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Protein

Basigin

Gene

BSG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:21778275). Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionBlood group antigen
LigandLectin, Mannose-binding

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-210991 Basigin interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-70268 Pyruvate metabolism

Protein family/group databases

TCDBi8.A.23.1.1 the basigin (basigin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Basigin
Alternative name(s):
5F7
Collagenase stimulatory factor
Extracellular matrix metalloproteinase inducer
Short name:
EMMPRIN
Leukocyte activation antigen M6
OK blood group antigen
Tumor cell-derived collagenase stimulatory factor
Short name:
TCSF
CD_antigen: CD147
Gene namesi
Name:BSG
ORF Names:UNQ6505/PRO21383
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000172270.18
HGNCiHGNC:1116 BSG
MIMi109480 gene
neXtProtiNX_P35613

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini138 – 323ExtracellularSequence analysisAdd BLAST186
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Topological domaini345 – 385CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi327P → A: Loss of interaction with PPIL2. 1 Publication1

Organism-specific databases

DisGeNETi682
MIMi111380 phenotype
OpenTargetsiENSG00000172270
PharmGKBiPA25433

Chemistry databases

ChEMBLiCHEMBL3580492

Polymorphism and mutation databases

BioMutaiBSG
DMDMi51704273

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001451822 – 385BasiginAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi157 ↔ 203Combined sources2 Publications
Glycosylationi160N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi242 ↔ 301Combined sources1 Publication
Glycosylationi268N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei362PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP35613
MaxQBiP35613
PaxDbiP35613
PeptideAtlasiP35613
PRIDEiP35613
ProteomicsDBi55113
55114 [P35613-2]
55115 [P35613-3]
55116 [P35613-4]
TopDownProteomicsiP35613-1 [P35613-1]
P35613-2 [P35613-2]
P35613-3 [P35613-3]

PTM databases

GlyConnecti1027
iPTMnetiP35613
PhosphoSitePlusiP35613
SwissPalmiP35613

Miscellaneous databases

PMAP-CutDBiP35613

Expressioni

Tissue specificityi

Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Inductioni

Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

Gene expression databases

BgeeiENSG00000172270 Expressed in 230 organ(s), highest expression level in apex of heart
CleanExiHS_BSG
ExpressionAtlasiP35613 baseline and differential
GenevisibleiP35613 HS

Organism-specific databases

HPAiCAB002427
HPA036048
HPA074870

Interactioni

Subunit structurei

Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane. Interacts with SLC16A11 (PubMed:28666119). Interacts with SLC16A12 (PubMed:21778275).By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B2L3N75EBI-11037868,EBI-16118096From Plasmodium falciparum.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107147, 160 interactors
CORUMiP35613
DIPiDIP-50310N
IntActiP35613, 47 interactors
MINTiP35613
STRINGi9606.ENSP00000333769

Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35613
SMRiP35613
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35613

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 219Ig-like C2-typeAdd BLAST82
Domaini221 – 315Ig-like V-typeAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi356 – 359Poly-Asp4

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJET Eukaryota
ENOG4111V1Q LUCA
GeneTreeiENSGT00390000010516
HOGENOMiHOG000263411
HOVERGENiHBG008120
InParanoidiP35613
KOiK06535
OMAiPNDTCSQ
OrthoDBiEOG091G07LY
PhylomeDBiP35613
TreeFamiTF326759

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR009151 Basigin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR10075:SF12 PTHR10075:SF12, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35613-1) [UniParc]FASTAAdd to basket
Also known as: Long, Basigin-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP
60 70 80 90 100
VPEIQWWFEG QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE
110 120 130 140 150
EDTGTYECRA SNDPDRNHLT RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG
160 170 180 190 200
SKILLTCSLN DSATEVTGHR WLKGGVVLKE DALPGQKTEF KVDSDDQWGE
210 220 230 240 250
YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML VCKSESVPPV
260 270 280 290 300
TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR
310 320 330 340 350
CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK
360 370 380
PEDVLDDDDA GSAPLKSSGQ HQNDKGKNVR QRNSS
Length:385
Mass (Da):42,200
Last modified:August 31, 2004 - v2
Checksum:iD74C37455BF26685
GO
Isoform 2 (identifier: P35613-2) [UniParc]FASTAAdd to basket
Also known as: Basigin-1

The sequence of this isoform differs from the canonical sequence as follows:
     24-139: Missing.

