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Protein

Ice-structuring protein RD3

Gene
N/A
Organism
Lycodichthys dearborni (Antarctic eelpout) (Rhigophila dearborni)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contributes to protect fish blood from freezing at subzero sea water temperatures. Lowers the blood freezing point. Binds to nascent ice crystals and prevents further growth (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei9Important for ice-bindingBy similarity1
Sitei14Important for ice-bindingBy similarity1
Sitei18Important for ice-bindingBy similarity1
Sitei44Important for ice-bindingBy similarity1
Sitei79Important for ice-bindingBy similarity1
Sitei84Important for ice-bindingBy similarity1
Sitei88Important for ice-bindingBy similarity1
Sitei114Important for ice-bindingBy similarity1

Keywordsi

Molecular functionAntifreeze protein

Names & Taxonomyi

Protein namesi
Recommended name:
Ice-structuring protein RD3
Short name:
ISP RD3
Alternative name(s):
Antifreeze peptide RD3
OrganismiLycodichthys dearborni (Antarctic eelpout) (Rhigophila dearborni)
Taxonomic identifieri8201 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesCottioideiZoarcalesZoarcidaeLycodinaeLycodichthys

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001551531 – 134Ice-structuring protein RD3Add BLAST134

Expressioni

Tissue specificityi

Detected in blood serum (at protein level).1 Publication

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35753
SMRiP35753
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35753

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 63AFP-like 1PROSITE-ProRule annotationAdd BLAST60
Domaini74 – 133AFP-like 2PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 70Linker6

Sequence similaritiesi

Belongs to the type-III AFP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG004240

Family and domain databases

InterProiView protein in InterPro
IPR006190 AFP_Neu5c_C
IPR036732 AFP_Neu5c_C_sf
IPR006013 Antifreeze_III
IPR013974 SAF
PRINTSiPR00357 ANTIFREEZIII
SMARTiView protein in SMART
SM00858 SAF, 2 hits
SUPFAMiSSF51269 SSF51269, 2 hits
PROSITEiView protein in PROSITE
PS50844 AFP_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

P35753-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NKASVVANQL IPINTALTLI MMKAEVVTPM GIPAEEIPNL VGMQVNRAVP
60 70 80 90 100
LGTTLMPDMV KNYEDGTTSP GLKSVVANQL IPINTALTLV MMKAEEVSPK
110 120 130
GIPSEEISKL VGMQVNRAVY LDQTLMPDMV KNYE
Length:134
Mass (Da):14,480
Last modified:June 1, 1994 - v1
Checksum:iF7F208BF3E2CAA54
GO

Sequence databases

PIRiS53514

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiS53514

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C89NMR-A1-134[»]
1C8ANMR-A1-134[»]
3NLANMR-A1-73[»]
3RDNNMR-A1-73[»]
ProteinModelPortaliP35753
SMRiP35753
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004240

Miscellaneous databases

EvolutionaryTraceiP35753

Family and domain databases

InterProiView protein in InterPro
IPR006190 AFP_Neu5c_C
IPR036732 AFP_Neu5c_C_sf
IPR006013 Antifreeze_III
IPR013974 SAF
PRINTSiPR00357 ANTIFREEZIII
SMARTiView protein in SMART
SM00858 SAF, 2 hits
SUPFAMiSSF51269 SSF51269, 2 hits
PROSITEiView protein in PROSITE
PS50844 AFP_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANP3_LYCDA
AccessioniPrimary (citable) accession number: P35753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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