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UniProtKB - P35750 (CAN1_PIG)

Entry version 177 (25 May 2022)
Sequence version 3 (11 Jan 2001)
Previous versions | rss
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Protein

Calpain-1 catalytic subunit

Gene

CAPN1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarityNote: Binds 4 Ca2+ ions.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by micromolar concentrations of calcium and inhibited by calpastatin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi109Calcium 1Curated1
Metal bindingi114Calcium 1Curated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei115By similarity1
Active sitei272By similarity1
Active sitei296By similarity1
Metal bindingi318Calcium 2Curated1
Metal bindingi323Calcium 2Curated1
Metal bindingi598Calcium 3PROSITE-ProRule annotation1
Metal bindingi600Calcium 3PROSITE-ProRule annotation1
Metal bindingi602Calcium 3PROSITE-ProRule annotation1
Metal bindingi604Calcium 3PROSITE-ProRule annotation1
Metal bindingi609Calcium 3PROSITE-ProRule annotation1
Metal bindingi628Calcium 4PROSITE-ProRule annotation1
Metal bindingi630Calcium 4PROSITE-ProRule annotation1
Metal bindingi632Calcium 4PROSITE-ProRule annotation1
Metal bindingi634Calcium 4PROSITE-ProRule annotation1
Metal bindingi639Calcium 4PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.22.52, 6170

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SSC-1474228, Degradation of the extracellular matrix
R-SSC-6798695, Neutrophil degranulation
R-SSC-6809371, Formation of the cornified envelope

Protein family/group databases

MEROPS protease database

More...MEROPSi		C02.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-1 catalytic subunitCurated (EC:3.4.22.52By similarity)
Alternative name(s):
Calcium-activated neutral proteinase 1By similarity
Short name:
CANP 1By similarity
Calpain mu-typeBy similarity
Calpain-1 large subunitBy similarity
Micromolar-calpainBy similarity
Short name:
muCANPBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAPN1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2
  • UP000008227 Componenti: Chromosome 2

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:86170, CAPN1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4062

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002076971 – 714Calpain-1 catalytic subunitAdd BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei354PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei15 – 16Cleavage; for 78 kDa formBy similarity2
Sitei27 – 28Cleavage; for 75 kDa formBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35750

PeptideAtlas

More...PeptideAtlasi		P35750

PRoteomics IDEntifications database

More...PRIDEi		P35750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSSSCG00000012999, Expressed in blood and 48 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35750, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35750, SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with a small (regulatory) subunit CAPNS1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9823.ENSSSCP00000013824

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P35750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P35750

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35750

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 354Calpain catalyticPROSITE-ProRule annotationAdd BLAST300
Domaini585 – 618EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini615 – 650EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini680 – 714EF-hand 3PROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni355 – 526Domain IIIAdd BLAST172
Regioni527 – 542LinkerAdd BLAST16
Regioni543 – 713Domain IVAdd BLAST171

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0045, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159147

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010982_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35750

Identification of Orthologs from Complete Genome Data

More...OMAi		TEWFDLR

Database of Orthologous Groups

More...OrthoDBi		704215at2759

TreeFam database of animal gene trees

More...TreeFami		TF314748

Family and domain databases

Conserved Domains Database

More...CDDi		cd00214, Calpain_III, 1 hit
cd00044, CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033883, C2_III
IPR022684, Calpain_cysteine_protease
IPR022682, Calpain_domain_III
IPR022683, Calpain_III
IPR036213, Calpain_III_sf
IPR029643, CAPN1
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat

The PANTHER Classification System

More...PANTHERi		PTHR10183:SF284, PTHR10183:SF284, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01067, Calpain_III, 1 hit
PF13833, EF-hand_8, 1 hit
PF00648, Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00704, CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00720, calpain_III, 1 hit
SM00230, CysPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS00139, THIOL_PROTEASE_CYS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P35750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEVITPVY CTGVSAQVQK LRAKELGLGR HENAIKYLGQ DYEQLRAHCL 
        60         70         80         90        100
QSGSLFRDEA FPPVPQSLGF KELGPNSSKT YGVKWKRPTE LFSNPQFIVD 
       110        120        130        140        150
GATRTDICQG ALGDCWLLAA IASLTLNDTL LHRVVPHGQS FQNGYAGIFH 
       160        170        180        190        200
FQLWQFGEWV DVVVDDLLPT KDGKLVFVHS AQGNEFWSAL LEKAYAKVNG 
       210        220        230        240        250
SYEALSGGST SEGFEDFTGG VTEWYELRKA PSDLYSIILK ALERGSLLGC 
       260        270        280        290        300
SIDISSVLDM EAVTFKKLVK GHAYSVTGAK QVNYQGQMVN LIRMRNPWGE 
       310        320        330        340        350
VEWTGAWSDG SSEWNGVDPY QRDQLRVRME DGEFWMSFRD FLREFTRLEI 
       360        370        380        390        400
CNLTPDALKS QRVRNWNTTL YEGTWRRGST AGGCRNYPAT FWVNPQFKIR 
       410        420        430        440        450
LEETDDPEDD YGGRESGCSF VLALMQKHRR RERRFGRDME TIGFAVYEVP 
       460        470        480        490        500
PELVGQPVHL KRDFFLANAS RARSEQFINL REVSTRFRLP PGEYVVVPST 
       510        520        530        540        550
FEPNKEGDFV LRFFSEKKAG TQELDDQVQA ILPDEQVLSE EEIDENFKAL 
       560        570        580        590        600
FRQLAGEDME ISVRELRTIL NRIISKHKDL RTKGFSLESC RSMVNLMDRD 
       610        620        630        640        650
GNGKLGLVEF NILWNRIRNY LSIFRKFDLD KSGSMSAYEM RMAIESAGFK 
       660        670        680        690        700
LNKKLFELII TRYSEPDLAV DFDNFVCCLV RLETMFRFFK TLDTDLDGVV 
       710 
TFDLFKWLQL TMFA
Length:714
Mass (Da):81,739
Last modified:January 11, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BB31DE4FC56363A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5S6GBZ7A0A5S6GBZ7_PIG
Calpain-1 catalytic subunit
CAPN1
775Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5S6H4P7A0A5S6H4P7_PIG
Calpain-1 catalytic subunit
CAPN1
650Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5G2QYC6A0A5G2QYC6_PIG
Calpain-1 catalytic subunit
CAPN1
601Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti528V → I in AAA65125 (PubMed:8312396).Curated1
Sequence conflicti531I → N in AAA65125 (PubMed:8312396).Curated1
Sequence conflicti541E → G in AAA65125 (PubMed:8312396).Curated1
Sequence conflicti622S → A in AAA65125 (PubMed:8312396).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF263610 mRNA Translation: AAF73444.1
F14611 mRNA Translation: CAA23154.1
U01180 mRNA Translation: AAA65125.1

NCBI Reference Sequences

More...RefSeqi		NP_001335713.1, NM_001348784.1
XP_005660759.1, XM_005660702.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSSSCT00000067293; ENSSSCP00000067028; ENSSSCG00000012999
ENSSSCT00030023973; ENSSSCP00030010752; ENSSSCG00030017341
ENSSSCT00030023978; ENSSSCP00030010754; ENSSSCG00030017341
ENSSSCT00035095488; ENSSSCP00035040163; ENSSSCG00035069457
ENSSSCT00045028973; ENSSSCP00045020058; ENSSSCG00045016673
ENSSSCT00055045028; ENSSSCP00055035871; ENSSSCG00055022554
ENSSSCT00060079788; ENSSSCP00060034533; ENSSSCG00060058087
ENSSSCT00060079791; ENSSSCP00060034536; ENSSSCG00060058087
ENSSSCT00065043021; ENSSSCP00065018268; ENSSSCG00065031759
ENSSSCT00070040541; ENSSSCP00070034011; ENSSSCG00070020405

