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Protein

Myosin-11

Gene

MYH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Muscle contraction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi178 – 185ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: UniProtKB-KW
  • motor activity Source: InterPro
  • structural constituent of muscle Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-445355 Smooth Muscle Contraction
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-11
Alternative name(s):
Myosin heavy chain 11
Myosin heavy chain, smooth muscle isoform
SMMHC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH11
Synonyms:KIAA0866
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000133392.16

Human Gene Nomenclature Database

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HGNCi
HGNC:7569 MYH11

Online Mendelian Inheritance in Man (OMIM)

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MIMi
160745 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P35749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Thick filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11.
Aortic aneurysm, familial thoracic 4 (AAT4)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
See also OMIM:132900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0317341241 – 1264Missing in AAT4. 1 PublicationAdd BLAST24
Natural variantiVAR_0317351758R → Q in AAT4. 1 PublicationCorresponds to variant dbSNP:rs142546324Ensembl.1

Keywords - Diseasei

Aortic aneurysm, Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
4629

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
MYH11

MalaCards human disease database

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MalaCardsi
MYH11
MIMi132900 phenotype

Open Targets

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OpenTargetsi
ENSG00000133392

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
98829 Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
229 Familial aortic dissection
91387 Familial thoracic aortic aneurysm and aortic dissection
2241 Megacystis-microcolon-intestinal hypoperistalsis syndrome
706 NON RARE IN EUROPE: Patent arterial duct

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31367

Chemistry databases

Drug and drug target database

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DrugBanki
DB04444 Tetrafluoroaluminate Ion

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MYH11

Domain mapping of disease mutations (DMDM)

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DMDMi
13432177

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234241 – 1972Myosin-11Add BLAST1972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei40PhosphoserineBy similarity1
Modified residuei129N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei1177PhosphothreonineBy similarity1
Modified residuei1684PhosphoserineBy similarity1
Modified residuei1722PhosphoserineBy similarity1
Modified residuei1954PhosphoserineCombined sources1
Modified residuei1958PhosphothreonineCombined sources1
Modified residuei1971PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P35749

MaxQB - The MaxQuant DataBase

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MaxQBi
P35749

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P35749

PeptideAtlas

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PeptideAtlasi
P35749

PRoteomics IDEntifications database

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PRIDEi
P35749

ProteomicsDB human proteome resource

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ProteomicsDBi
55147
55148 [P35749-2]
55149 [P35749-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P35749

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P35749

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P35749

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. Isoform 1 is mostly found in slowly contracting tonic muscles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000133392 Expressed in 236 organ(s), highest expression level in saphenous vein

CleanEx database of gene expression profiles

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CleanExi
HS_MYH11

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P35749 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P35749 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB002302
HPA014539
HPA015310

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MYL12BO149502EBI-1052928,EBI-1642165

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110714, 60 interactors

Database of interacting proteins

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DIPi
DIP-47268N

Protein interaction database and analysis system

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IntActi
P35749, 44 interactors

Molecular INTeraction database

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MINTi
P35749

STRING: functional protein association networks

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STRINGi
9606.ENSP00000379616

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P35749

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35749

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 81Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini85 – 783Myosin motorPROSITE-ProRule annotationAdd BLAST699
Domaini786 – 815IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni661 – 683Actin-bindingBy similarityAdd BLAST23
Regioni762 – 776Actin-bindingBy similarityAdd BLAST15
Regioni1935 – 1972C-terminalAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili844 – 1934Sequence analysisAdd BLAST1091

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155421

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000173958

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004704

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P35749

KEGG Orthology (KO)

