SOX11

Functionⁱ

Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	49 – 117	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
enhancer sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19808959
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: UniProtKB
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21124928
transcription coactivator activity Source: UniProtKB
transcription regulatory region sequence-specific DNA binding Source: UniProtKB
translation factor activity, RNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10606637

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac ventricle formation Source: UniProtKB
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
closure of optic fissure Source: UniProtKB
cornea development in camera-type eye Source: UniProtKB
embryonic digestive tract morphogenesis Source: UniProtKB
embryonic skeletal system morphogenesis Source: UniProtKB
eyelid development in camera-type eye Source: UniProtKB
glial cell development Source: UniProtKB
glial cell proliferation Source: UniProtKB
hard palate development Source: UniProtKB
kidney development Source: Ensembl
lens morphogenesis in camera-type eye Source: UniProtKB
limb bud formation Source: UniProtKB
lung morphogenesis Source: UniProtKB
negative regulation of cell death Source: UniProtKB
negative regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19808959
negative regulation of glial cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19808959
negative regulation of lymphocyte proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20624318
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 19808959
negative regulation of transcription regulatory region DNA binding Source: UniProtKB
neural crest cell development Source: UniProtKB
neural tube formation Source: UniProtKB
neuroepithelial cell differentiation Source: UniProtKB
neuron differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 10574465
noradrenergic neuron differentiation Source: UniProtKB
oligodendrocyte development Source: Ensembl
outflow tract morphogenesis Source: UniProtKB
positive regulation of BMP signaling pathway Source: UniProtKB
positive regulation of cell proliferation Source: UniProtKB
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19808959
positive regulation of hippo signaling Source: UniProtKB
positive regulation of hormone secretion Source: UniProtKB
positive regulation of lens epithelial cell proliferation Source: UniProtKB
positive regulation of neurogenesis Source: UniProtKB
positive regulation of neuron differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19808959
positive regulation of ossification
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20626275
positive regulation of osteoblast differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20626275
positive regulation of stem cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20626275
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 21124928
regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transforming growth factor beta receptor signaling pathway
Source: UniProtKB
Inferred from expression patternⁱ
- 20624318
signal transduction involved in cell cycle checkpoint
Source: UniProtKB
Inferred from expression patternⁱ
- 20624318
skeletal muscle cell differentiation Source: Ensembl
skeletal system development Source: UniProtKB
soft palate development Source: UniProtKB
somite development Source: UniProtKB
spinal cord development Source: UniProtKB
sympathetic nervous system development Source: UniProtKB
ventricular septum morphogenesis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P35716

SIGNORⁱ

P35716

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor SOX-11
Gene namesⁱ	Name:SOX11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176887.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11191 SOX11
MIMⁱ	600898 gene
neXtProtⁱ	NX_P35716

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mental retardation, autosomal dominant 27 (MRD27)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD27 patients show dysmorphic facial features, microcephaly, growth deficiency, hypoplastic fifth toenails, and mild intellectual disability.

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6664
MalaCards human disease database More...MalaCardsⁱ	SOX11
MIMⁱ	615866 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000176887
Orphanetⁱ	1465 Coffin-Siris syndrome
PharmGKBⁱ	PA36028

Polymorphism and mutation databases

BioMutaⁱ	SOX11
DMDMⁱ	1351142

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048750	1 – 441	Transcription factor SOX-11Add BLAST		441

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	206	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P35716
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35716
PaxDbⁱ	P35716
PeptideAtlas More...PeptideAtlasⁱ	P35716
PRIDEⁱ	P35716
ProteomicsDBⁱ	55146

PTM databases

iPTMnetⁱ	P35716
PhosphoSitePlusⁱ	P35716

Expressionⁱ

Tissue specificityⁱ

Expressed mainly in the nervous system, brain (fetus and adult) and hear (adult).2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000176887 Expressed in 76 organ(s), highest expression level in forebrain
CleanExⁱ	HS_SOX11
Genevisibleⁱ	P35716 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB056152 CAB056153 HPA000536

HPAⁱ

CAB056152
CAB056153
HPA000536

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112547, 2 interactors
IntActⁱ	P35716, 1 interactor
STRINGⁱ	9606.ENSP00000322568

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35716
SMRⁱ	P35716
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	144 – 148	Poly-Gly	5
Compositional biasⁱ	207 – 214	Poly-Gly	8
Compositional biasⁱ	223 – 233	Poly-AspAdd BLAST	11
Compositional biasⁱ	338 – 354	Poly-SerAdd BLAST	17

Phylogenomic databases

eggNOGⁱ	ENOG410IPZ2 Eukaryota ENOG4110BIV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231874
HOVERGENⁱ	HBG005040
InParanoidⁱ	P35716
KEGG Orthology (KO) More...KOⁱ	K09268
OMAⁱ	VKCVFMD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F15
PhylomeDBⁱ	P35716
TreeFamⁱ	TF351735

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR029551 SOX-11 IPR017386 SOX-11/4
PANTHERⁱ	PTHR10270:SF113 PTHR10270:SF113, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
PIRSFⁱ	PIRSF038098 SOX-12/11/4a, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P35716-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK 
        60         70         80         90        100
RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR 
       110        120        130        140        150
EAERLRLKHM ADYPDYKYRP RKKPKMDPSA KPSASQSPEK SAAGGGGGSA 
       160        170        180        190        200
GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA GAGKAAQSGD YGGAGDDYVL 
       210        220        230        240        250
GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK QEPDEEDEEP 
       260        270        280        290        300
PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG 
       310        320        330        340        350
ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS 
       360        370        380        390        400
SGSSGEDADD LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD 
       410        420        430        440 
SFSEGSLGSH FEFPDYCTPE LSEMIAGDWL EANFSDLVFT Y

