Ddit3

Functionⁱ

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling.11 Publications

GO - Molecular functionⁱ

cAMP response element binding protein binding Source: MGI
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 15601821
DNA-binding transcription factor activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 15601821
leucine zipper domain binding Source: MGI
protein heterodimerization activity
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 1547942
protein homodimerization activity Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
transcription factor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 10523647
- 1547942
transcription regulatory region DNA binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 15601821
transcription regulatory region sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22265908
blood vessel maturation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22265908
cell cycle arrest Source: MGI
cell redox homeostasis Source: MGI
endoplasmic reticulum unfolded protein response
Source: MGI
Inferred from mutant phenotypeⁱ
- 15601821
ER overload response
Source: MGI
Inferred from mutant phenotypeⁱ
- 11854325
establishment of protein localization to mitochondrion
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 14752510
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21159964
intrinsic apoptotic signaling pathway in response to nitrosative stress
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 14752510
mRNA transcription by RNA polymerase II Source: MGI
negative regulation of canonical Wnt signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 16434966
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 26370079
negative regulation of CREB transcription factor activity Source: MGI
negative regulation of determination of dorsal identity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16434966
negative regulation of DNA binding
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 1547942
negative regulation of DNA-binding transcription factor activity Source: MGI
negative regulation of fat cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 22441668
negative regulation of myoblast differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22242125
negative regulation of protein kinase B signaling Source: MGI
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 22242125
negative regulation of transcription by RNA polymerase II
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 1547942
positive regulation of apoptotic process Source: MGI
positive regulation of autophagy in response to ER overload Source: MGI
positive regulation of DNA-binding transcription factor activity Source: MGI
positive regulation of interleukin-8 production Source: MGI
positive regulation of neuron apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21159964
positive regulation of neuron death
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 16135078
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 21159964
positive regulation of transcription by RNA polymerase II
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 10523647
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 15601821
proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
protein complex oligomerization Source: MGI
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15775988
- 19752026
regulation of transcription involved in anterior/posterior axis specification
Source: BHF-UCL
Inferred from direct assayⁱ
- 16434966
release of sequestered calcium ion into cytosol
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19752026
response to endoplasmic reticulum stress
Source: UniProtKB
Inferred from direct assayⁱ
- 19752026
- 21159964
response to starvation
Source: UniProtKB
Inferred from direct assayⁱ
- 22242125
response to unfolded protein Source: MGI
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Apoptosis, Cell cycle, Growth arrest, Stress response, Transcription, Transcription regulation, Unfolded protein response, Wnt signaling pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA damage-inducible transcript 3 protein Short name: DDIT-3 Alternative name(s): C/EBP zeta C/EBP-homologous protein Short name: CHOP C/EBP-homologous protein 10 Short name: CHOP-10 CCAAT/enhancer-binding protein homologous protein Growth arrest and DNA-damage-inducible protein GADD153
Gene namesⁱ	Name:Ddit3 Synonyms:Chop, Chop10, Gadd153
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:109247 Ddit3

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	14	S → A: Loss of phosphorylation. 1 Publication	1
Mutagenesisⁱ	15	S → A: Loss of phosphorylation. 1 Publication	1
Mutagenesisⁱ	30	S → A: Loss of phosphorylation. 1 Publication	1
Mutagenesisⁱ	31	S → A: Loss of phosphorylation. 1 Publication	1

Chemistry databases

ChEMBLⁱ	CHEMBL2146304

ChEMBLⁱ

CHEMBL2146304

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076643	1 – 168	DNA damage-inducible transcript 3 proteinAdd BLAST		168

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	14	Phosphoserine; by CK21 Publication	1
Modified residueⁱ	15	Phosphoserine; by CK21 Publication	1
Modified residueⁱ	30	Phosphoserine; by CK21 Publication	1
Modified residueⁱ	31	Phosphoserine; by CK21 Publication	1
Modified residueⁱ	78	Phosphoserine; by MAPK141 Publication	1
Modified residueⁱ	81	Phosphoserine; by MAPK141 Publication	1

