Transcription factor SOX-11

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
• DNA-binding transcription factor activity Source: UniProtKB
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation."
    Hide T., Takezaki T., Nakatani Y., Nakamura H., Kuratsu J., Kondo T.
    Cancer Res 69:7953-7959(2009) [PubMed] [Europe PMC] [Abstract]
  • "Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma."
    Wang X., Bjorklund S., Wasik A.M., Grandien A., Andersson P., Kimby E., Dahlman-Wright K., Zhao C., Christensson B., Sander B.
    PLoS One 5:e14085-e14085(2010) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: UniProtKB

GO - Biological processⁱ

• anatomical structure morphogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cardiac ventricle formation Source: UniProtKB
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• closure of optic fissure Source: UniProtKB
• cornea development in camera-type eye Source: UniProtKB
• embryonic digestive tract morphogenesis Source: UniProtKB
• embryonic skeletal system morphogenesis Source: UniProtKB
• eyelid development in camera-type eye Source: UniProtKB
• glial cell development Source: UniProtKB
• glial cell proliferation Source: UniProtKB
• hard palate development Source: UniProtKB
• kidney development Source: Ensembl
• lens morphogenesis in camera-type eye Source: UniProtKB
• limb bud formation Source: UniProtKB
• lung morphogenesis Source: UniProtKB
• negative regulation of cell death Source: UniProtKB
• negative regulation of gene expression Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation."
    Hide T., Takezaki T., Nakatani Y., Nakamura H., Kuratsu J., Kondo T.
    Cancer Res 69:7953-7959(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of glial cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation."
    Hide T., Takezaki T., Nakatani Y., Nakamura H., Kuratsu J., Kondo T.
    Cancer Res 69:7953-7959(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of lymphocyte proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies."
    Gustavsson E., Sernbo S., Andersson E., Brennan D.J., Dictor M., Jerkeman M., Borrebaeck C.A., Ek S.
    Mol Cancer 9:187-187(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • "Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation."
    Hide T., Takezaki T., Nakatani Y., Nakamura H., Kuratsu J., Kondo T.
    Cancer Res 69:7953-7959(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription regulatory region DNA binding Source: UniProtKB
• neural crest cell development Source: UniProtKB
• neural tube formation Source: UniProtKB
• neuroepithelial cell differentiation Source: UniProtKB
• neuron differentiation Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.2

    "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region."
    Azuma T., Ao S., Saito Y., Yano K., Seki N., Wakao H., Masuho Y., Muramatsu M.
    DNA Res. 6:357-360(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• noradrenergic neuron differentiation Source: UniProtKB
• oligodendrocyte development Source: Ensembl
• outflow tract morphogenesis Source: UniProtKB
• positive regulation of BMP signaling pathway Source: UniProtKB
• positive regulation of cell population proliferation Source: UniProtKB
• positive regulation of gene expression Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation."
    Hide T., Takezaki T., Nakatani Y., Nakamura H., Kuratsu J., Kondo T.
    Cancer Res 69:7953-7959(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of hippo signaling Source: UniProtKB
• positive regulation of hormone secretion Source: UniProtKB
• positive regulation of lens epithelial cell proliferation Source: UniProtKB
• positive regulation of neurogenesis Source: UniProtKB
• positive regulation of neuron differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation."
    Hide T., Takezaki T., Nakatani Y., Nakamura H., Kuratsu J., Kondo T.
    Cancer Res 69:7953-7959(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ossification Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells."
    Larson B.L., Ylostalo J., Lee R.H., Gregory C., Prockop D.J.
    Tissue Eng Part A 16:3385-3394(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of osteoblast differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells."
    Larson B.L., Ylostalo J., Lee R.H., Gregory C., Prockop D.J.
    Tissue Eng Part A 16:3385-3394(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of stem cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells."
    Larson B.L., Ylostalo J., Lee R.H., Gregory C., Prockop D.J.
    Tissue Eng Part A 16:3385-3394(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from direct assayⁱ
  • "Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma."
    Wang X., Bjorklund S., Wasik A.M., Grandien A., Andersson P., Kimby E., Dahlman-Wright K., Zhao C., Christensson B., Sander B.
    PLoS One 5:e14085-e14085(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKBInferred from expression patternⁱ
  • "SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies."
    Gustavsson E., Sernbo S., Andersson E., Brennan D.J., Dictor M., Jerkeman M., Borrebaeck C.A., Ek S.
    Mol Cancer 9:187-187(2010) [PubMed] [Europe PMC] [Abstract]
• signal transduction involved in cell cycle checkpoint Source: UniProtKBInferred from expression patternⁱ
  • "SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies."
    Gustavsson E., Sernbo S., Andersson E., Brennan D.J., Dictor M., Jerkeman M., Borrebaeck C.A., Ek S.
    Mol Cancer 9:187-187(2010) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle cell differentiation Source: Ensembl
• skeletal system development Source: UniProtKB
• soft palate development Source: UniProtKB
• somite development Source: UniProtKB
• spinal cord development Source: UniProtKB
• sympathetic nervous system development Source: UniProtKB
• ventricular septum morphogenesis Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVQQAESLEA ESNLPREALD TEEGEFMACS PVALDESDPD WCKTASGHIK 
        60         70         80         90        100
RPMNAFMVWS KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR 
       110        120        130        140        150
EAERLRLKHM ADYPDYKYRP RKKPKMDPSA KPSASQSPEK SAAGGGGGSA 
       160        170        180        190        200
GGGAGGAKTS KGSSKKCGKL KAPAAAGAKA GAGKAAQSGD YGGAGDDYVL 
       210        220        230        240        250
GSLRVSGSGG GGAGKTVKCV FLDEDDDDDD DDDELQLQIK QEPDEEDEEP 
       260        270        280        290        300
PHQQLLQPPG QQPSQLLRRY NVAKVPASPT LSSSAESPEG ASLYDEVRAG 
       310        320        330        340        350
ATSGAGGGSR LYYSFKNITK QHPPPLAQPA LSPASSRSVS TSSSSSSGSS 
       360        370        380        390        400
SGSSGEDADD LMFDLSLNFS QSAHSASEQQ LGGGAAAGNL SLSLVDKDLD 
       410        420        430        440 
SFSEGSLGSH FEFPDYCTPE LSEMIAGDWL EANFSDLVFT Y          

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 2
   Human chromosome 2: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references