Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CD81 antigen

Gene

Cd81

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the regulation of lymphoma cell growth. May be involved in the acrosome reaction.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116Important for interaction with integrinBy similarity1
Sitei144Important for interaction with integrinBy similarity1
Sitei148Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
CD81 antigen
Alternative name(s):
26 kDa cell surface protein TAPA-1
Target of the antiproliferative antibody 1
CD_antigen: CD81
Gene namesi
Name:Cd81
Synonyms:Tapa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1096398 Cd81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 57ExtracellularSequence analysisAdd BLAST24
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 89CytoplasmicSequence analysisAdd BLAST11
Transmembranei90 – 115HelicalSequence analysisAdd BLAST26
Topological domaini116 – 201ExtracellularSequence analysisAdd BLAST86
Transmembranei202 – 226HelicalSequence analysisAdd BLAST25
Topological domaini227 – 236CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduction in the fecundity of female mice and their eggs have impaired ability to fuse with sperm.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192221 – 236CD81 antigenAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi156 ↔ 190By similarity
Disulfide bondi157 ↔ 175By similarity

Post-translational modificationi

Not glycosylated.Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP35762
PaxDbiP35762
PeptideAtlasiP35762
PRIDEiP35762

PTM databases

iPTMnetiP35762
PhosphoSitePlusiP35762
SwissPalmiP35762

Expressioni

Tissue specificityi

Expressed in oocytes. Highly expressed in granulosa cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000037706
CleanExiMM_CD81
ExpressionAtlasiP35762 baseline and differential
GenevisibleiP35762 MM

Interactioni

Subunit structurei

Homodimer. Interacts with CD53 and SCIMP (By similarity). Interacts directly with IGSF8 (PubMed:11673522). Interacts with IFITM2 and IFITM3 (PubMed:16395393). Interacts with IFITM1. Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 enhances the association of ADGRG1 with GNA11. Interacts with CLDN1, CLDN6 and CLDN9 (By similarity). Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198613, 3 interactors
IntActiP35762, 4 interactors
MINTiP35762
STRINGi10090.ENSMUSP00000043768

Structurei

Secondary structure

1236
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi116 – 136Combined sources21
Helixi141 – 154Combined sources14
Helixi161 – 170Combined sources10
Helixi172 – 174Combined sources3
Helixi183 – 186Combined sources4
Helixi190 – 197Combined sources8

3D structure databases

ProteinModelPortaliP35762
SMRiP35762
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP35762
KOiK06508
OMAiFEMIFSM
OrthoDBiEOG091G0K9H
TreeFamiTF352895

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

P35762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTSLLYLELG
60 70 80 90 100
NKPAPNTFYV GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI
110 120 130 140 150
LFACEVAAGI WGFVNKDQIA KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF
160 170 180 190 200
HETLNCCGSN ALTTLTTTIL RNSLCPSGGN ILTPLLQQDC HQKIDELFSG
210 220 230
KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
Length:236
Mass (Da):25,815
Last modified:October 3, 2012 - v2
Checksum:i7BDCB792E7F9FA4E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173S → T in AAB19417 (PubMed:1650385).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S45012
, S44957, S44966, S45001, S45008, S45010 Genomic DNA Translation: AAB19417.1
AJ251835 Genomic DNA Translation: CAB94774.1
AK166521 mRNA Translation: BAE38825.1
AK170741 mRNA Translation: BAE41994.1
AC015800 Genomic DNA No translation available.
CH466531 Genomic DNA Translation: EDL18195.1
BC011433 mRNA Translation: AAH11433.1
X59047 mRNA No translation available.
CCDSiCCDS22038.1
PIRiA46472
RefSeqiNP_598416.1, NM_133655.2
UniGeneiMm.806

Genome annotation databases

EnsembliENSMUST00000037941; ENSMUSP00000043768; ENSMUSG00000037706
GeneIDi12520
KEGGimmu:12520
UCSCiuc009kou.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCD81_MOUSE
AccessioniPrimary (citable) accession number: P35762
Secondary accession number(s): Q91V78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health