-DME-8943724 Regulation of PTEN gene transcription
R-DME-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group protein Psc
Alternative name(s):
Protein posterior sex combs
Gene namesi
Name:Psc
ORF Names:CG3886
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0005624 Psc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000563881 – 1601Polycomb group protein PscAdd BLAST1601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei656Phosphoserine1 Publication1
Modified residuei658Phosphoserine1 Publication1
Modified residuei1139Phosphoserine1 Publication1
Modified residuei1222Phosphothreonine1 Publication1
Modified residuei1236Phosphothreonine1 Publication1
Modified residuei1251Phosphothreonine1 Publication1
Modified residuei1253Phosphoserine1 Publication1
Modified residuei1266Phosphoserine1 Publication1
Modified residuei1274Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP35820
PRIDEiP35820

PTM databases

iPTMnetiP35820

Expressioni

Gene expression databases

BgeeiFBgn0005624
ExpressionAtlasiP35820 baseline and differential
GenevisibleiP35820 DM

Interactioni

Subunit structurei

Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.2 Publications

Protein-protein interaction databases

BioGridi62201, 31 interactors
IntActiP35820, 12 interactors
STRINGi7227.FBpp0086911

Structurei

3D structure databases

ProteinModelPortaliP35820
SMRiP35820
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 155Thr-richAdd BLAST141
Compositional biasi178 – 212Ser-richAdd BLAST35
Compositional biasi565 – 658Ser-richAdd BLAST94
Compositional biasi806 – 878Pro-richAdd BLAST73
Compositional biasi1022 – 1079Gly-richAdd BLAST58
Compositional biasi1170 – 1406Pro-richAdd BLAST237

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 302RING-typePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
InParanoidiP35820
KOiK11459
OMAiDTEHLIF
OrthoDBiEOG091G09IB
PhylomeDBiP35820

