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Protein

Nuclear pore complex protein Nup214

Gene

NUP214

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei812 – 813Breakpoint2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
SignaLinkiP35658
SIGNORiP35658

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup214
Alternative name(s):
214 kDa nucleoporin
Nucleoporin Nup214
Protein CAN
Gene namesi
Name:NUP214
Synonyms:CAIN, CAN, KIAA0023
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000126883.16
HGNCiHGNC:8064 NUP214
MIMi114350 gene
neXtProtiNX_P35658

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving NUP214 is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with DEK. It results in the formation of a DEK-CAN fusion gene.1 Publication
A chromosomal aberration involving NUP214 is found in some cases of acute undifferentiated leukemia (AUL). Translocation t(6;9)(q21;q34.1) with SET.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi353V → A: Reduced binding to DDX19B. 1 Publication1
Mutagenesisi359D → R: Impairs interaction with DDX19B. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8021
MalaCardsiNUP214
OpenTargetsiENSG00000126883
Orphaneti402014 'Acute myeloid leukemia with t(6;9)(p23;q34)'
PharmGKBiPA31851

Polymorphism and mutation databases

BioMutaiNUP214
DMDMi205831380

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002048612 – 2090Nuclear pore complex protein Nup214Add BLAST2089

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei416PhosphothreonineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei434PhosphothreonineCombined sources1
Modified residuei437PhosphothreonineCombined sources1
Modified residuei439PhosphothreonineCombined sources1
Modified residuei651PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei670PhosphothreonineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei760PhosphoserineCombined sources1
Modified residuei940PhosphoserineCombined sources1
Modified residuei970PhosphoserineCombined sources1
Modified residuei974PhosphoserineCombined sources1
Modified residuei989PhosphoserineCombined sources1
Modified residuei1021PhosphothreonineCombined sources1
Modified residuei1023PhosphoserineCombined sources1
Modified residuei1045PhosphoserineCombined sources1
Modified residuei1056PhosphoserineCombined sources1
Modified residuei1081PhosphoserineCombined sources1
Modified residuei1134PhosphothreonineCombined sources1
Modified residuei1150PhosphothreonineCombined sources1
Modified residuei1156PhosphothreonineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1312PhosphothreonineCombined sources1
Modified residuei1353PhosphoserineCombined sources1
Cross-linki1538Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1963PhosphoserineCombined sources1
Modified residuei1985PhosphoserineCombined sources1

Post-translational modificationi

Probably glycosylated as it reacts with wheat germ agglutinin (WGA).

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP35658
MaxQBiP35658
PaxDbiP35658
PeptideAtlasiP35658
PRIDEiP35658
ProteomicsDBi55122
55123 [P35658-2]
55124 [P35658-3]
55125 [P35658-4]
55126 [P35658-5]

PTM databases

iPTMnetiP35658
PhosphoSitePlusiP35658

Expressioni

Tissue specificityi

Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.

Gene expression databases

BgeeiENSG00000126883 Expressed in 205 organ(s), highest expression level in testis
CleanExiHS_NUP214
ExpressionAtlasiP35658 baseline and differential
GenevisibleiP35658 HS

Organism-specific databases

HPAiHPA048789

Interactioni

Subunit structurei

Homodimer. Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation (PubMed:14766228). Interacts with DDX19 (PubMed:19219046, PubMed:19208808). Interacts with NUP88 (PubMed:9049309). Interacts with XPO1 (PubMed:9049309). Interacts with XPO5 (PubMed:11777942).5 Publications
(Microbial infection) Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX19BQ9UMR2-19EBI-15757000,EBI-5773937

Protein-protein interaction databases

BioGridi113717, 82 interactors
CORUMiP35658
DIPiDIP-38367N
IntActiP35658, 42 interactors
MINTiP35658
STRINGi9606.ENSP00000352400

Structurei

Secondary structure

12090
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35658
SMRiP35658
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35658

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 93Blade 1Add BLAST53
Repeati94 – 150Blade 2Add BLAST57
Repeati151 – 193Blade 3Add BLAST43
Repeati194 – 239Blade 4Add BLAST46
Repeati240 – 303Blade 5Add BLAST64
Repeati304 – 359Blade 6Add BLAST56
Repeati360 – 404Blade 7Add BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 404Seven-bladed beta propellerAdd BLAST364
Regioni481 – 207611 X 5 AA approximate repeatsAdd BLAST1596
Regioni740 – 768Leucine-zipper 1Add BLAST29
Regioni861 – 882Leucine-zipper 2Add BLAST22
Regioni1409 – 208418 X 4 AA approximate repeatsAdd BLAST676
Regioni1427 – 208511 X 3 AA approximate repeatsAdd BLAST659

