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Entry version 160 (02 Jun 2021)
Sequence version 1 (01 Jun 1994)
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Protein

Manganese resistance protein MNR2

Gene

MNR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Present with 259 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • magnesium ion transmembrane transporter activity Source: SGD

GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.35.2.2, the cora metal ion transporter (mit) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Manganese resistance protein MNR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MNR2
Ordered Locus Names:YKL064W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001547, MNR2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YKL064W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 912CytoplasmicSequence analysisAdd BLAST912
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei913 – 933HelicalSequence analysisAdd BLAST21
Topological domaini934 – 941ExtracellularSequence analysis8
Transmembranei942 – 962HelicalSequence analysisAdd BLAST21
Topological domaini963 – 969CytoplasmicSequence analysis7

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002015371 – 969Manganese resistance protein MNR2Add BLAST969

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei177PhosphothreonineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei571PhosphothreonineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35724

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35724

PRoteomics IDEntifications database

More...
PRIDEi
P35724

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35724

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34069, 111 interactors

Database of interacting proteins

More...
DIPi
DIP-8080N

Protein interaction database and analysis system

More...
IntActi
P35724, 5 interactors

Molecular INTeraction database

More...
MINTi
P35724

STRING: functional protein association networks

More...
STRINGi
4932.YKL064W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P35724, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni96 – 153DisorderedSequence analysisAdd BLAST58
Regioni167 – 186DisorderedSequence analysisAdd BLAST20
Regioni199 – 256DisorderedSequence analysisAdd BLAST58
Regioni559 – 662DisorderedSequence analysisAdd BLAST104
Regioni746 – 769DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 24Polar residuesSequence analysisAdd BLAST24
Compositional biasi107 – 127Polar residuesSequence analysisAdd BLAST21
Compositional biasi559 – 580Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi581 – 609Polar residuesSequence analysisAdd BLAST29
Compositional biasi618 – 633Polar residuesSequence analysisAdd BLAST16
Compositional biasi634 – 662Basic and acidic residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPTQ, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007127_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35724

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSEIGMY

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12829, Alr1p-like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR044089, Alr1-like
IPR002523, MgTranspt_CorA/ZnTranspt_ZntB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01544, CorA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P35724-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTDNSQKDE GVPLLSPYSS SPQLRKKKRN QKRRKDKFVG HLKSDSRRPT
60 70 80 90 100
QLLHDNLQHN HGQITDFDQI DSWGMLHESD STSNDIIKSE DPSLKGAFID
110 120 130 140 150
HRPSMSQPRE GPQSVSSTVQ PQPIMKFSTP SYKKPAGLRP SDQNRSLVSD
160 170 180 190 200
LSPSELESWL KRRKSVHKSF VDENSPTDRR QSNANNDVVI DVDALMNHVN
210 220 230 240 250
NNASTGVNDN SKRRKKKRGS DDSSNKNSKS TSSDSNDEED EYNSRPSSSL
260 270 280 290 300
SSNNSSLDDV CLVLDDEGSE VPKAWPDCTV LEEFSKEETE RLRSQAIQDA
310 320 330 340 350
EAFHFQYDED EEDGTSNEDG ILFSKPIVTN IDVPELGNRR VNETENLKNG
360 370 380 390 400
RLRPKRIAPW HLIQRPMVLG SNSTKDSKSR IQSGLQDNLL VGRNIQYPPH
410 420 430 440 450
IISNNPEHFR FTYFRVDLDS TVHSPTISGL LQPGQKFQDL FVASIYSQDN
460 470 480 490 500
SAGHIKTHPN SPTPGIKAET VSQLQGLTAK NPSTLSSMSV ANIEDVPPFW
510 520 530 540 550
LDVSNPTEEE MKILSKAFGI HPLTTEDIFL GEVREKVELF RDYYLICFRS
560 570 580 590 600
FDIVAEKHVR RRRKEKQESA TLDHESISRR KSQAYGATMS NESNANNNNS
610 620 630 640 650
TSNASRSKWL PSILRARRRS SANRTTNTSS SSYKRRVKSE KKKMEENEKF
660 670 680 690 700
KRKSGDRHKP REGELEPLNV YIIVFRTGVL TFHFAPTPHP INVRRRARLL
710 720 730 740 750
KDYLNVTSDW IAYALIDDIT DAFAPMIELI EDEVYEIEDA ILKMHQSDDS
760 770 780 790 800
SDSDSSDSDS DSGASDEDAF PFDVYSKKTS YSSAKSSVSS RSMSTSEASF
810 820 830 840 850
NANLIGWKRK GDMLRRIGEC RKRVMSILRL LGSKADVIKG FAKRYNEQWE
860 870 880 890 900
ASPQSEIAMY LGDIQDHIVT MVSSLNHYEK LLSRSHSNYL AQINIDMTKV
910 920 930 940 950
NNDMNDVLGK ITILGTIVLP MNVITGLWGM NVIVPGQYRD SLTWFIGIVL
960
FMCMLACSAY MYTKRRFGF
Length:969
Mass (Da):109,737
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48D2125A1211104E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75781 Genomic DNA Translation: CAA53410.1
Z28064 Genomic DNA Translation: CAA81901.1
BK006944 Genomic DNA Translation: DAA09093.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S37886

NCBI Reference Sequences

More...
RefSeqi
NP_012859.1, NM_001179630.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL064W_mRNA; YKL064W; YKL064W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853801

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL064W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75781 Genomic DNA Translation: CAA53410.1
Z28064 Genomic DNA Translation: CAA81901.1
BK006944 Genomic DNA Translation: DAA09093.1
PIRiS37886
RefSeqiNP_012859.1, NM_001179630.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi34069, 111 interactors
DIPiDIP-8080N
IntActiP35724, 5 interactors
MINTiP35724
STRINGi4932.YKL064W

Protein family/group databases

TCDBi1.A.35.2.2, the cora metal ion transporter (mit) family

PTM databases

iPTMnetiP35724

Proteomic databases

MaxQBiP35724
PaxDbiP35724
PRIDEiP35724

Genome annotation databases

EnsemblFungiiYKL064W_mRNA; YKL064W; YKL064W
GeneIDi853801
KEGGisce:YKL064W

Organism-specific databases

SGDiS000001547, MNR2
VEuPathDBiFungiDB:YKL064W

Phylogenomic databases

eggNOGiENOG502QPTQ, Eukaryota
HOGENOMiCLU_007127_3_0_1
InParanoidiP35724
OMAiRSEIGMY

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P35724
RNActiP35724, protein

Family and domain databases

CDDicd12829, Alr1p-like, 1 hit
InterProiView protein in InterPro
IPR044089, Alr1-like
IPR002523, MgTranspt_CorA/ZnTranspt_ZntB
PfamiView protein in Pfam
PF01544, CorA, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMNR2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35724
Secondary accession number(s): D6VXM3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 2, 2021
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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