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Entry version 191 (13 Feb 2019)
Sequence version 2 (01 Feb 1995)
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Protein

Metalloproteinase inhibitor 3

Gene

TIMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi24Zinc; via amino nitrogen and carbonyl oxygen; shared with metalloproteinase partnerCombined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei85Involved in metalloproteinase-bindingCombined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
Biological processSensory transduction, Vision
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35625

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I35.003

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metalloproteinase inhibitor 3
Alternative name(s):
Protein MIG-5
Tissue inhibitor of metalloproteinases 3
Short name:
TIMP-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIMP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100234.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11822 TIMP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
188826 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35625

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Sorsby fundus dystrophy (SFD)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
See also OMIM:136900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007508179S → C in SFD. 1 PublicationCorresponds to variant dbSNP:rs137853300EnsemblClinVar.1
Natural variantiVAR_008290189G → C in SFD. 1 PublicationCorresponds to variant dbSNP:rs137853301EnsemblClinVar.1
Natural variantiVAR_010901190G → C in SFD. 1 Publication1
Natural variantiVAR_007509191Y → C in SFD. 2 PublicationsCorresponds to variant dbSNP:rs137853299EnsemblClinVar.1
Natural variantiVAR_007510204S → C in SFD. 1 PublicationCorresponds to variant dbSNP:rs137853298EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7078

MalaCards human disease database

More...
MalaCardsi
TIMP3
MIMi136900 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000100234

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
59181 Sorsby pseudoinflammatory fundus dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36528

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB05383 pimagedine HCl

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TIMP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
730948

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003434124 – 211Metalloproteinase inhibitor 3Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 91PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi26 ↔ 118PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi36 ↔ 143PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi145 ↔ 192PROSITE-ProRule annotation
Disulfide bondi150 ↔ 155PROSITE-ProRule annotation
Disulfide bondi163 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P35625

MaxQB - The MaxQuant DataBase

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MaxQBi
P35625

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35625

PeptideAtlas

More...
PeptideAtlasi
P35625

PRoteomics IDEntifications database

More...
PRIDEi
P35625

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55117

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35625

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35625

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100234 Expressed in 232 organ(s), highest expression level in decidua

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35625 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EFEMP1.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
AGTR2P500527EBI-1748085,EBI-1748067

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112934, 26 interactors

Protein interaction database and analysis system

More...
IntActi
P35625, 4 interactors

Molecular INTeraction database

More...
MINTi
P35625

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266085

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CKIX-ray2.30B24-144[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P35625

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35625

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35625

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 143NTRPROSITE-ProRule annotationAdd BLAST120

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 27Involved in metalloproteinase-bindingCombined sources1 Publication4
Regioni88 – 89Involved in metalloproteinase-bindingCombined sources1 Publication2
Regioni105 – 188Mediates interaction with EFEMP11 PublicationAdd BLAST84

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4745 Eukaryota
ENOG41103NU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000285981

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG068749

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35625

KEGG Orthology (KO)

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KOi
K16866

Identification of Orthologs from Complete Genome Data

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OMAi
CHYLPCF

Database of Orthologous Groups

More...
OrthoDBi
1122531at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35625

TreeFam database of animal gene trees

More...
TreeFami
TF317409

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.90.370.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001134 Netrin_domain
IPR001820 TIMP
IPR008993 TIMP-like_OB-fold
IPR015612 TIMP3
IPR027465 TIMP_C
IPR030490 TIMP_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11844 PTHR11844, 1 hit
PTHR11844:SF22 PTHR11844:SF22, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00965 TIMP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00206 NTR, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50242 SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50189 NTR, 1 hit
PS00288 TIMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P35625-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPWLGLIVL LGSWSLGDWG AEACTCSPSH PQDAFCNSDI VIRAKVVGKK
60 70 80 90 100
LVKEGPFGTL VYTIKQMKMY RGFTKMPHVQ YIHTEASESL CGLKLEVNKY
110 120 130 140 150
QYLLTGRVYD GKMYTGLCNF VERWDQLTLS QRKGLNYRYH LGCNCKIKSC
160 170 180 190 200
YYLPCFVTSK NECLWTDMLS NFGYPGYQSK HYACIRQKGG YCSWYRGWAP
210
PDKSIINATD P
Length:211
Mass (Da):24,145
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15CF831028BABF7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16 – 23LGDWGAEA → WGTGAPR in CAA82918 (PubMed:8034652).Curated8
Sequence conflicti21 – 22AE → R in AAA21815 (PubMed:8188246).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007508179S → C in SFD. 1 PublicationCorresponds to variant dbSNP:rs137853300EnsemblClinVar.1
Natural variantiVAR_008290189G → C in SFD. 1 PublicationCorresponds to variant dbSNP:rs137853301EnsemblClinVar.1
Natural variantiVAR_010901190G → C in SFD. 1 Publication1
Natural variantiVAR_007509191Y → C in SFD. 2 PublicationsCorresponds to variant dbSNP:rs137853299EnsemblClinVar.1
Natural variantiVAR_007510204S → C in SFD. 1 PublicationCorresponds to variant dbSNP:rs137853298EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X76227 mRNA Translation: CAA53813.1
S78453 mRNA Translation: AAB34532.1
U14394 mRNA Translation: AAB60373.1
U02571 mRNA Translation: AAA17672.1
Z30183 Genomic DNA Translation: CAA82918.1
U33114
, U33110, U33111, U33112, U33113 Genomic DNA Translation: AAC50393.1
U67195 mRNA Translation: AAB07547.1
CR456593 mRNA Translation: CAG30479.1
BT006848 mRNA Translation: AAP35494.1
AK314871 mRNA Translation: BAG37386.1
AL023282 Genomic DNA No translation available.
Z98256 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60038.1
BC014277 mRNA Translation: AAH14277.1
L15078 mRNA Translation: AAA21815.1
U38955
, U38952, U38953, U38954 Genomic DNA Translation: AAB17602.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13911.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45317