Length:441

Mass (Da):46,679

Last modified:February 1, 1996 - v2

Checksum:ⁱ50567A654F503C63

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071461	60	S → P in MRD27; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777480EnsemblClinVar.		1
Natural variantⁱVAR_071462	116	Y → C in MRD27; decreases transcriptional activity. 1 PublicationCorresponds to variant dbSNP:rs587777479EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U23752 mRNA Translation: AAB08518.1 AB028641 mRNA Translation: BAA88122.1 AC108025 Genomic DNA Translation: AAX88930.1 X73038 Genomic DNA Translation: CAA51519.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1654.1
PIRⁱ	G01758 S34118
NCBI Reference Sequences More...RefSeqⁱ	NP_003099.1, NM_003108.3
UniGeneⁱ	Hs.432638

Genome annotation databases

Ensemblⁱ	ENST00000322002; ENSP00000322568; ENSG00000176887
GeneIDⁱ	6664
KEGGⁱ	hsa:6664
UCSC genome browser More...UCSCⁱ	uc002qyj.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35716	Transcription factor SOX		GORGO		441	UniRef100_P35716
SOX11 protein (Fragment)		HUMAN		173

Protein	Similar proteins		Species	Score	Length	Source
P35716	Transcription factor SOX		GORGO		441	UniRef90_P35716
SOX11 protein (Fragment)		HUMAN		173
Transcription factor SOX		PROCO		442
Transcription factor SOX		PANTR		441
Transcription factor SOX		MACMU		441
+13

Protein	Similar proteins		Species	Score	Length	Source
P35716	Transcription factor SOX		GORGO		441	UniRef50_P35716
SOX11 protein (Fragment)		HUMAN		173
Transcription factor SOX		PROCO		442
Transcription factor SOX		PANTR		441
Transcription factor SOX		MACMU		441
+62

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U23752 mRNA Translation: AAB08518.1 AB028641 mRNA Translation: BAA88122.1 AC108025 Genomic DNA Translation: AAX88930.1 X73038 Genomic DNA Translation: CAA51519.1
CCDSⁱ	CCDS1654.1
PIRⁱ	G01758 S34118
RefSeqⁱ	NP_003099.1, NM_003108.3
UniGeneⁱ	Hs.432638

3D structure databases

ProteinModelPortalⁱ	P35716
SMRⁱ	P35716
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112547, 2 interactors
IntActⁱ	P35716, 1 interactor
STRINGⁱ	9606.ENSP00000322568

PTM databases

iPTMnetⁱ	P35716
PhosphoSitePlusⁱ	P35716

Polymorphism and mutation databases

BioMutaⁱ	SOX11
DMDMⁱ	1351142

Proteomic databases

EPDⁱ	P35716
MaxQBⁱ	P35716
PaxDbⁱ	P35716
PeptideAtlasⁱ	P35716
PRIDEⁱ	P35716
ProteomicsDBⁱ	55146

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6664
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000322002; ENSP00000322568; ENSG00000176887
GeneIDⁱ	6664
KEGGⁱ	hsa:6664
UCSCⁱ	uc002qyj.3 human

Organism-specific databases

CTDⁱ	6664
DisGeNETⁱ	6664
EuPathDBⁱ	HostDB:ENSG00000176887.6
GeneCardsⁱ	SOX11
HGNCⁱ	HGNC:11191 SOX11
HPAⁱ	CAB056152 CAB056153 HPA000536
MalaCardsⁱ	SOX11
MIMⁱ	600898 gene 615866 phenotype
neXtProtⁱ	NX_P35716
OpenTargetsⁱ	ENSG00000176887
Orphanetⁱ	1465 Coffin-Siris syndrome
PharmGKBⁱ	PA36028
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPZ2 Eukaryota ENOG4110BIV LUCA
GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231874
HOVERGENⁱ	HBG005040
InParanoidⁱ	P35716
KOⁱ	K09268
OMAⁱ	VKCVFMD
OrthoDBⁱ	EOG091G0F15
PhylomeDBⁱ	P35716
TreeFamⁱ	TF351735

Enzyme and pathway databases

SIGNORⁱ	P35716

SIGNORⁱ

P35716

Miscellaneous databases

ChiTaRSⁱ	SOX11 human
GeneWikiⁱ	SOX11
GenomeRNAiⁱ	6664
Protein Ontology More...PROⁱ	PR:P35716
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000176887 Expressed in 76 organ(s), highest expression level in forebrain
CleanExⁱ	HS_SOX11
Genevisibleⁱ	P35716 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR029551 SOX-11 IPR017386 SOX-11/4
PANTHERⁱ	PTHR10270:SF113 PTHR10270:SF113, 1 hit
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit
PIRSFⁱ	PIRSF038098 SOX-12/11/4a, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOX11_HUMAN
Accessionⁱ	P35716Primary (citable) accession number: P35716 Secondary accession number(s): Q4ZFV8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35716 (SOX11_HUMAN)

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Transcription factor SOX-11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