Post-translational modificationⁱ

Ubiquitinated, leading to its degradation by the proteasome.By similarity

Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.2 Publications

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35639
PaxDbⁱ	P35639
PRIDEⁱ	P35639

PTM databases

iPTMnetⁱ	P35639
PhosphoSitePlusⁱ	P35639

Expressionⁱ

Inductionⁱ

By oxidative stress, amino-acid deprivation, hypoxia and ER stress. During ER stress, induced by a EIF2AK3/ATF4 pathway and/or ERN1/ATF6 pathway. Expression is suppressed by TLR-TRIF signaling pathway during prolonged ER stress.6 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000025408 Expressed in 285 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	MM_DDIT3
ExpressionAtlasⁱ	P35639 baseline and differential
Genevisibleⁱ	P35639 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer. Interacts with TCF7L2/TCF4, EP300/P300, HDAC5 and HDAC6. Interacts with TRIB3 which blocks its association with EP300/P300. Interacts with FOXO3, CEBPB and ATF4 (By similarity). Interacts with HDAC1.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Atf4	Q06507	3	EBI-10636142,EBI-77383

With

Entry

#Exp.

IntAct

Notes

Atf4

Q06507

3

EBI-10636142,EBI-77383

GO - Molecular functionⁱ

cAMP response element binding protein binding Source: MGI
leucine zipper domain binding Source: MGI
protein heterodimerization activity
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 1547942
protein homodimerization activity Source: Ensembl
transcription factor binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 10523647
- 1547942

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199078, 2 interactors
ComplexPortalⁱ	CPX-65 CHOP-C/EBPalpha complex CPX-66 CHOP-C/EBPbeta complex
Database of interacting proteins More...DIPⁱ	DIP-60705N
IntActⁱ	P35639, 1 interactor
STRINGⁱ	10090.ENSMUSP00000026475

Chemistry databases

BindingDBⁱ

P35639

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35639
SMRⁱ	P35639
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	98 – 161	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	10 – 26	N-terminalBy similarityAdd BLAST	17
Regionⁱ	10 – 18	Interaction with TRIB3By similarity	9
Regionⁱ	100 – 129	Basic motifPROSITE-ProRule annotationAdd BLAST	30
Regionⁱ	133 – 147	Leucine-zipperPROSITE-ProRule annotationAdd BLAST	15

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	92 – 97	Poly-Glu		6

Domainⁱ

The N-terminal region is necessary for its proteasomal degradation, transcriptional activity and interaction with EP300/P300.By similarity

Sequence similaritiesⁱ

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410ISXY Eukaryota ENOG41127XB LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006305
HOGENOMⁱ	HOG000089934
HOVERGENⁱ	HBG051328
InParanoidⁱ	P35639
KEGG Orthology (KO) More...KOⁱ	K04452
OMAⁱ	MVNLHQA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UKC
PhylomeDBⁱ	P35639
TreeFamⁱ	TF105006

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR016670 DNA_damage_induc_transcript_3
PANTHERⁱ	PTHR16833 PTHR16833, 1 hit
PIRSFⁱ	PIRSF016571 C/EBPzeta_CHOP_DDIT3, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P35639-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAESLPFTL ETVSSWELEA WYEDLQEVLS SDEIGGTYIS SPGNEEEESK 
        60         70         80         90        100
TFTTLDPASL AWLTEEPGPT EVTRTSQSPR SPDSSQSSMA QEEEEEEQGR 
       110        120        130        140        150
TRKRKQSGQC PARPGKQRMK EKEQENERKV AQLAEENERL KQEIERLTRE 
       160 
VETTRRALID RMVSLHQA

Length:168

Mass (Da):19,189

Last modified:June 1, 1994 - v1

Checksum:ⁱCA423B79512F33AB

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YX14	D3YX14_MOUSE	DNA damage-inducible transcript 3 p... DNA damage-inducible transcript 3 protein	Ddit3	160	Annotation score:
A0A2R8VHR8	A0A2R8VHR8_MOUSE	Uncharacterized protein Uncharacterized protein	Ddit3	34	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	34	I → N in AAH13718 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X67083 mRNA Translation: CAA47465.1 BC013718 mRNA Translation: AAH13718.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24236.1
PIRⁱ	S26148
NCBI Reference Sequences More...RefSeqⁱ	NP_001277112.1, NM_001290183.1 NP_031863.3, NM_007837.4 XP_006513260.1, XM_006513197.3
UniGeneⁱ	Mm.110220