Database of genes from NCBI RefSeq genomes

More...GeneIDi		397027

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ssc:397027

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263610 mRNA Translation: AAF73444.1
F14611 mRNA Translation: CAA23154.1
U01180 mRNA Translation: AAA65125.1
RefSeqiNP_001335713.1, NM_001348784.1
XP_005660759.1, XM_005660702.2

3D structure databases

AlphaFoldDBiP35750
SMRiP35750
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000013824

Chemistry databases

BindingDBiP35750
ChEMBLiCHEMBL4062

Protein family/group databases

MEROPSiC02.001

Proteomic databases

PaxDbiP35750
PeptideAtlasiP35750
PRIDEiP35750

Genome annotation databases

EnsembliENSSSCT00000067293; ENSSSCP00000067028; ENSSSCG00000012999
ENSSSCT00030023973; ENSSSCP00030010752; ENSSSCG00030017341
ENSSSCT00030023978; ENSSSCP00030010754; ENSSSCG00030017341
ENSSSCT00035095488; ENSSSCP00035040163; ENSSSCG00035069457
ENSSSCT00045028973; ENSSSCP00045020058; ENSSSCG00045016673
ENSSSCT00055045028; ENSSSCP00055035871; ENSSSCG00055022554
ENSSSCT00060079788; ENSSSCP00060034533; ENSSSCG00060058087
ENSSSCT00060079791; ENSSSCP00060034536; ENSSSCG00060058087
ENSSSCT00065043021; ENSSSCP00065018268; ENSSSCG00065031759
ENSSSCT00070040541; ENSSSCP00070034011; ENSSSCG00070020405
GeneIDi397027
KEGGissc:397027

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		823
VGNCiVGNC:86170, CAPN1

Phylogenomic databases

eggNOGiKOG0045, Eukaryota
GeneTreeiENSGT00940000159147
HOGENOMiCLU_010982_0_1_1
InParanoidiP35750
OMAiTEWFDLR
OrthoDBi704215at2759
TreeFamiTF314748

Enzyme and pathway databases

BRENDAi3.4.22.52, 6170
ReactomeiR-SSC-1474228, Degradation of the extracellular matrix
R-SSC-6798695, Neutrophil degranulation
R-SSC-6809371, Formation of the cornified envelope

Miscellaneous databases

Protein Ontology

More...PROi		PR:P35750

Gene expression databases

BgeeiENSSSCG00000012999, Expressed in blood and 48 other tissues
ExpressionAtlasiP35750, baseline and differential
GenevisibleiP35750, SS

Family and domain databases

CDDicd00214, Calpain_III, 1 hit
cd00044, CysPc, 1 hit
InterProiView protein in InterPro
IPR033883, C2_III
IPR022684, Calpain_cysteine_protease
IPR022682, Calpain_domain_III
IPR022683, Calpain_III
IPR036213, Calpain_III_sf
IPR029643, CAPN1
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR038765, Papain-like_cys_pep_sf
IPR000169, Pept_cys_AS
IPR001300, Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF284, PTHR10183:SF284, 1 hit
PfamiView protein in Pfam
PF01067, Calpain_III, 1 hit
PF13833, EF-hand_8, 1 hit
PF00648, Peptidase_C2, 1 hit
PRINTSiPR00704, CALPAIN
SMARTiView protein in SMART
SM00720, calpain_III, 1 hit
SM00230, CysPc, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF49758, SSF49758, 1 hit
SSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203, CALPAIN_CAT, 1 hit
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 3 hits
PS00139, THIOL_PROTEASE_CYS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAN1_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35750
Secondary accession number(s): Q29600, Q9N0M6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2001
Last modified: May 25, 2022
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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