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili680 – 12091 PublicationAdd BLAST530

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1213 – 2090Pro/Ser/Thr-richAdd BLAST878

Domaini

Contains FG repeats.
The beta-propeller contains long interblade connector loops, and mediates interaction with DDX19B.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3630 Eukaryota
ENOG410YBVS LUCA
GeneTreeiENSGT00730000111045
HOVERGENiHBG052683
InParanoidiP35658
KOiK14317
OMAiQNERNRD
OrthoDBiEOG091G02Y1
PhylomeDBiP35658
TreeFamiTF323517

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR026054 Nucleoporin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
PANTHERiPTHR23193 PTHR23193, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35658-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL
60 70 80 90 100
VFAGGASGLQ IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL
110 120 130 140 150
SCDNLTLSAC MMSSEYGSII AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG
160 170 180 190 200
MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT ETVKVCATLP STVAVTSVCW
210 220 230 240 250
SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP VRVLDVLWIG
260 270 280 290 300
TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE
310 320 330 340 350
RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE
360 370 380 390 400
LPVTDKSDDS LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP
410 420 430 440 450
FYMINQNPGV KSLIKTPERL SLEGERQPKS PGSTPTTPTS SQAPQKLDAS
460 470 480 490 500
AAAAPASLPP SSPAAPIATF SLLPAGGAPT VFSFGSSSLK SSATVTGEPP
510 520 530 540 550
SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA PSAASFSFGS
560 570 580 590 600
SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEK FTAAATSTPV
610 620 630 640 650
SSSQSAPPMS PFSSASKPAA SGPLSHPTPL SAPPSSVPLK SSVLPSPSGR
660 670 680 690 700
SAQGSSSPVP SMVQKSPRIT PPAAKPGSPQ AKSLQPAVAE KQGHQWKDSD
710 720 730 740 750
PVMAGIGEEI AHFQKELEEL KARTSKACFQ VGTSEEMKML RTESDDLHTF
760 770 780 790 800
LLEIKETTES LHGDISSLKT TLLEGFAGVE EAREQNERNR DSGYLHLLYK
810 820 830 840 850
RPLDPKSEAQ LQEIRRLHQY VKFAVQDVND VLDLEWDQHL EQKKKQRHLL
860 870 880 890 900
VPERETLFNT LANNREIINQ QRKRLNHLVD SLQQLRLYKQ TSLWSLSSAV
910 920 930 940 950
PSQSSIHSFD SDLESLCNAL LKTTIESHTK SLPKVPAKLS PMKQAQLRNF
960 970 980 990 1000
LAKRKTPPVR STAPASLSRS AFLSQRYYED LDEVSSTSSV SQSLESEDAR
1010 1020 1030 1040 1050
TSCKDDEAVV QAPRHAPVVR TPSIQPSLLP HAAPFAKSHL VHGSSPGVMG
1060 1070 1080 1090 1100
TSVATSASKI IPQGADSTML ATKTVKHGAP SPSHPISAPQ AAAAAALRRQ
1110 1120 1130 1140 1150
MASQAPAVNT LTESTLKNVP QVVNVQELKN NPATPSTAMG SSVPYSTAKT
1160 1170 1180 1190 1200
PHPVLTPVAA NQAKQGSLIN SLKPSGPTPA SGQLSSGDKA SGTAKIETAV
1210 1220 1230 1240 1250
TSTPSASGQF SKPFSFSPSG TGFNFGIITP TPSSNFTAAQ GATPSTKESS
1260 1270 1280 1290 1300
QPDAFSSGGG SKPSYEAIPE SSPPSGITSA SNTTPGEPAA SSSRPVAPSG
1310 1320 1330 1340 1350
TALSTTSSKL ETPPSKLGEL LFPSSLAGET LGSFSGLRVG QADDSTKPTN
1360 1370 1380 1390 1400
KASSTSLTST QPTKTSGVPS GFNFTAPPVL GKHTEPPVTS SATTTSVAPP
1410 1420 1430 1440 1450
AATSTSSTAV FGSLPVTSAG SSGVISFGGT SLSAGKTSFS FGSQQTNSTV
1460 1470 1480 1490 1500
PPSAPPPTTA ATPLPTSFPT LSFGSLLSSA TTPSLPMSAG RSTEEATSSA
1510 1520 1530 1540 1550
LPEKPGDSEV SASAASLLEE QQSAQLPQAP PQTSDSVKKE PVLAQPAVSN
1560 1570 1580 1590 1600
SGTAASSTSL VALSAEATPA TTGVPDARTE AVPPASSFSV PGQTAVTAAA
1610 1620 1630 1640 1650
ISSAGPVAVE TSSTPIASST TSIVAPGPSA EAAAFGTVTS GSSVFAQPPA
1660 1670 1680 1690 1700
ASSSSAFNQL TNNTATAPSA TPVFGQVAAS TAPSLFGQQT GSTASTAAAT
1710 1720 1730 1740 1750
PQVSSSGFSS PAFGTTAPGV FGQTTFGQAS VFGQSASSAA SVFSFSQPGF
1760 1770 1780 1790 1800
SSVPAFGQPA SSTPTSTSGS VFGAASSTSS SSSFSFGQSS PNTGGGLFGQ
1810 1820 1830 1840 1850
SNAPAFGQSP GFGQGGSVFG GTSAATTTAA TSGFSFCQAS GFGSSNTGSV
1860 1870 1880 1890 1900
FGQAASTGGI VFGQQSSSSS GSVFGSGNTG RGGGFFSGLG GKPSQDAANK
1910 1920 1930 1940 1950
NPFSSASGGF GSTATSNTSN LFGNSGAKTF GGFASSSFGE QKPTGTFSSG
1960 1970 1980 1990 2000
GGSVASQGFG FSSPNKTGGF GAAPVFGSPP TFGGSPGFGG VPAFGSAPAF
2010 2020 2030 2040 2050
TSPLGSTGGK VFGEGTAAAS AGGFGFGSSS NTTSFGTLAS QNAPTFGSLS
2060 2070 2080 2090
QQTSGFGTQS SGFSGFGSGT GGFSFGSNNS SVQGFGGWRS
Length:2,090
Mass (Da):213,620
Last modified:July 22, 2008 - v2
Checksum:iEE6F0F3DE3D522C6
GO
Isoform 2 (identifier: P35658-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N

