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UniProtKB - P35803 (GPM6B_MOUSE)

Entry version 157 (07 Apr 2021)
Sequence version 2 (30 Apr 2003)
Previous versions | rss
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Protein

Neuronal membrane glycoprotein M6-b

Gene

Gpm6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOsteogenesis, Protein transport, Transport

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.38.1.3, the myelin proteolipid protein (mplp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuronal membrane glycoprotein M6-b
Short name:
M6b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gpm6b
Synonyms:M6b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107672, Gpm6b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001590221 – 328Neuronal membrane glycoprotein M6-bAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei318PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P35803

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35803

PeptideAtlas

More...PeptideAtlasi		P35803

PRoteomics IDEntifications database

More...PRIDEi		P35803

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		271145 [P35803-1]
271146 [P35803-2]
271147 [P35803-3]
271148 [P35803-4]
271149 [P35803-5]
271150 [P35803-6]
271151 [P35803-7]
271152 [P35803-8]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2551, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P35803, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35803

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35803

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P35803

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. In the brain, expressed in neurons and oligodendrocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected in presumptive postmitotic neurons in the developing neural tube at embryonic day 9.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000031342, Expressed in cerebellum and 305 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35803, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35803, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SERT.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		200024, 2 interactors

Protein interaction database and analysis system

More...IntActi		P35803, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000107848

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35803, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35803

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4800, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006915

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_064167_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35803

Identification of Orthologs from Complete Genome Data

More...OMAi		MMDQVFH

Database of Orthologous Groups

More...OrthoDBi		914457at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35803

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001614, Myelin_PLP
IPR018237, Myelin_PLP_CS

The PANTHER Classification System

More...PANTHERi		PTHR11683, PTHR11683, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01275, Myelin_PLP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00214, MYELINPLP

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00002, PLP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00575, MYELIN_PLP_1, 1 hit
PS01004, MYELIN_PLP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35803-1) [UniParc]FASTAAdd to basket
Also known as: Alpha-beta-TMD-omega

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPAMETAAE ENTEQSQERK VNSRAEMEIG RYHWMYPGSK NHQYRPVPNL 
        60         70         80         90        100
GDRAGPLSSP GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA 
       110        120        130        140        150
GTVAILEQHF STNTSDHALL SEVIQLMQYV IYGIASFFFL YGIILLAEGF 
       160        170        180        190        200
YTTSAVKELH GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM 
       210        220        230        240        250
FYNIWSTCEV IKSPQSNGTS GVEQICVDVR QYGIIPWNAF PGKICGSALE 
       260        270        280        290        300
NICNTNEFYM SYHLFIVACA GAGATVIALI HFLMILSSNW AYLKDASKMQ 
       310        320 
AYQDIKAKEE QELQDIQSRS KEQLNSYT
Length:328
Mass (Da):36,210
Last modified:April 30, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88BE3C67DF024B33
GO
Isoform 2 (identifier: P35803-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-beta-TMD-psi

The sequence of this isoform differs from the canonical sequence as follows:
     280-305: IHFLMILSSNWAYLKDASKMQAYQDI → LIYMMATTYNYAVLKFKSREDCCTKF
     306-328: Missing.

Show »
Length:305
Mass (Da):33,528
Checksum:iB71CC99392A41726
GO
Isoform 3 (identifier: P35803-3) [UniParc]FASTAAdd to basket
Also known as: TMD-omega

The sequence of this isoform differs from the canonical sequence as follows:
     2-60: Missing.

Show »
Length:269
Mass (Da):29,499
Checksum:i4F9114D6CEC9F1CC
GO
Isoform 4 (identifier: P35803-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-TMD-psi

The sequence of this isoform differs from the canonical sequence as follows:
     21-60: Missing.
     280-305: IHFLMILSSNWAYLKDASKMQAYQDI → LIYMMATTYNYAVLKFKSREDCCTKF
     306-328: Missing.

Show »
Length:265
Mass (Da):28,977
Checksum:i81BA7050D70C1333
GO
Isoform 5 (identifier: P35803-5) [UniParc]FASTAAdd to basket
Also known as: TMD-psi

The sequence of this isoform differs from the canonical sequence as follows:
     2-60: Missing.
     280-305: IHFLMILSSNWAYLKDASKMQAYQDI → LIYMMATTYNYAVLKFKSREDCCTKF
     306-328: Missing.

Show »
Length:246
Mass (Da):26,817
Checksum:i4A118F80F7760559
GO
Isoform 6 (identifier: P35803-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-beta-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     62-89: CFECCIKCLGGVPYASLVATILCFSGVA → SKNAKHLAKAGIANRFRMPHLSLGRWDC
     90-328: Missing.

