UniProtKB - P35748 (MYH11_RABIT)
Protein
Myosin-11
Gene
MYH11
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Muscle contraction.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 178 – 185 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin-dependent ATPase activity Source: CAFA
- actin filament binding Source: InterPro
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- microfilament motor activity Source: CAFA
- myosin II binding Source: CAFA
- structural constituent of muscle Source: CAFA
GO - Biological processi
- cardiac muscle fiber development Source: UniProtKB
- elastic fiber assembly Source: UniProtKB
- myofibril assembly Source: CAFA
- skeletal muscle myosin thick filament assembly Source: UniProtKB
- smooth muscle contraction Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-11Alternative name(s): Myosin heavy chain 11 Myosin heavy chain, smooth muscle isoform SMMHC |
Gene namesi | Name:MYH11 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Other locations
- Melanosome By similarity
- myofibril
Note: Thick filaments of the myofibrils.
Cytoskeleton
- muscle myosin complex Source: CAFA
Other locations
- melanosome Source: UniProtKB-SubCell
- myofibril Source: UniProtKB-SubCell
- myosin filament Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Thick filamentPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123427 | 1 – 1972 | Myosin-11Add BLAST | 1972 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineBy similarity | 1 | |
Modified residuei | 23 | PhosphoserineBy similarity | 1 | |
Modified residuei | 40 | PhosphoserineBy similarity | 1 | |
Modified residuei | 129 | N6,N6,N6-trimethyllysineSequence analysis | 1 | |
Modified residuei | 1177 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1684 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1722 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1954 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1971 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
PRIDEi | P35748 |
Interactioni
Subunit structurei
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
GO - Molecular functioni
- actin filament binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
- myosin II binding Source: CAFA
Protein-protein interaction databases
IntActi | P35748, 1 interactor |
STRINGi | 9986.ENSOCUP00000024188 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 81 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 85 – 783 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 699 | |
Domaini | 785 – 807 | IQPROSITE-ProRule annotationAdd BLAST | 23 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 661 – 683 | Actin-bindingBy similarityAdd BLAST | 23 | |
Regioni | 763 – 777 | Actin-bindingBy similarityAdd BLAST | 15 | |
Regioni | 1935 – 1972 | C-terminalAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 844 – 1934 | Sequence analysisAdd BLAST | 1091 |
Domaini
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0161, Eukaryota |
InParanoidi | P35748 |
OrthoDBi | 47111at2759 |
Family and domain databases
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
P35748-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQKGQLSDD EKFLFVDKNF INSPVAQADW VAKRLVWVPS EKQGFEAASI
60 70 80 90 100
KEEKGDEVVV ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS
110 120 130 140 150
VLHNLRERYF SGLIYTYSGL FCVVVNPYKQ LPIYSEKIVD MYKGKKRHEM
160 170 180 190 200
PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS
210 220 230 240 250
SHKGKKDTSI TGELEKQLLQ ANPILEAFGN AKTVKNDNSS RFGKFIRINF
260 270 280 290 300
DVTGYIVGAN IETYLLEKSR AIRQAREERT FHIFYYLIAG AKEKMRNDLL
