UniProtKB - P35637 (FUS_HUMAN)
RNA-binding protein FUS
FUS
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 422 – 453 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 32 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- RNA binding Source: MGI
- transcription coactivator activity Source: CACAO
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- mRNA splicing, via spliceosome Source: Reactome
- mRNA stabilization Source: MGI
- positive regulation of double-strand break repair via homologous recombination Source: UniProtKB
- protein homooligomerization Source: UniProtKB
- regulation of RNA splicing Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- RNA splicing Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, RNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P35637 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
SIGNORi | P35637 |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein FUSAlternative name(s): 75 kDa DNA-pairing protein Oncogene FUS Oncogene TLS POMp75 Translocated in liposarcoma protein |
Gene namesi | Name:FUS Synonyms:TLS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4010, FUS |
MIMi | 137070, gene |
neXtProti | NX_P35637 |
VEuPathDBi | HostDB:ENSG00000089280.18 |
Subcellular locationi
Nucleus
- Nucleus 5 Publications
Note: Displays a punctate pattern inside the nucleus and is excluded from nucleoli.1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Angiomatoid fibrous histiocytoma (AFH)1 Publication
Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia (ALS6)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068918 | 191 | G → S in ALS6. 1 PublicationCorresponds to variant dbSNP:rs148758737Ensembl. | 1 | |
Natural variantiVAR_068919 | 216 | R → C in ALS6 and ETM4. 2 PublicationsCorresponds to variant dbSNP:rs267606832EnsemblClinVar. | 1 | |
Natural variantiVAR_068920 | 225 | G → V in ALS6. 1 PublicationCorresponds to variant dbSNP:rs1567472455Ensembl. | 1 | |
Natural variantiVAR_068921 | 230 | G → C in ALS6. 1 PublicationCorresponds to variant dbSNP:rs748374535EnsemblClinVar. | 1 | |
Natural variantiVAR_068922 | 234 | R → C in ALS6. 1 PublicationCorresponds to variant dbSNP:rs777819849Ensembl. | 1 | |
Natural variantiVAR_054837 | 244 | R → C in ALS6. 1 PublicationCorresponds to variant dbSNP:rs1165095258Ensembl. | 1 | |
Natural variantiVAR_068924 | 507 | G → D in ALS6. 1 PublicationCorresponds to variant dbSNP:rs267606831EnsemblClinVar. | 1 | |
Natural variantiVAR_054838 | 514 | R → G in ALS6. 1 PublicationCorresponds to variant dbSNP:rs1555509609Ensembl. | 1 | |
Natural variantiVAR_054839 | 514 | R → S in ALS6. 1 Publication | 1 | |
Natural variantiVAR_054840 | 515 | G → C in ALS6. 1 PublicationCorresponds to variant dbSNP:rs369757630Ensembl. | 1 | |
Natural variantiVAR_054842 | 518 | R → K in ALS6. 1 PublicationCorresponds to variant dbSNP:rs121909669EnsemblClinVar. | 1 | |
Natural variantiVAR_054843 | 521 | R → C in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 3 PublicationsCorresponds to variant dbSNP:rs121909668EnsemblClinVar. | 1 | |
Natural variantiVAR_054844 | 521 | R → G in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 1 PublicationCorresponds to variant dbSNP:rs121909668EnsemblClinVar. | 1 | |
Natural variantiVAR_054845 | 521 | R → H in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 4 PublicationsCorresponds to variant dbSNP:rs121909671EnsemblClinVar. | 1 | |
Natural variantiVAR_054846 | 522 | R → G in ALS6. 1 PublicationCorresponds to variant dbSNP:rs1555509693EnsemblClinVar. | 1 | |
Natural variantiVAR_054847 | 524 | R → S in ALS6. 1 PublicationCorresponds to variant dbSNP:rs886041389EnsemblClinVar. | 1 | |
Natural variantiVAR_054848 | 524 | R → T in ALS6. 1 PublicationCorresponds to variant dbSNP:rs544088874Ensembl. | 1 | |
Natural variantiVAR_054849 | 525 | P → L in ALS6. 1 PublicationCorresponds to variant dbSNP:rs886041390EnsemblClinVar. | 1 | |
Natural variantiVAR_077328 | 526 | Y → YY in ALS6; unknown pathological significance. 1 Publication | 1 |
Tremor, hereditary essential 4 (ETM4)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068919 | 216 | R → C in ALS6 and ETM4. 2 PublicationsCorresponds to variant dbSNP:rs267606832EnsemblClinVar. | 1 | |
Natural variantiVAR_068923 | 431 | P → L in ETM4. 1 PublicationCorresponds to variant dbSNP:rs186547381EnsemblClinVar. | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 175 | Breakpoint for translocation to form chimeric FUS/ATF1 protein | 1 | |
