UniProtKB - P35803 (GPM6B_MOUSE)
Protein
Neuronal membrane glycoprotein M6-b
Gene
Gpm6b
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.1 Publication
GO - Biological processi
- extracellular matrix assembly Source: UniProtKB
- negative regulation of protein localization to cell surface Source: UniProtKB
- negative regulation of serotonin uptake Source: UniProtKB
- neuron projection development Source: GO_Central
- ossification Source: UniProtKB-KW
- positive regulation of bone mineralization Source: UniProtKB
- protein transport Source: UniProtKB-KW
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of focal adhesion assembly Source: UniProtKB
Keywordsi
Biological process | Osteogenesis, Protein transport, Transport |
Protein family/group databases
TCDBi | 9.B.38.1.3, the myelin proteolipid protein (mplp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal membrane glycoprotein M6-bShort name: M6b |
Gene namesi | Name:Gpm6b Synonyms:M6b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107672, Gpm6b |
Subcellular locationi
Plasma membrane
Other locations
Note: Colocalizes with SERT at the plasma membrane.
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane raft Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 71 – 91 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 130 – 150 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 265 – 285 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000159022 | 1 – 328 | Neuronal membrane glycoprotein M6-bAdd BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 113 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 217 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 318 | PhosphoserineCombined sources | 1 | |
Modified residuei | 320 | PhosphoserineCombined sources | 1 | |
Modified residuei | 326 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | P35803 |
PaxDbi | P35803 |
PeptideAtlasi | P35803 |
PRIDEi | P35803 |
ProteomicsDBi | 271145 [P35803-1] 271146 [P35803-2] 271147 [P35803-3] 271148 [P35803-4] 271149 [P35803-5] 271150 [P35803-6] 271151 [P35803-7] 271152 [P35803-8] |
PTM databases
GlyConnecti | 2551, 1 N-Linked glycan (1 site) |
GlyGeni | P35803, 2 sites |
iPTMneti | P35803 |
PhosphoSitePlusi | P35803 |
SwissPalmi | P35803 |
Expressioni
Tissue specificityi
Widely expressed. In the brain, expressed in neurons and oligodendrocytes.1 Publication
Developmental stagei
First detected in presumptive postmitotic neurons in the developing neural tube at embryonic day 9.
Gene expression databases
Bgeei | ENSMUSG00000031342, Expressed in cerebellum and 305 other tissues |
ExpressionAtlasi | P35803, baseline and differential |
Genevisiblei | P35803, MM |
Interactioni
Subunit structurei
Interacts with SERT.
1 PublicationProtein-protein interaction databases
BioGRIDi | 200024, 2 interactors |
IntActi | P35803, 1 interactor |
STRINGi | 10090.ENSMUSP00000107848 |
Miscellaneous databases
RNActi | P35803, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the myelin proteolipid protein family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4800, Eukaryota |
GeneTreei | ENSGT00390000006915 |
HOGENOMi | CLU_064167_2_0_1 |
InParanoidi | P35803 |
OMAi | MMDQVFH |
OrthoDBi | 914457at2759 |
PhylomeDBi | P35803 |
Family and domain databases
InterProi | View protein in InterPro IPR001614, Myelin_PLP IPR018237, Myelin_PLP_CS |
PANTHERi | PTHR11683, PTHR11683, 1 hit |
Pfami | View protein in Pfam PF01275, Myelin_PLP, 1 hit |
PRINTSi | PR00214, MYELINPLP |
SMARTi | View protein in SMART SM00002, PLP, 1 hit |
PROSITEi | View protein in PROSITE PS00575, MYELIN_PLP_1, 1 hit PS01004, MYELIN_PLP_2, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P35803-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-beta-TMD-omega
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKPAMETAAE ENTEQSQERK VNSRAEMEIG RYHWMYPGSK NHQYRPVPNL
60 70 80 90 100
