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UniProtKB - P35799 (DPY2_CAEEL)
Protein
Cuticle collagen dpy-2
Gene
dpy-2
Organism
Caenorhabditis elegans
Status
Functioni
Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.
GO - Molecular functioni
- structural constituent of collagen and cuticulin-based cuticle Source: WormBase
GO - Biological processi
- cuticle development involved in collagen and cuticulin-based cuticle molting cycle Source: WormBase
- post-embryonic body morphogenesis Source: WormBase
- regulation of multicellular organism growth Source: WormBase
Names & Taxonomyi
Protein namesi | Recommended name: Cuticle collagen dpy-2Alternative name(s): Protein dumpy-2 |
Gene namesi | Name:dpy-2 ORF Names:T14B4.6 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | T14B4.6 ; CE04953 ; WBGene00001064 ; dpy-2 |
Subcellular locationi
Other locations
- collagen trimer Source: WormBase
Keywords - Cellular componenti
CuticlePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 129 | G → E in dpy2(SC38). 1 Publication | 1 | |
Mutagenesisi | 183 | G → R in dpy2(E8). 1 Publication | 1 | |
Mutagenesisi | 247 | G → R in dpy2(E489). 1 Publication | 1 | |
Mutagenesisi | 253 | G → R in dpy2(Q292). 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – ? | Sequence analysis | ||
ChainiPRO_0000006428 | ? – 360 | Cuticle collagen dpy-2 |
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | P35799 |
PaxDbi | P35799 |
PeptideAtlasi | P35799 |
Expressioni
Gene expression databases
Bgeei | WBGene00001064, Expressed in multi-cellular organism and 4 other tissues |
Interactioni
Subunit structurei
Collagen polypeptide chains are complexed within the cuticle by disulfide bonds and other types of covalent cross-links.
Protein-protein interaction databases
BioGRIDi | 39445, 5 interactors |
IntActi | P35799, 1 interactor |
STRINGi | 6239.T14B4.6 |
Structurei
3D structure databases
AlphaFoldDBi | P35799 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 123 – 152 | Triple-helical regionAdd BLAST | 30 | |
Regioni | 127 – 158 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 174 – 360 | DisorderedSequence analysisAdd BLAST | 187 | |
Regioni | 174 – 230 | Triple-helical regionAdd BLAST | 57 | |
Regioni | 238 – 303 | Triple-helical regionAdd BLAST | 66 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 272 – 286 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 292 – 306 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the cuticular collagen family.Curated
Keywords - Domaini
Collagen, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00970000196743 |
HOGENOMi | CLU_001074_4_2_1 |
InParanoidi | P35799 |
OrthoDBi | 1181208at2759 |
PhylomeDBi | P35799 |
Family and domain databases
InterProi | View protein in InterPro IPR002486, Col_cuticle_N IPR008160, Collagen |
Pfami | View protein in Pfam PF01484, Col_cuticle_N, 1 hit PF01391, Collagen, 1 hit |
SMARTi | View protein in SMART SM01088, Col_cuticle_N, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35799-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSQTSGYVD PQTEEYDESR EKSYQVLIAV SGVLSITSLL ILVLFVPSMY
60 70 80 90 100
NYVDNISRFS RRDFEFCQAS ANDLETEMMS VREGLLRGRN VTKRAAGYGH
110 120 130 140 150
YNPSMLAADS PQFQECPACC IPGERGPSGD SGLPALPGAP GPDGAPGRPG
160 170 180 190 200
TTPNASCIPE RVFEPPPCLP CPQGPRGVPG HPGFPGDPGE YGIGGRPGSD
210 220 230 240 250
GMPGKPGDPG LAGPIGPPGE SGPIGDKGRT PEAHVIPGPP GDSGLPGPWG
260 270 280 290 300
PPGSAGMPGE DGYAGTPGEK GWPGPPGAPG PGGMPGPNGP TGEQGPSGTP
310 320 330 340 350
GTCVCQDTEV VMNDEKGRVP APRDNVAPGA TGGSYEPQGG NDAAAPSAIS
360
QSQNRRIRKW
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 355 – 360 | RRIRKW → DGYGNGESVSNHKNNGGYYH LRKFTQ in CCD65274 (PubMed:9851916).Curated | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12706 Genomic DNA Translation: AAA17398.2 FO080626 Genomic DNA Translation: CCD65274.1 |
PIRi | T28888 T37285 |
RefSeqi | NP_495367.1, NM_062966.5 |
Genome annotation databases
EnsemblMetazoai | T14B4.6.1; T14B4.6.1; WBGene00001064 |
GeneIDi | 174107 |
KEGGi | cel:CELE_T14B4.6 |
UCSCi | T14B4.6, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12706 Genomic DNA Translation: AAA17398.2 FO080626 Genomic DNA Translation: CCD65274.1 |
PIRi | T28888 T37285 |
RefSeqi | NP_495367.1, NM_062966.5 |
3D structure databases
AlphaFoldDBi | P35799 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 39445, 5 interactors |
IntActi | P35799, 1 interactor |
STRINGi | 6239.T14B4.6 |
Proteomic databases
EPDi | P35799 |
PaxDbi | P35799 |
PeptideAtlasi | P35799 |
Genome annotation databases
EnsemblMetazoai | T14B4.6.1; T14B4.6.1; WBGene00001064 |
GeneIDi | 174107 |
KEGGi | cel:CELE_T14B4.6 |
UCSCi | T14B4.6, c. elegans |
Organism-specific databases
CTDi | 174107 |
WormBasei | T14B4.6 ; CE04953 ; WBGene00001064 ; dpy-2 |
Phylogenomic databases
eggNOGi | KOG3544, Eukaryota |
GeneTreei | ENSGT00970000196743 |
HOGENOMi | CLU_001074_4_2_1 |
InParanoidi | P35799 |
OrthoDBi | 1181208at2759 |
PhylomeDBi | P35799 |
Miscellaneous databases
PROi | PR:P35799 |
Gene expression databases
Bgeei | WBGene00001064, Expressed in multi-cellular organism and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR002486, Col_cuticle_N IPR008160, Collagen |
Pfami | View protein in Pfam PF01484, Col_cuticle_N, 1 hit PF01391, Collagen, 1 hit |
SMARTi | View protein in SMART SM01088, Col_cuticle_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPY2_CAEEL | |
Accessioni | P35799Primary (citable) accession number: P35799 Secondary accession number(s): Q22477 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families