Sitei | 266 – 267 | Breakpoint for translocation to form FUS/TLS-CHOP oncogene | 2 |
Keywords - Diseasei
Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration, Proto-oncogeneOrganism-specific databases
DisGeNETi | 2521 |
GeneReviewsi | FUS |
MalaCardsi | FUS |
MIMi | 608030, phenotype 612160, phenotype 614782, phenotype |
OpenTargetsi | ENSG00000089280 |
Orphaneti | 803, Amyotrophic lateral sclerosis 275872, Frontotemporal dementia with motor neuron disease 300605, Juvenile amyotrophic lateral sclerosis 79105, Myxofibrosarcoma 99967, Myxoid/round cell liposarcoma 862, NON RARE IN EUROPE: Hereditary essential tremor |
PharmGKBi | PA28425 |
Miscellaneous databases
Pharosi | P35637, Tbio |
Genetic variation databases
BioMutai | FUS |
DMDMi | 544357 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081591 | 1 – 526 | RNA-binding protein FUSAdd BLAST | 526 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 26 | Phosphoserine1 Publication | 1 | |
Modified residuei | 30 | Phosphoserine1 Publication | 1 | |
Modified residuei | 42 | Phosphoserine; by ATM1 Publication | 1 | |
Modified residuei | 216 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 216 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 218 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 218 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 221 | PhosphoserineCombined sources | 1 | |
Modified residuei | 242 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 244 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 248 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 251 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 259 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 277 | PhosphoserineCombined sources | 1 | |
Modified residuei | 286 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 334 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 340 | PhosphoserineCombined sources | 1 | |
Modified residuei | 377 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 383 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 386 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 388 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 394 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 407 | Asymmetric dimethylarginine; alternate1 Publication | 1 | |
Modified residuei | 407 | Omega-N-methylarginine; alternateBy similarity | 1 | |
Modified residuei | 473 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 476 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 481 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 485 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 487 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 491 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 495 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 498 | Asymmetric dimethylarginine1 Publication | 1 | |
Modified residuei | 503 | Asymmetric dimethylarginine; alternate1 Publication | 1 | |
Modified residuei | 503 | Omega-N-methylarginine; alternateCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P35637 |
jPOSTi | P35637 |
MassIVEi | P35637 |
PaxDbi | P35637 |
PeptideAtlasi | P35637 |
PRIDEi | P35637 |
ProteomicsDBi | 55119 [P35637-1] 55120 [P35637-2] |
TopDownProteomicsi | P35637-1 [P35637-1] P35637-2 [P35637-2] |
PTM databases
GlyGeni | P35637, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35637 |
MetOSitei | P35637 |
PhosphoSitePlusi | P35637 |
SwissPalmi | P35637 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000089280, Expressed in right testis and 249 other tissues |
ExpressionAtlasi | P35637, baseline and differential |
Genevisiblei | P35637, HS |
Organism-specific databases
HPAi | ENSG00000089280, Low tissue specificity |
Interactioni
Subunit structurei
Self-oligomerizes (via N-terminal region) (PubMed:25453086). Oligomerization is essential for chromatin binding (PubMed:25453086).
Component of nuclear riboprotein complexes.
Interacts with ILF3, TDRD3 and SF1 (PubMed:9660765).
Interacts through its C-terminus with SFRS13A (PubMed:9774382).
Interacts with OTUB1 and SARNP.
Interacts with LRSAM1 (PubMed:27615052).
Interacts with SAFB1 in a DNA-dependent manner; this interaction tethers FUS to chromatin (PubMed:27731383).
Interacts with MATR3 (PubMed:27731383).
Interacts with SNRNP70 and POLR2A; these interactions couple RNA transcription and splicing (PubMed:26124092).
Interacts (through its RNA-binding domain) with RALY (through its RNA-binding domain); both are components of the same RNPs (PubMed:30354839).
