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Protein

Neuronal membrane glycoprotein M6-a

Gene

Gpm6a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-independent membrane deformation. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurogenesis

Protein family/group databases

TCDBi9.B.38.1.1 the myelin proteolipid protein (mplp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal membrane glycoprotein M6-a
Short name:
M6a
Gene namesi
Name:Gpm6a
Synonyms:M6a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:107671 Gpm6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 84ExtracellularSequence analysisAdd BLAST41
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 127CytoplasmicSequence analysisAdd BLAST22
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 213ExtracellularBy similarityAdd BLAST65
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 278CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001590191 – 278Neuronal membrane glycoprotein M6-aAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi174 ↔ 192By similarity
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei256PhosphoserineCombined sources1
Modified residuei278PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP35802
PeptideAtlasiP35802
PRIDEiP35802

PTM databases

iPTMnetiP35802
PhosphoSitePlusiP35802
SwissPalmiP35802

Expressioni

Tissue specificityi

Widely expressed in the CNS. Found especially in the granule cell layer of the cerebellum but not in the molecular layer or white matter. Expressed in the immature embryonic retina including the nerve fiber layer (NFL), inner plexiform layer (IPL), and outer plexiform layer (OPL). Weakly expressed in processes of Mueller glia cells.1 Publication

Developmental stagei

First detected in presumptive postmitotic neurons in the developing neural tube at embryonic day 9. Expressed in E14 retinas, and expression continued after birth with a slight decrease between P12 and P15. In the E14 retina is mainly and strongly expressed in the NFL. In P1 and P5 retinas strong expression is confined to the IPL and also in NFL. At P10 and in the adult retina strong expression is detected in the IPL, and weak expression in NFL, OPL, and inner nuclear layer. Is expressed on postmitotic mature neurons.1 Publication

Gene expression databases

BgeeiENSMUSG00000031517 Expressed in 244 organ(s), highest expression level in subiculum
CleanExiMM_GPM6A
ExpressionAtlasiP35802 baseline and differential
GenevisibleiP35802 MM

Interactioni

Protein-protein interaction databases

BioGridi231507, 2 interactors
IntActiP35802, 6 interactors
MINTiP35802

Structurei

3D structure databases

ProteinModelPortaliP35802
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4800 Eukaryota
ENOG4110EPW LUCA
GeneTreeiENSGT00390000006915
HOGENOMiHOG000231338
HOVERGENiHBG000096
InParanoidiP35802
OMAiIAMIHYL
OrthoDBiEOG091G0IM5
PhylomeDBiP35802
TreeFamiTF315162

Family and domain databases

InterProiView protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS
PANTHERiPTHR11683 PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275 Myelin_PLP, 1 hit
PRINTSiPR00214 MYELINPLP
SMARTiView protein in SMART
SM00002 PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35802-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA
60 70 80 90 100
LSGTVNILQT YFELARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM
110 120 130 140 150
VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL
160 170 180 190 200
PVYMYFNVWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTASENFLR
210 220 230 240 250
MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK
260 270
YEDIKSKEEQ ELHDIHSTRS KERLNAYT
Length:278
Mass (Da):31,149
Last modified:June 1, 1994 - v1
Checksum:iCEE0688873E786CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65735 mRNA Translation: AAB28350.1
BC024759 mRNA Translation: AAH24759.1
BC029683 mRNA Translation: AAH29683.1
BC029711 mRNA Translation: AAH29711.1
BC033357 mRNA Translation: AAH33357.1
BC033394 mRNA Translation: AAH33394.1
BC043130 mRNA Translation: AAH43130.1
CCDSiCCDS22310.1
RefSeqiNP_001240683.1, NM_001253754.1
NP_001240685.1, NM_001253756.1
NP_705809.1, NM_153581.6
UniGeneiMm.241700

Genome annotation databases

EnsembliENSMUST00000033915; ENSMUSP00000033915; ENSMUSG00000031517
GeneIDi234267
KEGGimmu:234267
UCSCiuc009lsl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65735 mRNA Translation: AAB28350.1
BC024759 mRNA Translation: AAH24759.1
BC029683 mRNA Translation: AAH29683.1
BC029711 mRNA Translation: AAH29711.1
BC033357 mRNA Translation: AAH33357.1
BC033394 mRNA Translation: AAH33394.1
BC043130 mRNA Translation: AAH43130.1
CCDSiCCDS22310.1
RefSeqiNP_001240683.1, NM_001253754.1
NP_001240685.1, NM_001253756.1
NP_705809.1, NM_153581.6
UniGeneiMm.241700

3D structure databases

ProteinModelPortaliP35802
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231507, 2 interactors
IntActiP35802, 6 interactors
MINTiP35802

Protein family/group databases

TCDBi9.B.38.1.1 the myelin proteolipid protein (mplp) family

PTM databases

iPTMnetiP35802
PhosphoSitePlusiP35802
SwissPalmiP35802

Proteomic databases

PaxDbiP35802
PeptideAtlasiP35802
PRIDEiP35802

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033915; ENSMUSP00000033915; ENSMUSG00000031517
GeneIDi234267
KEGGimmu:234267
UCSCiuc009lsl.2 mouse

Organism-specific databases

CTDi2823
MGIiMGI:107671 Gpm6a

Phylogenomic databases

eggNOGiKOG4800 Eukaryota
ENOG4110EPW LUCA
GeneTreeiENSGT00390000006915
HOGENOMiHOG000231338
HOVERGENiHBG000096
InParanoidiP35802
OMAiIAMIHYL
OrthoDBiEOG091G0IM5
PhylomeDBiP35802
TreeFamiTF315162

Miscellaneous databases

ChiTaRSiGpm6a mouse
PROiPR:P35802
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031517 Expressed in 244 organ(s), highest expression level in subiculum
CleanExiMM_GPM6A
ExpressionAtlasiP35802 baseline and differential
GenevisibleiP35802 MM

Family and domain databases

InterProiView protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS
PANTHERiPTHR11683 PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275 Myelin_PLP, 1 hit
PRINTSiPR00214 MYELINPLP
SMARTiView protein in SMART
SM00002 PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPM6A_MOUSE
AccessioniPrimary (citable) accession number: P35802
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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