Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear pore complex protein Nup214

Gene

NUP214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei812 – 813Breakpoint2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • nuclear export signal receptor activity Source: GO_Central
  • nuclear localization sequence binding Source: GO_Central
  • structural constituent of nuclear pore Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P35658

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35658

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup214
Alternative name(s):
214 kDa nucleoporin
Nucleoporin Nup214
Protein CAN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUP214
Synonyms:CAIN, CAN, KIAA0023
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000126883.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8064 NUP214

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
114350 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35658

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.1 Publication
A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi353V → A: Reduced binding to DDX19B. 1 Publication1
Mutagenesisi359D → R: Impairs interaction with DDX19B. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
8021

MalaCards human disease database

More...
MalaCardsi
NUP214

Open Targets

More...
OpenTargetsi
ENSG00000126883

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
402014 Acute myeloid leukemia with t(6;9)(p23;q34)
99861 Precursor T-cell acute lymphoblastic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31851

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NUP214

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205831380

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048612 – 2090Nuclear pore complex protein Nup214Add BLAST2089

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylglycineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei416PhosphothreonineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei434PhosphothreonineCombined sources1
Modified residuei437PhosphothreonineCombined sources1
Modified residuei439PhosphothreonineCombined sources1
Modified residuei651PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei670PhosphothreonineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei940PhosphoserineCombined sources1
Modified residuei970PhosphoserineCombined sources1
Modified residuei974PhosphoserineCombined sources1
Modified residuei989PhosphoserineCombined sources1
Modified residuei1021PhosphothreonineCombined sources1
Modified residuei1023PhosphoserineCombined sources1
Modified residuei1045PhosphoserineCombined sources1
Modified residuei1056PhosphoserineCombined sources1
Modified residuei1081PhosphoserineCombined sources1
Modified residuei1134PhosphothreonineCombined sources1
Modified residuei1150PhosphothreonineCombined sources1
Modified residuei1156PhosphothreonineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1312PhosphothreonineCombined sources1
Modified residuei1353PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1538Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1963PhosphoserineCombined sources1
Modified residuei1985PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably glycosylated as it reacts with wheat germ agglutinin (WGA).

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P35658

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P35658

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35658

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35658

PeptideAtlas

More...
PeptideAtlasi
P35658

PRoteomics IDEntifications database

More...
PRIDEi
P35658

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55122
55123 [P35658-2]
55124 [P35658-3]
55125 [P35658-4]
55126 [P35658-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35658

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35658

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126883 Expressed in 205 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_NUP214

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35658 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35658 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048789

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation (PubMed:14766228). Interacts with DDX19 (PubMed:19219046, PubMed:19208808). Interacts with NUP88 (PubMed:9049309). Interacts with XPO1 (PubMed:9049309). Interacts with XPO5 (PubMed:11777942).5 Publications
(Microbial infection) Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DDX19BQ9UMR2-19EBI-15757000,EBI-5773937

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113717, 84 interactors

Database of interacting proteins

More...
DIPi
DIP-38367N

Protein interaction database and analysis system

More...
IntActi
P35658, 43 interactors

Molecular INTeraction database

More...
MINTi
P35658

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000352400

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12090
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OITX-ray1.65A1-434[»]
3FHCX-ray2.80A1-405[»]
3FMOX-ray2.51A1-450[»]
3FMPX-ray3.19A/C1-450[»]
5DISX-ray2.85D1916-2027[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P35658

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35658

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35658

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 93Blade 1Add BLAST53
Repeati94 – 150Blade 2Add BLAST57
Repeati151 – 193Blade 3Add BLAST43
Repeati194 – 239Blade 4Add BLAST46
Repeati240 – 303Blade 5Add BLAST64
Repeati304 – 359Blade 6Add BLAST56
Repeati360 – 404Blade 7Add BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 404Seven-bladed beta propellerAdd BLAST364
Regioni481 – 207611 X 5 AA approximate repeatsAdd BLAST1596
Regioni740 – 768Leucine-zipper 1Add BLAST29
Regioni861 – 882Leucine-zipper 2Add BLAST22
Regioni1409 – 208418 X 4 AA approximate repeatsAdd BLAST676
Regioni1427 – 208511 X 3 AA approximate repeatsAdd BLAST659

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili680 – 12091 PublicationAdd BLAST530

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1213 – 2090Pro/Ser/Thr-richAdd BLAST878