Show »
Length:89
Mass (Da):10,077
Checksum:i5AA429B3A5E80403
GO
Isoform 7 (identifier: P35803-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     21-49: VNSRAEMEIGRYHWMYPGSKNHQYRPVPN → GSKNAKHLAKAGIANRFRMPHLSLGRWDC
     50-328: Missing.

Show »
Length:49
Mass (Da):5,526
Checksum:iF124F3E524C12D48
GO
Isoform 8 (identifier: P35803-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-TMD-omega

The sequence of this isoform differs from the canonical sequence as follows:
     21-60: Missing.

Show »
Length:288
Mass (Da):31,659
Checksum:iFD57E4EEFDB8BDC9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AEG6A2AEG6_MOUSE
Neuronal membrane glycoprotein M6-b
Gpm6b
328Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AEG3A2AEG3_MOUSE
Neuronal membrane glycoprotein M6-b
Gpm6b
305Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BIV8H3BIV8_MOUSE
Neuronal membrane glycoprotein M6-b
Gpm6b
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti288S → P (PubMed:11749036).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0073182 – 60Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST59
Alternative sequenceiVSP_00732021 – 60Missing in isoform 4 and isoform 8. 2 PublicationsAdd BLAST40
Alternative sequenceiVSP_00731921 – 49VNSRA…RPVPN → GSKNAKHLAKAGIANRFRMP HLSLGRWDC in isoform 7. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_00732150 – 328Missing in isoform 7. 1 PublicationAdd BLAST279
Alternative sequenceiVSP_00732262 – 89CFECC…FSGVA → SKNAKHLAKAGIANRFRMPH LSLGRWDC in isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_00732390 – 328Missing in isoform 6. 1 PublicationAdd BLAST239
Alternative sequenceiVSP_007324280 – 305IHFLM…AYQDI → LIYMMATTYNYAVLKFKSRE DCCTKF in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_007325306 – 328Missing in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
S65737 mRNA Translation: AAB28351.1
AF254869 mRNA Translation: AAF87987.1
AF254870 mRNA Translation: AAF87988.1
AF254871 mRNA Translation: AAF87989.1
AF254872 mRNA Translation: AAF87990.1
AF254873 mRNA Translation: AAF87991.1
AF254874 mRNA Translation: AAF87992.1
AF254875 mRNA Translation: AAF87993.1
AF254876 mRNA Translation: AAF87994.1
AF254877 mRNA Translation: AAF87995.1
AF254878 mRNA Translation: AAF87996.1
AF254879 mRNA Translation: AAF87997.1
AK016567 mRNA Translation: BAB30309.1
AL671905 Genomic DNA No translation available.
BC003912 mRNA Translation: AAH03912.1
BC025165 mRNA Translation: AAH25165.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30526.1 [P35803-3]
CCDS53243.1 [P35803-5]
CCDS53244.1 [P35803-2]
CCDS53245.1 [P35803-1]
CCDS53246.1 [P35803-4]
CCDS53247.1 [P35803-8]

NCBI Reference Sequences

More...RefSeqi		NP_001171426.1, NM_001177955.1
NP_001171427.1, NM_001177956.1
NP_001171428.1, NM_001177957.1
NP_001171429.1, NM_001177958.1 [P35803-8]
NP_001171430.1, NM_001177959.1 [P35803-4]
NP_001171431.1, NM_001177960.1 [P35803-4]
NP_001171432.1, NM_001177961.1 [P35803-5]
NP_001171433.1, NM_001177962.1 [P35803-5]
NP_075611.1, NM_023122.3 [P35803-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000060210; ENSMUSP00000060442; ENSMUSG00000031342 [P35803-3]
ENSMUST00000112224; ENSMUSP00000107843; ENSMUSG00000031342 [P35803-4]
ENSMUST00000112226; ENSMUSP00000107845; ENSMUSG00000031342 [P35803-4]
ENSMUST00000112228; ENSMUSP00000107847; ENSMUSG00000031342 [P35803-8]
ENSMUST00000112233; ENSMUSP00000107852; ENSMUSG00000031342 [P35803-5]
ENSMUST00000112235; ENSMUSP00000107854; ENSMUSG00000031342 [P35803-5]
ENSMUST00000143263; ENSMUSP00000135378; ENSMUSG00000031342 [P35803-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		14758

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:14758

UCSC genome browser

More...UCSCi		uc009uwg.2, mouse [P35803-3]
uc009uwm.2, mouse [P35803-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65737 mRNA Translation: AAB28351.1
AF254869 mRNA Translation: AAF87987.1
AF254870 mRNA Translation: AAF87988.1
AF254871 mRNA Translation: AAF87989.1
AF254872 mRNA Translation: AAF87990.1
AF254873 mRNA Translation: AAF87991.1
AF254874 mRNA Translation: AAF87992.1
AF254875 mRNA Translation: AAF87993.1
AF254876 mRNA Translation: AAF87994.1
AF254877 mRNA Translation: AAF87995.1
AF254878 mRNA Translation: AAF87996.1
AF254879 mRNA Translation: AAF87997.1
AK016567 mRNA Translation: BAB30309.1
AL671905 Genomic DNA No translation available.
BC003912 mRNA Translation: AAH03912.1
BC025165 mRNA Translation: AAH25165.1
CCDSiCCDS30526.1 [P35803-3]
CCDS53243.1 [P35803-5]
CCDS53244.1 [P35803-2]
CCDS53245.1 [P35803-1]
CCDS53246.1 [P35803-4]
CCDS53247.1 [P35803-8]
RefSeqiNP_001171426.1, NM_001177955.1
NP_001171427.1, NM_001177956.1
NP_001171428.1, NM_001177957.1
NP_001171429.1, NM_001177958.1 [P35803-8]
NP_001171430.1, NM_001177959.1 [P35803-4]
NP_001171431.1, NM_001177960.1 [P35803-4]
NP_001171432.1, NM_001177961.1 [P35803-5]
NP_001171433.1, NM_001177962.1 [P35803-5]
NP_075611.1, NM_023122.3 [P35803-3]

3D structure databases

SMRiP35803
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200024, 2 interactors
IntActiP35803, 1 interactor
STRINGi10090.ENSMUSP00000107848

Protein family/group databases

TCDBi9.B.38.1.3, the myelin proteolipid protein (mplp) family

PTM databases

GlyConnecti2551, 1 N-Linked glycan (1 site)
GlyGeniP35803, 2 sites
iPTMnetiP35803
PhosphoSitePlusiP35803
SwissPalmiP35803

Proteomic databases

MaxQBiP35803
PaxDbiP35803
PeptideAtlasiP35803
PRIDEiP35803
ProteomicsDBi271145 [P35803-1]
271146 [P35803-2]
271147 [P35803-3]
271148 [P35803-4]
271149 [P35803-5]
271150 [P35803-6]
271151 [P35803-7]
271152 [P35803-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		484, 142 antibodies

Genome annotation databases

EnsembliENSMUST00000060210; ENSMUSP00000060442; ENSMUSG00000031342 [P35803-3]
ENSMUST00000112224; ENSMUSP00000107843; ENSMUSG00000031342 [P35803-4]
ENSMUST00000112226; ENSMUSP00000107845; ENSMUSG00000031342 [P35803-4]
ENSMUST00000112228; ENSMUSP00000107847; ENSMUSG00000031342 [P35803-8]
ENSMUST00000112233; ENSMUSP00000107852; ENSMUSG00000031342 [P35803-5]
ENSMUST00000112235; ENSMUSP00000107854; ENSMUSG00000031342 [P35803-5]
ENSMUST00000143263; ENSMUSP00000135378; ENSMUSG00000031342 [P35803-7]
GeneIDi14758
KEGGimmu:14758
UCSCiuc009uwg.2, mouse [P35803-3]
uc009uwm.2, mouse [P35803-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2824
MGIiMGI:107672, Gpm6b

Phylogenomic databases

eggNOGiKOG4800, Eukaryota
GeneTreeiENSGT00390000006915
HOGENOMiCLU_064167_2_0_1
InParanoidiP35803
OMAiMMDQVFH
OrthoDBi914457at2759
PhylomeDBiP35803

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		14758, 0 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Gpm6b, mouse

Protein Ontology

More...PROi		PR:P35803
RNActiP35803, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000031342, Expressed in cerebellum and 305 other tissues
ExpressionAtlasiP35803, baseline and differential
GenevisibleiP35803, MM

Family and domain databases

InterProiView protein in InterPro
IPR001614, Myelin_PLP
IPR018237, Myelin_PLP_CS
PANTHERiPTHR11683, PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275, Myelin_PLP, 1 hit
PRINTSiPR00214, MYELINPLP
SMARTiView protein in SMART
SM00002, PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575, MYELIN_PLP_1, 1 hit
PS01004, MYELIN_PLP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPM6B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35803
Secondary accession number(s): A2AEG4
, Q8R3J6, Q99L14, Q9D4F5, Q9JHG9, Q9JHI1, Q9JHK2, Q9JI62, Q9JI63, Q9JI64, Q9JI65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 30, 2003
Last modified: April 7, 2021
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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