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF16207 RAWUL, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTPESKAIQ PAAATTKQTA EATATTTMAH TQQKSQLSTL AKTTTTTATN
60 70 80 90 100
KAAKSVVSNA NSSGNNSSKK LALSQSQKTT TTTTPPTTTT TTTAAAAAEA
110 120 130 140 150
TTNADKMQKQ QQLKQQLFAA CSIKVKSENT LATTANAALA AATTTTTTAT
160 170 180 190 200
PALATGKAAK TILENGIKKE STPPAVESVE ASSSSSSSSS SSSSSSSSWP
210 220 230 240 250
TTRRATSEDA SSNGGASADE EKSEEDPTAA VAASSTATTT SDLATTSRPR
260 270 280 290 300
PVLLTAVNPH IICHLCQGYL INATTIVECL HSFCHSCLIN HLRKERFCPR
310 320 330 340 350
CEMVINNAKP NIKSDTTLQA IVYKLVPGLY ERELMRKRAF YKDRPEEAAL
360 370 380 390 400
ATPEQRGDDT EHLIFSPSDD MSLSLEYAEL GELKTDSEPE LVDTLRPRYL
410 420 430 440 450
QCPAMCRVSH LKKFVYDKFE IDAQRFSIDI MYKVKTIVLL DYYTLMDIAY
460 470 480 490 500
IYTWKRDAPM RFYYRVYESP QPLVKPAPRR VLPLKLEKQE RENQEQQLAV
510 520 530 540 550
EVASSKVEPV SLPEDQKAEA SIKVEEQEST REIVKEVIKD VAATPPTETL
560 570 580 590 600
KLVINRNMLD KREKSHSPQM SSKSSSKSSP CTPVSSPSEP NIKLKIDLSK
610 620 630 640 650
QNSVTIIDMS DPERREIVKP LKPEKESRSK KKDKDGSPKS SSSSSSSSSG
660 670 680 690 700
ERKRKSPSPL TVPPLTIRTE RIMSPSGVST LSPRVTSGAF SEDPKSEFLK
710 720 730 740 750
SFALKPIKVK VESPERTLNN RAITPPSPSV QQSASPKSKG NNLDDSILMK
760 770 780 790 800
PPSCMPPKSI ASSKRKSKEP VKAVSKKQKL SPPLPTVDFK IRLPVTNGNS
810 820 830 840 850
SGTASPKIEK PLMPPPAKPP MLAPRKLQPS AQFAPPPSPI HHHAGVQMSA
860 870 880 890 900
PGNRTPIAKR YQPILPKASR PNPFANIPND VNRLLKDAGT EIKSIGGGSV
910 920 930 940 950
ENNSNAAQKP HLYGPKGESK MGPPALPATT PSQGNKNVGK QAGNLPMSAP
960 970 980 990 1000
PNKGNSSNNY LNLALFNSSK CKGKEAPPGC RTPMYTPNSP IYSPSSPQYV
1010 1020 1030 1040 1050
PSYNIPTMPT YKYTPKPTPN SGSGNGGSGS YLQNMLGGGN GGSLGGLFPS
1060 1070 1080 1090 1100
PPTKSDQNTN PAQGGGGSSS ATQSGGNNGI VNNNIYMPNE DAPEKQQVKV
1110 1120 1130 1140 1150
KSLLNSCNIN IPSSLSITIS RDNGDSSSPN NGQHPKHKSP VNNYIEIVKL
1160 1170 1180 1190 1200
PDQPQDQVQA AKEAQKRQSP PAAVPGHLAA KLPPPPPSKA IPSPQHLVSR
1210 1220 1230 1240 1250
MTPPQLPKVA TPPPPSSPRV ITPPKTSPPA NAAKVTPLKP VLTPTQVDKK
1260 1270 1280 1290 1300
TPSPEKRTAA QMGSHSPTAS ENKSPKGGPA GVANSTGGAQ NGDPAAKKFR
1310 1320 1330 1340 1350
PILPRQNGMP ELAPKLPTLA PFVGFNPLQN PAAGKKVPPS KKSPNAGAAA
1360 1370 1380 1390 1400
HQSGQQKLVN GGQSQPAQQK TSPPAQKNQQ QVKKVSKNPT PPPPSLPAVG
1410 1420 1430 1440 1450
KMMPHPVMHS QNAPLSIASS ASAAAVASGQ LDLSNFLKEN LRRVHAAQAA
1460 1470 1480 1490 1500
QAAQVAAAAN QSNMMYNLAQ MGHMTPAMYN YQQAYFREQL SRMQRVGNEV
1510 1520 1530 1540 1550
FNDYLQKLKT AAATGGGGPV EGELKPMLPT VTLPSPGATP PAASPKTSPL
1560 1570 1580 1590 1600
PAGKLTAAAT APQTKGNSSS GAANARQQTA ATGNNGATVP AASLPPATKS

K
Length:1,601
Mass (Da):169,833
Last modified:September 27, 2005 - v2
Checksum:i7C6264A12CDF3D49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23T → TPEAT (PubMed:1833647).Curated1
Sequence conflicti94 – 96AAA → T in CAA41965 (PubMed:1833647).Curated3
Sequence conflicti130T → A in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti136N → T in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti200P → S in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti451I → T in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti513P → A in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti526 – 527EQ → GE in CAA41965 (PubMed:1833647).Curated2
Sequence conflicti570M → L in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti906A → S in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti919S → T in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti969S → N in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti1279P → A in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti1289A → T in CAA41965 (PubMed:1833647).Curated1
Sequence conflicti1364 – 1366SQP → PQS in CAA41965 (PubMed:1833647).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59275 mRNA Translation: CAA41965.1
DQ022542 mRNA Translation: AAZ20646.1
AE013599 Genomic DNA Translation: AAF58434.1
PIRiS17983
RefSeqiNP_001286368.1, NM_001299439.1
NP_001286369.1, NM_001299440.1
NP_523725.2, NM_079001.3
UniGeneiDm.2703

Genome annotation databases

EnsemblMetazoaiFBtr0087798; FBpp0086911; FBgn0005624
FBtr0345196; FBpp0311395; FBgn0005624
FBtr0345375; FBpp0311526; FBgn0005624
GeneIDi36431
KEGGidme:Dmel_CG3886

Similar proteinsi

Entry informationi

Entry nameiPSC_DROME
AccessioniPrimary (citable) accession number: P35820
Secondary accession number(s): Q9V6I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 27, 2005
Last modified: July 18, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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