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KOi
K10352

Identification of Orthologs from Complete Genome Data

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OMAi
LEAMGIM

Database for complete collections of gene phylogenies

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PhylomeDBi
P35749

TreeFam database of animal gene trees

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TreeFami
TF333601

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50084 SSF50084, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P35749-1) [UniParc]FASTAAdd to basket
Also known as: SM-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI
60 70 80 90 100
KEEKGDEVVV ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS
110 120 130 140 150
VLHNLRERYF SGLIYTYSGL FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM
160 170 180 190 200
PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS
210 220 230 240 250
SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS RFGKFIRINF
260 270 280 290 300
DVTGYIVGAN IETYLLEKSR AIRQARDERT FHIFYYMIAG AKEKMRSDLL
310 320 330 340 350
LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMAIMGFSE EEQLSILKVV
360 370 380 390 400
SSVLQLGNIV FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR
410 420 430 440 450
IKVGRDVVQK AQTKEQADFA VEALAKATYE RLFRWILTRV NKALDKTHRQ
460 470 480 490 500
GASFLGILDI AGFEIFEVNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ
510 520 530 540 550
REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW FPKATDKSFV
560 570 580 590 600
EKLCTEQGSH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN
610 620 630 640 650
DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF
660 670 680 690 700
RTVGQLYKEQ LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR
710 720 730 740 750
CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LAANAIPKGF MDGKQACILM
760 770 780 790 800
IKALELDPNL YRIGQSKIFF RTGVLAHLEE ERDLKITDVI MAFQAMCRGY
810 820 830 840 850
LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK VKPLLQVTRQ
860 870 880 890 900
EEEMQAKEDE LQKTKERQQK AENELKELEQ KHSQLTEEKN LLQEQLQAET
910 920 930 940 950
ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ
960 970 980 990 1000
QMLDLEEQLE EEEAARQKLQ LEKVTAEAKI KKLEDEILVM DDQNNKLSKE
1010 1020 1030 1040 1050
RKLLEERISD LTTNLAEEEE KAKNLTKLKN KHESMISELE VRLKKEEKSR
1060 1070 1080 1090 1100
QELEKLKRKL EGDASDFHEQ IADLQAQIAE LKMQLAKKEE ELQAALARLD
1110 1120 1130 1140 1150
DEIAQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ KRDLGEELEA
1160 1170 1180 1190 1200
LKTELEDTLD STATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK
1210 1220 1230 1240 1250
HAQAVEELTE QLEQFKRAKA NLDKNKQTLE KENADLAGEL RVLGQAKQEV
1260 1270 1280 1290 1300
EHKKKKLEAQ VQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLNEAE
1310 1320 1330 1340 1350
GKAIKLAKDV ASLSSQLQDT QELLQEETRQ KLNVSTKLRQ LEEERNSLQD
1360 1370 1380 1390 1400
QLDEEMEAKQ NLERHISTLN IQLSDSKKKL QDFASTVEAL EEGKKRFQKE
1410 1420 1430 1440 1450
IENLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR QLVSNLEKKQ
1460 1470 1480 1490 1500
RKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550
ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE
1560 1570 1580 1590 1600
LEDELQATED AKLRLEVNMQ ALKGQFERDL QARDEQNEEK RRQLQRQLHE
1610 1620 1630 1640 1650
YETELEDERK QRALAAAAKK KLEGDLKDLE LQADSAIKGR EEAIKQLRKL
1660 1670 1680 1690 1700
QAQMKDFQRE LEDARASRDE IFATAKENEK KAKSLEADLM QLQEDLAAAE
1710 1720 1730 1740 1750
RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ LEEELEEEQG
1760 1770 1780 1790 1800
NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELRSK
1810 1820 1830 1840 1850
LHEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA TKSLKQKDKK
1860 1870 1880 1890 1900
LKEILLQVED ERKMAEQYKE QAEKGNARVK QLKRQLEEAE EESQRINANR
1910 1920 1930 1940 1950
RKLQRELDEA TESNEAMGRE VNALKSKLRR GNETSFVPSR RSGGRRVIEN
1960 1970
ADGSEEETDT RDADFNGTKA SE
Length:1,972
Mass (Da):227,339
Last modified:April 27, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67665BB2AECE1277
GO
Isoform 2 (identifier: P35749-2) [UniParc]FASTAAdd to basket
Also known as: SM-B1

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.
Show »
Length:1,979
Mass (Da):228,090
Checksum:i9B70CDC6279DC694
GO
Isoform 3 (identifier: P35749-3) [UniParc]FASTAAdd to basket
Also known as: SM-B2

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: T → TQGPSFAY
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: This isoform with a 7 AA insert in the head domain is predominantly expressed in rapidly contracting phasic muscles.
Show »
Length:1,945
Mass (Da):224,328
Checksum:i0FA4E1636B68B8AC
GO
Isoform 4 (identifier: P35749-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1930-1972: RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE → GPPPQETSQ