310 320 330 340 350
LEGFNNYTFL SNGFVPIPAA QDDEMFQETV EAMSIMGFSE EEQLSVLKVV
360 370 380 390 400
SSVLQLGNIV FKKERNTDQA SMPDNTAAQK VCHLMGINVT DFTRSILTPR
410 420 430 440 450
IKVGRDVVQK AQTKEQADFA VEALAKATYE RLFRWILSRV NKALDKTHRQ
460 470 480 490 500
GASFLGILDI AGFEIFEVNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ
510 520 530 540 550
REGIEWNFID FGLDLQPCIE LIERPNNPPG VLALLDEECW FPKATDKSFV
560 570 580 590 600
EKLCTEQGNH PKFQKPKQLK DKTEFSIIHY AGKVDYNASA WLTKNMDPLN
610 620 630 640 650
DNVTSLLNAS SDKFVADLWK DVDRIVGLDQ MAKMTESSLP SASKTKKGMF
660 670 680 690 700
RTVGQLYKEQ LGKLMTTLRN TTPNFVRCII PNHEKRSGKL DAFLVLEQLR
710 720 730 740 750
CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LAANAIPKGF MDGKQACILM
760 770 780 790 800
IKALELDPNL YRIGQSKIFF RTGVLAHLEE ERDLKITDVI MAFQAMCRGY
810 820 830 840 850
LARKAFAKRQ QQLTAMKVIQ RNCAAYLKLR NWQWWRLFTK VKPLLQVTRQ
860 870 880 890 900
EEEMQAKEDE LQKIKERQQK AESELQELQQ KHTQLSEEKN LLQEQLQAET
910 920 930 940 950
ELYAEAEEMR VRLAAKKQEL EEILHEMEAR LEEEEDRGQQ LQAERKKMAQ
960 970 980 990 1000
QMLDLEEQLE EEEAARQKLQ LEKVTAEAKI KKLEDDILVM DDQNNKLSKE
1010 1020 1030 1040 1050
RKLLEERISD LTTNLAEEEE KAKNLTKLKN KHESMISELE VRLKKEEKSR
1060 1070 1080 1090 1100
QELEKLKRKM DGEASDLHEQ IADLQAQIAE LKMQLAKKEE ELQAALARLE
1110 1120 1130 1140 1150
DETSQKNNAL KKIRELEGHI SDLQEDLDSE RAARNKAEKQ KRDLGEELEA
1160 1170 1180 1190 1200
LKTELEDTLD TTATQQELRA KREQEVTVLK KALDEETRSH EAQVQEMRQK
1210 1220 1230 1240 1250
HTQVVEELTE QLEQFKRAKA NLDKTKQTLE KENADLAGEL RVLGQAKQEV
1260 1270 1280 1290 1300
EHKKKKLEVQ LQELQSKCSD GERARAELND KVHKLQNEVE SVTGMLSEAE
1310 1320 1330 1340 1350
GKAIKLAKEV ASLGSQLQDT QELLQEETRQ KLNVSTKLRQ LEDERNSLQE
1360 1370 1380 1390 1400
QLDEEMEAKQ NLERHISTLN IQLSDSKKKL QDFASTVESL EEGKKRFQKE
1410 1420 1430 1440 1450
IESLTQQYEE KAAAYDKLEK TKNRLQQELD DLVVDLDNQR QLVSNLEKKQ
1460 1470 1480 1490 1500
KKFDQLLAEE KNISSKYADE RDRAEAEARE KETKALSLAR ALEEALEAKE
1510 1520 1530 1540 1550
ELERTNKMLK AEMEDLVSSK DDVGKNVHEL EKSKRALETQ MEEMKTQLEE
1560 1570 1580 1590 1600
LEDELQATED AKLRLEVNMQ ALKVQFERDL QARDEQNEEK RRQLQRQLHE
1610 1620 1630 1640 1650
YETELEDERK QRALAAAAKK KLEGDLKDLE LQADSAIKGR EEAIKQLLKL
1660 1670 1680 1690 1700
QAQMKDFQRE LEDARASRDE IFATAKENEK KAKSLEADLM QLQEDLAAAE
1710 1720 1730 1740 1750
RARKQADLEK EELAEELASS LSGRNALQDE KRRLEARIAQ LEEELEEEQG
1760 1770 1780 1790 1800
NMEAMSDRVR KATQQAEQLS NELATERSTA QKNESARQQL ERQNKELKSK
1810 1820 1830 1840 1850
LQEMEGAVKS KFKSTIAALE AKIAQLEEQV EQEAREKQAA AKALKQRDKK
1860 1870 1880 1890 1900
LKEMLLQVED ERKMAEQYKE QAEKGNAKVK QLKRQLEEAE EESQRINANR
1910 1920 1930 1940 1950
RKLQRELDEA TESNEAMGRE VNALKSKLRR GNETSFVPTR RSGGRRVIEN
1960 1970
ADGSEEEVDA RDADFNGTKS SE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77812 mRNA Translation: AAA31395.1 |
RefSeqi | NP_001075777.1, NM_001082308.1 |
Genome annotation databases
GeneIDi | 100009145 |
KEGGi | ocu:100009145 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77812 mRNA Translation: AAA31395.1 |
RefSeqi | NP_001075777.1, NM_001082308.1 |
3D structure databases
SMRi | P35748 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P35748, 1 interactor |
STRINGi | 9986.ENSOCUP00000024188 |
Proteomic databases
PRIDEi | P35748 |
Genome annotation databases
GeneIDi | 100009145 |
KEGGi | ocu:100009145 |
Organism-specific databases
CTDi | 4629 |
Phylogenomic databases
eggNOGi | KOG0161, Eukaryota |
InParanoidi | P35748 |
OrthoDBi | 47111at2759 |
Family and domain databases
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYH11_RABIT | |
Accessioni | P35748Primary (citable) accession number: P35748 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families