GLRX

Functionⁱ

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO - Molecular functionⁱ

electron transfer activity Source: InterPro
glutathione disulfide oxidoreductase activity
Source: Reactome
Inferred from experimentⁱ
- 7851394
glutathione oxidoreductase activity
Source: BHF-UCL
Traceable author statementⁱ
- 19542013
protein N-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16884690

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell redox homeostasis Source: InterPro
nucleobase-containing small molecule interconversion Source: Reactome
positive regulation of membrane potential
Source: BHF-UCL
Inferred from direct assayⁱ
- 19542013
positive regulation of sodium ion transmembrane transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19542013
protein deglutathionylation
Source: BHF-UCL
Traceable author statementⁱ
- 19542013

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Transport

Biological process

Electron transport, Transport

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04268-MONOMER
Reactomeⁱ	R-HSA-499943 Interconversion of nucleotide di- and triphosphates
SABIO-RKⁱ	P35754

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutaredoxin-1 Alternative name(s): Thioltransferase-1 Short name: TTase-1
Gene namesⁱ	Name:GLRX Synonyms:GRX
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173221.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4330 GLRX
MIMⁱ	600443 gene
neXtProtⁱ	NX_P35754

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2745
Open Targets More...OpenTargetsⁱ	ENSG00000173221
PharmGKBⁱ	PA28731

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00143 Glutathione

DrugBankⁱ

DB00143 Glutathione

Polymorphism and mutation databases

BioMutaⁱ	GLRX
DMDMⁱ	1346143

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000141600	2 – 106	Glutaredoxin-1Add BLAST		105

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	9	N6-succinyllysineBy similarity	1
Disulfide bondⁱ	23 ↔ 26	Redox-active
Disulfide bondⁱ	79 ↔ 83

Keywords - PTMⁱ

Acetylation, Disulfide bond

Proteomic databases

EPDⁱ	P35754
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35754
PaxDbⁱ	P35754
PeptideAtlas More...PeptideAtlasⁱ	P35754
PRIDEⁱ	P35754
ProteomicsDBⁱ	55150

2D gel databases

UCD-2DPAGEⁱ	P35754

UCD-2DPAGEⁱ

P35754

PTM databases

iPTMnetⁱ	P35754
PhosphoSitePlusⁱ	P35754

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173221 Expressed in 226 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_GLRX
ExpressionAtlasⁱ	P35754 baseline and differential
Genevisibleⁱ	P35754 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB008634 CAB069419 HPA046431

HPAⁱ

CAB008634
CAB069419
HPA046431

Interactionⁱ

GO - Molecular functionⁱ

protein N-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16884690

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109007, 30 interactors
IntActⁱ	P35754, 7 interactors
Molecular INTeraction database More...MINTⁱ	P35754
STRINGⁱ	9606.ENSP00000237858

Chemistry databases

BindingDBⁱ

P35754

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	2 – 9	Combined sources	8
Beta strandⁱ	15 – 19	Combined sources	5
Helixⁱ	24 – 34	Combined sources	11
Beta strandⁱ	42 – 47	Combined sources	6
Turnⁱ	48 – 51	Combined sources	4
Helixⁱ	54 – 65	Combined sources	12
Beta strandⁱ	72 – 75	Combined sources	4
Beta strandⁱ	78 – 82	Combined sources	5
Helixⁱ	83 – 92	Combined sources	10
Helixⁱ	94 – 101	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P35754
SMRⁱ	P35754
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P35754

EvolutionaryTraceⁱ

P35754

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 106	GlutaredoxinPROSITE-ProRule annotationAdd BLAST		104

Sequence similaritiesⁱ

Belongs to the glutaredoxin family.Curated

Keywords - Domainⁱ

Redox-active center

Phylogenomic databases

eggNOGⁱ	KOG1752 Eukaryota COG0695 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000141068
HOGENOMⁱ	HOG000095204
HOVERGENⁱ	HBG000283
InParanoidⁱ	P35754
KEGG Orthology (KO) More...KOⁱ	K03676
OMAⁱ	KPGHLEC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WLY
PhylomeDBⁱ	P35754
TreeFamⁱ	TF326994

Family and domain databases

InterProⁱ	View protein in InterPro IPR011767 GLR_AS IPR002109 Glutaredoxin IPR011899 Glutaredoxin_euk/vir IPR014025 Glutaredoxin_subgr IPR036249 Thioredoxin-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00462 Glutaredoxin, 1 hit
PRINTSⁱ	PR00160 GLUTAREDOXIN
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR02180 GRX_euk, 1 hit
PROSITEⁱ	View protein in PROSITE PS00195 GLUTAREDOXIN_1, 1 hit PS51354 GLUTAREDOXIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P35754-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA 
        60         70         80         90        100
TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK 

QIGALQ

Length:106

Mass (Da):11,776

Last modified:January 23, 2007 - v2

Checksum:ⁱBB86FED55967EBE2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	96	L → V in BAA04769 (PubMed:8018729).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049189	47	D → Y. Corresponds to variant dbSNP:rs4767Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D21238 mRNA Translation: BAA04769.1 X76648 mRNA Translation: CAA54094.1 AF069668 mRNA Translation: AAC35798.1 AF115105, AF115104 Genomic DNA Translation: AAC98318.1 AF162769 mRNA Translation: AAD43353.1 BT006689 mRNA Translation: AAP35335.1 CR450312 mRNA Translation: CAG29308.1 CR542165 mRNA Translation: CAG46962.1 AK311868 mRNA Translation: BAG34809.1 DQ026062 Genomic DNA Translation: AAY29058.1 CH471084 Genomic DNA Translation: EAW96056.1 BC005304 mRNA Translation: AAH05304.1 BC010965 mRNA Translation: AAH10965.1 BC106075 mRNA Translation: AAI06076.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4078.1
PIRⁱ	S68701 S47472
NCBI Reference Sequences More...RefSeqⁱ	NP_001112362.1, NM_001118890.1 NP_001230587.1, NM_001243658.1 NP_001230588.1, NM_001243659.1 NP_002055.1, NM_002064.2
UniGeneⁱ	Hs.28988

Genome annotation databases

Ensemblⁱ	ENST00000237858; ENSP00000237858; ENSG00000173221 ENST00000379979; ENSP00000369314; ENSG00000173221 ENST00000505427; ENSP00000427353; ENSG00000173221 ENST00000508780; ENSP00000422708; ENSG00000173221 ENST00000512469; ENSP00000424636; ENSG00000173221
GeneIDⁱ	2745
KEGGⁱ	hsa:2745
UCSC genome browser More...UCSCⁱ	uc003kln.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35754	Glutaredoxin (Thioltransferase), isoform CRA_c		HUMAN		106	UniRef100_P35754
GLRX isoform 1		PANTR		106
GLRX isoform 1		PONAB		106
Uncharacterized protein		PANPA		106
Uncharacterized protein		NOMLE		106
+1

Protein	Similar proteins		Species	Score	Length	Source
P35754	Glutaredoxin (Thioltransferase), isoform CRA_c		HUMAN		106	UniRef90_P35754
GLRX isoform 1		PANTR		106
GLRX isoform 1		PONAB		106
Uncharacterized protein		PANPA		106
Uncharacterized protein		NOMLE		106
+27

Protein	Similar proteins		Species	Score	Length	Source
P35754	Glutaredoxin (Thioltransferase), isoform CRA_c		HUMAN		106	UniRef50_P35754
GLRX isoform 1		PANTR		106
GLRX isoform 1		PONAB		106
Uncharacterized protein		PANPA		106
Uncharacterized protein		NOMLE		106
+46

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D21238 mRNA Translation: BAA04769.1 X76648 mRNA Translation: CAA54094.1 AF069668 mRNA Translation: AAC35798.1 AF115105, AF115104 Genomic DNA Translation: AAC98318.1 AF162769 mRNA Translation: AAD43353.1 BT006689 mRNA Translation: AAP35335.1 CR450312 mRNA Translation: CAG29308.1 CR542165 mRNA Translation: CAG46962.1 AK311868 mRNA Translation: BAG34809.1 DQ026062 Genomic DNA Translation: AAY29058.1 CH471084 Genomic DNA Translation: EAW96056.1 BC005304 mRNA Translation: AAH05304.1 BC010965 mRNA Translation: AAH10965.1 BC106075 mRNA Translation: AAI06076.1
CCDSⁱ	CCDS4078.1
PIRⁱ	S68701 S47472
RefSeqⁱ	NP_001112362.1, NM_001118890.1 NP_001230587.1, NM_001243658.1 NP_001230588.1, NM_001243659.1 NP_002055.1, NM_002064.2
UniGeneⁱ	Hs.28988