Note: No experimental confirmation available.
Show »
Length:1,938
Mass (Da):223,577
Checksum:i61D4A502A155BEC0
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA74889 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti887 – 889EEK → NSE in D10667 (PubMed:7684189).Curated3
Sequence conflicti1558T → S in D10667 (PubMed:7684189).Curated1
Sequence conflicti1610 – 1611KQ → NE in D10667 (PubMed:7684189).Curated2
Sequence conflicti1786A → S in CAA49154 (Ref. 10) Curated1
Sequence conflicti1958T → L in D10667 (PubMed:7684189).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0502051104A → T. Corresponds to variant dbSNP:rs34263860EnsemblClinVar.1
Natural variantiVAR_0302391234A → T. Corresponds to variant dbSNP:rs16967494Ensembl.1
Natural variantiVAR_0317341241 – 1264Missing in AAT4. 1 PublicationAdd BLAST24
Natural variantiVAR_0302401289V → A. Corresponds to variant dbSNP:rs16967510EnsemblClinVar.1
Natural variantiVAR_0302411310V → M. Corresponds to variant dbSNP:rs7196804EnsemblClinVar.1
Natural variantiVAR_0502061508M → V. Corresponds to variant dbSNP:rs35176378EnsemblClinVar.1
Natural variantiVAR_0317351758R → Q in AAT4. 1 PublicationCorresponds to variant dbSNP:rs142546324Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043017211T → TQGPSFAY in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_0430181930 – 1972RGNET…TKASE → GPPPQETSQ in isoform 3 and isoform 4. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY520816 mRNA Translation: AAS98910.1
AY520817 mRNA Translation: AAS98911.1
AF001548 Genomic DNA Translation: AAC31665.1
U91323 Genomic DNA Translation: AAC35212.1
AB020673 mRNA Translation: BAA74889.2 Different initiation.
GU143399 Genomic DNA Translation: ACZ58373.1
GU143400 Genomic DNA Translation: ACZ58374.1
AC024120 Genomic DNA No translation available.
AC026401 Genomic DNA No translation available.
AC130651 Genomic DNA No translation available.
CH471226 Genomic DNA Translation: EAW53924.1
CH471226 Genomic DNA Translation: EAW53926.1
BC101677 mRNA Translation: AAI01678.1
BC104906 mRNA Translation: AAI04907.1
BC143364 mRNA Translation: AAI43365.1
D10667 mRNA No translation available.
X69292 mRNA Translation: CAA49154.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10565.1 [P35749-1]
CCDS10566.1 [P35749-4]
CCDS45423.1 [P35749-2]
CCDS45424.1 [P35749-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001035202.1, NM_001040113.1 [P35749-3]
NP_001035203.1, NM_001040114.1 [P35749-2]
NP_002465.1, NM_002474.2 [P35749-1]
NP_074035.1, NM_022844.2 [P35749-4]
XP_016878739.1, XM_017023250.1 [P35749-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.460109

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300036; ENSP00000300036; ENSG00000133392 [P35749-1]
ENST00000396324; ENSP00000379616; ENSG00000133392 [P35749-2]
ENST00000452625; ENSP00000407821; ENSG00000133392 [P35749-3]
ENST00000576790; ENSP00000458731; ENSG00000133392 [P35749-4]
ENST00000612165; ENSP00000478092; ENSG00000276480 [P35749-3]
ENST00000616422; ENSP00000478816; ENSG00000276480 [P35749-4]
ENST00000621545; ENSP00000478109; ENSG00000276480 [P35749-2]
ENST00000634050; ENSP00000488461; ENSG00000276480 [P35749-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4629