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains FG repeats.
The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3630 Eukaryota
ENOG410YBVS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153253

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052683

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35658

KEGG Orthology (KO)

More...
KOi
K14317

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQTSQWS

Database of Orthologous Groups

More...
OrthoDBi
747759at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35658

TreeFam database of animal gene trees

More...
TreeFami
TF323517

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026054 Nucleoporin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23193 PTHR23193, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35658-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL
60 70 80 90 100
VFAGGASGLQ IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL
110 120 130 140 150
SCDNLTLSAC MMSSEYGSII AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG
160 170 180 190 200
MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT ETVKVCATLP STVAVTSVCW
210 220 230 240 250
SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP VRVLDVLWIG
260 270 280 290 300
TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE
310 320 330 340 350
RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE
360 370 380 390 400
LPVTDKSDDS LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP
410 420 430 440 450
FYMINQNPGV KSLIKTPERL SLEGERQPKS PGSTPTTPTS SQAPQKLDAS
460 470 480 490 500
AAAAPASLPP SSPAAPIATF SLLPAGGAPT VFSFGSSSLK SSATVTGEPP
510 520 530 540 550
SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA PSAASFSFGS
560 570 580 590 600
SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEK FTAAATSTPV
610 620 630 640 650
SSSQSAPPMS PFSSASKPAA SGPLSHPTPL SAPPSSVPLK SSVLPSPSGR
660 670 680 690 700
SAQGSSSPVP SMVQKSPRIT PPAAKPGSPQ AKSLQPAVAE KQGHQWKDSD
710 720 730 740 750
PVMAGIGEEI AHFQKELEEL KARTSKACFQ VGTSEEMKML RTESDDLHTF
760 770 780 790 800
LLEIKETTES LHGDISSLKT TLLEGFAGVE EAREQNERNR DSGYLHLLYK
810 820 830 840 850
RPLDPKSEAQ LQEIRRLHQY VKFAVQDVND VLDLEWDQHL EQKKKQRHLL
860 870 880 890 900
VPERETLFNT LANNREIINQ QRKRLNHLVD SLQQLRLYKQ TSLWSLSSAV
910 920 930 940 950
PSQSSIHSFD SDLESLCNAL LKTTIESHTK SLPKVPAKLS PMKQAQLRNF
960 970 980 990 1000
LAKRKTPPVR STAPASLSRS AFLSQRYYED LDEVSSTSSV SQSLESEDAR
1010 1020 1030 1040 1050
TSCKDDEAVV QAPRHAPVVR TPSIQPSLLP HAAPFAKSHL VHGSSPGVMG
1060 1070 1080 1090 1100
TSVATSASKI IPQGADSTML ATKTVKHGAP SPSHPISAPQ AAAAAALRRQ
1110 1120 1130 1140 1150
MASQAPAVNT LTESTLKNVP QVVNVQELKN NPATPSTAMG SSVPYSTAKT
1160 1170 1180 1190 1200
PHPVLTPVAA NQAKQGSLIN SLKPSGPTPA SGQLSSGDKA SGTAKIETAV
1210 1220 1230 1240 1250
TSTPSASGQF SKPFSFSPSG TGFNFGIITP TPSSNFTAAQ GATPSTKESS
1260 1270 1280 1290 1300
QPDAFSSGGG SKPSYEAIPE SSPPSGITSA SNTTPGEPAA SSSRPVAPSG
1310 1320 1330 1340 1350
TALSTTSSKL ETPPSKLGEL LFPSSLAGET LGSFSGLRVG QADDSTKPTN
1360 1370 1380 1390 1400
KASSTSLTST QPTKTSGVPS GFNFTAPPVL GKHTEPPVTS SATTTSVAPP
1410 1420 1430 1440 1450
AATSTSSTAV FGSLPVTSAG SSGVISFGGT SLSAGKTSFS FGSQQTNSTV
1460 1470 1480 1490 1500
PPSAPPPTTA ATPLPTSFPT LSFGSLLSSA TTPSLPMSAG RSTEEATSSA
1510 1520 1530 1540 1550
LPEKPGDSEV SASAASLLEE QQSAQLPQAP PQTSDSVKKE PVLAQPAVSN
1560 1570 1580 1590 1600
SGTAASSTSL VALSAEATPA TTGVPDARTE AVPPASSFSV PGQTAVTAAA
1610 1620 1630 1640 1650
ISSAGPVAVE TSSTPIASST TSIVAPGPSA EAAAFGTVTS GSSVFAQPPA
1660 1670 1680 1690 1700
ASSSSAFNQL TNNTATAPSA TPVFGQVAAS TAPSLFGQQT GSTASTAAAT
1710 1720 1730 1740 1750
PQVSSSGFSS PAFGTTAPGV FGQTTFGQAS VFGQSASSAA SVFSFSQPGF
1760 1770 1780 1790 1800
SSVPAFGQPA SSTPTSTSGS VFGAASSTSS SSSFSFGQSS PNTGGGLFGQ
1810 1820 1830 1840 1850
SNAPAFGQSP GFGQGGSVFG GTSAATTTAA TSGFSFCQAS GFGSSNTGSV
1860 1870 1880 1890 1900
FGQAASTGGI VFGQQSSSSS GSVFGSGNTG RGGGFFSGLG GKPSQDAANK
1910 1920 1930 1940 1950
NPFSSASGGF GSTATSNTSN LFGNSGAKTF GGFASSSFGE QKPTGTFSSG
1960 1970 1980 1990 2000
GGSVASQGFG FSSPNKTGGF GAAPVFGSPP TFGGSPGFGG VPAFGSAPAF
2010 2020 2030 2040 2050
TSPLGSTGGK VFGEGTAAAS AGGFGFGSSS NTTSFGTLAS QNAPTFGSLS
2060 2070 2080 2090
QQTSGFGTQS SGFSGFGSGT GGFSFGSNNS SVQGFGGWRS
Length:2,090
Mass (Da):213,620
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE6F0F3DE3D522C6
GO
Isoform 2 (identifier: P35658-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N

