Transcription factor SOX-6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 1614875
• DNA-binding transcription factor activity Source: UniProtKBNon-traceable author statementⁱ
  • 1614875
• protein heterodimerization activity Source: Ensembl
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
• RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
• transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

• astrocyte differentiation Source: Ensembl
• cardiac muscle cell differentiation Source: Ensembl
• cartilage development Source: Ensembl
• cell morphogenesis Source: Ensembl
• cellular response to transforming growth factor beta stimulus Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 21401405
• erythrocyte development Source: Ensembl
• gene silencing Source: Ensembl
• in utero embryonic development Source: Ensembl
• muscle organ development Source: UniProtKBNon-traceable author statementⁱ
  • 11255018
• negative regulation of cardiac muscle cell differentiation Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 20081117
• oligodendrocyte cell fate specification Source: Ensembl
• positive regulation of cartilage development Source: UniProtKBInferred from direct assayⁱ
  • 21401405
• positive regulation of chondrocyte differentiation Source: UniProtKBInferred from direct assayⁱ
  • 21401405
• positive regulation of mesenchymal stem cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • 21401405
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• post-embryonic development Source: Ensembl
• regulation of transcription, DNA-templated Source: UniProtKBNon-traceable author statementⁱ
  • 1614875
• transcription, DNA-templated Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Coiled coil

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSSKQATSPF ACAADGEDAM TQDLTSREKE EGSDQHVASH LPLHPIMHNK 
        60         70         80         90        100
PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH 
       110        120        130        140        150
KPDEGSRDRE IMTSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS 
       160        170        180        190        200
SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS 
       210        220        230        240        250
LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK 
       260        270        280        290        300
INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG 
       310        320        330        340        350
DNYPVQFIPS TMAAAAASGL SPLQLQKGHV SHPQINQRLK GLSDRFGRNL 
       360        370        380        390        400
DTFEHGGGHS YNHKQIEQLY AAQLASMQVS PGAKMPSTPQ PPNTAGTVSP 
       410        420        430        440        450
TGIKNEKRGT SPVTQVKDEA AAQPLNLSSR PKTAEPVKSP TSPTQNLFPA 
       460        470        480        490        500
SKTSPVNLPN KSSIPSPIGG SLGRGSSLDI LSSLNSPALF GDQDTVMKAI 
       510        520        530        540        550
QEARKMREQI QREQQQQQPH GVDGKLSSIN NMGLNSCRNE KERTRFENLG 
       560        570        580        590        600
PQLTGKSNED GKLGPGVIDL TRPEDAEGSK AMNGSAAKLQ QYYCWPTGGA 
       610        620        630        640        650
TVAEARVYRD ARGRASSEPH IKRPMNAFMV WAKDERRKIL QAFPDMHNSN 
       660        670        680        690        700
ISKILGSRWK SMSNQEKQPY YEEQARLSKI HLEKYPNYKY KPRPKRTCIV 
       710        720        730        740        750
DGKKLRIGEY KQLMRSRRQE MRQFFTVGQQ PQIPITTGTG VVYPGAITMA 
       760        770        780        790        800
TTTPSPQMTS DCSSTSASPE PSLPVIQSTY GMKTDGGSLA GNEMINGEDE 
       810        820 
MEMYDDYEDD PKSDYSSENE APEAVSAN                         

        10         20         30         40         50
MGRMSSKQAT SPFACAADGE DAMTQDLTSR EKEEGSDQHV ASHLPLHPIM 
        60         70         80         90        100
HNKPHSEELP TLVSTIQQDA DWDSVLSSQQ RMESENNKLC SLYSFRNTST 
       110        120        130        140        150
SPHKPDEGSR DREIMTSVTF GTPERRKGSL ADVVDTLKQK KLEEMTRTEQ 
       160        170        180        190        200
EDSSCMEKLL SKDWKEKMER LNTSELLGEI KGTPESLAEK ERQLSTMITQ 
       210        220        230        240        250
LISLREQLLA AHDEQKKLAA SQIEKQRQQM DLARQQQEQI ARQQQQLLQQ 
       260        270        280        290        300
QHKINLLQQQ IQVQGHMPPL MIPIFPHDQR TLAAAAAAQQ GFLFPPGITY 
       310        320        330        340        350
KPGDNYPVQF IPSTMAAAAA SGLSPLQLQQ LYAAQLASMQ VSPGAKMPST 
       360        370        380        390        400
PQPPNTAGTV SPTGIKNEKR GTSPVTQVKD EAAAQPLNLS SRPKTAEPVK 
       410        420        430        440        450
SPTSPTQNLF PASKTSPVNL PNKSSIPSPI GGSLGRGSSL GKWKSQHQEE 
       460        470        480        490        500
TYELDILSSL NSPALFGDQD TVMKAIQEAR KMREQIQREQ QQQQPHGVDG 
       510        520        530        540        550
KLSSINNMGL NSCRNEKERT RFENLGPQLT GKSNEDGKLG PGVIDLTRPE 
       560        570        580        590        600
DAEGSKAMNG SAAKLQQYYC WPTGGATVAE ARVYRDARGR ASSEPHIKRP 
       610        620        630        640        650
MNAFMVWAKD ERRKILQAFP DMHNSNISKI LGSRWKSMSN QEKQPYYEEQ 
       660        670        680        690        700
ARLSKIHLEK YPNYKYKPRP KRTCIVDGKK LRIGEYKQLM RSRRQEMRQF 
       710        720        730        740        750
FTVGQQPQIP ITTGTGVVYP GAITMATTTP SPQMTSDCSS TSASPEPSLP 
       760        770        780        790        800
VIQSTYGMKT DGGSLAGNEM INGEDEMEMY DDYEDDPKSD YSSENEAPEA 

