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Entry version 182 (17 Jun 2020)
Sequence version 4 (10 Jan 2006)
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Protein

Zinc finger protein 93

Gene

ZNF93

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).1 Publication

Miscellaneous

ZNF93 is only present in primates and evolved to repress the primate L1 lineage until 12.5 million years. Evolution stopped when the L1PA3-subfamily of retrotransposons, that escape repression by ZNF93 through the removal of the ZNF93-binding site, appeared (PubMed:25274305).1 Publication
Confers resistance to ET-743 (trabectedin, Yondelis) and PM00104 (Zalypsis), 2 marine derived compounds with antitumor activity in cancer cell lines.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 93
Alternative name(s):
Zinc finger protein 505
Zinc finger protein HTF34
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF93
Synonyms:ZNF505
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184635.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13169 ZNF93

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603975 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35789

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
81931

Open Targets

More...
OpenTargetsi
ENSG00000184635

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37741

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P35789 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF93

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85681872

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474021 – 620Zinc finger protein 93Add BLAST620

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P35789

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P35789

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P35789

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35789

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35789

PeptideAtlas

More...
PeptideAtlasi
P35789

PRoteomics IDEntifications database

More...
PRIDEi
P35789

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55151 [P35789-1]
55152 [P35789-2]
55153 [P35789-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35789

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35789

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed early during embryonic development.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184635 Expressed in secondary oocyte and 184 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35789 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35789 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184635 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123631, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P35789, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342002

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P35789 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35789

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 195C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162960

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35789

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANPSVIC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35789

TreeFam database of animal gene trees

More...
TreeFami
TF342117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR017125 Znf_PRDM5-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037162 PRDM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35789-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP
60 70 80 90 100
DLIAHLEQGK KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL
110 120 130 140 150
RRYEKRGHGN LQLIKRCESV DECKVHTGGY NGLNQCSTTT QSKVFQCDKY
160 170 180 190 200
GKVFHKFSNS NRHNIRHTEK KPFKCIECGK AFNQFSTLIT HKKIHTGEKP
210 220 230 240 250
YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA SSTLSKHEII
260 270 280 290 300
HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL
310 320 330 340 350
TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF
360 370 380 390 400
IASSTLSRHE FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE
410 420 430 440 450
ECGKAFKYSS TLSSHKRSHT GEKPYKCEEC GKAFVASSTL SKHEIIHTGK
460 470 480 490 500
KPYKCEECGK AFNQSSSLTK HKKIHTGEKP YKCEECGKAF NQSSSLTKHK
510 520 530 540 550
KIHTGEKPYK CEECGKAFNQ SSTLIKHKKI HTREKPYKCE ECGKAFHLST
560 570 580 590 600
HLTTHKILHT GEKPYRCREC GKAFNHSATL SSHKKIHSGE KPYECDKCGK
610 620
AFISPSSLSR HEIIHTGEKP
Length:620
Mass (Da):70,971
Last modified:January 10, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i722A49B2EA82801A
GO
Isoform 2 (identifier: P35789-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-418: Missing.

Show »
Length:592
Mass (Da):67,799
Checksum:i6718FB94ED926F46
GO
Isoform 3 (identifier: P35789-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     499-582: Missing.