9 PublicationsBinary interactionsi
Hide detailsP35637
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 108797, 617 interactors |
CORUMi | P35637 |
DIPi | DIP-29857N |
IntActi | P35637, 312 interactors |
MINTi | P35637 |
STRINGi | 9606.ENSP00000254108 |
Miscellaneous databases
RNActi | P35637, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P35637 |
SMRi | P35637 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 285 – 371 | RRMPROSITE-ProRule annotationAdd BLAST | 87 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 165 | Gln/Gly/Ser/Tyr-richAdd BLAST | 165 | |
Compositional biasi | 166 – 267 | Gly-richAdd BLAST | 102 | |
Compositional biasi | 371 – 526 | Arg/Gly-richAdd BLAST | 156 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 422 – 453 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 32 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1995, Eukaryota |
GeneTreei | ENSGT00940000157290 |
InParanoidi | P35637 |
PhylomeDBi | P35637 |
TreeFami | TF322599 |
Family and domain databases
DisProti | DP01102 |
Gene3Di | 3.30.70.330, 1 hit |
IDEALi | IID00451 |
InterProi | View protein in InterPro IPR034459, FUS IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034870, TET_fam IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR23238, PTHR23238, 1 hit PTHR23238:SF5, PTHR23238:SF5, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF00641, zf-RanBP, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY
60 70 80 90 100
GQSSYSSYGQ SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY
110 120 130 140 150
GQQPAPSSTS GSYGSSSQSS SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN
160 170 180 190 200
PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD QSSMSSGGGS GGGYGNQDQS
210 220 230 240 250
GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE PRGRGGGRGG
260 270 280 290 300
RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES
310 320 330 340 350
VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA
360 370 380 390 400
IDWFDGKEFS GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG
410 420 430 440 450
GSGGGGRGGF PSGGGGGGGQ QRAGDWKCPN PTCENMNFSW RNECNQCKAP
460 470 480 490 500
KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD RGGYRGRGGD RGGFRGGRGG
510 520
GDRGGFGPGK MDSRGEHRQD RRERPY
The sequence of this isoform differs from the canonical sequence as follows:
64-65: TG → S
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BPE7 | H3BPE7_HUMAN | RNA-binding protein FUS | FUS | 527 | Annotation score: | ||
H3BNZ4 | H3BNZ4_HUMAN | RNA-binding protein FUS | FUS | 263 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 338 | T → N AA sequence (PubMed:10567410).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068918 | 191 | G → S in ALS6. 1 PublicationCorresponds to variant dbSNP:rs148758737Ensembl. | 1 | |
Natural variantiVAR_068919 | 216 | R → C in ALS6 and ETM4. 2 PublicationsCorresponds to variant dbSNP:rs267606832EnsemblClinVar. | 1 | |
Natural variantiVAR_068920 | 225 | G → V in ALS6. 1 PublicationCorresponds to variant dbSNP:rs1567472455Ensembl. | 1 | |
Natural variantiVAR_068921 | 230 | G → C in ALS6. 1 PublicationCorresponds to variant dbSNP:rs748374535EnsemblClinVar. | 1 | |
Natural variantiVAR_068922 | 234 | R → C in ALS6. 1 PublicationCorresponds to variant dbSNP:rs777819849Ensembl. | 1 | |
Natural variantiVAR_054837 | 244 | R → C in ALS6. 1 PublicationCorresponds to variant dbSNP:rs1165095258Ensembl. | 1 | |
Natural variantiVAR_065229 | 254 | M → V Found in a patient with frontotemporal lobar degeneration. 1 PublicationCorresponds to variant dbSNP:rs752076094EnsemblClinVar. | 1 | |
Natural variantiVAR_035481 | 312 | K → Q in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_068923 | 431 | P → L in ETM4. 1 PublicationCorresponds to variant dbSNP:rs186547381EnsemblClinVar. | 1 | |