VSAN                                                   

        10         20         30         40         50
MSSKQATSPF ACAADGEDAM TQDLTSREKE EGSDQHVASH LPLHPIMHNK 
        60         70         80         90        100
PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH 
       110        120        130        140        150
KPDEGSRDRE IMTSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS 
       160        170        180        190        200
SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS 
       210        220        230        240        250
LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK 
       260        270        280        290        300
INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG 
       310        320        330        340        350
DNYPVQFIPS TMAAAAASGL SPLQLQKGHV SHPQINQRLK GLSDRFGRNL 
       360        370        380        390        400
DTFEHGGGHS YNHKQIEQLY AAQLASMQVS PGAKMPSTPQ PPNTAGTVSP 
       410        420        430        440        450
TGIKNEKRGT SPVTQVKDEA AAQPLNLSSR PKTAEPVKSP TSPTQNLFPA 
       460        470        480        490        500
SKTSPVNLPN KSSIPSPIGG SLGRGSSLDI LSSLNSPALF GDQDTVMKAI 
       510        520        530        540        550
QEARKMREQI QREQQQQQPH GVDGKLSSIN NMGLNSCRNE KERTRFENLG 
       560        570        580        590        600
PQLTGKSNED GKLGPGVIDL TRPEDAEGGA TVAEARVYRD ARGRASSEPH 
       610        620        630        640        650
IKRPMNAFMV WAKDERRKIL QAFPDMHNSN ISKILGSRWK SMSNQEKQPY 
       660        670        680        690        700
YEEQARLSKI HLEKYPNYKY KPRPKRTCIV DGKKLRIGEY KQLMRSRRQE 
       710        720        730        740        750
MRQFFTVGQQ PQIPITTGTG VVYPGAITMA TTTPSPQMTS DCSSTSASPE 
       760        770        780        790        800
PSLPVIQSTY GMKTDGGSLA GNEMINGEDE MEMYDDYEDD PKSDYSSENE 

APEAVSAN                                               

        10         20         30         40         50
MSSKQATSPF ACAADGEDAM TQDLTSREKE EGSDQHVASH LPLHPIMHNK 
        60         70         80         90        100
PHSEELPTLV STIQQDADWD SVLSSQQRME SENNKLCSLY SFRNTSTSPH 
       110        120        130        140        150
KPDEGSRDRE IMTSVTFGTP ERRKGSLADV VDTLKQKKLE EMTRTEQEDS 
       160        170        180        190        200
SCMEKLLSKD WKEKMERLNT SELLGEIKGT PESLAEKERQ LSTMITQLIS 
       210        220        230        240        250
LREQLLAAHD EQKKLAASQI EKQRQQMDLA RQQQEQIARQ QQQLLQQQHK 
       260        270        280        290        300
INLLQQQIQV QGHMPPLMIP IFPHDQRTLA AAAAAQQGFL FPPGITYKPG 
       310        320        330        340        350
DNYPVQFIPS TMAAAAASGL SPLQLQQLYA AQLASMQVSP GAKMPSTPQP 
       360        370        380        390        400
PNTAGTVSPT GIKNEKRGTS PVTQVKDEAA AQPLNLSSRP KTAEPVKSPT 
       410        420        430        440        450
SPTQNLFPAS KTSPVNLPNK SSIPSPIGGS LGRGSSLGKW KSQHQEETYE 
       460        470        480        490        500
LDILSSLNSP ALFGDQDTVM KAIQEARKMR EQIQREQQQQ QPHGVDGKLS 
       510        520        530        540        550
SINNMGLNSC RNEKERTRFE NLGPQLTGKS NEDGKLGPGV IDLTRPEDAE 
       560        570        580        590        600
GSKAMNGSAA KLQQYYCWPT GGATVAEARV YRDARGRASS EPHIKRPMNA 
       610        620        630        640        650
FMVWAKDERR KILQAFPDMH NSNISKILGS RWKSMSNQEK QPYYEEQARL 
       660        670        680        690        700
SKIHLEKYPN YKYKPRPKRT CIVDGKKLRI GEYKQLMRSR RQEMRQFFTV 
       710        720        730        740        750
GQQPQIPITT GTGVVYPGAI TMATTTPSPQ MTSDCSSTSA SPEPSLPVIQ 
       760        770        780        790        800
STYGMKTDGG SLAGNEMING EDEMEMYDDY EDDPKSDYSS ENEAPEAVSA 

N                                                      

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 11
   Human chromosome 11: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot