UniProtKB - P35672 (SCTC_SALTY)
Type 3 secretion system secretin
sctC
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- pathogenesis Source: UniProtKB-KW
- protein secretion Source: GO_Central
- protein secretion by the type III secretion system Source: UniProtKB-UniRule
Keywordsi
Biological process | Protein transport, Translocation, Transport, Virulence |
Protein family/group databases
TCDBi | 1.B.22.3.2, the outer bacterial membrane secretin (secretin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Type 3 secretion system secretinUniRule annotationCuratedShort name: T3SS secretinUniRule annotationCurated Alternative name(s): Protein InvG |
Gene namesi | Name:sctC1 PublicationUniRule annotation Synonyms:invG1 Publication Ordered Locus Names:STM2898 |
Organismi | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
Taxonomic identifieri | 99287 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
- Cell outer membrane UniRule annotation2 Publications Note: Localization to the outer membrane requires InvH/SctG.1 Publication
GO - Cellular componenti
- cell outer membrane Source: UniProtKB-SubCell
- type III protein secretion system complex Source: CACAO
- type II protein secretion system complex Source: GO_Central
Keywords - Cellular componenti
Cell outer membrane, MembranePathology & Biotechi
Disruption phenotypei
Miscellaneous databases
PHI-basei | PHI:8730 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | UniRule annotationAdd BLAST | 24 | |
ChainiPRO_0000013111 | 25 – 562 | Type 3 secretion system secretinUniRule annotationAdd BLAST | 538 |
Proteomic databases
PaxDbi | P35672 |
Interactioni
Subunit structurei
The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope (PubMed:21385715, PubMed:23633951, PubMed:27974800, PubMed:30242280).
Forms a stable homooligomeric complex (PubMed:9786184, PubMed:21385715, PubMed:23633951, PubMed:27974800, PubMed:30242280). The complex is composed of 15 subunits (PubMed:21385715, PubMed:23633951, PubMed:27974800).
1 Publication5 PublicationsBinary interactionsi
P35672
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-15771877,EBI-15771877 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
DIPi | DIP-48517N |
IntActi | P35672, 2 interactors |
Structurei
Secondary structure
3D structure databases
BMRBi | P35672 |
SMRi | P35672 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35672 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
HOGENOMi | CLU_022474_3_0_6 |
OMAi | VWYDDGA |
PhylomeDBi | P35672 |
Family and domain databases
Gene3Di | 3.30.1370.120, 2 hits |
HAMAPi | MF_02219, Type_III_secretin, 1 hit |
InterProi | View protein in InterPro IPR005644, NolW-like IPR038591, NolW-like_sf IPR004846, T2SS/T3SS IPR004845, T2SS_GspD_CS IPR003522, T3SS_OM_pore_YscC |
Pfami | View protein in Pfam PF00263, Secretin, 1 hit PF03958, Secretin_N, 1 hit |
PRINTSi | PR01337, TYPE3OMGPROT |
TIGRFAMsi | TIGR02516, type_III_yscC, 1 hit |
PROSITEi | View protein in PROSITE PS00875, T2SP_D, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MKTHILLARV LACAALVLVT PGYSSEKIPV TGSGFVAKDD SLRTFFDAMA
60 70 80 90 100
LQLKEPVIVS KMAARKKITG NFEFHDPNAL LEKLSLQLGL IWYFDGQAIY
110 120 130 140 150
IYDASEMRNA VVSLRNVSLN EFNNFLKRSG LYNKNYPLRG DNRKGTFYVS
160 170 180 190 200
GPPVYVDMVV NAATMMDKQN DGIELGRQKI GVMRLNNTFV GDRTYNLRDQ
210 220 230 240 250
KMVIPGIATA IERLLQGEEQ PLGNIVSSEP PAMPAFSANG EKGKAANYAG
260 270 280 290 300
GMSLQEALKQ NAAAGNIKIV AYPDTNSLLV KGTAEQVHFI EMLVKALDVA
310 320 330 340 350
KRHVELSLWI VDLNKSDLER LGTSWSGSIT IGDKLGVSLN QSSISTLDGS
360 370 380 390 400
RFIAAVNALE EKKQATVVSR PVLLTQENVP AIFDNNRTFY TKLIGERNVA
410 420 430 440 450
LEHVTYGTMI RVLPRFSADG QIEMSLDIED GNDKTPQSDT TTSVDALPEV
460 470 480 490 500
GRTLISTIAR VPHGKSLLVG GYTRDANTDT VQSIPFLGKL PLIGSLFRYS
510 520 530 540 550
SKNKSNVVRV FMIEPKEIVD PLTPDASESV NNILKQSGAW SGDDKLQKWV
560
RVYLDRGQEA IK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | A → R in AAA74040 (PubMed:7997169).Curated | 1 | |
Sequence conflicti | 121 | E → Q in AAA74040 (PubMed:7997169).Curated | 1 | |