Note: No experimental confirmation available.
Show »
Length:2,079
Mass (Da):212,571
Checksum:i159D32101C9DF54A
GO
Isoform 3 (identifier: P35658-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-648: S → SA

Note: No experimental confirmation available.
Show »
Length:2,091
Mass (Da):213,691
Checksum:i765727236C2B47C8
GO
Isoform 4 (identifier: P35658-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N
     648-648: S → SA

Show »
Length:2,080
Mass (Da):212,643
Checksum:iA5ECD51E41D40F1F
GO
Isoform 5 (identifier: P35658-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N
     1139-1148: Missing.
     2026-2090: FGSSSNTTSF...SVQGFGGWRS → SLAMSLSPTL...PTDFWFWDPE

Show »
Length:2,093
Mass (Da):215,401
Checksum:i4C67CE62D57E590F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YED3H0YED3_HUMAN
Nuclear pore complex protein Nup214
NUP214
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSW3A0A0A0MSW3_HUMAN
Nuclear pore complex protein Nup214
NUP214
1,519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZAV2B7ZAV2_HUMAN
cDNA, FLJ79316, highly similar to N...
NUP214
916Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDS4H0YDS4_HUMAN
Nuclear pore complex protein Nup214
NUP214
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKD2E9PKD2_HUMAN
Nuclear pore complex protein Nup214
NUP214
495Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF36H0YF36_HUMAN
Nuclear pore complex protein Nup214
NUP214
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y837H0Y837_HUMAN
Nuclear pore complex protein Nup214
NUP214
967Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDH2H0YDH2_HUMAN
Nuclear pore complex protein Nup214
NUP214
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PS86E9PS86_HUMAN
Nuclear pore complex protein Nup214
NUP214
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDI2H0YDI2_HUMAN
Nuclear pore complex protein Nup214
NUP214
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD07398 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149G → A in CAA45535 (PubMed:1549122).Curated1
Sequence conflicti175A → D in CAA45535 (PubMed:1549122).Curated1
Sequence conflicti1091 – 1092AA → QL in CAA45535 (PubMed:1549122).Curated2
Sequence conflicti1872S → N in AAH45620 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035856424G → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_045691574P → S2 PublicationsCorresponds to variant dbSNP:rs103612Ensembl.1
Natural variantiVAR_0358571378P → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs777822003Ensembl.1
Natural variantiVAR_0358581392A → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0615331592G → A. Corresponds to variant dbSNP:rs28594669Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034896590 – 601KFTAA…STPVS → N in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_034897648S → SA in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_0348981139 – 1148Missing in isoform 5. 1 Publication10
Alternative sequenceiVSP_0348992026 – 2090FGSSS…GGWRS → SLAMSLSPTLKGRLLLMRPK AGGGREQAAPGRKSNESRSL GHLCMERALTSPLKVWEQQQ HHILRHARESECPHFRITVP TDFWFWDPE in isoform 5. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X64228 mRNA Translation: CAA45535.1
AB159230 mRNA Translation: BAD07398.1 Different initiation.
D14689 mRNA Translation: BAA03515.1
AL157938 Genomic DNA No translation available.
BC045620 mRNA Translation: AAH45620.2
BC105998 mRNA Translation: AAI05999.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6940.1 [P35658-1]
CCDS83429.1 [P35658-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
S26058

NCBI Reference Sequences

More...
RefSeqi
NP_001305253.1, NM_001318324.1 [P35658-4]
NP_001305254.1, NM_001318325.1
NP_005076.3, NM_005085.3 [P35658-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654530

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359428; ENSP00000352400; ENSG00000126883 [P35658-1]
ENST00000411637; ENSP00000396576; ENSG00000126883 [P35658-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8021

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8021

UCSC genome browser

More...
UCSCi
uc004cag.4 human [P35658-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64228 mRNA Translation: CAA45535.1
AB159230 mRNA Translation: BAD07398.1 Different initiation.
D14689 mRNA Translation: BAA03515.1
AL157938 Genomic DNA No translation available.
BC045620 mRNA Translation: AAH45620.2
BC105998 mRNA Translation: AAI05999.1
CCDSiCCDS6940.1 [P35658-1]
CCDS83429.1 [P35658-4]
PIRiS26058
RefSeqiNP_001305253.1, NM_001318324.1 [P35658-4]
NP_001305254.1, NM_001318325.1
NP_005076.3, NM_005085.3 [P35658-1]
UniGeneiHs.654530

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OITX-ray1.65A1-434[»]
3FHCX-ray2.80A1-405[»]
3FMOX-ray2.51A1-450[»]
3FMPX-ray3.19A/C1-450[»]
5DISX-ray2.85D1916-2027[»]
ProteinModelPortaliP35658
SMRiP35658
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113717, 84 interactors
DIPiDIP-38367N
IntActiP35658, 43 interactors
MINTiP35658
STRINGi9606.ENSP00000352400

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiP35658
PhosphoSitePlusiP35658

Polymorphism and mutation databases

BioMutaiNUP214
DMDMi205831380

Proteomic databases

EPDiP35658
jPOSTiP35658
MaxQBiP35658
PaxDbiP35658
PeptideAtlasiP35658
PRIDEiP35658
ProteomicsDBi55122
55123 [P35658-2]
55124 [P35658-3]
55125 [P35658-4]
55126 [P35658-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359428; ENSP00000352400; ENSG00000126883 [P35658-1]
ENST00000411637; ENSP00000396576; ENSG00000126883 [P35658-4]
GeneIDi8021
KEGGihsa:8021
UCSCiuc004cag.4 human [P35658-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8021
DisGeNETi8021
EuPathDBiHostDB:ENSG00000126883.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NUP214
HGNCiHGNC:8064 NUP214
HPAiHPA048789
MalaCardsiNUP214
MIMi114350 gene
neXtProtiNX_P35658
OpenTargetsiENSG00000126883
Orphaneti402014 Acute myeloid leukemia with t(6;9)(p23;q34)
99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA31851

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3630 Eukaryota
ENOG410YBVS LUCA
GeneTreeiENSGT00940000153253
HOVERGENiHBG052683
InParanoidiP35658
KOiK14317
OMAiNQTSQWS
OrthoDBi747759at2759
PhylomeDBiP35658
TreeFamiTF323517

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
SignaLinkiP35658
SIGNORiP35658

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NUP214 human
EvolutionaryTraceiP35658

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NUP214

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8021

Protein Ontology

More...
PROi
PR:P35658

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126883 Expressed in 205 organ(s), highest expression level in testis
CleanExiHS_NUP214
ExpressionAtlasiP35658 baseline and differential
GenevisibleiP35658 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR026054 Nucleoporin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
PANTHERiPTHR23193 PTHR23193, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU214_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35658
Secondary accession number(s): A6NFQ0
, Q15010, Q3KQZ0, Q5JUP7, Q75R47, Q86XD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 22, 2008
Last modified: January 16, 2019
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again