Natural variantiVAR_068924 | 507 | G → D in ALS6. 1 PublicationCorresponds to variant dbSNP:rs267606831EnsemblClinVar. | 1 | |
Natural variantiVAR_054838 | 514 | R → G in ALS6. 1 PublicationCorresponds to variant dbSNP:rs1555509609Ensembl. | 1 | |
Natural variantiVAR_054839 | 514 | R → S in ALS6. 1 Publication | 1 | |
Natural variantiVAR_054840 | 515 | G → C in ALS6. 1 PublicationCorresponds to variant dbSNP:rs369757630Ensembl. | 1 | |
Natural variantiVAR_054841 | 517 | H → Q Does not affect protein nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs121909667EnsemblClinVar. | 1 | |
Natural variantiVAR_054842 | 518 | R → K in ALS6. 1 PublicationCorresponds to variant dbSNP:rs121909669EnsemblClinVar. | 1 | |
Natural variantiVAR_054843 | 521 | R → C in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 3 PublicationsCorresponds to variant dbSNP:rs121909668EnsemblClinVar. | 1 | |
Natural variantiVAR_054844 | 521 | R → G in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 1 PublicationCorresponds to variant dbSNP:rs121909668EnsemblClinVar. | 1 | |
Natural variantiVAR_054845 | 521 | R → H in ALS6; results in aberrant trafficking and cytoplasmic retention of the protein. 4 PublicationsCorresponds to variant dbSNP:rs121909671EnsemblClinVar. | 1 | |
Natural variantiVAR_054846 | 522 | R → G in ALS6. 1 PublicationCorresponds to variant dbSNP:rs1555509693EnsemblClinVar. | 1 | |
Natural variantiVAR_054847 | 524 | R → S in ALS6. 1 PublicationCorresponds to variant dbSNP:rs886041389EnsemblClinVar. | 1 | |
Natural variantiVAR_054848 | 524 | R → T in ALS6. 1 PublicationCorresponds to variant dbSNP:rs544088874Ensembl. | 1 | |
Natural variantiVAR_054849 | 525 | P → L in ALS6. 1 PublicationCorresponds to variant dbSNP:rs886041390EnsemblClinVar. | 1 | |
Natural variantiVAR_077328 | 526 | Y → YY in ALS6; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005798 | 64 – 65 | TG → S in isoform Short. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S62140 mRNA Translation: AAB27102.1 S62138 mRNA Translation: AAB27103.1 Sequence problems. X71427 mRNA Translation: CAA50558.1 Sequence problems. X71428 mRNA Translation: CAA50559.1 Sequence problems. AF071213 Genomic DNA Translation: AAC35285.1 AF071213 Genomic DNA Translation: AAC35284.1 AC009088 Genomic DNA No translation available. BC000402 mRNA Translation: AAH00402.1 BC002459 mRNA Translation: AAH02459.1 AJ295163 mRNA Translation: CAC15058.1 Different termination. |
CCDSi | CCDS10707.1 [P35637-1] CCDS58454.1 [P35637-2] |
PIRi | S33798 S33799 |
RefSeqi | NP_001164105.1, NM_001170634.1 [P35637-2] NP_004951.1, NM_004960.3 [P35637-1] |
Genome annotation databases
Ensembli | ENST00000254108; ENSP00000254108; ENSG00000089280 [P35637-1] ENST00000380244; ENSP00000369594; ENSG00000089280 [P35637-2] |
GeneIDi | 2521 |
KEGGi | hsa:2521 |
UCSCi | uc002ebh.4, human [P35637-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S62140 mRNA Translation: AAB27102.1 S62138 mRNA Translation: AAB27103.1 Sequence problems. X71427 mRNA Translation: CAA50558.1 Sequence problems. X71428 mRNA Translation: CAA50559.1 Sequence problems. AF071213 Genomic DNA Translation: AAC35285.1 AF071213 Genomic DNA Translation: AAC35284.1 AC009088 Genomic DNA No translation available. BC000402 mRNA Translation: AAH00402.1 BC002459 mRNA Translation: AAH02459.1 AJ295163 mRNA Translation: CAC15058.1 Different termination. |
CCDSi | CCDS10707.1 [P35637-1] CCDS58454.1 [P35637-2] |
PIRi | S33798 S33799 |
RefSeqi | NP_001164105.1, NM_001170634.1 [P35637-2] NP_004951.1, NM_004960.3 [P35637-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LA6 | NMR | - | A | 282-370 | [»] | |
2LCW | NMR | - | A | 278-385 | [»] | |
4FDD | X-ray | 2.30 | B | 498-526 | [»] | |
4FQ3 | X-ray | 3.00 | B | 495-526 | [»] | |
5W3N | NMR | - | A/B/C/D/E/F/G/H/I | 2-214 | [»] | |
5XRR | X-ray | 1.50 | A | 54-59 | [»] | |