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1B4Q	NMR	-	A	2-106	[»]
	1JHB	NMR	-	A	1-106	[»]
	4RQR	X-ray	1.08	A	2-106	[»]
ProteinModelPortalⁱ	P35754
SMRⁱ	P35754
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109007, 30 interactors
IntActⁱ	P35754, 7 interactors
MINTⁱ	P35754
STRINGⁱ	9606.ENSP00000237858

Chemistry databases

BindingDBⁱ	P35754
DrugBankⁱ	DB00143 Glutathione

PTM databases

iPTMnetⁱ	P35754
PhosphoSitePlusⁱ	P35754

Polymorphism and mutation databases

BioMutaⁱ	GLRX
DMDMⁱ	1346143

2D gel databases

UCD-2DPAGEⁱ	P35754

UCD-2DPAGEⁱ

P35754

Proteomic databases

EPDⁱ	P35754
MaxQBⁱ	P35754
PaxDbⁱ	P35754
PeptideAtlasⁱ	P35754
PRIDEⁱ	P35754
ProteomicsDBⁱ	55150

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2745
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000237858; ENSP00000237858; ENSG00000173221 ENST00000379979; ENSP00000369314; ENSG00000173221 ENST00000505427; ENSP00000427353; ENSG00000173221 ENST00000508780; ENSP00000422708; ENSG00000173221 ENST00000512469; ENSP00000424636; ENSG00000173221
GeneIDⁱ	2745
KEGGⁱ	hsa:2745
UCSCⁱ	uc003kln.5 human

Organism-specific databases

CTDⁱ	2745
DisGeNETⁱ	2745
EuPathDBⁱ	HostDB:ENSG00000173221.13
GeneCardsⁱ	GLRX
HGNCⁱ	HGNC:4330 GLRX
HPAⁱ	CAB008634 CAB069419 HPA046431
MIMⁱ	600443 gene
neXtProtⁱ	NX_P35754
OpenTargetsⁱ	ENSG00000173221
PharmGKBⁱ	PA28731
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1752 Eukaryota COG0695 LUCA
GeneTreeⁱ	ENSGT00900000141068
HOGENOMⁱ	HOG000095204
HOVERGENⁱ	HBG000283
InParanoidⁱ	P35754
KOⁱ	K03676
OMAⁱ	KPGHLEC
OrthoDBⁱ	EOG091G0WLY
PhylomeDBⁱ	P35754
TreeFamⁱ	TF326994

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04268-MONOMER
Reactomeⁱ	R-HSA-499943 Interconversion of nucleotide di- and triphosphates
SABIO-RKⁱ	P35754

Miscellaneous databases

ChiTaRSⁱ	GLRX human
EvolutionaryTraceⁱ	P35754
GeneWikiⁱ	GLRX
GenomeRNAiⁱ	2745
Protein Ontology More...PROⁱ	PR:P35754
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173221 Expressed in 226 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_GLRX
ExpressionAtlasⁱ	P35754 baseline and differential
Genevisibleⁱ	P35754 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011767 GLR_AS IPR002109 Glutaredoxin IPR011899 Glutaredoxin_euk/vir IPR014025 Glutaredoxin_subgr IPR036249 Thioredoxin-like_sf
Pfamⁱ	View protein in Pfam PF00462 Glutaredoxin, 1 hit
PRINTSⁱ	PR00160 GLUTAREDOXIN
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
TIGRFAMsⁱ	TIGR02180 GRX_euk, 1 hit
PROSITEⁱ	View protein in PROSITE PS00195 GLUTAREDOXIN_1, 1 hit PS51354 GLUTAREDOXIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLRX1_HUMAN
Accessionⁱ	P35754Primary (citable) accession number: P35754 Secondary accession number(s): B2R4L2, Q3KQS1, Q6ICT1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35754 (GLRX1_HUMAN)

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Glutaredoxin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