Sequence conflicti | 197 – 205 | LRDQKMVIP → CAIRKWLFR in AAA74040 (PubMed:7997169).Curated | 9 | |
Sequence conflicti | 232 – 240 | AMPAFSANG → RCQRFQRM in AAA74040 (PubMed:7997169).Curated | 9 | |
Sequence conflicti | 243 | G → S in AAA74040 (PubMed:7997169).Curated | 1 | |
Sequence conflicti | 262 – 264 | AAA → KPAEQ in AAA74040 (PubMed:7997169).Curated | 3 | |
Sequence conflicti | 328 | S → T in CAA53049 (PubMed:7868245).Curated | 1 | |
Sequence conflicti | 328 | S → T in AAA74040 (PubMed:7997169).Curated | 1 | |
Sequence conflicti | 329 | I → V in AAA74040 (PubMed:7997169).Curated | 1 | |
Sequence conflicti | 370 – 380 | RPVLLTQENVP → APGITSSGKCS in AAA74040 (PubMed:7997169).CuratedAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75302 Genomic DNA Translation: CAA53049.1 U08280 Genomic DNA Translation: AAA74040.1 AE006468 Genomic DNA Translation: AAL21778.1 |
PIRi | S54420 |
RefSeqi | NP_461819.1, NC_003197.2 WP_000848113.1, NC_003197.2 |
Genome annotation databases
EnsemblBacteriai | AAL21778; AAL21778; STM2898 |
GeneIDi | 1254421 |
KEGGi | stm:STM2898 |
PATRICi | fig|99287.12.peg.3054 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X75302 Genomic DNA Translation: CAA53049.1 U08280 Genomic DNA Translation: AAA74040.1 AE006468 Genomic DNA Translation: AAL21778.1 |
PIRi | S54420 |
RefSeqi | NP_461819.1, NC_003197.2 WP_000848113.1, NC_003197.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Y9K | electron microscopy | 8.30 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O | 34-170 | [»] | |
3J1V | electron microscopy | - | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O | 22-178 | [»] | |
4G08 | X-ray | 1.80 | A | 22-178 | [»] | |
5TCQ | electron microscopy | 3.60 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O | 1-562 | [»] | |
5TCR | electron microscopy | 6.30 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O | 1-562 | [»] | |
6DV3 | electron microscopy | 4.10 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O | 1-562 | [»] | |
6DV6 | electron microscopy | 3.90 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O | 1-562 | [»] | |
6PEE | electron microscopy | 3.42 | A/B/C/D/F/G/H/I/J/K/L/M/N/O/P | 1-562 | [»] | |
6PEM | electron microscopy | 3.50 | A/B/C/D/F/G/H/I/J/K/L/M/N/O/P/Q | 1-562 | [»] | |
6PEP | electron microscopy | 3.80 | A/B/C/D/F/G/H/I/J/K/L/M/N/O/P/Q | 1-562 | [»] | |
6Q14 | electron microscopy | 3.80 | A/B/C/D/F/G/H/I/J/K/L/M/N/O/P/Q | 1-562 | [»] | |
6Q15 | electron microscopy | 5.15 | A/B/C/D/F/G/H/I/J/K/L/M/N/O/P/Q | 1-562 | [»] | |
6Q16 | electron microscopy | 4.10 | A/B/C/D/F/G/H/I/J/K/L/M/N/O/P/Q | 1-562 | [»] | |
6XFK | X-ray | 1.85 | B | 543-558 | [»] | |
6XFL | NMR | - | B | 520-562 | [»] | |
BMRBi | P35672 | |||||
SMRi | P35672 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-48517N |
IntActi | P35672, 2 interactors |
Protein family/group databases
TCDBi | 1.B.22.3.2, the outer bacterial membrane secretin (secretin) family |
Proteomic databases
PaxDbi | P35672 |
Genome annotation databases
EnsemblBacteriai | AAL21778; AAL21778; STM2898 |
GeneIDi | 1254421 |
KEGGi | stm:STM2898 |
PATRICi | fig|99287.12.peg.3054 |
Phylogenomic databases
HOGENOMi | CLU_022474_3_0_6 |
OMAi | VWYDDGA |
PhylomeDBi | P35672 |
Miscellaneous databases
EvolutionaryTracei | P35672 |
PHI-basei | PHI:8730 |
Family and domain databases
Gene3Di | 3.30.1370.120, 2 hits |
HAMAPi | MF_02219, Type_III_secretin, 1 hit |
InterProi | View protein in InterPro IPR005644, NolW-like IPR038591, NolW-like_sf IPR004846, T2SS/T3SS IPR004845, T2SS_GspD_CS IPR003522, T3SS_OM_pore_YscC |
Pfami | View protein in Pfam PF00263, Secretin, 1 hit PF03958, Secretin_N, 1 hit |
PRINTSi | PR01337, TYPE3OMGPROT |
TIGRFAMsi | TIGR02516, type_III_yscC, 1 hit |
PROSITEi | View protein in PROSITE PS00875, T2SP_D, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCTC_SALTY | |
Accessioni | P35672Primary (citable) accession number: P35672 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 23, 2002 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families