5XSG | electron microscopy | 0.73 | A | 37-42 | [»] | |
5YVG | X-ray | 4.05 | X/Y | 1-526 | [»] | |
5YVH | X-ray | 3.15 | B | 371-526 | [»] | |
5YVI | X-ray | 2.90 | B | 456-526 | [»] | |
6BWZ | X-ray | 1.10 | A | 37-42 | [»] | |
6BXV | X-ray | 1.10 | A | 54-61 | [»] | |
6BZP | electron microscopy | 1.10 | A/B | 77-82 | [»] | |
6G99 | NMR | - | B | 419-454 | [»] | |
6GBM | NMR | - | B | 280-377 | [»] | |
6KJ1 | electron microscopy | 0.65 | A | 37-42 | [»] | |
6KJ2 | electron microscopy | 0.67 | A | 37-42 | [»] | |
6KJ3 | electron microscopy | 0.60 | A | 37-42 | [»] | |
6KJ4 | electron microscopy | 0.65 | A | 37-42 | [»] | |
6SNJ | NMR | - | A | 260-390 | [»] | |
6XFM | electron microscopy | 2.62 | 1/2/3/4/5/6/7/8 | 111-214 | [»] | |
BMRBi | P35637 | |||||
SMRi | P35637 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108797, 617 interactors |
CORUMi | P35637 |
DIPi | DIP-29857N |
IntActi | P35637, 312 interactors |
MINTi | P35637 |
STRINGi | 9606.ENSP00000254108 |
PTM databases
GlyGeni | P35637, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35637 |
MetOSitei | P35637 |
PhosphoSitePlusi | P35637 |
SwissPalmi | P35637 |
Genetic variation databases
BioMutai | FUS |
DMDMi | 544357 |
Proteomic databases
EPDi | P35637 |
jPOSTi | P35637 |
MassIVEi | P35637 |
PaxDbi | P35637 |
PeptideAtlasi | P35637 |
PRIDEi | P35637 |
ProteomicsDBi | 55119 [P35637-1] 55120 [P35637-2] |
TopDownProteomicsi | P35637-1 [P35637-1] P35637-2 [P35637-2] |
Protocols and materials databases
Antibodypediai | 1307, 428 antibodies |
DNASUi | 2521 |
Genome annotation databases
Ensembli | ENST00000254108; ENSP00000254108; ENSG00000089280 [P35637-1] ENST00000380244; ENSP00000369594; ENSG00000089280 [P35637-2] |
GeneIDi | 2521 |
KEGGi | hsa:2521 |
UCSCi | uc002ebh.4, human [P35637-1] |
Organism-specific databases
CTDi | 2521 |
DisGeNETi | 2521 |
GeneCardsi | FUS |
GeneReviewsi | FUS |
HGNCi | HGNC:4010, FUS |
HPAi | ENSG00000089280, Low tissue specificity |
MalaCardsi | FUS |
MIMi | 137070, gene 608030, phenotype 612160, phenotype 614782, phenotype |
neXtProti | NX_P35637 |
OpenTargetsi | ENSG00000089280 |
Orphaneti | 803, Amyotrophic lateral sclerosis 275872, Frontotemporal dementia with motor neuron disease 300605, Juvenile amyotrophic lateral sclerosis 79105, Myxofibrosarcoma 99967, Myxoid/round cell liposarcoma 862, NON RARE IN EUROPE: Hereditary essential tremor |
PharmGKBi | PA28425 |
VEuPathDBi | HostDB:ENSG00000089280.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1995, Eukaryota |
GeneTreei | ENSGT00940000157290 |
InParanoidi | P35637 |
PhylomeDBi | P35637 |
TreeFami | TF322599 |
Enzyme and pathway databases
PathwayCommonsi | P35637 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
SIGNORi | P35637 |
Miscellaneous databases
BioGRID-ORCSi | 2521, 42 hits in 888 CRISPR screens |
ChiTaRSi | FUS, human |
GeneWikii | FUS |
GenomeRNAii | 2521 |
Pharosi | P35637, Tbio |
PROi | PR:P35637 |
RNActi | P35637, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000089280, Expressed in right testis and 249 other tissues |
ExpressionAtlasi | P35637, baseline and differential |
Genevisiblei | P35637, HS |
Family and domain databases
DisProti | DP01102 |
Gene3Di | 3.30.70.330, 1 hit |
IDEALi | IID00451 |
InterProi | View protein in InterPro IPR034459, FUS IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR034870, TET_fam IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR23238, PTHR23238, 1 hit PTHR23238:SF5, PTHR23238:SF5, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit PF00641, zf-RanBP, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FUS_HUMAN | |
Accessioni | P35637Primary (citable) accession number: P35637 Secondary accession number(s): Q9H4A8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 227 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families