Note: No experimental confirmation available.
Show »
Length:2,079
Mass (Da):212,571
Checksum:i159D32101C9DF54A
GO
Isoform 3 (identifier: P35658-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-648: S → SA

Note: No experimental confirmation available.
Show »
Length:2,091
Mass (Da):213,691
Checksum:i765727236C2B47C8
GO
Isoform 4 (identifier: P35658-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N
     648-648: S → SA

Show »
Length:2,080
Mass (Da):212,643
Checksum:iA5ECD51E41D40F1F
GO
Isoform 5 (identifier: P35658-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     590-601: KFTAAATSTPVS → N
     1139-1148: Missing.
     2026-2090: FGSSSNTTSF...SVQGFGGWRS → SLAMSLSPTL...PTDFWFWDPE

Show »
Length:2,093
Mass (Da):215,401
Checksum:i4C67CE62D57E590F
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YED3H0YED3_HUMAN
Nuclear pore complex protein Nup214
NUP214
113Annotation score:
A0A0A0MSW3A0A0A0MSW3_HUMAN
Nuclear pore complex protein Nup214
NUP214
1,519Annotation score:
B7ZAV2B7ZAV2_HUMAN
cDNA, FLJ79316, highly similar to N...
NUP214
916Annotation score:
E9PKD2E9PKD2_HUMAN
Nuclear pore complex protein Nup214
NUP214
495Annotation score:
H0YDS4H0YDS4_HUMAN
Nuclear pore complex protein Nup214
NUP214
187Annotation score:
H0YF36H0YF36_HUMAN
Nuclear pore complex protein Nup214
NUP214
140Annotation score:
H0Y837H0Y837_HUMAN
Nuclear pore complex protein Nup214
NUP214
967Annotation score:
H0YDH2H0YDH2_HUMAN
Nuclear pore complex protein Nup214
NUP214
145Annotation score:
E9PS86E9PS86_HUMAN
Nuclear pore complex protein Nup214
NUP214
52Annotation score:
H0YDI2H0YDI2_HUMAN
Nuclear pore complex protein Nup214
NUP214
78Annotation score:

Sequence cautioni

The sequence BAD07398 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149G → A in CAA45535 (PubMed:1549122).Curated1
Sequence conflicti175A → D in CAA45535 (PubMed:1549122).Curated1
Sequence conflicti1091 – 1092AA → QL in CAA45535 (PubMed:1549122).Curated2
Sequence conflicti1872S → N in AAH45620 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035856424G → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_045691574P → S2 PublicationsCorresponds to variant dbSNP:rs103612Ensembl.1
Natural variantiVAR_0358571378P → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs777822003Ensembl.1
Natural variantiVAR_0358581392A → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0615331592G → A. Corresponds to variant dbSNP:rs28594669Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034896590 – 601KFTAA…STPVS → N in isoform 2, isoform 4 and isoform 5. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_034897648S → SA in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_0348981139 – 1148Missing in isoform 5. 1 Publication10
Alternative sequenceiVSP_0348992026 – 2090FGSSS…GGWRS → SLAMSLSPTLKGRLLLMRPK AGGGREQAAPGRKSNESRSL GHLCMERALTSPLKVWEQQQ HHILRHARESECPHFRITVP TDFWFWDPE in isoform 5. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64228 mRNA Translation: CAA45535.1
AB159230 mRNA Translation: BAD07398.1 Different initiation.
D14689 mRNA Translation: BAA03515.1
AL157938 Genomic DNA No translation available.
BC045620 mRNA Translation: AAH45620.2
BC105998 mRNA Translation: AAI05999.1
CCDSiCCDS6940.1 [P35658-1]
CCDS83429.1 [P35658-4]
PIRiS26058
RefSeqiNP_001305253.1, NM_001318324.1 [P35658-4]
NP_001305254.1, NM_001318325.1
NP_005076.3, NM_005085.3 [P35658-1]
UniGeneiHs.654530

Genome annotation databases

EnsembliENST00000359428; ENSP00000352400; ENSG00000126883 [P35658-1]
ENST00000411637; ENSP00000396576; ENSG00000126883 [P35658-4]
GeneIDi8021
KEGGihsa:8021
UCSCiuc004cag.4 human [P35658-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64228 mRNA Translation: CAA45535.1
AB159230 mRNA Translation: BAD07398.1 Different initiation.
D14689 mRNA Translation: BAA03515.1
AL157938 Genomic DNA No translation available.
BC045620 mRNA Translation: AAH45620.2
BC105998 mRNA Translation: AAI05999.1
CCDSiCCDS6940.1 [P35658-1]
CCDS83429.1 [P35658-4]
PIRiS26058
RefSeqiNP_001305253.1, NM_001318324.1 [P35658-4]
NP_001305254.1, NM_001318325.1
NP_005076.3, NM_005085.3 [P35658-1]
UniGeneiHs.654530

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OITX-ray1.65A1-434[»]
3FHCX-ray2.80A1-405[»]
3FMOX-ray2.51A1-450[»]
3FMPX-ray3.19A/C1-450[»]
5DISX-ray2.85D1916-2027[»]
ProteinModelPortaliP35658
SMRiP35658
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113717, 82 interactors
CORUMiP35658
DIPiDIP-38367N
IntActiP35658, 42 interactors
MINTiP35658
STRINGi9606.ENSP00000352400

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiP35658
PhosphoSitePlusiP35658

Polymorphism and mutation databases

BioMutaiNUP214
DMDMi205831380

Proteomic databases

EPDiP35658
MaxQBiP35658
PaxDbiP35658
PeptideAtlasiP35658
PRIDEiP35658
ProteomicsDBi55122
55123 [P35658-2]
55124 [P35658-3]
55125 [P35658-4]
55126 [P35658-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359428; ENSP00000352400; ENSG00000126883 [P35658-1]
ENST00000411637; ENSP00000396576; ENSG00000126883 [P35658-4]
GeneIDi8021
KEGGihsa:8021
UCSCiuc004cag.4 human [P35658-1]

Organism-specific databases

CTDi8021
DisGeNETi8021
EuPathDBiHostDB:ENSG00000126883.16
GeneCardsiNUP214
HGNCiHGNC:8064 NUP214
HPAiHPA048789
MalaCardsiNUP214
MIMi114350 gene
neXtProtiNX_P35658
OpenTargetsiENSG00000126883
Orphaneti402014 'Acute myeloid leukemia with t(6;9)(p23;q34)'
PharmGKBiPA31851
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3630 Eukaryota
ENOG410YBVS LUCA
GeneTreeiENSGT00730000111045
HOVERGENiHBG052683
InParanoidiP35658
KOiK14317
OMAiQNERNRD
OrthoDBiEOG091G02Y1
PhylomeDBiP35658
TreeFamiTF323517

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
SignaLinkiP35658
SIGNORiP35658

Miscellaneous databases

ChiTaRSiNUP214 human
EvolutionaryTraceiP35658
GeneWikiiNUP214
GenomeRNAii8021
PROiPR:P35658
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126883 Expressed in 205 organ(s), highest expression level in testis
CleanExiHS_NUP214
ExpressionAtlasiP35658 baseline and differential
GenevisibleiP35658 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR026054 Nucleoporin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
PANTHERiPTHR23193 PTHR23193, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNU214_HUMAN
AccessioniPrimary (citable) accession number: P35658
Secondary accession number(s): A6NFQ0
, Q15010, Q3KQZ0, Q5JUP7, Q75R47, Q86XD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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