GDRAGPLSSP GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA
110 120 130 140 150
GTVAILEQHF STNTSDHALL SEVIQLMQYV IYGIASFFFL YGIILLAEGF
160 170 180 190 200
YTTSAVKELH GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM
210 220 230 240 250
FYNIWSTCEV IKSPQSNGTS GVEQICVDVR QYGIIPWNAF PGKICGSALE
260 270 280 290 300
NICNTNEFYM SYHLFIVACA GAGATVIALI HFLMILSSNW AYLKDASKMQ
310 320
AYQDIKAKEE QELQDIQSRS KEQLNSYT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2AEG6 | A2AEG6_MOUSE | Neuronal membrane glycoprotein M6-b | Gpm6b | 328 | Annotation score: | ||
A2AEG3 | A2AEG3_MOUSE | Neuronal membrane glycoprotein M6-b | Gpm6b | 305 | Annotation score: | ||
H3BIV8 | H3BIV8_MOUSE | Neuronal membrane glycoprotein M6-b | Gpm6b | 89 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 288 | S → P (PubMed:11749036).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007318 | 2 – 60 | Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST | 59 | |
Alternative sequenceiVSP_007320 | 21 – 60 | Missing in isoform 4 and isoform 8. 2 PublicationsAdd BLAST | 40 | |
Alternative sequenceiVSP_007319 | 21 – 49 | VNSRA…RPVPN → GSKNAKHLAKAGIANRFRMP HLSLGRWDC in isoform 7. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_007321 | 50 – 328 | Missing in isoform 7. 1 PublicationAdd BLAST | 279 | |
Alternative sequenceiVSP_007322 | 62 – 89 | CFECC…FSGVA → SKNAKHLAKAGIANRFRMPH LSLGRWDC in isoform 6. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_007323 | 90 – 328 | Missing in isoform 6. 1 PublicationAdd BLAST | 239 | |
Alternative sequenceiVSP_007324 | 280 – 305 | IHFLM…AYQDI → LIYMMATTYNYAVLKFKSRE DCCTKF in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST | 26 | |
Alternative sequenceiVSP_007325 | 306 – 328 | Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST | 23 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
SMRi | P35803 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200024, 2 interactors |
IntActi | P35803, 1 interactor |
STRINGi | 10090.ENSMUSP00000107848 |
Protein family/group databases
TCDBi | 9.B.38.1.3, the myelin proteolipid protein (mplp) family |
PTM databases
GlyConnecti | 2551, 1 N-Linked glycan (1 site) |
GlyGeni | P35803, 2 sites |
iPTMneti | P35803 |
PhosphoSitePlusi | P35803 |
SwissPalmi | P35803 |
Proteomic databases
MaxQBi | P35803 |
PaxDbi | P35803 |
PeptideAtlasi | P35803 |
PRIDEi | P35803 |
ProteomicsDBi | 271145 [P35803-1] 271146 [P35803-2] 271147 [P35803-3] 271148 [P35803-4] 271149 [P35803-5] 271150 [P35803-6] 271151 [P35803-7] 271152 [P35803-8] |
Protocols and materials databases
Antibodypediai | 484, 142 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 2824 |
MGIi | MGI:107672, Gpm6b |
Phylogenomic databases
eggNOGi | KOG4800, Eukaryota |
GeneTreei | ENSGT00390000006915 |
HOGENOMi | CLU_064167_2_0_1 |
InParanoidi | P35803 |
OMAi | MMDQVFH |
OrthoDBi | 914457at2759 |
PhylomeDBi | P35803 |
Miscellaneous databases
BioGRID-ORCSi | 14758, 0 hits in 53 CRISPR screens |
ChiTaRSi | Gpm6b, mouse |
PROi | PR:P35803 |
RNActi | P35803, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031342, Expressed in cerebellum and 305 other tissues |
ExpressionAtlasi | P35803, baseline and differential |
Genevisiblei | P35803, MM |
Family and domain databases
InterProi | View protein in InterPro IPR001614, Myelin_PLP IPR018237, Myelin_PLP_CS |
PANTHERi | PTHR11683, PTHR11683, 1 hit |
Pfami | View protein in Pfam PF01275, Myelin_PLP, 1 hit |
PRINTSi | PR00214, MYELINPLP |
SMARTi | View protein in SMART SM00002, PLP, 1 hit |
PROSITEi | View protein in PROSITE PS00575, MYELIN_PLP_1, 1 hit PS01004, MYELIN_PLP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPM6B_MOUSE | |
Accessioni | P35803Primary (citable) accession number: P35803 Secondary accession number(s): A2AEG4 Q9JI65 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | April 30, 2003 | |
Last modified: | April 7, 2021 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families