Show »
Length:536
Mass (Da):61,323
Checksum:iD9515EAF8AE19FD1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES58K7ES58_HUMAN
Zinc finger protein 93
ZNF93
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ36K7EQ36_HUMAN
Zinc finger protein 93
ZNF93 hCG_1775441
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPG7K7EPG7_HUMAN
Zinc finger protein 93
ZNF93 hCG_1775441
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPV7K7EPV7_HUMAN
Zinc finger protein 93
ZNF93
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PNY2A0A1W2PNY2_HUMAN
Zinc finger protein 93
ZNF93
340Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD22981 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB14093 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75S → SGP in AAA83548 (PubMed:2023909).Curated1
Sequence conflicti89Q → H in AAA83548 (PubMed:2023909).Curated1
Sequence conflicti119S → R in AAA83548 (PubMed:2023909).Curated1
Sequence conflicti136C → S in AAA83548 (PubMed:2023909).Curated1
Sequence conflicti153V → D in AAA83548 (PubMed:2023909).Curated1
Sequence conflicti337G → E in BAC04764 (PubMed:14702039).Curated1
Sequence conflicti597K → E in BAC04764 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05276893D → Y1 PublicationCorresponds to variant dbSNP:rs12151060Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016988391 – 418Missing in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_016989499 – 582Missing in isoform 3. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK022550 mRNA Translation: BAB14093.1 Different initiation.
AK096342 mRNA Translation: BAC04764.1
AC007204 Genomic DNA Translation: AAD22981.1 Sequence problems.
AC011477 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84866.1
BC136718 mRNA Translation: AAI36719.1
BC136719 mRNA Translation: AAI36720.1
M61873 Genomic DNA Translation: AAA83548.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32973.1 [P35789-1]

Protein sequence database of the Protein Information Resource

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PIRi
H39384

NCBI Reference Sequences

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RefSeqi
NP_112495.2, NM_031218.3 [P35789-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343769; ENSP00000342002; ENSG00000184635 [P35789-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81931

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81931

UCSC genome browser

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UCSCi
uc002non.4 human [P35789-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022550 mRNA Translation: BAB14093.1 Different initiation.
AK096342 mRNA Translation: BAC04764.1
AC007204 Genomic DNA Translation: AAD22981.1 Sequence problems.
AC011477 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84866.1
BC136718 mRNA Translation: AAI36719.1
BC136719 mRNA Translation: AAI36720.1
M61873 Genomic DNA Translation: AAA83548.1
CCDSiCCDS32973.1 [P35789-1]
PIRiH39384
RefSeqiNP_112495.2, NM_031218.3 [P35789-1]

3D structure databases

SMRiP35789
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123631, 2 interactors
IntActiP35789, 1 interactor
STRINGi9606.ENSP00000342002

PTM databases

iPTMnetiP35789
PhosphoSitePlusiP35789

Polymorphism and mutation databases

BioMutaiZNF93
DMDMi85681872

Proteomic databases

EPDiP35789
jPOSTiP35789
MassIVEiP35789
MaxQBiP35789
PaxDbiP35789
PeptideAtlasiP35789
PRIDEiP35789
ProteomicsDBi55151 [P35789-1]
55152 [P35789-2]
55153 [P35789-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
56725 118 antibodies

Genome annotation databases

EnsembliENST00000343769; ENSP00000342002; ENSG00000184635 [P35789-1]
GeneIDi81931
KEGGihsa:81931
UCSCiuc002non.4 human [P35789-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81931
DisGeNETi81931
EuPathDBiHostDB:ENSG00000184635.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF93
HGNCiHGNC:13169 ZNF93
HPAiENSG00000184635 Low tissue specificity
MIMi603975 gene
neXtProtiNX_P35789
OpenTargetsiENSG00000184635
PharmGKBiPA37741

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162960
HOGENOMiCLU_002678_0_2_1
InParanoidiP35789
KOiK09228
OMAiANPSVIC
PhylomeDBiP35789
TreeFamiTF342117

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
81931 7 hits in 809 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF93 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81931
PharosiP35789 Tbio

Protein Ontology

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PROi
PR:P35789
RNActiP35789 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184635 Expressed in secondary oocyte and 184 other tissues
ExpressionAtlasiP35789 baseline and differential
GenevisibleiP35789 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR017125 Znf_PRDM5-like
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
PIRSFiPIRSF037162 PRDM, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 17 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 17 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF93_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35789
Secondary accession number(s): A6NMY2
, B9EGT2, Q8N8Q4, Q9H9X5, Q9Y2N8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 10, 2006
Last modified: June 17, 2020
This is version 182 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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