UniProtKB - P35754 (GLRX1_HUMAN)
Protein
Glutaredoxin-1
Gene
GLRX
Organism
Homo sapiens (Human)
Status
Functioni
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
GO - Molecular functioni
- electron transfer activity Source: InterPro
- glutathione disulfide oxidoreductase activity Source: Reactome
- glutathione oxidoreductase activity Source: BHF-UCL
- protein N-terminus binding Source: UniProtKB
GO - Biological processi
- nucleobase-containing small molecule interconversion Source: Reactome
- positive regulation of membrane potential Source: BHF-UCL
- positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
- protein deglutathionylation Source: BHF-UCL
Keywordsi
Biological process | Electron transport, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS04268-MONOMER |
PathwayCommonsi | P35754 |
Reactomei | R-HSA-499943, Interconversion of nucleotide di- and triphosphates |
SABIO-RKi | P35754 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutaredoxin-1Alternative name(s): Thioltransferase-1 Short name: TTase-1 |
Gene namesi | Name:GLRX Synonyms:GRX |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4330, GLRX |
MIMi | 600443, gene |
neXtProti | NX_P35754 |
VEuPathDBi | HostDB:ENSG00000173221.13 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 2745 |
OpenTargetsi | ENSG00000173221 |
PharmGKBi | PA28731 |
Miscellaneous databases
Pharosi | P35754, Tbio |
Chemistry databases
DrugBanki | DB00143, Glutathione |
Genetic variation databases
BioMutai | GLRX |
DMDMi | 1346143 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000141600 | 2 – 106 | Glutaredoxin-1Add BLAST | 105 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 9 | N6-succinyllysineBy similarity | 1 | |
Disulfide bondi | 23 ↔ 26 | Redox-active | ||
Disulfide bondi | 79 ↔ 83 |
Keywords - PTMi
Acetylation, Disulfide bondProteomic databases
EPDi | P35754 |
jPOSTi | P35754 |
MassIVEi | P35754 |
MaxQBi | P35754 |
PaxDbi | P35754 |
PeptideAtlasi | P35754 |
PRIDEi | P35754 |
ProteomicsDBi | 55150 |
2D gel databases
UCD-2DPAGEi | P35754 |
PTM databases
GlyGeni | P35754, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35754 |
PhosphoSitePlusi | P35754 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173221, Expressed in chorionic villus and 234 other tissues |
ExpressionAtlasi | P35754, baseline and differential |
Genevisiblei | P35754, HS |
Organism-specific databases
HPAi | ENSG00000173221, Tissue enhanced (blood, skeletal muscle) |
Interactioni
Binary interactionsi
P35754
With | #Exp. | IntAct |
---|---|---|
TRIM62 [Q9BVG3] | 5 | EBI-3905236,EBI-6929619 |
GO - Molecular functioni
- protein N-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109007, 33 interactors |
IntActi | P35754, 8 interactors |
MINTi | P35754 |
STRINGi | 9606.ENSP00000369314 |
Chemistry databases
BindingDBi | P35754 |
Miscellaneous databases
RNActi | P35754, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P35754 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35754 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 106 | GlutaredoxinPROSITE-ProRule annotationAdd BLAST | 104 |
Sequence similaritiesi
Belongs to the glutaredoxin family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | KOG1752, Eukaryota |
GeneTreei | ENSGT00900000141068 |
HOGENOMi | CLU_026126_7_2_1 |
InParanoidi | P35754 |
OMAi | YKFKPGH |
OrthoDBi | 1535999at2759 |
PhylomeDBi | P35754 |
TreeFami | TF326994 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR011767, GLR_AS IPR002109, Glutaredoxin IPR011899, Glutaredoxin_euk/vir IPR014025, Glutaredoxin_subgr IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00462, Glutaredoxin, 1 hit |
PRINTSi | PR00160, GLUTAREDOXIN |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02180, GRX_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00195, GLUTAREDOXIN_1, 1 hit PS51354, GLUTAREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35754-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA
60 70 80 90 100
TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK
QIGALQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 96 | L → V in BAA04769 (PubMed:8018729).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049189 | 47 | D → Y. Corresponds to variant dbSNP:rs4767Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D21238 mRNA Translation: BAA04769.1 X76648 mRNA Translation: CAA54094.1 AF069668 mRNA Translation: AAC35798.1 AF115105, AF115104 Genomic DNA Translation: AAC98318.1 AF162769 mRNA Translation: AAD43353.1 BT006689 mRNA Translation: AAP35335.1 CR450312 mRNA Translation: CAG29308.1 CR542165 mRNA Translation: CAG46962.1 AK311868 mRNA Translation: BAG34809.1 DQ026062 Genomic DNA Translation: AAY29058.1 CH471084 Genomic DNA Translation: EAW96056.1 BC005304 mRNA Translation: AAH05304.1 BC010965 mRNA Translation: AAH10965.1 BC106075 mRNA Translation: AAI06076.1 |