Show »
Length:269
Mass (Da):29,221
Checksum:i0C9D6BEB966AC258
GO
Isoform 3 (identifier: P35613-3) [UniParc]FASTAAdd to basket
Also known as: Basigin-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.
Show »
Length:176
Mass (Da):19,438
Checksum:i1FF03934256AE63E
GO
Isoform 4 (identifier: P35613-4) [UniParc]FASTAAdd to basket
Also known as: Basigin-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MAAALFVLLGF → MKQSDASPQER
     12-191: Missing.

Note: Produced by alternative promoter usage. N-glycosylated.
Show »
Length:205
Mass (Da):22,764
Checksum:i27B3348C16A690BD
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUV8A0A087WUV8_HUMAN
Basigin
BSG
189Annotation score:
A0A087X2B5A0A087X2B5_HUMAN
Basigin
BSG
221Annotation score:
I3L192I3L192_HUMAN
Basigin
BSG
160Annotation score:
A0A2R8YDZ0A0A2R8YDZ0_HUMAN
Basigin
BSG
132Annotation score:
A0A087X215A0A087X215_HUMAN
Basigin
BSG
55Annotation score:
R4GN83R4GN83_HUMAN
Basigin
BSG
52Annotation score:
R4GMX5R4GMX5_HUMAN
Basigin
BSG
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328F → L in BAC76828 (PubMed:1783610).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013574208E → K in Ok(A-). 1 PublicationCorresponds to variant dbSNP:rs104894669Ensembl.1
Natural variantiVAR_011720269G → V. Corresponds to variant dbSNP:rs1803203Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0432251 – 209Missing in isoform 3. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_0432261 – 11MAAALFVLLGF → MKQSDASPQER in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04322712 – 191Missing in isoform 4. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_01150124 – 139Missing in isoform 2. 3 PublicationsAdd BLAST116

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64364 mRNA Translation: CAA45716.1
D45131 mRNA Translation: BAA08109.1
L10240 mRNA Translation: AAA68936.1
M87879 mRNA Translation: AAA91084.1
L20471 mRNA Translation: AAB41120.1
AF042854
, AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA Translation: AAD10704.1
AB072923 mRNA Translation: BAB88938.1
AB085790 mRNA Translation: BAC76828.1
AF548371 mRNA Translation: AAN40694.1
GU557064 mRNA Translation: ADD31881.1
GU557065 mRNA Translation: ADD31882.1
AY358113 mRNA Translation: AAQ88480.1
AY942196 Genomic DNA Translation: AAX20110.1
AC005559 Genomic DNA Translation: AAC33279.1
CH471242 Genomic DNA Translation: EAW61181.1
CH471242 Genomic DNA Translation: EAW61185.1
BC009040 mRNA Translation: AAH09040.1
CCDSiCCDS12032.1 [P35613-4]
CCDS12033.1 [P35613-1]
CCDS12034.1 [P35613-2]
CCDS58635.1 [P35613-3]
PIRiA46506
RefSeqiNP_001309172.1, NM_001322243.1 [P35613-2]
NP_001719.2, NM_001728.3 [P35613-1]
NP_940991.1, NM_198589.2 [P35613-2]
NP_940992.1, NM_198590.2 [P35613-3]
NP_940993.1, NM_198591.2 [P35613-4]
XP_016882662.1, XM_017027173.1 [P35613-1]
UniGeneiHs.501293

Genome annotation databases

EnsembliENST00000333511; ENSP00000333769; ENSG00000172270 [P35613-1]
ENST00000346916; ENSP00000344707; ENSG00000172270 [P35613-4]
ENST00000353555; ENSP00000343809; ENSG00000172270 [P35613-2]
ENST00000545507; ENSP00000473664; ENSG00000172270 [P35613-3]
GeneIDi682
KEGGihsa:682
UCSCiuc002loy.5 human [P35613-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64364 mRNA Translation: CAA45716.1
D45131 mRNA Translation: BAA08109.1
L10240 mRNA Translation: AAA68936.1
M87879 mRNA Translation: AAA91084.1
L20471 mRNA Translation: AAB41120.1
AF042854
, AF042848, AF042849, AF042850, AF042851, AF042852, AF042853 Genomic DNA Translation: AAD10704.1
AB072923 mRNA Translation: BAB88938.1
AB085790 mRNA Translation: BAC76828.1
AF548371 mRNA Translation: AAN40694.1
GU557064 mRNA Translation: ADD31881.1
GU557065 mRNA Translation: ADD31882.1
AY358113 mRNA Translation: AAQ88480.1
AY942196 Genomic DNA Translation: AAX20110.1
AC005559 Genomic DNA Translation: AAC33279.1
CH471242 Genomic DNA Translation: EAW61181.1
CH471242 Genomic DNA Translation: EAW61185.1
BC009040 mRNA Translation: AAH09040.1
CCDSiCCDS12032.1 [P35613-4]
CCDS12033.1 [P35613-1]
CCDS12034.1 [P35613-2]
CCDS58635.1 [P35613-3]
PIRiA46506
RefSeqiNP_001309172.1, NM_001322243.1 [P35613-2]
NP_001719.2, NM_001728.3 [P35613-1]
NP_940991.1, NM_198589.2 [P35613-2]
NP_940992.1, NM_198590.2 [P35613-3]
NP_940993.1, NM_198591.2 [P35613-4]
XP_016882662.1, XM_017027173.1 [P35613-1]
UniGeneiHs.501293

