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Protein

Protein DEK

Gene

DEK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in chromatin organization.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi337 – 351Add BLAST15
DNA bindingi367 – 3715

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • DNA binding Source: UniProtKB-KW
  • histone binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • chromatin remodeling Source: GO_Central
  • positive regulation of gene expression, epigenetic Source: Reactome
  • regulation of double-strand break repair Source: MGI
  • regulation of double-strand break repair via nonhomologous end joining Source: Ensembl
  • regulation of transcription by RNA polymerase II Source: Reactome
  • signal transduction Source: ProtInc
  • transcription by RNA polymerase II Source: ProtInc
  • viral genome replication Source: ProtInc

Keywordsi

Molecular functionChromatin regulator, DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
SIGNORiP35659

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DEK
Gene namesi
Name:DEK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124795.14
HGNCiHGNC:2768 DEK
MIMi125264 gene
neXtProtiNX_P35659

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi7913
MalaCardsiDEK
OpenTargetsiENSG00000124795
Orphaneti402014 'Acute myeloid leukemia with t(6;9)(p23;q34)'
PharmGKBiPA27251

Polymorphism and mutation databases

BioMutaiDEK
DMDMi544150

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000798582 – 375Protein DEKAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei13PhosphothreonineCombined sources1
Modified residuei15PhosphothreonineBy similarity1
Modified residuei19PhosphoserineCombined sources1
Modified residuei32Phosphoserine; by CK2Combined sources1 Publication1
Modified residuei51PhosphoserineCombined sources1
Modified residuei72PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei159Phosphoserine; by CK21 Publication1
Modified residuei199Phosphothreonine; by CK21 Publication1
Modified residuei201Phosphoserine; by CK21 Publication1
Modified residuei204Phosphoserine; by CK21 Publication1
Modified residuei210PhosphoserineCombined sources1
Modified residuei227PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei243Phosphoserine; by CK21 Publication1
Modified residuei244Phosphoserine; by CK21 Publication1
Modified residuei251Phosphoserine; by CK21 Publication1
Modified residuei279ADP-ribosylserine1 Publication1
Modified residuei287Phosphoserine; by CK21 Publication1
Modified residuei288Phosphoserine; by CK21 Publication1
Modified residuei289Phosphothreonine; by CK21 Publication1
Modified residuei290Phosphothreonine; by CK21 Publication1
Modified residuei296Phosphoserine; by CK21 Publication1
Modified residuei301Phosphoserine; by CK2Combined sources1 Publication1
Modified residuei303Phosphoserine; by CK2Combined sources1 Publication1
Modified residuei306Phosphoserine; by CK2Combined sources1 Publication1
Modified residuei307Phosphoserine; by CK2Combined sources1 Publication1

Post-translational modificationi

Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G1 phase, and weakens the binding of DEK to DNA.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiP35659
MaxQBiP35659
PaxDbiP35659
PeptideAtlasiP35659
PRIDEiP35659
ProteomicsDBi55127
55128 [P35659-2]

PTM databases

iPTMnetiP35659
PhosphoSitePlusiP35659
SwissPalmiP35659

Expressioni

Tissue specificityi

Ubiquitous. Expressed at relatively high levels.

Gene expression databases

BgeeiENSG00000124795
CleanExiHS_DEK
ExpressionAtlasiP35659 baseline and differential
GenevisibleiP35659 HS

Organism-specific databases

HPAiCAB015226
HPA054505
HPA057799

Interactioni

Subunit structurei

Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.3 Publications

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113643, 58 interactors
ComplexPortaliCPX-1099 B-WICH chromatin remodelling complex
CORUMiP35659
IntActiP35659, 21 interactors
MINTiP35659
STRINGi9606.ENSP00000380414

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni88 – 90Combined sources3
Helixi92 – 99Combined sources8
Helixi103 – 112Combined sources10
Beta strandi114 – 116Combined sources3
Helixi121 – 128Combined sources8
Helixi140 – 162Combined sources23
Turni163 – 165Combined sources3
Helixi172 – 181Combined sources10
Turni182 – 184Combined sources3
Helixi322 – 333Combined sources12
Helixi338 – 340Combined sources3
Helixi343 – 353Combined sources11
Beta strandi355 – 357Combined sources3
Helixi361 – 375Combined sources15

3D structure databases

ProteinModelPortaliP35659
SMRiP35659
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35659

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 183SAPAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi205 – 221Nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 49Asp/Glu-rich (highly acidic)Add BLAST20
Compositional biasi228 – 236Asp/Glu-rich (acidic)9
Compositional biasi241 – 254Asp/Glu-rich (acidic)Add BLAST14
Compositional biasi300 – 310Asp/Glu-rich (acidic)Add BLAST11

Phylogenomic databases

eggNOGiKOG2266 Eukaryota
ENOG410XTJA LUCA
GeneTreeiENSGT00390000017282
HOGENOMiHOG000059552
HOVERGENiHBG004944
InParanoidiP35659
KOiK17046
OMAiMPGPREE
OrthoDBiEOG091G0UKX
PhylomeDBiP35659
TreeFamiTF324696

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR014876 DEK_C
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
PfamiView protein in Pfam
PF08766 DEK_C, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35659-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK
60 70 80 90 100
SLIVEGKREK KKVERLTMQV SSLQREPFTI AQGKGQKLCE IERIHFFLSK
110 120 130 140 150
KKTDELRNLH KLLYNRPGTV SSLKKNVGQF SGFPFEKGSV QYKKKEEMLK
160 170 180 190 200
KFRNAMLKSI CEVLDLERSG VNSELVKRIL NFLMHPKPSG KPLPKSKKTC
210 220 230 240 250
SKGSKKERNS SGMARKAKRT KCPEILSDES SSDEDEKKNK EESSDDEDKE
260 270 280 290 300
SEEEPPKKTA KREKPKQKAT SKSKKSVKSA NVKKADSSTT KKNQNSSKKE
310 320 330 340 350
SESEDSSDDE PLIKKLKKPP TDEELKETIK KLLASANLEE VTMKQICKKV
360 370
YENYPTYDLT ERKDFIKTTV KELIS
Length:375
Mass (Da):42,674
Last modified:June 1, 1994 - v1
Checksum:iC07D22B37B719A23
GO
Isoform 2 (identifier: P35659-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-82: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):38,705
Checksum:i7BA02406C674EDD4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050949140V → A. Corresponds to variant dbSNP:rs17336208Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04295149 – 82Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64229 mRNA Translation: CAA45536.1
AK297749 mRNA Translation: BAG60099.1
AK312616 mRNA Translation: BAG35503.1
AL031774 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55402.1
BC035259 mRNA Translation: AAH35259.1
CCDSiCCDS34344.1 [P35659-1]
CCDS47382.1 [P35659-2]
PIRiS26059
RefSeqiNP_001128181.1, NM_001134709.1 [P35659-2]
NP_003463.1, NM_003472.3 [P35659-1]
UniGeneiHs.484813

Genome annotation databases

EnsembliENST00000244776; ENSP00000244776; ENSG00000124795 [P35659-2]
ENST00000397239; ENSP00000380414; ENSG00000124795 [P35659-1]
GeneIDi7913
KEGGihsa:7913
UCSCiuc003ncr.2 human [P35659-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDEK_HUMAN
AccessioniPrimary (citable) accession number: P35659
Secondary accession number(s): B2R6K6
, B4DN37, Q5TGV4, Q5TGV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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