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UniProtKB - P35672 (SCTC_SALTY)

Entry version 122 (18 Sep 2019)
Sequence version 3 (23 Jan 2002)
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Protein

Type 3 secretion system secretin

Gene

sctC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:9786184, PubMed:27974800, PubMed:30242280). Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane (PubMed:9786184, PubMed:21385715, PubMed:27974800, PubMed:30242280).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport, Virulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		SENT99287:STM2898-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		1.B.22.3.2 the outer bacterial membrane secretin (secretin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type 3 secretion system secretinUniRule annotationCurated
Short name:
T3SS secretinUniRule annotationCurated
Alternative name(s):
Protein InvG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sctC1 PublicationUniRule annotation
Synonyms:invG1 Publication
Ordered Locus Names:STM2898
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Insertion mutants are hypoinvasive in the HEp-2 cell assay.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24UniRule annotationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001311125 – 562Type 3 secretion system secretinUniRule annotationAdd BLAST538

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35672

PRoteomics IDEntifications database

More...PRIDEi		P35672

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569). This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope (PubMed:21385715, PubMed:23633951, PubMed:27974800, PubMed:30242280).

Forms a stable homooligomeric complex (PubMed:9786184, PubMed:21385715, PubMed:23633951, PubMed:27974800, PubMed:30242280). The complex is composed of 15 subunits (PubMed:21385715, PubMed:23633951, PubMed:27974800).

1 Publication5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15771877,EBI-15771877

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-48517N

Protein interaction database and analysis system

More...IntActi		P35672, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1562
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35672

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P35672

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bacterial secretin family. T3SS SctC subfamily.UniRule annotationCurated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105K44 Bacteria
COG1450 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000219449

KEGG Orthology (KO)

More...KOi		K22504

Identification of Orthologs from Complete Genome Data

More...OMAi		VWYDDGA

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35672

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1370.120, 2 hits

HAMAP database of protein families

More...HAMAPi		MF_02219 Type_III_secretin, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005644 NolW-like
IPR038591 NolW-like_sf
IPR004846 T2SS/T3SS
IPR004845 T2SS_GspD_CS
IPR003522 T3SS_OM_pore_YscC

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00263 Secretin, 1 hit
PF03958 Secretin_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01337 TYPE3OMGPROT

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02516 type_III_yscC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00875 T2SP_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P35672-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTHILLARV LACAALVLVT PGYSSEKIPV TGSGFVAKDD SLRTFFDAMA 
        60         70         80         90        100
LQLKEPVIVS KMAARKKITG NFEFHDPNAL LEKLSLQLGL IWYFDGQAIY 
       110        120        130        140        150
IYDASEMRNA VVSLRNVSLN EFNNFLKRSG LYNKNYPLRG DNRKGTFYVS 
       160        170        180        190        200
GPPVYVDMVV NAATMMDKQN DGIELGRQKI GVMRLNNTFV GDRTYNLRDQ 
       210        220        230        240        250
KMVIPGIATA IERLLQGEEQ PLGNIVSSEP PAMPAFSANG EKGKAANYAG 
       260        270        280        290        300
GMSLQEALKQ NAAAGNIKIV AYPDTNSLLV KGTAEQVHFI EMLVKALDVA 
       310        320        330        340        350
KRHVELSLWI VDLNKSDLER LGTSWSGSIT IGDKLGVSLN QSSISTLDGS 
       360        370        380        390        400
RFIAAVNALE EKKQATVVSR PVLLTQENVP AIFDNNRTFY TKLIGERNVA 
       410        420        430        440        450
LEHVTYGTMI RVLPRFSADG QIEMSLDIED GNDKTPQSDT TTSVDALPEV 
       460        470        480        490        500
GRTLISTIAR VPHGKSLLVG GYTRDANTDT VQSIPFLGKL PLIGSLFRYS 
       510        520        530        540        550
SKNKSNVVRV FMIEPKEIVD PLTPDASESV NNILKQSGAW SGDDKLQKWV 
       560 
RVYLDRGQEA IK
Length:562
Mass (Da):61,766
Last modified:January 23, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8022905BE256058D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12A → R in AAA74040 (PubMed:7997169).Curated1
Sequence conflicti121E → Q in AAA74040 (PubMed:7997169).Curated1
Sequence conflicti197 – 205LRDQKMVIP → CAIRKWLFR in AAA74040 (PubMed:7997169).Curated9
Sequence conflicti232 – 240AMPAFSANG → RCQRFQRM in AAA74040 (PubMed:7997169).Curated9
Sequence conflicti243G → S in AAA74040 (PubMed:7997169).Curated1
Sequence conflicti262 – 264AAA → KPAEQ in AAA74040 (PubMed:7997169).Curated3
Sequence conflicti328S → T in CAA53049 (PubMed:7868245).Curated1
Sequence conflicti328S → T in AAA74040 (PubMed:7997169).Curated1
Sequence conflicti329I → V in AAA74040 (PubMed:7997169).Curated1
Sequence conflicti370 – 380RPVLLTQENVP → APGITSSGKCS in AAA74040 (PubMed:7997169).CuratedAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X75302 Genomic DNA Translation: CAA53049.1
U08280 Genomic DNA Translation: AAA74040.1
AE006468 Genomic DNA Translation: AAL21778.1