NCBI Reference Sequences

More...
RefSeqi
NP_000353.1, NM_000362.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.644633

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266085; ENSP00000266085; ENSG00000100234

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7078

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7078

UCSC genome browser

More...
UCSCi
uc003anb.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Mutations of the TIMP3 gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76227 mRNA Translation: CAA53813.1
S78453 mRNA Translation: AAB34532.1
U14394 mRNA Translation: AAB60373.1
U02571 mRNA Translation: AAA17672.1
Z30183 Genomic DNA Translation: CAA82918.1
U33114
, U33110, U33111, U33112, U33113 Genomic DNA Translation: AAC50393.1
U67195 mRNA Translation: AAB07547.1
CR456593 mRNA Translation: CAG30479.1
BT006848 mRNA Translation: AAP35494.1
AK314871 mRNA Translation: BAG37386.1
AL023282 Genomic DNA No translation available.
Z98256 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60038.1
BC014277 mRNA Translation: AAH14277.1
L15078 mRNA Translation: AAA21815.1
U38955
, U38952, U38953, U38954 Genomic DNA Translation: AAB17602.1
CCDSiCCDS13911.1
PIRiS45317
RefSeqiNP_000353.1, NM_000362.4
UniGeneiHs.644633

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CKIX-ray2.30B24-144[»]
ProteinModelPortaliP35625
SMRiP35625
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112934, 26 interactors
IntActiP35625, 4 interactors
MINTiP35625
STRINGi9606.ENSP00000266085

Chemistry databases

DrugBankiDB05383 pimagedine HCl

Protein family/group databases

MEROPSiI35.003

PTM databases

iPTMnetiP35625
PhosphoSitePlusiP35625

Polymorphism and mutation databases

BioMutaiTIMP3
DMDMi730948

Proteomic databases

jPOSTiP35625
MaxQBiP35625
PaxDbiP35625
PeptideAtlasiP35625
PRIDEiP35625
ProteomicsDBi55117

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7078
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266085; ENSP00000266085; ENSG00000100234
GeneIDi7078
KEGGihsa:7078
UCSCiuc003anb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7078
DisGeNETi7078
EuPathDBiHostDB:ENSG00000100234.11

GeneCards: human genes, protein and diseases

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GeneCardsi
TIMP3
HGNCiHGNC:11822 TIMP3
MalaCardsiTIMP3
MIMi136900 phenotype
188826 gene
neXtProtiNX_P35625
OpenTargetsiENSG00000100234
Orphaneti59181 Sorsby pseudoinflammatory fundus dystrophy
PharmGKBiPA36528

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4745 Eukaryota
ENOG41103NU LUCA
GeneTreeiENSGT00940000159601
HOGENOMiHOG000285981
HOVERGENiHBG068749
InParanoidiP35625
KOiK16866
OMAiCHYLPCF
OrthoDBi1122531at2759
PhylomeDBiP35625
TreeFamiTF317409

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SIGNORiP35625

Miscellaneous databases

EvolutionaryTraceiP35625

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TIMP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7078

Protein Ontology

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PROi
PR:P35625

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100234 Expressed in 232 organ(s), highest expression level in decidua
GenevisibleiP35625 HS

Family and domain databases

Gene3Di3.90.370.10, 1 hit
InterProiView protein in InterPro
IPR001134 Netrin_domain
IPR001820 TIMP
IPR008993 TIMP-like_OB-fold
IPR015612 TIMP3
IPR027465 TIMP_C
IPR030490 TIMP_CS
PANTHERiPTHR11844 PTHR11844, 1 hit
PTHR11844:SF22 PTHR11844:SF22, 1 hit
PfamiView protein in Pfam
PF00965 TIMP, 1 hit
SMARTiView protein in SMART
SM00206 NTR, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS50189 NTR, 1 hit
PS00288 TIMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIMP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35625
Secondary accession number(s): B2RBY9
, Q5THV4, Q9UC74, Q9UGS2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1995
Last modified: February 13, 2019
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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