Genome annotation databases

Ensemblⁱ	ENSMUST00000026475; ENSMUSP00000026475; ENSMUSG00000025408
GeneIDⁱ	13198
KEGGⁱ	mmu:13198
UCSC genome browser More...UCSCⁱ	uc007hiy.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35639	DNA damage-inducible transcript 3 protein (Fragment)		MOUSE		160	UniRef100_P35639
UPI0003D730F0		MOUSE		182

Protein	Similar proteins		Species	Score	Length	Source
P35639	DNA damage-inducible transcript 3 protein (Fragment)		MOUSE		160	UniRef90_P35639
UPI000B4F2B2A		MERUN		167
DNA damage-inducible transcript 3 protein		MOUSE		168
UPI0003D730F0		MOUSE		182

Protein	Similar proteins		Species	Score	Length	Source
P35639	DNA damage-inducible transcript 3 protein		HUMAN		169	UniRef50_P35638
DNA damage-inducible transcript 3 protein		CRIGR		168
DNA damage-inducible transcript 3 protein		RAT		168
DNA damage-inducible transcript 3 protein		BOVIN		168
DNA damage-inducible transcript 3 protein		PANPA		169
+136

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X67083 mRNA Translation: CAA47465.1 BC013718 mRNA Translation: AAH13718.1
CCDSⁱ	CCDS24236.1
PIRⁱ	S26148
RefSeqⁱ	NP_001277112.1, NM_001290183.1 NP_031863.3, NM_007837.4 XP_006513260.1, XM_006513197.3
UniGeneⁱ	Mm.110220

3D structure databases

ProteinModelPortalⁱ	P35639
SMRⁱ	P35639
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199078, 2 interactors
ComplexPortalⁱ	CPX-65 CHOP-C/EBPalpha complex CPX-66 CHOP-C/EBPbeta complex
DIPⁱ	DIP-60705N
IntActⁱ	P35639, 1 interactor
STRINGⁱ	10090.ENSMUSP00000026475

Chemistry databases

BindingDBⁱ	P35639
ChEMBLⁱ	CHEMBL2146304

PTM databases

iPTMnetⁱ	P35639
PhosphoSitePlusⁱ	P35639

Proteomic databases

MaxQBⁱ	P35639
PaxDbⁱ	P35639
PRIDEⁱ	P35639

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000026475; ENSMUSP00000026475; ENSMUSG00000025408
GeneIDⁱ	13198
KEGGⁱ	mmu:13198
UCSCⁱ	uc007hiy.2 mouse

Organism-specific databases

CTDⁱ	1649
MGIⁱ	MGI:109247 Ddit3

Phylogenomic databases

eggNOGⁱ	ENOG410ISXY Eukaryota ENOG41127XB LUCA
GeneTreeⁱ	ENSGT00390000006305
HOGENOMⁱ	HOG000089934
HOVERGENⁱ	HBG051328
InParanoidⁱ	P35639
KOⁱ	K04452
OMAⁱ	MVNLHQA
OrthoDBⁱ	EOG091G0UKC
PhylomeDBⁱ	P35639
TreeFamⁱ	TF105006

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P35639
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025408 Expressed in 285 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	MM_DDIT3
ExpressionAtlasⁱ	P35639 baseline and differential
Genevisibleⁱ	P35639 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR016670 DNA_damage_induc_transcript_3
PANTHERⁱ	PTHR16833 PTHR16833, 1 hit
PIRSFⁱ	PIRSF016571 C/EBPzeta_CHOP_DDIT3, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DDIT3_MOUSE
Accessionⁱ	P35639Primary (citable) accession number: P35639 Secondary accession number(s): Q91YW9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35639 (DDIT3_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

DNA damage-inducible transcript 3 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Endosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