Protein sequence database of the Protein Information Resource

More...PIRi		S54420

NCBI Reference Sequences

More...RefSeqi		NP_461819.1, NC_003197.2
WP_000848113.1, NC_003197.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAL21778; AAL21778; STM2898

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1254421

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		stm:STM2898

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|99287.12.peg.3054

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75302 Genomic DNA Translation: CAA53049.1
U08280 Genomic DNA Translation: AAA74040.1
AE006468 Genomic DNA Translation: AAL21778.1
PIRiS54420
RefSeqiNP_461819.1, NC_003197.2
WP_000848113.1, NC_003197.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y9Kelectron microscopy8.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O34-170[»]
3J1Velectron microscopy-A/B/C/D/E/F/G/H/I/J/K/L/M/N/O22-178[»]
4G08X-ray1.80A22-178[»]
5TCQelectron microscopy3.60A/B/C/D/E/F/G/H/I/J/K/L/M/N/O1-562[»]
5TCRelectron microscopy6.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O1-562[»]
6DV3electron microscopy4.10A/B/C/D/E/F/G/H/I/J/K/L/M/N/O1-562[»]
6DV6electron microscopy3.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O1-562[»]
SMRiP35672
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-48517N
IntActiP35672, 2 interactors

Protein family/group databases

TCDBi1.B.22.3.2 the outer bacterial membrane secretin (secretin) family

Proteomic databases

PaxDbiP35672
PRIDEiP35672

Genome annotation databases

EnsemblBacteriaiAAL21778; AAL21778; STM2898
GeneIDi1254421
KEGGistm:STM2898
PATRICifig|99287.12.peg.3054

Phylogenomic databases

eggNOGiENOG4105K44 Bacteria
COG1450 LUCA
HOGENOMiHOG000219449
KOiK22504
OMAiVWYDDGA
PhylomeDBiP35672

Enzyme and pathway databases

BioCyciSENT99287:STM2898-MONOMER

Miscellaneous databases

EvolutionaryTraceiP35672

Family and domain databases

Gene3Di3.30.1370.120, 2 hits
HAMAPiMF_02219 Type_III_secretin, 1 hit
InterProiView protein in InterPro
IPR005644 NolW-like
IPR038591 NolW-like_sf
IPR004846 T2SS/T3SS
IPR004845 T2SS_GspD_CS
IPR003522 T3SS_OM_pore_YscC
PfamiView protein in Pfam
PF00263 Secretin, 1 hit
PF03958 Secretin_N, 1 hit
PRINTSiPR01337 TYPE3OMGPROT
TIGRFAMsiTIGR02516 type_III_yscC, 1 hit
PROSITEiView protein in PROSITE
PS00875 T2SP_D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCTC_SALTY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35672
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2002
Last modified: September 18, 2019
This is version 122 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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