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Protein

Glutaredoxin-1

Gene

GLRX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO - Molecular functioni

  • electron transfer activity Source: InterPro
  • glutathione disulfide oxidoreductase activity Source: Reactome
  • glutathione oxidoreductase activity Source: BHF-UCL
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS04268-MONOMER
ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates
SABIO-RKiP35754

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Alternative name(s):
Thioltransferase-1
Short name:
TTase-1
Gene namesi
Name:GLRX
Synonyms:GRX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000173221.13
HGNCiHGNC:4330 GLRX
MIMi600443 gene
neXtProtiNX_P35754

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2745
OpenTargetsiENSG00000173221
PharmGKBiPA28731

Chemistry databases

DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGLRX
DMDMi1346143

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001416002 – 106Glutaredoxin-1Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9N6-succinyllysineBy similarity1
Disulfide bondi23 ↔ 26Redox-active
Disulfide bondi79 ↔ 83

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiP35754
MaxQBiP35754
PaxDbiP35754
PeptideAtlasiP35754
PRIDEiP35754
ProteomicsDBi55150

2D gel databases

UCD-2DPAGEiP35754

PTM databases

iPTMnetiP35754
PhosphoSitePlusiP35754

Expressioni

Gene expression databases

BgeeiENSG00000173221 Expressed in 226 organ(s), highest expression level in chorionic villus
CleanExiHS_GLRX
ExpressionAtlasiP35754 baseline and differential
GenevisibleiP35754 HS

Organism-specific databases

HPAiCAB008634
CAB069419
HPA046431

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109007, 30 interactors
IntActiP35754, 7 interactors
MINTiP35754
STRINGi9606.ENSP00000237858

Chemistry databases

BindingDBiP35754

Structurei

Secondary structure

1106
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35754
SMRiP35754
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35754

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 106GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
COG0695 LUCA
GeneTreeiENSGT00900000141068
HOGENOMiHOG000095204
HOVERGENiHBG000283
InParanoidiP35754
KOiK03676
OMAiKPGHLEC
OrthoDBiEOG091G0WLY
PhylomeDBiP35754
TreeFamiTF326994

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35754-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA
60 70 80 90 100
TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK

QIGALQ
Length:106
Mass (Da):11,776
Last modified:January 23, 2007 - v2
Checksum:iBB86FED55967EBE2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96L → V in BAA04769 (PubMed:8018729).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04918947D → Y. Corresponds to variant dbSNP:rs4767Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21238 mRNA Translation: BAA04769.1
X76648 mRNA Translation: CAA54094.1
AF069668 mRNA Translation: AAC35798.1
AF115105, AF115104 Genomic DNA Translation: AAC98318.1
AF162769 mRNA Translation: AAD43353.1
BT006689 mRNA Translation: AAP35335.1
CR450312 mRNA Translation: CAG29308.1
CR542165 mRNA Translation: CAG46962.1
AK311868 mRNA Translation: BAG34809.1
DQ026062 Genomic DNA Translation: AAY29058.1
CH471084 Genomic DNA Translation: EAW96056.1
BC005304 mRNA Translation: AAH05304.1
BC010965 mRNA Translation: AAH10965.1
BC106075 mRNA Translation: AAI06076.1
CCDSiCCDS4078.1
PIRiS68701 S47472
RefSeqiNP_001112362.1, NM_001118890.1
NP_001230587.1, NM_001243658.1
NP_001230588.1, NM_001243659.1
NP_002055.1, NM_002064.2
UniGeneiHs.28988

Genome annotation databases

EnsembliENST00000237858; ENSP00000237858; ENSG00000173221
ENST00000379979; ENSP00000369314; ENSG00000173221
ENST00000505427; ENSP00000427353; ENSG00000173221
ENST00000508780; ENSP00000422708; ENSG00000173221
ENST00000512469; ENSP00000424636; ENSG00000173221
GeneIDi2745
KEGGihsa:2745
UCSCiuc003kln.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21238 mRNA Translation: BAA04769.1
X76648 mRNA Translation: CAA54094.1
AF069668 mRNA Translation: AAC35798.1
AF115105, AF115104 Genomic DNA Translation: AAC98318.1
AF162769 mRNA Translation: AAD43353.1
BT006689 mRNA Translation: AAP35335.1
CR450312 mRNA Translation: CAG29308.1
CR542165 mRNA Translation: CAG46962.1
AK311868 mRNA Translation: BAG34809.1
DQ026062 Genomic DNA Translation: AAY29058.1
CH471084 Genomic DNA Translation: EAW96056.1
BC005304 mRNA Translation: AAH05304.1
BC010965 mRNA Translation: AAH10965.1
BC106075 mRNA Translation: AAI06076.1
CCDSiCCDS4078.1
PIRiS68701 S47472
RefSeqiNP_001112362.1, NM_001118890.1
NP_001230587.1, NM_001243658.1
NP_001230588.1, NM_001243659.1
NP_002055.1, NM_002064.2
UniGeneiHs.28988

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B4QNMR-A2-106[»]
1JHBNMR-A1-106[»]
4RQRX-ray1.08A2-106[»]
ProteinModelPortaliP35754
SMRiP35754
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109007, 30 interactors
IntActiP35754, 7 interactors
MINTiP35754
STRINGi9606.ENSP00000237858

Chemistry databases

BindingDBiP35754
DrugBankiDB00143 Glutathione

PTM databases

iPTMnetiP35754
PhosphoSitePlusiP35754

Polymorphism and mutation databases

BioMutaiGLRX
DMDMi1346143

2D gel databases

UCD-2DPAGEiP35754

Proteomic databases

EPDiP35754
MaxQBiP35754
PaxDbiP35754
PeptideAtlasiP35754
PRIDEiP35754
ProteomicsDBi55150

Protocols and materials databases

DNASUi2745
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237858; ENSP00000237858; ENSG00000173221
ENST00000379979; ENSP00000369314; ENSG00000173221
ENST00000505427; ENSP00000427353; ENSG00000173221
ENST00000508780; ENSP00000422708; ENSG00000173221
ENST00000512469; ENSP00000424636; ENSG00000173221
GeneIDi2745
KEGGihsa:2745
UCSCiuc003kln.5 human

Organism-specific databases

CTDi2745
DisGeNETi2745
EuPathDBiHostDB:ENSG00000173221.13
GeneCardsiGLRX
HGNCiHGNC:4330 GLRX
HPAiCAB008634
CAB069419
HPA046431
MIMi600443 gene
neXtProtiNX_P35754
OpenTargetsiENSG00000173221
PharmGKBiPA28731
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
COG0695 LUCA
GeneTreeiENSGT00900000141068
HOGENOMiHOG000095204
HOVERGENiHBG000283
InParanoidiP35754
KOiK03676
OMAiKPGHLEC
OrthoDBiEOG091G0WLY
PhylomeDBiP35754
TreeFamiTF326994

Enzyme and pathway databases

BioCyciMetaCyc:HS04268-MONOMER
ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates
SABIO-RKiP35754

Miscellaneous databases

ChiTaRSiGLRX human
EvolutionaryTraceiP35754
GeneWikiiGLRX
GenomeRNAii2745
PROiPR:P35754
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173221 Expressed in 226 organ(s), highest expression level in chorionic villus
CleanExiHS_GLRX
ExpressionAtlasiP35754 baseline and differential
GenevisibleiP35754 HS

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLRX1_HUMAN
AccessioniPrimary (citable) accession number: P35754
Secondary accession number(s): B2R4L2, Q3KQS1, Q6ICT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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