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B5HX-ray2.80A/B/C/D140-321[»]
3I84X-ray2.00A/B13-219[»]
3I85X-ray2.50A/B13-219[»]
3QQNX-ray2.31A/B23-138[»]
3QR2X-ray2.30A/B23-138[»]
4U0QX-ray3.10B/D1-385[»]
5X0TX-ray2.50E/F138-217[»]
5XF0NMR-A215-321[»]
ProteinModelPortaliP35613
SMRiP35613
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107147, 160 interactors
CORUMiP35613
DIPiDIP-50310N
IntActiP35613, 47 interactors
MINTiP35613
STRINGi9606.ENSP00000333769

Chemistry databases

ChEMBLiCHEMBL3580492

Protein family/group databases

TCDBi8.A.23.1.1 the basigin (basigin) family

PTM databases

GlyConnecti1027
iPTMnetiP35613
PhosphoSitePlusiP35613
SwissPalmiP35613

Polymorphism and mutation databases

BioMutaiBSG
DMDMi51704273

Proteomic databases

EPDiP35613
MaxQBiP35613
PaxDbiP35613
PeptideAtlasiP35613
PRIDEiP35613
ProteomicsDBi55113
55114 [P35613-2]
55115 [P35613-3]
55116 [P35613-4]
TopDownProteomicsiP35613-1 [P35613-1]
P35613-2 [P35613-2]
P35613-3 [P35613-3]

Protocols and materials databases

DNASUi682
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333511; ENSP00000333769; ENSG00000172270 [P35613-1]
ENST00000346916; ENSP00000344707; ENSG00000172270 [P35613-4]
ENST00000353555; ENSP00000343809; ENSG00000172270 [P35613-2]
ENST00000545507; ENSP00000473664; ENSG00000172270 [P35613-3]
GeneIDi682
KEGGihsa:682
UCSCiuc002loy.5 human [P35613-1]

Organism-specific databases

CTDi682
DisGeNETi682
EuPathDBiHostDB:ENSG00000172270.18
GeneCardsiBSG
HGNCiHGNC:1116 BSG
HPAiCAB002427
HPA036048
HPA074870
MIMi109480 gene
111380 phenotype
neXtProtiNX_P35613
OpenTargetsiENSG00000172270
PharmGKBiPA25433
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJET Eukaryota
ENOG4111V1Q LUCA
GeneTreeiENSGT00390000010516
HOGENOMiHOG000263411
HOVERGENiHBG008120
InParanoidiP35613
KOiK06535
OMAiPNDTCSQ
OrthoDBiEOG091G07LY
PhylomeDBiP35613
TreeFamiTF326759

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-210991 Basigin interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-433692 Proton-coupled monocarboxylate transport
R-HSA-70268 Pyruvate metabolism

Miscellaneous databases

ChiTaRSiBSG human
EvolutionaryTraceiP35613
GeneWikiiBasigin
GenomeRNAii682
PMAP-CutDBiP35613
PROiPR:P35613
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172270 Expressed in 230 organ(s), highest expression level in apex of heart
CleanExiHS_BSG
ExpressionAtlasiP35613 baseline and differential
GenevisibleiP35613 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR009151 Basigin
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR10075:SF12 PTHR10075:SF12, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiBASI_HUMAN
AccessioniPrimary (citable) accession number: P35613
Secondary accession number(s): A6NJW1
, D3YLG5, Q7Z796, Q8IZL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 202 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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