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4629

UCSC genome browser

More...
UCSCi
uc002ddv.4 human [P35749-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY520816 mRNA Translation: AAS98910.1
AY520817 mRNA Translation: AAS98911.1
AF001548 Genomic DNA Translation: AAC31665.1
U91323 Genomic DNA Translation: AAC35212.1
AB020673 mRNA Translation: BAA74889.2 Different initiation.
GU143399 Genomic DNA Translation: ACZ58373.1
GU143400 Genomic DNA Translation: ACZ58374.1
AC024120 Genomic DNA No translation available.
AC026401 Genomic DNA No translation available.
AC130651 Genomic DNA No translation available.
CH471226 Genomic DNA Translation: EAW53924.1
CH471226 Genomic DNA Translation: EAW53926.1
BC101677 mRNA Translation: AAI01678.1
BC104906 mRNA Translation: AAI04907.1
BC143364 mRNA Translation: AAI43365.1
D10667 mRNA No translation available.
X69292 mRNA Translation: CAA49154.1
CCDSiCCDS10565.1 [P35749-1]
CCDS10566.1 [P35749-4]
CCDS45423.1 [P35749-2]
CCDS45424.1 [P35749-3]
RefSeqiNP_001035202.1, NM_001040113.1 [P35749-3]
NP_001035203.1, NM_001040114.1 [P35749-2]
NP_002465.1, NM_002474.2 [P35749-1]
NP_074035.1, NM_022844.2 [P35749-4]
XP_016878739.1, XM_017023250.1 [P35749-3]
UniGeneiHs.460109

3D structure databases

ProteinModelPortaliP35749
SMRiP35749
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110714, 60 interactors
DIPiDIP-47268N
IntActiP35749, 44 interactors
MINTiP35749
STRINGi9606.ENSP00000379616

Chemistry databases

DrugBankiDB04444 Tetrafluoroaluminate Ion

PTM databases

iPTMnetiP35749
PhosphoSitePlusiP35749
SwissPalmiP35749

Polymorphism and mutation databases

BioMutaiMYH11
DMDMi13432177

Proteomic databases

EPDiP35749
MaxQBiP35749
PaxDbiP35749
PeptideAtlasiP35749
PRIDEiP35749
ProteomicsDBi55147
55148 [P35749-2]
55149 [P35749-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300036; ENSP00000300036; ENSG00000133392 [P35749-1]
ENST00000396324; ENSP00000379616; ENSG00000133392 [P35749-2]
ENST00000452625; ENSP00000407821; ENSG00000133392 [P35749-3]
ENST00000576790; ENSP00000458731; ENSG00000133392 [P35749-4]
ENST00000612165; ENSP00000478092; ENSG00000276480 [P35749-3]
ENST00000616422; ENSP00000478816; ENSG00000276480 [P35749-4]
ENST00000621545; ENSP00000478109; ENSG00000276480 [P35749-2]
ENST00000634050; ENSP00000488461; ENSG00000276480 [P35749-1]
GeneIDi4629
KEGGihsa:4629
UCSCiuc002ddv.4 human [P35749-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4629
DisGeNETi4629
EuPathDBiHostDB:ENSG00000133392.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYH11
GeneReviewsiMYH11
HGNCiHGNC:7569 MYH11
HPAiCAB002302
HPA014539
HPA015310
MalaCardsiMYH11
MIMi132900 phenotype
160745 gene
neXtProtiNX_P35749
OpenTargetsiENSG00000133392
Orphaneti98829 Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
229 Familial aortic dissection
91387 Familial thoracic aortic aneurysm and aortic dissection
2241 Megacystis-microcolon-intestinal hypoperistalsis syndrome
706 NON RARE IN EUROPE: Patent arterial duct
PharmGKBiPA31367

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000155421
HOGENOMiHOG000173958
HOVERGENiHBG004704
InParanoidiP35749
KOiK10352
OMAiLEAMGIM
PhylomeDBiP35749
TreeFamiTF333601

Enzyme and pathway databases

ReactomeiR-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-445355 Smooth Muscle Contraction
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYH11 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYH11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4629

Protein Ontology

More...
PROi
PR:P35749

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133392 Expressed in 236 organ(s), highest expression level in saphenous vein
CleanExiHS_MYH11
ExpressionAtlasiP35749 baseline and differential
GenevisibleiP35749 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF50084 SSF50084, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35749
Secondary accession number(s): D2JYH7
, O00396, O94944, P78422, Q3MIV8, Q3MNF0, Q3MNF1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 27, 2001
Last modified: December 5, 2018
This is version 198 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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