CCDSi | CCDS4078.1 |
PIRi | S68701, S47472 |
RefSeqi | NP_001112362.1, NM_001118890.1 NP_001230587.1, NM_001243658.1 NP_001230588.1, NM_001243659.1 NP_002055.1, NM_002064.2 |
Genome annotation databases
Ensembli | ENST00000237858; ENSP00000237858; ENSG00000173221 ENST00000379979; ENSP00000369314; ENSG00000173221 ENST00000505427; ENSP00000427353; ENSG00000173221 ENST00000508780; ENSP00000422708; ENSG00000173221 ENST00000512469; ENSP00000424636; ENSG00000173221 |
GeneIDi | 2745 |
KEGGi | hsa:2745 |
UCSCi | uc003kln.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D21238 mRNA Translation: BAA04769.1 X76648 mRNA Translation: CAA54094.1 AF069668 mRNA Translation: AAC35798.1 AF115105, AF115104 Genomic DNA Translation: AAC98318.1 AF162769 mRNA Translation: AAD43353.1 BT006689 mRNA Translation: AAP35335.1 CR450312 mRNA Translation: CAG29308.1 CR542165 mRNA Translation: CAG46962.1 AK311868 mRNA Translation: BAG34809.1 DQ026062 Genomic DNA Translation: AAY29058.1 CH471084 Genomic DNA Translation: EAW96056.1 BC005304 mRNA Translation: AAH05304.1 BC010965 mRNA Translation: AAH10965.1 BC106075 mRNA Translation: AAI06076.1 |
CCDSi | CCDS4078.1 |
PIRi | S68701, S47472 |
RefSeqi | NP_001112362.1, NM_001118890.1 NP_001230587.1, NM_001243658.1 NP_001230588.1, NM_001243659.1 NP_002055.1, NM_002064.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B4Q | NMR | - | A | 2-106 | [»] | |
1JHB | NMR | - | A | 1-106 | [»] | |
4RQR | X-ray | 1.08 | A | 2-106 | [»] | |
SMRi | P35754 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109007, 33 interactors |
IntActi | P35754, 8 interactors |
MINTi | P35754 |
STRINGi | 9606.ENSP00000369314 |
Chemistry databases
BindingDBi | P35754 |
DrugBanki | DB00143, Glutathione |
PTM databases
GlyGeni | P35754, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35754 |
PhosphoSitePlusi | P35754 |
Genetic variation databases
BioMutai | GLRX |
DMDMi | 1346143 |
2D gel databases
UCD-2DPAGEi | P35754 |
Proteomic databases
EPDi | P35754 |
jPOSTi | P35754 |
MassIVEi | P35754 |
MaxQBi | P35754 |
PaxDbi | P35754 |
PeptideAtlasi | P35754 |
PRIDEi | P35754 |
ProteomicsDBi | 55150 |
Protocols and materials databases
Antibodypediai | 3264, 256 antibodies |
DNASUi | 2745 |
Genome annotation databases
Ensembli | ENST00000237858; ENSP00000237858; ENSG00000173221 ENST00000379979; ENSP00000369314; ENSG00000173221 ENST00000505427; ENSP00000427353; ENSG00000173221 ENST00000508780; ENSP00000422708; ENSG00000173221 ENST00000512469; ENSP00000424636; ENSG00000173221 |
GeneIDi | 2745 |
KEGGi | hsa:2745 |
UCSCi | uc003kln.5, human |
Organism-specific databases
CTDi | 2745 |
DisGeNETi | 2745 |
GeneCardsi | GLRX |
HGNCi | HGNC:4330, GLRX |
HPAi | ENSG00000173221, Tissue enhanced (blood, skeletal muscle) |
MIMi | 600443, gene |
neXtProti | NX_P35754 |
OpenTargetsi | ENSG00000173221 |
PharmGKBi | PA28731 |
VEuPathDBi | HostDB:ENSG00000173221.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1752, Eukaryota |
GeneTreei | ENSGT00900000141068 |
HOGENOMi | CLU_026126_7_2_1 |
InParanoidi | P35754 |
OMAi | YKFKPGH |
OrthoDBi | 1535999at2759 |
PhylomeDBi | P35754 |
TreeFami | TF326994 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS04268-MONOMER |
PathwayCommonsi | P35754 |
Reactomei | R-HSA-499943, Interconversion of nucleotide di- and triphosphates |
SABIO-RKi | P35754 |
Miscellaneous databases
BioGRID-ORCSi | 2745, 31 hits in 852 CRISPR screens |
ChiTaRSi | GLRX, human |
EvolutionaryTracei | P35754 |
GeneWikii | GLRX |
GenomeRNAii | 2745 |
Pharosi | P35754, Tbio |
PROi | PR:P35754 |
RNActi | P35754, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173221, Expressed in chorionic villus and 234 other tissues |
ExpressionAtlasi | P35754, baseline and differential |
Genevisiblei | P35754, HS |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR011767, GLR_AS IPR002109, Glutaredoxin IPR011899, Glutaredoxin_euk/vir IPR014025, Glutaredoxin_subgr IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00462, Glutaredoxin, 1 hit |
PRINTSi | PR00160, GLUTAREDOXIN |
SUPFAMi | SSF52833, SSF52833, 1 hit |
TIGRFAMsi | TIGR02180, GRX_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00195, GLUTAREDOXIN_1, 1 hit PS51354, GLUTAREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLRX1_HUMAN | |
Accessioni | P35754Primary (citable) accession number: P35754 Secondary accession number(s): B2R4L2, Q3KQS1, Q6ICT1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM