UniProtKB - P35789 (ZNF93_HUMAN)
Zinc finger protein 93
ZNF93
Functioni
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305).
Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).
1 PublicationMiscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 145 – 167 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 173 – 195 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 201 – 223 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 257 – 279 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transposon integration Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P35789 |
SignaLinki | P35789 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 93Alternative name(s): Zinc finger protein 505 Zinc finger protein HTF34 |
Gene namesi | Name:ZNF93 Synonyms:ZNF505 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13169, ZNF93 |
MIMi | 603975, gene |
neXtProti | NX_P35789 |
VEuPathDBi | HostDB:ENSG00000184635 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 81931 |
OpenTargetsi | ENSG00000184635 |
PharmGKBi | PA37741 |
Miscellaneous databases
Pharosi | P35789, Tbio |
Genetic variation databases
BioMutai | ZNF93 |
DMDMi | 85681872 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047402 | 1 – 620 | Zinc finger protein 93Add BLAST | 620 |
Proteomic databases
EPDi | P35789 |
jPOSTi | P35789 |
MassIVEi | P35789 |
MaxQBi | P35789 |
PaxDbi | P35789 |
PeptideAtlasi | P35789 |
PRIDEi | P35789 |
ProteomicsDBi | 55151 [P35789-1] 55152 [P35789-2] 55153 [P35789-3] |
PTM databases
iPTMneti | P35789 |
PhosphoSitePlusi | P35789 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSG00000184635, Expressed in secondary oocyte and 199 other tissues |
ExpressionAtlasi | P35789, baseline and differential |
Genevisiblei | P35789, HS |
Organism-specific databases
HPAi | ENSG00000184635, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123631, 3 interactors |
IntActi | P35789, 2 interactors |
STRINGi | 9606.ENSP00000342002 |
Miscellaneous databases
RNActi | P35789, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 75 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 145 – 167 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 173 – 195 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 201 – 223 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 229 – 251 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 257 – 279 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162960 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | P35789 |
OMAi | HEFIHMG |
PhylomeDBi | P35789 |
TreeFami | TF342117 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 17 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 16 hits PS50157, ZINC_FINGER_C2H2_2, 17 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP
60 70 80 90 100
DLIAHLEQGK KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL
110 120 130 140 150
RRYEKRGHGN LQLIKRCESV DECKVHTGGY NGLNQCSTTT QSKVFQCDKY
160 170 180 190 200
GKVFHKFSNS NRHNIRHTEK KPFKCIECGK AFNQFSTLIT HKKIHTGEKP
210 220 230 240 250
YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA SSTLSKHEII
260 270 280 290 300
HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL
310 320 330 340 350
TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF
360 370 380 390 400
IASSTLSRHE FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE
410 420 430 440 450
ECGKAFKYSS TLSSHKRSHT GEKPYKCEEC GKAFVASSTL SKHEIIHTGK
460 470 480 490 500
KPYKCEECGK AFNQSSSLTK HKKIHTGEKP YKCEECGKAF NQSSSLTKHK
510 520 530 540 550
KIHTGEKPYK CEECGKAFNQ SSTLIKHKKI HTREKPYKCE ECGKAFHLST
560 570 580 590 600
HLTTHKILHT GEKPYRCREC GKAFNHSATL SSHKKIHSGE KPYECDKCGK
610 620
AFISPSSLSR HEIIHTGEKP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ES58 | K7ES58_HUMAN | Zinc finger protein 93 | ZNF93 | 84 | Annotation score: | ||
K7EPG7 | K7EPG7_HUMAN | Zinc finger protein 93 | ZNF93 hCG_1775441 | 123 | Annotation score: | ||
K7EQ36 | K7EQ36_HUMAN | Zinc finger protein 93 | ZNF93 hCG_1775441 | 119 | Annotation score: | ||
K7EPV7 | K7EPV7_HUMAN | Zinc finger protein 93 | ZNF93 | 120 | Annotation score: | ||
A0A1W2PNY2 | A0A1W2PNY2_HUMAN | Zinc finger protein 93 | ZNF93 | 340 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 75 | S → SGP in AAA83548 (PubMed:2023909).Curated | 1 | |
Sequence conflicti | 89 | Q → H in AAA83548 (PubMed:2023909).Curated | 1 | |
Sequence conflicti | 119 | S → R in AAA83548 (PubMed:2023909).Curated | 1 | |
Sequence conflicti | 136 | C → S in AAA83548 (PubMed:2023909).Curated | 1 | |
Sequence conflicti | 153 | V → D in AAA83548 (PubMed:2023909).Curated | 1 | |
Sequence conflicti | 337 | G → E in BAC04764 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 597 | K → E in BAC04764 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052768 | 93 | D → Y1 PublicationCorresponds to variant dbSNP:rs12151060Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016988 | 391 – 418 | Missing in isoform 2. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_016989 | 499 – 582 | Missing in isoform 3. 1 PublicationAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022550 mRNA Translation: BAB14093.1 Different initiation. AK096342 mRNA Translation: BAC04764.1 AC007204 Genomic DNA Translation: AAD22981.1 Sequence problems. AC011477 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84866.1 BC136718 mRNA Translation: AAI36719.1 BC136719 mRNA Translation: AAI36720.1 M61873 Genomic DNA Translation: AAA83548.1 |
CCDSi | CCDS32973.1 [P35789-1] |
PIRi | H39384 |
RefSeqi | NP_112495.2, NM_031218.3 [P35789-1] |
Genome annotation databases
Ensembli | ENST00000343769; ENSP00000342002; ENSG00000184635 |
GeneIDi | 81931 |
KEGGi | hsa:81931 |
MANE-Selecti | ENST00000343769.6; ENSP00000342002.4; NM_031218.4; NP_112495.2 |
UCSCi | uc002non.4, human [P35789-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK022550 mRNA Translation: BAB14093.1 Different initiation. AK096342 mRNA Translation: BAC04764.1 AC007204 Genomic DNA Translation: AAD22981.1 Sequence problems. AC011477 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84866.1 BC136718 mRNA Translation: AAI36719.1 BC136719 mRNA Translation: AAI36720.1 M61873 Genomic DNA Translation: AAA83548.1 |
CCDSi | CCDS32973.1 [P35789-1] |
PIRi | H39384 |
RefSeqi | NP_112495.2, NM_031218.3 [P35789-1] |
3D structure databases
SMRi | P35789 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123631, 3 interactors |
IntActi | P35789, 2 interactors |
STRINGi | 9606.ENSP00000342002 |
PTM databases
iPTMneti | P35789 |
PhosphoSitePlusi | P35789 |
Genetic variation databases
BioMutai | ZNF93 |
DMDMi | 85681872 |
Proteomic databases
EPDi | P35789 |
jPOSTi | P35789 |
MassIVEi | P35789 |
MaxQBi | P35789 |
PaxDbi | P35789 |
PeptideAtlasi | P35789 |
PRIDEi | P35789 |
ProteomicsDBi | 55151 [P35789-1] 55152 [P35789-2] 55153 [P35789-3] |
Protocols and materials databases
Antibodypediai | 56725, 119 antibodies from 15 providers |
DNASUi | 81931 |
Genome annotation databases
Ensembli | ENST00000343769; ENSP00000342002; ENSG00000184635 |
GeneIDi | 81931 |
KEGGi | hsa:81931 |
MANE-Selecti | ENST00000343769.6; ENSP00000342002.4; NM_031218.4; NP_112495.2 |
UCSCi | uc002non.4, human [P35789-1] |
Organism-specific databases
CTDi | 81931 |
DisGeNETi | 81931 |
GeneCardsi | ZNF93 |
HGNCi | HGNC:13169, ZNF93 |
HPAi | ENSG00000184635, Low tissue specificity |
MIMi | 603975, gene |
neXtProti | NX_P35789 |
OpenTargetsi | ENSG00000184635 |
PharmGKBi | PA37741 |
VEuPathDBi | HostDB:ENSG00000184635 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162960 |
HOGENOMi | CLU_002678_0_2_1 |
InParanoidi | P35789 |
OMAi | HEFIHMG |
PhylomeDBi | P35789 |
TreeFami | TF342117 |
Enzyme and pathway databases
PathwayCommonsi | P35789 |
SignaLinki | P35789 |
Miscellaneous databases
BioGRID-ORCSi | 81931, 15 hits in 1033 CRISPR screens |
ChiTaRSi | ZNF93, human |
GenomeRNAii | 81931 |
Pharosi | P35789, Tbio |
PROi | PR:P35789 |
RNActi | P35789, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184635, Expressed in secondary oocyte and 199 other tissues |
ExpressionAtlasi | P35789, baseline and differential |
Genevisiblei | P35789, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 17 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 16 hits PS50157, ZINC_FINGER_C2H2_2, 17 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF93_HUMAN | |
Accessioni | P35789Primary (citable) accession number: P35789 Secondary accession number(s): A6NMY2 Q9Y2N8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 10, 2006 | |
Last modified: | February 23, 2022 | |
This is version 190 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families